Article
Biochemistry & Molecular Biology
Cristina Rodriguez-Diaz, Flores Martin-Reyes, Bernard Taminiau, Ailec Ho-Plagaro, Raquel Camargo, Felix Fernandez-Garcia, Jose Pinazo-Bandera, Juan Pedro Toro-Ortiz, Montserrat Gonzalo, Carlos Lopez-Gomez, Francisca Rodriguez-Pacheco, Damaris Rodriguez de los Rios, Georges Daube, Guillermo Alcain-Martinez, Eduardo Garcia-Fuentes
Summary: The composition and impact of fecal-microbe-derived extracellular vesicles (EVs) in different diseases were studied. Metagenomic profiling of feces and fecal-microbe-derived EVs revealed significant differences in microbial composition between feces and EVs in disease groups. Moreover, fecal EVs from different diseases had varying effects on the permeability of Caco-2 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Zhiyuan Cai, Ping Li, Wen Zhu, Jingyue Wei, Jieyu Lu, Xiaoyi Song, Kunwei Li, Sikai Li, Man Li
Summary: This study identified gut plasmid features associated with colorectal cancer (CRC) and demonstrated that a combination of plasmid and bacterial markers can improve the accuracy of CRC diagnosis.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Shanchao Wang, Zeyan Zhang, Qianfu Gao
Summary: In this study, it was found that cancer cell-derived extracellular vesicles (EVs) promoted colorectal cancer (CRC) progression by delivering miR-25, which targeted SIRT6. SIRT6, in turn, inhibited NRP-1 through downregulation of Lin28b. Tumor-bearing nude mouse experiments confirmed that EVs transferred miR-25 to facilitate tumor formation and metastasis by inhibiting SIRT6.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Immunology
Joyce Aarts, Annemarie Boleij, Bartijn C. H. Pieters, Anouk L. Feitsma, R. J. Joost van Neerven, Jean Paul ten Klooster, Laura M'Rabet, Onno J. Arntz, Marije I. Koenders, Fons A. J. van de Loo
Summary: Studies have shown that milk-derived EVs have anti-inflammatory effects and play a role in immune modulation by regulating the interaction between gut microbiota and host health. Milk-derived EVs have the potential to be used as a therapy for inflammatory diseases such as rheumatoid arthritis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Lingjun Tong, Haining Hao, Zhe Zhang, Youyou Lv, Xi Liang, Qiqi Liu, Tongjie Liu, Pimin Gong, Lanwei Zhang, Fangfang Cao, Giorgia Pastorin, Chuen Neng Lee, Xiaoyuan Chen, Jiong-Wei Wang, Huaxi Yi
Summary: This study demonstrates that mEVs alleviate colitis by regulating intestinal immune homeostasis via inhibiting TLR4-NF-kappa B and NLRP3 signaling pathways, restoring Treg/Th17 cell balance, and reshaping the gut microbiota. The findings suggest that mEVs have the potential to be a therapeutic approach for inflammatory bowel diseases.
Article
Gastroenterology & Hepatology
Molly Pratt, Jessica D. Forbes, Natalie C. Knox, Gary Van Domselaar, Charles N. Bernstein
Summary: Current noninvasive methods for CRC screening are not suitable for individuals with IBD. However, recent studies have shown that stool-based biomarker detection using metagenomics and other culture-independent technologies may be a promising approach for personalized, early, noninvasive CRC screening in IBD patients. More research is needed to further evaluate the performance of microbiome-based CRC classifiers.
Article
Chemistry, Analytical
Xiaohui Chen, Yun Deng, Ruyan Niu, Zixin Sun, Alya Batool, Liu Wang, Chong Zhang, Ningyu Ma, Qingtang Yang, Guoxiang Liu, Jichun Yang, Yang Luo
Summary: In this study, a Programmable Isothermal Cascade Keen Enzyme-free Reporter (PICKER) was constructed for the accurate detection of cancer-derived small extracellular vesicles (csEVs). A novel particle ratio index (PRcsEV/tsEV) was proposed as a potential indicator of breast cancer staging.
ANALYTICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Carlos M. Cuesta, Consuelo Guerri, Juan Urena, Maria Pascual
Summary: This study discusses the critical role of bacterial extracellular vesicles (EVs) from the gut in the neuropathology of brain dysfunctions by modulating the immune response, leading to neuroinflammatory immune response activation. These vesicles, containing harmful bacterial contents, can cross tissue barriers and interact with immune receptors to produce cytokines and inflammatory mediators, ultimately causing brain impairment and behavioral dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Ajay Prakash, Travis Gates, Xianda Zhao, Dechen Wangmo, Subbaya Subramanian
Summary: Despite advancements in colorectal cancer (CRC) screening, diagnosis, and treatment, immune checkpoint inhibitors (ICIs) have limited efficacy in CRC except for microsatellite-high disease. The use of tumor-derived extracellular vesicles (TEVs) as therapeutic targets in modifying CRC immunogenicity and improving ICI treatment response shows promise. Pre-clinical models have demonstrated the involvement of TEVs in antigen presentation and DNA damage signaling. Clinical trials evaluating modified TEVs are underway, indicating their potential as a therapy for CRC.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Analytical
Xiaohui Chen, Yun Deng, Ruyan Niu, Zixin Sun, Alya Batool, Liu Wang, Chong Zhang, Ningyu Ma, Qingtang Yang, Guoxiang Liu, Jichun Yang, Yang Luo
Summary: In this study, a Programmable Isothermal Cascade Keen Enzyme-free Reporter (PICKER) was constructed to accurately detect and acquire the relative abundance of cancer-derived small extracellular vesicles (csEVs) in total small extracellular vesicles (tsEVs). By integrating dual-aptamer recognition and catalytic hairpin assembly amplification, the PICKER showed a detection limit of 420 particles/μL csEVs. A novel particle ratio index of csEV against tsEV (PRcsEV/tsEV) was proposed to eliminate errors from inconsistent centrifugation. PRcsEV/tsEV value was found to increase proportionally to breast cancer stages.
ANALYTICAL CHEMISTRY
(2022)
Article
Microbiology
Siyuan Shen, Dongxue Huo, Chenchen Ma, Shuaiming Jiang, Jiachao Zhang
Summary: This study identified five potential intestinal bacteriophages as CRC biomarkers, demonstrating their high diagnostic value across different populations. The results from the validation cohort and cross-disease cohorts support the potential of these biomarkers in CRC diagnosis and gut phagotherapy.
MICROBIOLOGY SPECTRUM
(2021)
Article
Chemistry, Analytical
Xiaowei Wei, Lijun Cai, Hanxu Chen, Luoran Shang, Yuanjin Zhao, Weijian Sun
Summary: This study proposes a novel system for multiplexed analysis of bladder cancer-derived urine exosomes using magnetic microspheres as barcoded microcarriers. The unique structure of the microcarriers allows for controllable movement and high sensitivity detection of exosomes. The noninvasive nature of the platform, combined with its good sensitivity, specificity, low sample consumption, and ease of use, indicates its great potential for bladder cancer diagnosis in clinical applications.
ANALYTICAL CHEMISTRY
(2022)
Review
Immunology
Boris Vidal-Veuthey, Damariz Gonzalez, Juan P. Cardenas
Summary: This article reviews the literature on the functions of secreted proteins from the gut microbiota and discusses their impact on host physiology and health, as well as how these effects can be utilized for the development of postbiotic products.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Monika Yadav, Avinash Lomash, Seema Kapoor, Rajesh Pandey, Nar Singh Chauhan
Summary: The study utilized a multi-omic approach to investigate the role of human gut microbes in sodium benzoate metabolism, revealing the dominant microbial diversity and pathways involved. The presence of benzoate catabolic protein features in human gut microbes was identified across diverse human populations, indicating their significant role in benzoate catabolism and food-derived microbiome evolution.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Ana Maria Porras, Hao Zhou, Qiaojuan Shi, Xieyue Xiao, Randy JRI Live Cell Bank, Randy Longman, Ilana Lauren Brito
Summary: A healthy gut barrier formed by epithelial cells prevents bacteria and substances from entering the body. Inflammatory bowel disease (IBD) patients have increased protease activity in their gut microbiota, which may contribute to ECM remodeling and worsen colonic inflammation. The study discovered that some commensal bacteria in the gut can degrade human ECM in vitro, suggesting their involvement in the progression of IBD.
Article
Gastroenterology & Hepatology
Jihye Park, Jae Hee Cheon, Kang-Moon Lee, Young-Ho Kim, Byong Duk Ye, Chang Soo Eun, Sung Hyun Kim, Sun Hee Lee, Joon Ho Lee, Stefan Schreiber
Summary: This study aimed to compare the clinical efficacy and safety of CT-P13 and originator infliximab in Crohn's disease treatment. The study found a significant correlation between early serum infliximab trough levels and treatment outcomes, and there were no statistical differences in serum trough levels and anti-drug antibody levels between CT-P13 and originator infliximab.
