Putative Repurposing of Lamivudine, a Nucleoside/Nucleotide Analogue and Antiretroviral to Improve the Outcome of Cancer and COVID-19 Patients

Prophylactic antiviral therapy for HBsAg‐positive patients with DLBCL treated with rituximab‐containing chemotherapy

(2021) Nobuhiko Yamauchi et al.   CANCER SCIENCE

Structural insight into the binding interactions of NTPs and nucleotide analogues to RNA dependent RNA polymerase of SARS-CoV-2

(2021) Shruti Koulgi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Hepatitis B virus induces sorafenib resistance in liver cancer via upregulation of cIAP2 expression

(2021) Shouhua Zhang et al.   Infectious Agents and Cancer

A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase

(2021) Suliman Khan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

(2020) Calvin J Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-HCV, nucleotide inhibitors, repurposing against COVID-19

(2020) Abdo A. Elfiky   LIFE SCIENCES

Mitochondrial toxicity and body shape changes during nucleos(t)ide analogues administration in patients with chronic hepatitis B

(2020) Giordano Madeddu et al.   Scientific Reports

Repurposed anti-cancer drugs: the future for anti-infective therapy?

(2020) Héctor Quezada et al.   Expert Review of Anti-Infective Therapy

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

(2020) Yan Gao et al.   SCIENCE

Drug treatment options for the 2019-new coronavirus (2019-nCoV)

(2020) Hongzhou Lu   BioScience Trends

COVID-19 in patients with HIV: clinical case series

(2020) Jose L Blanco et al.   Lancet HIV

Incidence and Severity of COVID-19 in HIV-Positive Persons Receiving Antiretroviral Therapy

(2020) Julia del Amo et al.   ANNALS OF INTERNAL MEDICINE

Antiretrovirals and risk of COVID-19 diagnosis and hospitalization in HIV-positive persons

(2020) Julia del Amo et al.   EPIDEMIOLOGY

Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase, a Key Drug Target for COVID-19

(2020) Minchen Chien et al.   JOURNAL OF PROTEOME RESEARCH

Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study

(2020) Abdo A. Elfiky   LIFE SCIENCES

Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic

(2020) Rodrigo Jácome et al.   Scientific Reports

Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses

(2020) E. Susan Amirian et al.   One Health

Effects of Reverse Transcriptase Inhibitors on Proliferation, Apoptosis, and Migration in Breast Carcinoma Cells

(2020) Zülal Atlı Şekeroğlu et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

In vitro cytotoxicity studies of smart pH-sensitive lamivudine-loaded CaAl-LDH magnetic nanoparticles against Mel-Rm and A-549 cancer cells

(2020) Nahid Shahabadi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Click-Free Synthesis of a Multivalent Tricyclic Peptide as a Molecular Transporter

(2020) Sumit Kumar et al.   Pharmaceutics

The dual protease inhibitor lopinavir/ritonavir (LPV/r) exerts genotoxic stress on lung cells

(2020) Rahaba Marima et al.   BIOMEDICINE & PHARMACOTHERAPY

Inhibitory potential of repurposed drugs against the SARS-CoV-2 main protease: a computational-aided approach

(2020) Adewale Oluwaseun Fadaka et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Virtual screening and molecular dynamics study of approved drugs as inhibitors of spike protein S1 domain and ACE2 interaction in SARS-CoV-2

(2020) Manisha Prajapat et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Non-Steroidal Anti-Inflammatory Drugs Increase Cisplatin, Paclitaxel, and Doxorubicin Efficacy against Human Cervix Cancer Cells

(2020) Diana Xochiquetzal Robledo-Cadena et al.   Pharmaceuticals

Targeting the Viral Polymerase of Diarrhea-Causing Viruses as a Strategy to Develop a Single Broad-Spectrum Antiviral Therapy

(2019) Marcella Bassetto et al.   Viruses-Basel

Repurposing drugs as pro‐oxidant redox modifiers to eliminate cancer stem cells and improve the treatment of advanced stage cancers

(2019) Stephen J. Ralph et al.   MEDICINAL RESEARCH REVIEWS

Nucleoside Analogues as Antibacterial Agents

(2019) Jessica M. Thomson et al.   Frontiers in Microbiology

Nucleos(t)ide Analogues for Reducing Hepatocellular Carcinoma in Chronic Hepatitis B Patients: A Systematic Review and Meta-Analysis

(2019) Xinhui Wang et al.   Gut and Liver

Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV‐1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine

(2019) Nicole Bertoletti et al.   PROTEIN SCIENCE

Twenty-Five Years of Lamivudine

(2018) Romina Quercia et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

(2017) Dustin Siegel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lamivudine versus entecavir in the rescue of chemotherapy-induced hepatitis B flare-up

(2017) Yi-Jun Liao et al.   Journal of the Chinese Medical Association

Cysteine and arginine-rich peptides as molecular carriers

(2016) Amir Nasrolahi Shirazi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Zidovudine, abacavir and lamivudine increase the radiosensitivity of human esophageal squamous cancer cell lines

(2016) XUAN CHEN et al.   ONCOLOGY REPORTS

Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation

(2016) Bo Shu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerability of Tenofovir-Lamivudine-Rilpivirine as the Human Immunodeficiency Virus (HIV) Occupational Post-exposure Prophylaxis For HIV Infection

(2016) Vee Chavapong et al.   Open Forum Infectious Diseases

Structural Analysis of Monomeric RNA-Dependent Polymerases: Evolutionary and Therapeutic Implications

(2015) Rodrigo Jácome et al.   PLoS One

Inhibition of Telomerase Activity by Human Immunodeficiency Virus (HIV) Nucleos(t)ide Reverse Transcriptase Inhibitors: A Potential Factor Contributing to HIV-Associated Accelerated Aging

(2013) Edwin Leeansyah et al.   JOURNAL OF INFECTIOUS DISEASES

Mitochondrial DNA Depletion Syndromes: Review and Updates of Genetic Basis, Manifestations, and Therapeutic Options

(2013) Ayman W. El-Hattab et al.   Neurotherapeutics

Combination antiretroviral therapy as treatment for human immunodeficiency virus-associated mucosa-associated lymphoid tissue type lymphoma of the nasopharynx

(2011) R. Varma et al.   INTERNAL MEDICINE JOURNAL

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

(2010) Eisuke Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus

(2010) Michael J. Sofia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

(2010) P. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of HAART in 254 consecutive patients with AIDS-related Kaposiʼs sarcoma

(2009) Mark Bower et al.   AIDS

Another ten stories in antiviral drug discovery (part C): “Old” and “new” antivirals, strategies, and perspectives

(2009) Erik De Clercq   MEDICINAL RESEARCH REVIEWS

Mechanism of Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase by a Stavudine Analogue, 4'-Ethynyl Stavudine Triphosphate

(2008) G. Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY