Review
Oncology
Bomi Song, Eun Young Park, Kwang Joon Kim, Sung Hwan Ki
Summary: This review investigates the potential and limitations of benzimidazole anthelmintics as a cancer therapy, suggesting ways to overcome these limitations. The results demonstrate the potential of repurposing benzimidazoles for cancer treatment based on preclinical evidence, and highlight the need for further studies on anti-cancer pathways and development strategies.
Review
Agriculture, Dairy & Animal Science
Antonio Giuliano, Rodrigo S. Horta, Rafael A. M. Vieira, Kelly R. Hume, Jane Dobson
Summary: Repurposing drugs in oncology involves using off-label drugs that are licensed for non-oncological medical conditions to treat cancer. This approach offers the advantage of using already commercialized drugs with known safety profiles and mechanisms of action. This review summarizes the benefits and challenges of repurposing anti-cancer drugs, discusses relevant studies in small animal oncology, and proposes potential drugs for clinical investigation in dogs and cats.
Article
Physics, Atomic, Molecular & Chemical
Christine Skaggs, Lindsey Kirkpatrick, Chau Nguyen, Sarah Dowling, Hannah Zimmerman, Greta Ren, Nicholas Manicke
Summary: This study investigated the effects of substrate-solvent composition on signal intensity and signal-to-blank ratio in paper spray mass spectrometry analysis. The results showed that optimizing the combination can significantly improve the detection limits of analytes.
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
(2021)
Article
Environmental Sciences
Elizabeth Holton, Edward Archer, James Fidal, Thomas Kjeldsen, Gideon Wolfaardt, Barbara Kasprzyk-Hordern
Summary: The study investigated AA usage in the Eerste River catchment in South Africa using urban water profiling, and found that wastewater treatment efficiency is crucial for reducing environmental burden. Seasonal and geographic factors also influence AA loads.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Pharmacology & Pharmacy
Josef Jampilek
Summary: Infections pose an escalating global threat due to the alarming rise in resistant microbial pathogens. This review summarizes the causes of antimicrobial resistance, discusses various approaches to the discovery of new anti-infective drugs, and focuses on the strategy of drug repurposing, offering critical remarks on the repurposing of non-antibiotics. A comprehensive overview of drugs tested for their antimicrobial activity is provided to support existing anti-infective therapeutics.
DRUG DISCOVERY TODAY
(2022)
Review
Biochemistry & Molecular Biology
Andrea Miro Canturri, Younes Smani
Summary: Bacterial infections are a leading cause of death worldwide, and the emergence of antimicrobial resistance poses a serious threat. Repurposing approved drugs may provide a faster and more cost-effective approach to drug development.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Oncology
Weibao Song, Hongjuan Zhang, Yu Zhang, Rui Li, Yanxing Han, Yuan Lin, Jiandong Jiang
Summary: Zika virus is a newly emerging pathogen associated with neurological complications, but there are currently no approved drugs or vaccines for its treatment. Repurposing clinically approved drugs could be an effective and efficient approach to combat Zika virus infections.
FRONTIERS OF MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Catarina Moura, Nuno Vale
Summary: Dopamine is a neurotransmitter that regulates cognitive and emotional processes in the brain. Its role in cancer is uncertain, but it interacts with receptors in tumor cells and influences cellular processes such as proliferation and migration. Drugs developed for other purposes have been explored for potential cancer treatment, but the role of dopamine in this context needs further clarification.
Article
Microbiology
Veronica Folliero, Federica Dell'Annunziata, Biagio Santella, Emanuela Roscetto, Carla Zannella, Nicoletta Capuano, Alessandro Perrella, Anna De Filippis, Giovanni Boccia, Maria Rosaria Catania, Massimiliano Galdiero, Gianluigi Franci
Summary: The emergence of multidrug-resistant strains requires the urgent discovery of new antibacterial drugs. In this study, the anthelmintic avermectins were screened for antibacterial activity against gram-positive and gram-negative strains. Selamectin, a subset of avermectins, showed potent antibacterial activity against gram-positive strains, particularly Staphylococcus aureus. Further studies demonstrated its ability to inhibit bacterial growth, alter cell surface, and reduce biofilm biomass. Synergistic effects were also observed with other antibiotics. These findings suggest that selamectin may be a promising candidate for the treatment of S. aureus infections.