Article
Gastroenterology & Hepatology
Yonghoon Choi, Soo In Choi, Nayoung Kim, Ryoung Hee Nam, Jae Young Jang, Hee Young Na, Cheol Min Shin, Dong Ho Lee, Huitae Min, Yeon-Ran Kim, Yeong-Jae Seok
Summary: This study aimed to investigate the response of rat colon to a high-fat diet (HFD) and the effect of Clostridium butyricum on HFD-induced intestinal inflammation and production of short-chain fatty acids (SCFAs) according to sex. The results showed that HFD significantly increased inflammation scores and fat proportions. Clostridium butyricum improved HFD-induced colonic inflammation, increased SCFA production, and enhanced the expression of tight junction proteins. These effects were more pronounced in male rats, showing a sex difference.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Hyeong Ho Jo, Nayoung Kim, Hyeon Jeong Oh, Du Hyun Song, Yonghoon Choi, Jaehyung Park, Jongchan Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Hye Seung Lee, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung Ho Kim, Ji-Won Kim, Jin Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim, Soyeon Ahn
Summary: This study examined the proportion and characteristics of mixed carcinoma in gastric cancer patients and found that mixed carcinoma is associated with lymph node metastasis. It is more common to see submucosal invasion in early gastric cancer, but less likely to have venous invasion and distant metastasis in advanced gastric cancer.
Article
Gastroenterology & Hepatology
Jihye Park, Soo Jung Park, Jae Jun Park, Tae Il Kim, Jae Hee Cheon
Summary: The study identified the long-term clinical outcomes and prognostic factors for intestinal BD. The results showed that various treatments were required during the follow-up, and certain factors were associated with poor prognosis. These findings provide guidance for physicians in monitoring and optimizing individualized treatment for patients with intestinal BD.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Tae-Han Kim, In-Ho Kim, Seung Joo Kang, Miyoung Choi, Baek-Hui Kim, Bang Wool Eom, Bum Jun Kim, Byung-Hoon Min, Chang In Choi, Cheol Min Shin, Chung Hyun Tae, Chung Sik Gong, Dong Jin Kim, Arthur Eung-Hyuck Cho, Eun Jeong Gong, Geum Jong Song, Hyeon-Su Im, Hye Seong Ahn, Hyun Lim, Hyung-Don Kim, Jae-Joon Kim, Jeong Il Yu, Jeong Won Lee, Ji Yeon Park, Jwa Hoon Kim, Kyoung Doo Song, Minkyu Jung, Mi Ran Jung, Sang-Yong Son, Shin-Hoo Park, Soo Jin Kim, Sung Hak Lee, Tae-Yong Kim, Woo Kyun Bae, Woong Sub Koom, Yeseob Jee, Yoo Min Kim, Yoonjin Kwak, Young Suk Park, Hye Sook Han, Su Youn Nam, Seong-Ho Kong
Summary: This is the fourth gastric cancer guideline published in Korea, revised in 2018 based on evidence-based approach. It is a collaborative work of an interdisciplinary working group and includes 33 updated or proposed key questions, with 40 statements developed based on systematic review. The evidence level and recommendations were categorized according to the Grading of Recommendations, Assessment, Development and Evaluation proposition. The guideline covers screening, diagnosis, staging and follow-up.
JOURNAL OF GASTRIC CANCER
(2023)
Article
Gastroenterology & Hepatology
Du Hyun Song, Nayoung Kim, Hyeong Ho Jo, Sangbin Kim, Yonghoon Choi, Hyeon Jeong Oh, Hye Seung Lee, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, So Hyun Kang, Young Suk Park, Sang-Hoon Ahn, Yun-Suhk Suh, Do Joong Park, Hyung Ho Kim, Ji-Won Kim, Keun-Wook Lee, Won Chang, Ji Hoon Park, Jin Won Kim, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim, Soyeon Ahn, Young-Joon Surh
Summary: This study aimed to identify risk factors for synchronous multiple gastric cancer (SMGC). Data from 14,603 patients with gastric cancer were analyzed, and the incidence of SMGC was found to be 4.04%, which was associated with male sex, age ≥65 years, and early gastric cancer. Unlike single gastric cancer, SMGC had a high survival rate.
Article
Gastroenterology & Hepatology
Sang Bin Kim, Nayoung Kim, Jaehyung Park, In-Chang Hwang, Seon Hee Lim, Du Hyun Song, Yonghoon Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Soyeon Ahn
Summary: This study investigated the association between Helicobacter pylori (HP) infection and coronary heart disease (CHD). The results showed that HP eradication prevented CHD, but the effect varied based on age and sex.
