Article
Immunology
Monica S. Sierra, Sabrina H. Tsang, Shangying Hu, Carolina Porras, Rolando Herrero, Aimee R. Kreimer, John Schussler, Joseph Boland, Sarah Wagner, Bernal Cortes, Ana C. Rodriguez, Wim Quint, Leen-Jan van Doorn, Mark Schiffman, Joshua N. Sampson, Allan Hildesheim
Summary: The study found that age and sexual behavior variables were associated with acquisition of oncogenic non-HPV-16/18 infections among HPV-vaccinated women, while no notable factors were associated with persistence of acquired infections. Factors such as age, parity, and hormonally related exposures were associated with progression to CIN2+ among the same group of women.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Giorgio Bogani, Barbara Gardella, Ermelinda Monti, Carlo Antonio Liverani, Alessandro Ghelardi, Salvatore Insinga, Michele Montanari, Francesco Raspagliesi, Arsenio Spinillo, Paolo Vercellini, Elena Roncella, Andrea Ciavattini
Summary: The study found a decreasing trend in HPV 16/18 prevalence in women with CIN3 over the years, indicating the herd effect of the HPV vaccine, but the increase in high-risk HPV genotypes must be closely monitored.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Biology
Gulzhanat Aimagambetova, Aisha Babi, Alpamys Issanov, Sholpan Akhanova, Natalya Udalova, Svetlana Koktova, Askhat Balykov, Zhanna Sattarkyzy, Zhuldyz Abakasheva, Azliyati Azizan, Chee Kai Chan, Torgyn Issa
Summary: This study focused on the prevalence of high-risk human papilloma virus (HR-HPV) infection types, other than HPV-16 and -18, in women throughout Kazakhstan. The results showed that HPV-31 was the most prevalent in single infections and HPV-68 in multiple infections among women in Kazakhstan. Introducing HR-HPV testing into cervical cancer screening programs could help reduce rates of cervical cancer in the country.
Article
Virology
Fabio Bottari, Anna Daniela Iacobone, Davide Radice, Eleonora Petra Preti, Mario Preti, Dorella Franchi, Andrea Fausto Piana, Maria Teresa Sandri, Rita Passerini
Summary: The study evaluated the performance of the Seegene Anyplex II HPV HR (Anyplex) assay in detecting cervical intraepithelial lesions (CIN) and in post-treatment follow-up, showing potential value in HPV detection and genotyping for stratifying high-risk women and monitoring treatment outcomes for CIN2+ lesions.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Giorgio Bogani, Luca Lalli, Francesco Sopracordevole, Andrea Ciavattini, Alessandro Ghelardi, Tommaso Simoncini, Francesco Plotti, Jvan Casarin, Maurizio Serati, Ciro Pinelli, Alice Bergamini, Barbara Gardella, Andrea Dell'Acqua, Ermelinda Monti, Paolo Vercellini, Innocenza Palaia, Giorgia Perniola, Margherita Fischetti, Giusi Santangelo, Alice Fracassi, Giovanni D'Ippolito, Lorenzo Aguzzoli, Vincenzo Dario Mandato, Luca Giannella, Cono Scaffa, Francesca Falcone, Chiara Borghi, Mario Malzoni, Andrea Giannini, Maria Giovanna Salerno, Viola Liberale, Biagio Contino, Cristina Donfrancesco, Michele Desiato, Anna Myriam Perrone, Giulia Dondi, Pierandrea De Iaco, Simone Ferrero, Giuseppe Sarpietro, Maria G. Matarazzo, Antonio Cianci, Stefano Cianci, Sara Bosio, Simona Ruisi, Lavinia Mosca, Raffaele Tinelli, Rosa De Vincenzo, Gian Franco Zannoni, Gabriella Ferrandina, Marco Petrillo, Giampiero Capobianco, Salvatore Dessiole, Annunziata Carlea, Fulvio Zullo, Barbara Muschiato, Stefano Palomba, Stefano Greggi, Arsenio Spinillo, Fabio Ghezzi, Nicola Colacurci, Roberto Angioli, Pierluigi Benedetti Panici, Ludovico Muzii, Giovanni Scambia, Francesco Raspagliesi, Violante Di Donato
Summary: In this study, a prognostic nomogram was developed to assess the risk of cervical dysplasia persistence/recurrence after primary conization. Variables such as diagnosis of CIN3, presence of high-risk HPV types, positive endocervical margins, HPV persistence, and omission of HPV vaccination after conization were found to significantly increase the risk of cervical dysplasia persistence/recurrence. The nomogram can be a useful tool for counseling women about their risk and the importance of HPV vaccination after conization.