Review
Biochemistry & Molecular Biology
Yasmim Mendes Rocha, Gabriel Acacio de Moura, Juliana Ramos de Oliveira, Larissa Deadame de Figueiredo Nicolete, Roberto Nicolete
Summary: COVID-19, similar to previous pandemics like SARS and MERS, remains a major threat to public health. Developing new drugs is costly and time-consuming, leading to the proposal of repositioning drugs as an attractive strategy. Certain reused drugs, like Entricitabine and Tenofovir, show potential therapeutic efficacy, with in silico analyses being a useful tool for predicting drug effectiveness.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Oncology
Mohamad Ali Hijazi, Andre Gessner, Nahed El-Najjar
Summary: Cancer mortalities are increasing globally at an alarming pace, and drug repurposing is a favored strategy to overcome challenges in cancer therapy. This review highlights the clinical benefits of repurposing anti-diabetic and anti-hypertensive drugs in preventing and treating various malignancies. The safety, effectiveness, and suitability of chronically used medications provide exceptional advantages over other drug classes, making them promising in managing cancer, diabetes, and hypertension.
Review
Chemistry, Medicinal
Jimin Xu, Yu Xue, Richard Zhou, Pei-Yong Shi, Hongmin Li, Jia Zhou
Summary: This review summarizes therapeutic targets for treating coronaviruses and focuses on existing small molecule drugs that have potential for repurposing in future coronavirus infections, as well as discussing clinical progress in developing small molecule drugs for COVID-19.
MEDICINAL RESEARCH REVIEWS
(2021)
Review
Infectious Diseases
Fabio Borgonovo, Massimiliano Quici, Antonio Gidaro, Davide Giustivi, Dario Cattaneo, Cristina Gervasoni, Maria Calloni, Elena Martini, Leyla La Cava, Spinello Antinori, Chiara Cogliati, Andrea Gori, Antonella Foschi
Summary: This systematic review provides practical recommendations on diluent, pH, osmolarity, dosage, infusion rate, vesicant properties, and phlebitis rate of commonly used antimicrobial drugs based on randomized controlled studies (RCT) until March 31, 2023. A total of 931 papers were evaluated, with 232 studies included, identifying 82 antimicrobials. The correct vascular access device selection is crucial for avoiding complications when administering antimicrobials through a peripheral vein.
Review
Medicine, Research & Experimental
Roohi Mohi-ud-din, Apporva Chawla, Pooja Sharma, Prince Ahad Mir, Faheem Hyder Potoo, Zeljko Reiner, Ivan Reiner, Dilek Arslan Atessahin, Javad Sharifi-Rad, Reyaz Hassan Mir, Daniela Calina
Summary: Cancer is a significant global health challenge, and the high cost and lengthy process of developing new anti-cancer drugs hinder progress in cancer treatment. Therefore, repurposing approved non-oncology drugs as alternative options for cancer treatment has the potential to be effective and cost-efficient.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Lais Pessanha de Carvalho, Andrea Kreidenweiss, Jana Held
Summary: Malaria is a life-threatening infectious disease and a major health problem in Africa. Antibiotics have been used for prophylaxis and treatment of malaria for many years, as they may have a different mode of action compared to current antimalarials and can simultaneously treat concomitant bacterial infections.
Article
Multidisciplinary Sciences
Nahed El-Najjar, Evelyn Orso, Stefan Wallner, Gerhard Liebisch, Gerd Schmitz
Article
Biochemical Research Methods
Nahed El-Najjar, Jonathan Jantsch, Andre Gessner
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2017)
Article
Biotechnology & Applied Microbiology
Nahed El-Najjar, Rashmi P. Kulkarni, Nancy Nader, Rawad Hodeify, Khaled Machaca
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Immunology
Sucheera Chotikatum, Hassan Y. Naim, Nahed El-Najjar
INTERNATIONAL IMMUNOPHARMACOLOGY
(2018)
Article
Chemistry, Analytical
Julian Hoesl, Andre Gessner, Nahed El-Najjar
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2018)
Article
Infectious Diseases
Christoph Dorn, David Petroff, Nancy Neumann, Alexander Kratzer, Nahed El-Najjar, Arne Dietrich, Charlotte Kloft, Markus Zeitlinger, Martin G. Kees, Frieder Kees, Hermann Wrigge, Philipp Simon
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Correction
Infectious Diseases
Christoph Dorn, David Petroff, Nancy Neumann, Alexander Kratzer, Nahed El-Najjar, Arne Dietrich, Charlotte Kloft, Markus Zeitlinger, Martin G. Kees, Frieder Kees, Hermann Wrigge, Philipp Simon
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2019)
Article
Infectious Diseases
Maximilian Stolte, Weaam Ali, Janne Janis, Andre Gessner, Nahed El-Najjar
Article
Biochemical Research Methods
Nahed El-Najjar, Julian Hoesl, Thomas Holzmann, Jonathan Jantsch, Andre Gessner
DRUG TESTING AND ANALYSIS
(2018)
Meeting Abstract
Hematology
M. Mohrez, N. El-Najjar, R. Offner, N. Ahrens
TRANSFUSION MEDICINE AND HEMOTHERAPY
(2017)
Review
Medical Laboratory Technology
Nahed El-Najjar, Jonathan Jantsch, Andre Gessner
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2017)