Human Microcephaly Protein RTTN Is Required for Proper Mitotic Progression and Correct Spindle Position

Loss of CPAP in developing mouse brain and its functional implication in human primary microcephaly

(2020) Yi-Nan Lin et al.   JOURNAL OF CELL SCIENCE

Heterogeneous clinical phenotypes and cerebral malformations reflected by rotatin cellular dynamics

(2019) Laura V Vandervore et al.   BRAIN

The Genetics of Primary Microcephaly

(2018) Divya Jayaraman et al.   Annual Review of Genomics and Human Genetics

Functional characterization of biallelic RTTN variants identified in an infant with microcephaly, simplified gyral pattern, pontocerebellar hypoplasia, and seizures

(2018) Jennifer A. Wambach et al.   PEDIATRIC RESEARCH

A neuropathological study of novel RTTN gene mutations causing a familial microcephaly with simplified gyral pattern

(2018) Suzanne Chartier et al.   Birth Defects Research

p53 deletion rescues lethal microcephaly in a mouse model with neural stem cell abscission defects

(2018) Jessica Neville Little et al.   HUMAN MOLECULAR GENETICS

Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles

(2017) Hsin-Yi Chen et al.   Nature Communications

Expanding the phenotype of RTTN variations: a new family with primary microcephaly, severe growth failure, brain malformations and dermatitis

(2016) A. Grandone et al.   CLINICAL GENETICS

The Mother Centriole Appendage Protein Cenexin Modulates Lumen Formation through Spindle Orientation

(2016) Hui-Fang Hung et al.   CURRENT BIOLOGY

Mutations in the murine homologue ofTUBB5cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis

(2016) Martin Breuss et al.   DEVELOPMENT

Regulation of mitotic spindle orientation: an integrated view

(2016) Florencia di Pietro et al.   EMBO REPORTS

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate

(2016) Divya Jayaraman et al.   NEURON

Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis

(2016) En-Ju Chou et al.   Cell Reports

NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures

(2016) Lindsey Seldin et al.   eLife

RTTN Mutations Cause Primary Microcephaly and Primordial Dwarfism in Humans

(2015) Hanan Shamseldin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Centrosome function and assembly in animal cells

(2015) Paul T. Conduit et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination

(2015) Marko Marjanović et al.   Nature Communications

Cortical neurogenesis in the absence of centrioles

(2014) Ryan Insolera et al.   NATURE NEUROSCIENCE

Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo

(2014) H. Bazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size

(2014) Jian-Fu Chen et al.   Nature Communications

Interaction of NuMA protein with the kinesin Eg5: its possible role in bipolar spindle assembly and chromosome alignment

(2013) Yuko Iwakiri et al.   BIOCHEMICAL JOURNAL

Mechanisms of spindle positioning: cortical force generators in the limelight

(2013) Sachin Kotak et al.   CURRENT OPINION IN CELL BIOLOGY

Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly

(2013) Yu-Chih Lin et al.   EMBO JOURNAL

CEP120 interacts with CPAP and positively regulates centriole elongation

(2013) Yi-Nan Lin et al.   JOURNAL OF CELL BIOLOGY

Evidence for dynein and astral microtubule–mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells

(2013) Zhen Zheng et al.   MOLECULAR BIOLOGY OF THE CELL

RTTN Mutations Link Primary Cilia Function to Organization of the Human Cerebral Cortex

(2012) Sima Kheradmand Kia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Spindle orientation in mammalian cerebral cortical development

(2012) Madeline A Lancaster et al.   CURRENT OPINION IN NEUROBIOLOGY

What disorders of cortical development tell us about the cortex: one plus one does not always make two

(2011) M Chiara Manzini et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

(2011) Chieh-Ju C Tang et al.   EMBO JOURNAL

Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL

(2011) D. Kitagawa et al.   JOURNAL OF CELL SCIENCE

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

(2011) Erich A. Nigg et al.   NATURE CELL BIOLOGY

A primary microcephaly protein complex forms a ring around parental centrioles

(2011) Joo-Hee Sir et al.   NATURE GENETICS

Building the Centriole

(2010) Juliette Azimzadeh et al.   CURRENT BIOLOGY

Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors

(2010) S. B. Lizarraga et al.   DEVELOPMENT

Asterless is a scaffold for the onset of centriole assembly

(2010) Nikola S. Dzhindzhev et al.   NATURE

Control of Centriole Length by CPAP and CP110

(2009) Thorsten I. Schmidt et al.   CURRENT BIOLOGY

Overly Long Centrioles and Defective Cell Division upon Excess of the SAS-4-Related Protein CPAP

(2009) Gregor Kohlmaier et al.   CURRENT BIOLOGY

Ana3 is a conserved protein required for the structural integrity of centrioles and basal bodies

(2009) Naomi R. Stevens et al.   JOURNAL OF CELL BIOLOGY

Requirements for NuMA in maintenance and establishment of mammalian spindle poles

(2009) Alain D. Silk et al.   JOURNAL OF CELL BIOLOGY

CPAP is a cell-cycle regulated protein that controls centriole length

(2009) Chieh-Ju C. Tang et al.   NATURE CELL BIOLOGY

Primary microcephaly: do all roads lead to Rome?

(2009) Gemma K. Thornton et al.   TRENDS IN GENETICS