Article
Multidisciplinary Sciences
Jorge Alejandro Basiletti, Joan Valls, Tomas Poklepovich, Maria Dolores Fellner, Maryluz Rol, Rafael Alonso, Rita Mariel Correa, Maria Celeste Colucci, Mercedes Rodriguez de la Pena, Paula Gabriela Falabella, Agustina Saino, Josefina Campos, Rolando Herrero, Maribel Almonte, Maria Alejandra Picconi
Summary: Sensitive and specific genotyping of HPV is crucial for vaccine surveillance. This study used Nested-PCR and NGS to identify HPV genotypes in cervical samples, and found that multiple infections were more common in ≤CIN1 cases, while high-risk HPV genotypes were predominant in CIN3+ cases.
Article
Immunology
Frederique J. Vink, Chris J. L. M. Meijer, Albertus T. Hesselink, Arno N. Floore, Birgit Lissenberg-Witte, Jesper H. Bonde, Helle Pedersen, Kate Cuschieri, Ramya Bhatia, Mario Poljak, Anja Ostrbenk Valencak, Peter Hillemanns, Wim G. Quint, Marta del Pino, Gemma G. Kenter, Renske D. M. Steenbergen, Danielle A. M. Heideman, Maaike C. G. Bleeker
Summary: The FAM19A4/miR124-2 methylation test can detect nonproductive, transforming CIN2/3 lesions with high specificity in HPV-positive women under 30 years old, providing valuable information for treatment decisions.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Oncology
Hui-Fang Xu, Yin Liu, Yan-Lin Luo, Dong-Mei Zhao, Man-Man Jia, Pei-Pei Chen, Meng-Jie Li, Xing-Ai Sun, Shu-Zheng Liu, Xi-Bin Sun, Shao-Kai Zhang
Summary: This study evaluated the clinical performance and utility of DH3 HPV assay in women with NILM cytology. The results showed that HPV 16/18 positive women had the highest risk of developing CIN2+, with a significantly higher relative risk compared to other groups.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Heike Hoyer, Grit Mehlhorn, Cornelia Scheungraber, Ingke Hagemann, Christine Hirchenhain, Linn Woelber, Claudia Stolte, Monika Hampl, Sarah Scherbring, Agnieszka Denecke, Janina Bartels, Andreas D. Ebert, Sabina Meneder, Annett Petzold, Tabitha Heller, Karsten R. Heidtke, Elisabeth Schwarz, Frederik Stubs, Stefanie Schutze, Eva-Lena Stange, Anna Jaeger, Franca Martignoni, Ansgar Dellmann, Achim Rody, Peter Hillemanns, Tanja Fehm, Karl-Ulrich Petry, Gerd Boehmer, Barbara Schmalfeldt, Pauline Wimberger, Matthias W. Beckmann, Ingo B. Runnebaum, Matthias Duerst
Summary: HPV-DNA integration into the host genome is important in cervical carcinogenesis, but integration sites as individualized biomarkers cannot detect all recurrent pre-cancers. The integration frequency in CIN3 was lower than expected, and integrated HPV-DNA in CIN3 is likely confined to clonally expanding subpopulations.
