Article
Oncology
Yuna Shin, Wonhee Jung, Mi-Yeon Kim, Dongjo Shin, Geun Hee Kim, Chun Ho Kim, Sun-Hoo Park, Eung-Ho Cho, Dong Wook Choi, Chul Ju Han, Kee Ho Lee, Sang-Bum Kim, Hyun Jin Shin
Summary: GPCRs are critical for drug development and abnormal activation of GPCRs is implicated in cancer. We discovered that NPFFR2 is aberrantly expressed in liver cancer and promotes malignancy through RhoA/YAP signaling.
Article
Microbiology
Yang Chen, Junjie Ma, Yunze Dong, Ziyu Yang, Na Zhao, Qian Liu, Wei Zhai, Junhua Zheng
Summary: This study analyzed the differences in gut microbiota between individuals with clear cell renal cell carcinoma (ccRCC) and healthy individuals. The results showed that specific gut microbiota were positively associated with ccRCC and promoted its proliferation, migration, and invasion via the TGF-signaling pathway. These findings suggest that gut microbiota could serve as a potential non-invasive tool for predicting ccRCC risk and as a target for cancer therapy.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Environmental Sciences
Bin Meng, Pengfei Wang, Chaofei Zhao, Guangwei Yin, Xin Meng, Lin Li, Shengyong Cai, Chengquan Yan
Summary: This study reveals the stimulatory role of miR-21-5p in renal cell carcinoma and its contribution to the progression of the disease through the modulation of its downstream target gene ARHGAP24 expression.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Oncology
Yuhui Fan, Zhipeng Du, Qiang Ding, Jiang Zhang, Mark O. P. Den Winkel, Alexander L. Gerbes, Mei Liu, Christian J. Steib
Summary: SEPT6 is highly expressed in HCC tissues and may serve as a poor prognostic marker. Overexpression of SEPT6 promotes HCC cell proliferation, migration, and invasion, while knockdown of SEPT6 has significant inhibitory effects on HCC cells. SEPT6 may promote HCC progression by enhancing YAP activation.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tsai-Yi Tseng, Chien-Hsing Lee, Hsiang-Lin Lee, Chien-Yu Su, Cheng-Yen Kao, Jen-Pi Tsai, Yi-Hsien Hsieh
Summary: Licochalcone A (LicA) is a potent anti-inflammatory, antioxidant, and anticarcinogenic substance that shows therapeutic potential against renal cell carcinoma (RCC). LicA limits cell growth, induces cell cycle arrest, promotes autophagy and LC3B expression, and inhibits migration and invasion of RCC cells. The chemotherapeutic effects of LicA on RCC are mediated through the activation of LC3B expression, ultimately modulating the FAK/Src signaling pathway-mediated Sp1 expression.
Article
Biotechnology & Applied Microbiology
Qisheng Su, Zheng Yang, Xiaobin Guo, Wuning Mo, Xiaohong Li
Summary: The study revealed that TPPP3 is significantly down-regulated in NPC tissues and cells, and its overexpression can inhibit cell proliferation and invasion ability, while having no significant effect on migration ability. Overexpression of TPPP3 also decreases the expression of MMP-2 and MMP-9 mRNA.
Article
Medicine, Research & Experimental
Mengmeng Wang, Shuqiao Xing, Jiamei Jia, Weiquan Zeng, Jia Lei, Yiming Qian, Zhenrong Xiong, Xin Wang, Liying Cao, Yongjie Wang, Ying Wang, Yuanyuan Jiang, Zhihui Huang
Summary: In this study, it was found that angelicin has anti-tumor effects on glioblastoma (GBM) by inhibiting proliferation and migration of GBM cells through modulation of the YAP signaling pathway. This natural compound has potential as a promising treatment for GBM.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Bin Gao, Lijuan Wang, Na Zhang, Miaomiao Han, Yubo Zhang, Huancai Liu, Dongli Sun, Xiaolong Xiao, Yifei Liu
Summary: Our study reveals that miR-129-5p is down-regulated and SPN is up-regulated in ccRCC. Overexpressed miR-129-5p inhibits cell proliferation, migration, and invasion, induces cell cycle arrest, and promotes apoptosis. Dual-luciferase assay confirms the binding relationship between miR-129-5p and SPN, suggesting a potential target for precise treatment of ccRCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Weiye Liang, Jia Zuo, Mingkai Liu, Yuling Su, Baoyin Guo, Jiangtao Hou, Qi Xing, Yinglong Peng, Lian Fang, Yihui Cao, Jiajie Shan, Ruixia Sun, Jie Zhao, Jian Wang
Summary: VASN is upregulated in CRC and correlates with tumor progression. Overexpression of VASN promotes CRC cell progression, while knockdown of VASN inhibits CRC progression. VASN interacts with YAP/TAZ and PI3K/AKT pathways, and may serve as a novel biomarker for CRC.