Article
Oncology
Eun Hyo Jin, Kyungdo Han, Cheol Min Shin, Dong Ho Lee, Seung Joo Kang, Joo Hyun Lim, Yoon Jin Choi
Summary: This study investigated the correlation between alcohol consumption in the young population and the risk of early-onset colorectal cancer (CRC). It found that moderate and heavy drinkers had a higher risk of early-onset CRC compared to light drinkers. Furthermore, there was a dose-response relationship between drinking frequency and early-onset CRC risk.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Kichul Yoon, Cheol Min Shin, Kyungdo Han, Jin Hyung Jung, Eun Hyo Jin, Joo Hyun Lim, Seung Joo Kang, Yoon Jin Choi, Dong Ho Lee
Summary: This study used the Korean National Health Insurance Service database to investigate the association between insomnia and the risk of various cancers. The results showed that insomnia was associated with an increased or decreased risk of certain cancers depending on age, cancer type, and sex.
Article
Oncology
Yoon Jin Choi, Kyungdo Han, Eun Hyo Jin, Joo Hyun Lim, Cheol Min Shin, Dong Ho Lee
Summary: Allergic diseases, such as allergic rhinitis, asthma, and atopic dermatitis, were found to reduce the risk of gastrointestinal (GI) cancers, including esophageal, stomach, colorectal, and liver cancers. This inverse association suggests that allergic diseases may have a protective effect against GI cancers, possibly through enhanced immune defenses and reduced inflammation. This finding has important implications for the prevention and treatment of GI cancers.
Article
Gastroenterology & Hepatology
Eun Jeong Gong, Hye-Kyung Jung, Bora Lee, Jitaek Hong, Jong Wook Kim, Cheol Min Shin, Young Hoon Youn, Kwang Jae Lee
Summary: This study investigated the impact of long-term proton pump inhibitor (PPI) use on metachronous gastric cancer in high-risk patients who underwent endoscopic resection of gastric neoplasms after Helicobacter pylori eradication. The results showed that long-term PPI use was associated with an increased risk of metachronous gastric cancer. These findings remained robust after sensitivity analysis and propensity score-matched analysis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Eun Hyo Jin, Yoon Jin Choi, Joo Hyun Lim, Cheol Min Shin, Kyungdo Han, Dong Ho Lee
Summary: Active control of metabolic syndrome (MetS) can reduce the risk of colorectal cancer (CRC). Individuals who recover from MetS have a lower risk of CRC compared to those with persistent MetS. Resolving high blood pressure, abdominal obesity, and blood sugar levels can prevent CRC, while normalizing lipid profile does not independently decrease CRC risk. Therefore, controlling MetS is crucial for CRC prevention.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Young Hoon Chang, Cheol Min Shin, Dong Ho Lee, Hyuk Yoon, Young Soo Park, Nayoung Kim
Summary: This study found an inverse association between H. pylori infection and EoE. Further prospective studies are needed to validate the protective effects of H. pylori infection for EoE.
KOREAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Medicine, General & Internal
Hyo-Joon Yang, Seung In Seo, Jin Lee, Cheal Wung Huh, Joon Sung Kim, Jun Chul Park, Hyunki Kim, Hakdong Shin, Cheol Min Shin, Chan Hyuk Park, Sang Kil Lee
Summary: Significant translational research advances have been made in the upper gastrointestinal (GI) research field in recent years. Endoscopic evaluation is a reasonable option for acquiring upper GI tissue for research purposes with minimal risk. The optimal number of biopsy samples and sample storage is crucial and might influence results. Few reports have been published on methods for sample collection from endoscopic biopsies. This review provides a protocol for collecting study samples for upper GI research, including microbiome, DNA, RNA, protein, single-cell RNA sequencing, and organoid culture, through a comprehensive literature review. Different methods and sample sizes are recommended for different types of analysis.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Correction
Oncology
Tae-Han Kim, In-Ho Kim, Seung Joo Kang, Miyoung Choi, Baek-Hui Kim, Bang Wool Eom, Bum Jun Kim, Byung-Hoon Min, Chang In Choi, Cheol Min Shin, Chung Hyun Tae, Chung Sik Gong, Dong Jin Kim, Arthur Eung-Hyuck Cho, Eun Jeong Gong, Geum Jong Song, Hyeon-Su Im, Hye Seong Ahn, Hyun Lim, Hyung-Don Kim, Jae-Joon Kim, Jeong Il Yu, Jeong Won Lee, Ji Yeon Park, Jwa Hoon Kim, Kyoung Doo Song, Minkyu Jung, Mi Ran Jung, Sang-Yong Son, Shin-Hoo Park, Soo Jin Kim, Sung Hak Lee, Tae-Yong Kim, Woo Kyun Bae, Woong Sub Koom, Yeseob Jee, Yoo Min Kim, Yoonjin Kwak, Young Suk Park, Hye Sook Han, Su Youn Nam, Seong-Ho Kong
JOURNAL OF GASTRIC CANCER
(2023)