Article
Health Care Sciences & Services
Rita Reyburn, Evelyn Tuivaga, Tupou Ratu, Seruwaia Young, Suzanne M. Garland, Gerald Murray, Alyssa Cornall, Sepehr Tabrizi, Cattram D. Nguyen, Kylie Jenkins, Lisi Tikoduadua, Joseph Kado, Mike Kama, Eric Rafai, Rachel Devi, Kim Mulholland, James Fong, Fiona M. Russell
Summary: Fiji vaccinated >30,000 girls aged 9-12 with 4vHPV vaccine in 2008/9, and the vaccine coverage was >60%. The vaccine effectiveness of one, two, and three doses of 4vHPV against oncogenic HPV genotypes 16/18 eight years later was 81%, 100%, and 89% respectively.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Immunology
Brittney L. Dickey, Anna R. Giuliano, Bradley Sirak, Martha Abrahamsen, Eduardo Lazcano-Ponce, Luisa L. Villa, Anna E. Coghill
Summary: Detection of oral EBV shedding is associated with the persistence of oral HPV16/18 infection, and may serve as a biomarker for oral HPV persistence.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Joseph E. Tota, Frank Struyf, Allan Hildesheim, Paula Gonzalez, Martin Ryser, Rolando Herrero, John Schussler, Naveen Karkada, Ana Cecilia Rodriguez, Nicolas Folschweiller, Carolina Porras, Mark Schiffman, John T. Schiller, Wim Quint, Aimee R. Kreimer, Matti Lehtinen, Cosette M. Wheeler, Joshua N. Sampson
Summary: Clinical trial data and real-world evidence suggest that the AS04-adjuvanted vaccine targeting human papillomavirus types 16 and 18 provides nearly 90% protection against cervical intraepithelial neoplasia grade 3 or higher among women vaccinated before sexual debut. This high efficacy is not fully explained by cross-protection, and although the vaccine does not affect clearance of prevalent infections, it may accelerate clearance of newly acquired infections. However, pooled data from 2 large-scale randomized controlled trials did not show a significant effect in expediting clearance of incident infections.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Giovanni Cristalli, Aldo Venuti, Fabiola Giudici, Francesca Paolini, Fabio Ferreli, Giuseppe Mercante, Giuseppe Spriano, Francesca Boscolo Nata
Summary: Beta HPV is more common than alpha HPV in MESCC. The presence or genotype of HPV is not statistically related to disease-specific survival or cumulative incidence of recurrence in MESCC. p16 expression is not predictive for HPV infection in MESCC.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yuee Zu, Zhihua Ou, Dan Wu, Wei Liu, Liwen Liu, Di Wu, Yanping Zhao, Peidi Ren, Yanqing Zhang, Wangsheng Li, Shujin Fu, Yongchun Wen, Xianchu Cai, Wenbo Liao, Chunyu Geng, Hongcheng Zhou, Xiaman Wang, Haorong Lu, Huanhuan Peng, Na Liu, Shida Zhu, Jiyang Liu, Dongbo Wang, Junhua Li
Summary: This study collected cervical exfoliated cell samples from females in Changsha city, Hunan Province to investigate the distribution of four major HPV types in China. The lineage distribution of HPV 16, 18, 52, and 58 was confirmed, with the identification of potentially high oncogenic sublineages. The findings contribute valuable evidence for HPV DNA screening, vaccine effectiveness evaluation, and control strategy development.
Article
Biotechnology & Applied Microbiology
Byung-Wook Eun, Enas Bahar, Stebin Xavier, Hyungwoo Kim, Dorota Borys
Summary: The HPV-16/18 vaccine was included in the national immunization program of Korea in 2016 to prevent certain cancers. A post-marketing surveillance study conducted from 2017 to 2021 assessed the safety of the vaccine in Korean participants aged between 9 and 25 years. The study showed that the vaccine was safe and well tolerated in the Korean population.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Pathology
Anna D. Iacobone, Fabio Bottari, Maria E. Guerrieri, Ailyn M. Vidal Urbinati, Mariacristina Ghioni, Noemi Spolti, Ida Pino, Rita Passerini, Raffaela C. Di Pace, Dorella Franchi, Eleonora P. Preti
Summary: This study aimed to investigate the prevalence of high-risk HPV-negative CIN2+ cases, with results showing a notable proportion. It suggests that cotesting for HPV would help prevent missing such cases.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Medicine, General & Internal
Antonio Angeloni, Corrado De Vito, Antonella Farina, Daniela Terracciano, Michele Cennamo, Rita Passerini, Fabio Bottari, Annalisa Schirinzi, Roberto Vettori, Agostino Steffan, Valerio Mais, Ferdinando Coghe, Luigi Della Corte, Giuseppe Bifulco, Valentina Baccolini, Elena Berardelli, Giuseppe Migliara, Emanuela Anastasi
Summary: This study aimed to develop an analytical approach to harmonize HE4 values obtained with different laboratory resources. By using a common reference calibration curve and bias correction, the study found that HE4 showed better accuracy than Ca125 in the diagnosis of malignant gynecological diseases, especially in post-menopausal and pre-menopausal women.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Francesco Petrella, Monica Casiraghi, Davide Radice, Claudia Bardoni, Andrea Cara, Shehab Mohamed, Daniele Sances, Lorenzo Spaggiari
Summary: This study evaluated the role and influencing factors of unplanned returns to the operating room (URORs) after elective oncologic thoracic surgery. The findings revealed that patients experiencing UROR after surgery had significantly higher morbidity and mortality rates, with bronchopleural fistula being the most lethal complication.
