Article
Pathology
Svenja Kolb, Inga Hoffmann, Nanna Monje, Mihnea P. Dragomir, Paul Jank, Philip Bischoff, Carlotta Keunecke, Jonathan Pohl, Catarina Alisa Kunze, Sofya Marchenko, Wolfgang D. Schmitt, Hagen Kulbe, Christine Sers, Jalid Sehouli, Elena Ioana Braicu, Carsten Denkert, Silvia Darb-Esfahani, David Horst, Bruno V. Sinn, Eliane T. Taube
Summary: This study highlights the significant prognostic role of the LRP1B protein in tubo-ovarian high-grade serous carcinoma, showing that its high expression is associated with prolonged overall survival and progression-free survival in patients.
Article
Oncology
Katherine I. Foster, Kenna R. M. Shaw, Jeff Jin, Shannon N. Westin, Timothy A. Yap, Deanna M. Glassman, Amir A. Jazaeri, Jose A. Rauh-Hain, Sanghoon Lee, Bryan M. Fellman, Zhenlin Ju, Yuexin Liu, Nicole D. Fleming, Anil K. Sood
Summary: This study assessed the clinical relevance of tumor-based next-generation sequencing in patients with ovarian cancer. It found that tumor-based next-generation sequencing often provides clinically relevant information, helping to identify therapeutic targets and guide the development of clinical decision support tools.
Article
Oncology
Puja Dey, Kentaro Nakayama, Sultana Razia, Masako Ishikawa, Tomoka Ishibashi, Hitomi Yamashita, Kosuke Kanno, Seiya Sato, Tohru Kiyono, Satoru Kyo
Summary: This study successfully developed an in vitro carcinogenic model of LGSOCs and found that the mutations of KRAS and PIK3CA play a causative role in LGSOC tumorigenesis. Simultaneous activation of the KRAS/ERK and PIK3CA/AKT signaling pathways is essential for LGSOC development.
Article
Oncology
Rachel Topno, Ibha Singh, Manoj Kumar, Pallavi Agarwal
Summary: The study identified UBE2Q1 as a potential prognostic marker associated with poor relapse-free survival and response outcome to platin/taxane treatment in patients with high grade serous ovarian cancer.
Review
Biochemistry & Molecular Biology
Paula Punzon-Jimenez, Victor Lago, Santiago Domingo, Carlos Simon, Aymara Mas
Summary: High-grade serous ovarian carcinoma (HGSOC) is the most common form of epithelial ovarian carcinoma, and its early diagnosis still relies on traditional methods. Research on its etiopathogenesis provides new insights for finding early detection methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jesus Gonzalez-Bosquet, Nicholas D. D. Cardillo, Henry D. D. Reyes, Brian J. J. Smith, Kimberly K. K. Leslie, David P. P. Bender, Michael J. J. Goodheart, Eric J. J. Devor
Summary: Prediction models based on genomic variation can accurately discriminate high grade serous ovarian cancer from benign tissue. Further refining of these models has the potential to detect ovarian cancer in blood with cell free DNA, even in early stage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Qian Hao, Jiajia Li, Qinghua Zhang, Fei Xu, Bangxiang Xie, Hua Lu, Xiaohua Wu, Xiang Zhou
Summary: This study using single-cell transcriptomics analysis of HGSOC samples reveals new molecular features and potential therapeutic targets, which could advance the understanding and treatment of the disease.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Suhyun Hwangbo, Se Ik Kim, Ju-Hyun Kim, Kyung Jin Eoh, Chanhee Lee, Young Tae Kim, Dae-Shik Suh, Taesung Park, Yong Sang Song
Summary: The study aimed to develop machine learning models predicting platinum sensitivity in patients with high-grade serous ovarian carcinoma (HGSOC). Six variables associated with platinum sensitivity were selected using clinical data from multiple hospitals, and the LR-based model was found to perform the best. A web-based nomogram was developed for clinical use based on the LR model results.
Article
Oncology
C. J. H. Kramer, L. Lanjouw, D. Ruano, A. ter Elst, G. Santandrea, N. Solleveld-Westerink, N. Werner, A. H. van Der Hout, C. D. de Kroon, T. van Wezel, L. P. Berger, M. Jalving, J. Wesseling, V. T. H. B. M. Smit, G. H. de Bock, C. J. van Asperen, M. J. E. Mourits, M. P. G. Vreeswijk, J. Bart, T. Bosse
Summary: This study analyzed the causal BRCA1/2 gene variants in different types of ovarian cancer tissues. The results showed that except for high-grade serous ovarian carcinoma, there were minimal BRCA1/2 PVs in other types of ovarian cancer. The study also identified some potentially misdiagnosed cases and conducted in-depth analysis of the pathogenic mechanism of BRCA1/2 variants. These findings suggest that histotype-directed sequencing may be more informative than universal sequencing.
JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Andreea Newtson, Henry Reyes, Eric J. Devor, Michael J. Goodheart, Jesus Gonzalez Bosquet
Summary: The study revealed a higher number of fusion transcripts in high grade serous ovarian cancer compared to normal fallopian tubes, with certain fusion transcripts significantly associated with overall survival. Validation was conducted using various analytical platforms and algorithms to identify fusion transcripts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jesus Machuca-Aguado, Antonio Felix Conde-Martin, Alejandro Alvarez-Munoz, Enrique Rodriguez-Zarco, Alfredo Polo-Velasco, Antonio Rueda-Ramos, Rosa Rendon-Garcia, Juan Jose Rios-Martin, Miguel A. Idoate, Apostolos Zaravinos
Summary: This study utilized a machine learning system to classify and quantify tumor-infiltrating lymphocytes in high-grade serous ovarian carcinoma (HGSOC) patients, and correlated the results with patient survival. The results showed that intense colonization of tumor cords by TILs was associated with a better prognosis. Furthermore, the concentration of intraepithelial TILs was found to be an independent prognostic factor for overall survival and progression-free survival. Additionally, a synergistic effect was observed between complete surgical cytoreduction and high levels of intraepithelial TILs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Marko Hojnik, Natasa Kenda Suster, Spela Smrkolj, Damjan Sisinger, Snjezana Frkovic Grazio, Ivan Verdenik, Tea Lanisnik Rizner
Summary: This study evaluated the levels of AKR1B1 and AKR1B10 in patients with high-grade serous ovarian cancer and their association with clinicopathological characteristics, survival, and response to chemotherapy. The results showed that higher AKR1B1 levels were associated with better disease-free survival, making it a potential prognostic biomarker for this cancer. However, AKR1B1 and AKR1B10 were not associated with different responses to chemotherapy.
Article
Genetics & Heredity
Ju-Won Kim, Sewha Kim, So-Yun Yang, Je-Gun Joung, Sohyun Hwang
Summary: This study analyzed the TCR repertoire and its prognostic significance in 51 patients with HGSOC. The results showed that TCR diversity was associated with immune response, and patients with recurrence had lower TCR diversity and the expansion of eight TCR segments. Additionally, several genes correlated with TCRs showed differences in expression according to the prognosis. The study suggests that the differences in TCR repertoire and associated immune pathways could affect the prognosis of HGSOC.
Article
Oncology
Li Zhao, Sara Corvigno, Shaolin Ma, Joseph Celestino, Nicole D. Fleming, Richard A. Hajek, Adrian Lankenau Ahumada, Nicholas B. Jennings, Erika J. Thompson, Hongli Tang, Shannon N. Westin, Amir A. Jazaeri, Jianhua Zhang, P. Andrew Futreal, Anil K. Sood, Sanghoon Lee
Summary: This study aimed to investigate if a simple blood sample can predict the response of ovarian cancer patients to treatment. The results showed that circulating extracellular vesicles isolated at diagnosis can distinguish between patients who will respond differently to the treatment, potentially serving as a novel predictive marker.
Article
Multidisciplinary Sciences
Leslie Calapre, Tindaro Giardina, Aaron B. B. Beasley, Anna L. L. Reid, Colin Stewart, Benhur Amanuel, Tarek M. M. Meniawy, Elin S. S. Gray
Summary: This study compared the suitability of the Accel and Oncomine panels for identification of TP53 mutations in ctDNA of HGSOC patients. Results showed that only 60% of patients were found to have TP53 mutations using the Accel panel, but the addition of molecular tags in the Oncomine panel improved ctDNA detection with at least one mutation detected in all cases. Orthogonal validation using droplet digital PCR confirmed 79% of the identified mutations. Overall, the Oncomine panel with unique molecular identifiers (UMI) appears more useful for ctDNA analysis in HGSOC.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ah-Young Kwon, Ju-Yeon Jeong, Hyun Park, Sohyun Hwang, Gwangil Kim, Haeyoun Kang, Jin-Hyung Heo, Hye Jin Lee, Tae-Heon Kim, Hee Jung An
Summary: Alterations in miRNA expression are associated with cervical SqCC and metastasis, and miR-30e-5p may serve as an independent poor prognostic factor for survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Eunhyang Park, Hyunho Han, Sung-Eun Choi, Hyunjin Park, Ha-Young Woo, Mi Jang, Hyo-Sup Shim, Sohyun Hwang, Haeyoun Kang, Nam-Hoon Cho
Summary: This study analyzed TP53 gene mutations in a total of 236 cases of ovarian HGSCa and found that both mutation types and IHC patterns of p53 are important sources of information to provide a precise diagnosis of HGSCa. Approximately 9% of the cases showed mismatching results between sequencing and IHC, mainly in the p53 c-terminal encoding nuclear localization signal and oligomerization domain, which affected the subcellular locations of the p53 protein.