Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.724815
Keywords
pancreatic cancer; brain metastases; ALK Kinase; EML4-ALK fusion protein; crizotinib; alectinib
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Funding
- Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences [2019PT310026]
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This study reported a 34-year-old patient with ALK rearrangement-positive and KRAS-wild pancreatic cancer, who showed significant responses to targeted therapies after developing resistance to chemotherapy, indicating that comprehensive molecular profiling for guiding targeted therapies can significantly improve survival outcomes for a subgroup of patients with pancreatic cancer.
Patients with metastatic pancreatic cancer typically have poor prognosis due to the limited effectiveness of existing treatment options. ALK rearrangement-positive is rare in pancreatic cancer, but may occur in those with KRAS-wild type. We present a 34-year-old young man with ALK rearrangement-positive and KRAS-wild pancreatic cancer who had a remarkable response to crizotinib after resistance to prior chemotherapy and re-response to alectinib after brain metastases developed. This clinical observation suggests that comprehensive molecular profiling to guide targeted therapies is not only feasible, but also significantly improves survival outcomes for a subgroup of patients with pancreatic cancer.
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