4.7 Article

Formulations Based on Drug Loaded Aptamer-Conjugated Liposomes as a Viable Strategy for the Topical Treatment of Basal Cell Carcinoma-In Vitro Tests

Journal

PHARMACEUTICS
Volume 13, Issue 6, Pages -

Publisher

MDPI
DOI: 10.3390/pharmaceutics13060866

Keywords

liposomal formulation; transdermal delivery; aptamer AS1411; basal cell carcinoma

Funding

  1. Romanian Ministry of Research and Innovation, CNCS-UEFISCDI, within PNCDI III [PN-III-P4-ID-PCE-2016-0613]

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Topical liposomal drug formulations containing AS1411-aptamer conjugated liposomes were designed to deliver 5-fluorouracil to tumor sites in a sustained manner and improve patient compliance for basal cell carcinoma. In vitro evaluations showed that the optimal liposomal formulation, a crosslinked gel based on sodium alginate and hyaluronic acid, loaded with 5-fluorouracil and AS1411-aptamer, demonstrated favorable biosafety effects and potential as a new therapeutic approach for topical treatment of basal cell carcinoma.
Topical liposomal drug formulations containing AS1411-aptamer conjugated liposomes were designed to deliver in a sustained way the 5-fluorouracil to the tumor site but also to increase the compliance of patients with basal cell carcinoma. The 5-fluorouracil penetrability efficiency through the Strat-M membrane and the skin irritation potential of the obtained topical liposomal formulations were evaluated in vitro and the Korsmeyer Peppas equation was considered as the most appropriate to model the drug release. Additionally, the efficiency of cytostatic activity for targeted antitumor therapy and the hemolytic capacity were performed in vitro. The obtained results showed that the optimal liposomal formulation is a crosslinked gel based on sodium alginate and hyaluronic acid containing AS1411-aptamer conjugated liposomes loaded with 5-fluorouracil, which appeared to have favorable biosafety effects and may be used as a new therapeutic approach for the topical treatment of basal cell carcinoma.

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