Article
Oncology
Ida Pino, Anna Daniela Iacobone, Ailyn Mariela Vidal Urbinati, Maria Di Giminiani, Davide Radice, Maria Elena Guerrieri, Eleonora Petra Preti, Silvia Martella, Dorella Franchi
Summary: This article discusses the experience of fertility-sparing treatment for endometrial cancer and compares the oncological and reproductive outcomes of different hormonal therapies. The study suggests that the combination of LNG-IUD and metformin showed a significantly lower risk of recurrence compared to other treatment regimens.
Article
Oncology
Chiara Alessandra Cella, Francesca Spada, Alfredo Berruti, Francesco Bertolini, Patrizia Mancuso, Massimo Barberis, Eleonora Pisa, Manila Rubino, Lorenzo Gervaso, Alice Laffi, Stefania Pellicori, Davide Radice, Laura Zorzino, Angelica Calleri, Luigi Funicelli, Giuseppe Petralia, Nicola Fazio
Summary: The early identification of resistant tumors remains a major challenge in the treatment of pancreatic neuroendocrine tumors (PanNETs). This study evaluated a specific angiogenesis panel as possible predictors of resistance to everolimus or everolimus efficacy in PanNETs. The findings suggest that circulating endothelial progenitors might be surrogate biomarkers for angiogenesis activity in PanNETs during everolimus treatment.
Article
Medicine, General & Internal
Fabio Bottari, Anna Daniela Iacobone, Davide Radice, Eleonora Petra Preti, Mario Preti, Dorella Franchi, Sara Boveri, Maria Teresa Sandri, Rita Passerini
Summary: This study evaluated the performance of six HPV DNA tests and one mRNA test in detecting cervical intraepithelial lesions (CIN) and as a test-of-cure in follow-up after surgical conservative treatment. The results showed that these tests had good concordance with HC2 and a very good and comparable sensitivity in CIN2+ detection.
Article
Medicine, General & Internal
Anna Daniela Iacobone, Davide Radice, Maria Elena Guerrieri, Noemi Spolti, Barbara Grossi, Fabio Bottari, Sara Boveri, Silvia Martella, Ailyn Mariela Vidal Urbinati, Ida Pino, Dorella Franchi, Eleonora Petra Preti
Summary: The aim of this study was to investigate the correlation between clinical and colposcopic features and the development of high-grade Vaginal Intraepithelial Neoplasia (VAIN). A retrospective analysis of 255 women diagnosed with VAIN revealed that smoking and a history of hysterectomy for CIN2+ were associated with VAIN development. Colposcopic grade G2, papillary lesion, and vascularity were significantly associated with a greater risk of VAIN3. Accurate diagnosis based on risk factors, colposcopic patterns, and histologic grade is crucial for personalized management of VAIN.
Article
Medicine, General & Internal
Anna Daniela Iacobone, Maria Elena Guerrieri, Eleonora Petra Preti, Noemi Spolti, Gianluigi Radici, Giulia Peveri, Vincenzo Bagnardi, Giulio Tosti, Angelo Maggioni, Fabio Bottari, Chiara Scacchi, Mariacristina Ghioni
Summary: In this retrospective analysis, the incidence, clinical and pathological features of cervico-vaginal involvement in extra-mammary Paget's disease (EMPD) of the vulva were investigated. It was found that 2.5% of patients developed cervico-vaginal involvement at 5 years, 6.5% at 10 years, and 14.0% at 15 years. Abnormal glandular cytology was the primary method of detection, and most patients had invasive EMPD and required hysterectomy with colpectomy. Liquid-based cytology with immunocytochemistry was recommended for early diagnosis and lifelong follow-up.
Article
Health Care Sciences & Services
Ida Pino, Maria Di Giminiani, Davide Radice, Ailyn Mariela Vidal Urbinati, Anna Daniela Iacobone, Maria Elena Guerrieri, Eleonora Petra Preti, Silvia Martella, Dorella Franchi
Summary: This retrospective study evaluated the safety, oncological, and pregnancy outcomes of repeated fertility-sparing treatment (FST) in women with recurrent endometrial cancer (EC). The results showed that repeated FST is a safe and effective option for women who desire to preserve fertility after the recurrence of early-stage EC.
Article
Medicine, General & Internal
Juliana Guarize, Cristina Diotti, Monica Casiraghi, Stefano Donghi, Clementina Di Tonno, Patrizia Mancuso, Laura Zorzino, Giulia Sedda, Davide Radice, Luca Bertolaccini, Lorenzo Spaggiari
Summary: This prospective controlled study compared the diagnostic yield of the 19-G flex needle and the 22-G needle in endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). The results showed that there was no significant difference in the diagnostic sensitivity, cell count, and cytologic results between the two needles.
JOURNAL OF CLINICAL MEDICINE
(2023)