Article
Oncology
Yeda Chen, Zhu Wang, Qiong Deng, Yuting Chen, Hui Liang
Summary: Mitochondrial phosphoenolpyruvate carboxykinase (PCK2) is a key gluconeogenesis enzyme that may play a significant role in the emergence and progression of kidney renal clear cell carcinoma (KIRC) by influencing energy metabolism. The study investigated the significance of PCK2 in KIRC by examining its relationship with clinical features and prognoses of different clinical subgroups. Experimental methods confirmed the downregulation of PCK2 in KIRC cell lines and tissues and revealed its inhibitory effects on cell proliferation, migration, and invasion, as well as its ability to regulate energy metabolite expression. PCK2 could serve as a diagnostic and prognostic biomarker for KIRC and a therapeutic target for the disease.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Article
Medicine, Research & Experimental
Wanli Duan, Siyuan Pan, Yuyao Zhai, Qian Deng, Wei Ren, Chun Du, Yi Sun
Summary: The function of miR-613 in RCC was investigated and it was confirmed that upregulation of miR-613 can control proliferation, metastasis, and invasion in RCC cells by reducing AXL levels and controlling the PI3K/AKT signaling pathway.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
Dian Lv, Qi Lai, Qi Zhang, Ji-Hong Wang, Yuan-Ce Li, Guang-Zhi Zeng, Jun-Lin Yin
Summary: The compound 3-desoxysulforaphane (3-DSC) isolated from Caesalpinia sinensis showed antitumor activity by inhibiting cell proliferation, migration, and invasion in HeLa and PC3 cells through modulation of multiple signaling pathways.
Article
Oncology
Zhi Chen, Zuan Li, Chunlin Li, Bingcai Li, Haojian Wang, Deyong Nong, Ximing Li, Guihai Huang, Junhao Lin, Wei Li
Summary: The overexpression of SPOP in RCC cells suppresses cell proliferation, migration, and invasion while increasing cell apoptosis. Additionally, the use of sunitinib and IFN-alpha 2b enhances the inhibitory effects on proliferation and apoptosis in SPOP-overexpressing cells. In RCC tissues, SPOP protein expression is significantly decreased in clear cell RCC (ccRCC) tissues compared to adjacent normal tissues.
Article
Gastroenterology & Hepatology
Menglin Zhao, Yanyan Wang, Yue Zhang, Xinwei Li, Jiaqi Mi, Qiang Wang, Zhijun Geng, Lugen Zuo, Xue Song, Sitang Ge, Zining Zhang, Mingyue Tang, Huiyuan Li, Zishu Wang, Chenchen Jiang, Fang Su
Summary: STAG3 exhibits anticancer effects against hepatocellular carcinoma (HCC) via the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA pathways. STAG3 is a tumor-suppressor gene and may serve as a potential target for molecular therapy, providing a new idea for the treatment of HCC.
