Glioblastoma Multiforme-A Look at the Past and a Glance at the Future

Gliomas are the most common type of brain tumor that occur in adults and children. Glioblastoma multiforme (GBM) is the most common, aggressive form of brain cancer in adults and is universally fatal. The current standard-of-care options for GBM include surgical resection, radiotherapy, and concomitant and/or adjuvant chemotherapy. One of the major challenges that impedes success of chemotherapy is the presence of the blood-brain barrier (BBB). Because of the tightly regulated BBB, immune surveillance in the central nervous system (CNS) is poor, contributing to unregulated glioma cell growth. This review gives a comprehensive overview of the latest advances in treatment of GBM with emphasis on the significant advances in immunotherapy and novel therapeutic delivery strategies to enhance treatment for GBM.

Automated summary

Gliomas are the most common type of brain tumor in adults and children, with GBM being the most aggressive and fatal form of brain cancer. The major challenge in successful chemotherapy lies in the presence of the blood-brain barrier. The latest treatment advances focus on immunotherapy and novel therapeutic delivery strategies to enhance treatment efficacy for GBM.