The Anti-Non-Small Cell Lung Cancer Cell Activity by a mTOR Kinase Inhibitor PQR620

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting the PI3K/Akt/mTOR pathway in non‐small cell lung cancer (NSCLC)

(2020) Aaron C. Tan   Thoracic Cancer

MicroRNA-4651 targets bromodomain-containing protein 4 to inhibit non-small cell lung cancer cell progression

(2020) Jiangnan Zheng et al.   CANCER LETTERS

The therapeutic value of SC66 in human renal cell carcinoma cells

(2020) Ming Xu et al.   Cell Death & Disease

SphK1 promotes development of non‑small cell lung cancer through activation of STAT3

(2020) Yuefeng Ma et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Sphingosine kinase‑1 predicts overall survival outcomes in non‑small cell lung cancer patients treated with carboplatin and navelbine

(2019) Mariam Gachechiladze et al.   Oncology Letters

The Novel TORC1/2 Kinase Inhibitor PQR620 Has Anti-Tumor Activity in Lymphomas as a Single Agent and in Combination with Venetoclax

(2019) Chiara Tarantelli et al.   Cancers

Systemic Therapy for Locally Advanced and Metastatic Non–Small Cell Lung Cancer

(2019) Kathryn C. Arbour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prognostic roles of the expression of sphingosine-1-phosphate metabolism enzymes in non-small cell lung cancer

(2019) Yingqin Wang et al.   Translational Lung Cancer Research

Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD

(2019) Elisabeth Singer et al.   NEUROPHARMACOLOGY

Long non-coding RNA EPIC1 promotes human lung cancer cell growth

(2018) Bing Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

(2018) Claudia Brandt et al.   NEUROPHARMACOLOGY

Circular RNA HIPK3 exerts oncogenic properties through suppression of miR-124 in lung cancer

(2018) Hanqing Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders

(2018) Denise Rageot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triptonide inhibits human nasopharyngeal carcinoma cell growth via disrupting Lnc-RNA THOR-IGF2BP1 signaling

(2018) Shu-sheng Wang et al.   CANCER LETTERS

MIND4-17 protects retinal pigment epithelium cells and retinal ganglion cells from UV

(2017) Chaopeng Li et al.   Oncotarget

Long noncoding RNAs: new insights into non-small cell lung cancer biology, diagnosis and therapy

(2016) Biagio Ricciuti et al.   MEDICAL ONCOLOGY

The anti-ovarian cancer activity by WYE-132, a mTORC1/2 dual inhibitor

(2015) Dan Zhang et al.   TUMOR BIOLOGY

Epithelial mesenchymal transition of non–small–cell lung cancer cells A549 induced by SPHK1

(2015) Min Ni et al.   Asian Pacific Journal of Tropical Medicine

mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling

(2014) Huiyuan Zhang et al.   APOPTOSIS

Targeting PI3K/AKT/mTOR pathway in non small cell lung cancer

(2014) Claudia Fumarola et al.   BIOCHEMICAL PHARMACOLOGY

Antitumor activity of selective MEK1/2 inhibitor AZD6244 in combination with PI3K/mTOR inhibitor BEZ235 in gefitinib-resistant NSCLC xenograft models

(2014) Yiqing Qu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Phase I Safety and Pharmacokinetic Study of the PI3K/mTOR Inhibitor SAR245409 (XL765) in Combination with Erlotinib in Patients with Advanced Solid Tumors

(2014) Pasi A. Jänne et al.   Journal of Thoracic Oncology

Sphingosine kinase 1 enhances the invasion and migration of non-small cell lung cancer cells via the AKT pathway

(2014) LIANGMING ZHU et al.   ONCOLOGY REPORTS

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

(2013) Kurt G. Pike et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bortezomib-induced apoptosis in cultured pancreatic cancer cells is associated with ceramide production

(2013) Lei Gong et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

mTOR inhibitors in cancer therapy

(2012) Yekaterina Y. Zaytseva et al.   CANCER LETTERS

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

mTOR Signaling Pathway and mTOR Inhibitors in Cancer Therapy

(2012) Alejandro Gomez-Pinillos et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Sphingosine Kinase-1 Enhances Resistance to Apoptosis through Activation of PI3K/Akt/NF- B Pathway in Human Non-Small Cell Lung Cancer

(2011) L. Song et al.   CLINICAL CANCER RESEARCH

Curcumin Induces Small Cell Lung Cancer NCI-H446 Cell Apoptosis via the Reactive Oxygen Species-Mediated Mitochondrial Pathway and Not the Cell Death Receptor Pathway

(2011) Cheng-Liang Yang et al.   DNA AND CELL BIOLOGY

First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

(2011) Timothy A. Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

Pushing the Envelope in the mTOR Pathway: The Second Generation of Inhibitors

(2011) E. Vilar et al.   MOLECULAR CANCER THERAPEUTICS

Current development of the second generation of mTOR inhibitors as anticancer agents

(2011) Hong-Yu Zhou et al.   Chinese Journal of Cancer

Paradigm of kinase-driven pathway downstream of epidermal growth factor receptor/Akt in human lung carcinomas

(2010) Yoh Dobashi et al.   HUMAN PATHOLOGY

Activation status of receptor tyrosine kinase downstream pathways in primary lung adenocarcinoma with reference of KRAS and EGFR mutations

(2010) Miyako Hiramatsu et al.   LUNG CANCER

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

Multi-walled carbon nanotubes induce oxidative stress and apoptosis in human lung cancer cell line-A549

(2010) Ritesh K Srivastava et al.   Nanotoxicology

mTOR signaling and drug development in cancer

(2010) Janet Dancey   Nature Reviews Clinical Oncology

Critical and diverse involvement of Akt/mammalian target of rapamycin signaling in human lung carcinomas

(2008) Yoh Dobashi et al.   CANCER