Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.693814
Keywords
carbon nanotubes; malignant mesothelioma; carcinogen; nanomaterials; asbestos
Categories
Funding
- Jinan Clinical Medicine Research Program for Thoracic Cancer [201912007]
- Special Construction Project Fund for Taishan Mountain Scholars of Shandong Province
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Carbon nanotubes (CNTs) are widely used nanomaterials produced on a large scale, but exposure to them, especially one type called MWCNT-7, can cause malignant transformation. CNTs share characteristics and carcinogenic mechanisms with asbestos, highlighting the need for safer nanomaterials to reduce the hazards associated with current CNT usage.
Carbon nanotubes (CNTs) are nanomaterials with broad applications that are produced on a large scale. Animal experiments have shown that exposure to CNTs, especially one type of multi-walled carbon nanotube, MWCNT-7, can lead to malignant transformation. CNTs have characteristics similar to asbestos (size, shape, and biopersistence) and use the same molecular mechanisms and signaling pathways as those involved in asbestos tumorigenesis. Here, a comprehensive review of the characteristics of carbon nanotubes is provided, as well as insights that may assist in the design and production of safer nanomaterials to limit the hazards of currently used CNTs.
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