BMC GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sang-Hyun Lee, Jin-Man Kim, Dong Gwang Lee, Jangwook Lee, Jong-Gil Park, Tae-Su Han, Hyun-Soo Cho, Young-Lai Cho, Kwang-Hee Bae, Young-Jun Park, Seon-Jin Lee, Moo-Seung Lee, Yong-Min Huh, Deog Yeon Jo, Hwan-Jung Yun, Heung Jin Jeon, Nayoung Kim, Mina Joo, Jang-Seong Kim, Hyo Jin Lee, Jeong-Ki Min
Summary: The reduction of Dsg2 in gallbladder carcinoma is associated with poor prognosis, treatment resistance, and disease progression. Inhibiting Src activity could enhance therapeutic response to anti-EGFR therapy and improve clinical efficacy.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Genetics & Heredity
Heung Jin Jeon, Yonho Lee, Monford Paul N. Abishek, Xun Wang, Dhruba K. Chattoraj, Heon M. Lim
Summary: Small RNA plays a crucial role in regulating gene expression in all forms of life, particularly in bacteria where it can lead to transcription termination and mRNA degradation through base-pairing with mRNA. This study demonstrates that both transcription termination and transcript cleavage can occur on the same sRNA-mRNA pair, generating new stable mRNA species with functional significance. The choice between these mechanisms is determined by the location of base pairing on the mRNA, offering a novel mode of action for sRNAs in bacterial gene regulation.
Article
Biochemistry & Molecular Biology
In-Ho Kim, Hyo Jin Lee
Summary: Approximately 400,000 patients are diagnosed with kidney cancer annually worldwide, resulting in approximately 170,000 deaths. Clear cell RCC is the most common subtype, accounting for about 85% of metastatic RCC cases. Immunotherapy with checkpoint inhibitors has shown promising results and become the standard of care for advanced clear cell RCC.
Article
Microbiology
Heung Jin Jeon, Monford Paul N. Abishek, Yonho Lee, Heon M. Lim
Summary: In this study, we demonstrate that Rho-dependent termination of transcription occurs stochastically at cistron junctions, generating a stable mRNA that is shorter than the full-length mRNA. We further show that the failure in translation initiation of the next gene, rather than the failure of translation termination of the preceding gene, causes the Rho-dependent termination. Additionally, we find that transcription pauses 130 nucleotides downstream from the site of translation termination, and this pause is necessary for Rho-dependent termination.
Article
Biochemistry & Molecular Biology
Mina Joo, Donghyun Kim, Myung-Won Lee, Hyo Jin Lee, Jin-Man Kim
Summary: GDF15 is highly expressed in gastric cancer and promotes cancer progression through the phosphorylation of STAT3, suggesting that the GDF15-STAT3 signaling axis may serve as a potential therapeutic target against gastric cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Xun Wang, N. Monford Paul Abishek, Heung Jin Jeon, Jin He, Heon M. M. Lim
Summary: sysRNA, as a regulatory tool, has lost popularity due to its unstable inhibition effect and low efficiency. However, it remains interesting for its easy design and low metabolic burden. In this study, we discovered a new method to identify RDT regions in vivo using sysRNA, which is important for addressing the challenge of rapid RNA degradation.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, General & Internal
Hyewon Ryu
Summary: Advances in genomics and molecular biology have resulted in numerous targeted cancer therapies that use monoclonal antibodies and small molecules. Despite the expectation of few side effects, a new class of toxicities has been reported, replacing the traditional chemotherapy-induced toxicities with dermatologic, cardiovascular, gastrointestinal, endocrine, ocular, and pulmonary toxicities, as well as infusion reactions.
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Solbi Kim, Kyung-Ha Lee, Hui-Ji Choi, Eunji Kim, Sora Kang, Minju Han, Heung Jin Jeon, Mi-Young Yun, Gyu-Yong Song, Hyo Jin Lee
Summary: This study investigated the inhibitory effect of HA1 on cell growth and autophagy in colon cancer, suggesting its potential as a therapeutic agent.
Article
Biochemistry & Molecular Biology
Heung Jin Jeon, Yonho Lee, N. Monford Paul Abishek, Changjo Kang, Heon M. Lim
Summary: In bacteria, most small RNA (sRNA) can induce RNase E-mediated degradation of target mRNA by binding near the translation initiation site at the 5' end of the target mRNA. However, the mechanism of sRNA-mediated degradation of gal mRNA remains unclear. In this study, we found that binding of sRNA Spot 42 only caused degradation of a specific group of gal mRNA that shares their 3' end with full-length mRNA. The results suggest an unprecedented role of sRNA in mRNA biology by accelerating the decay processes.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Medicine, General & Internal
Myung-Won Lee, Sang-Hoon Yeon, Hyewon Ryu, Ik-Chan Song, Hyo-Jin Lee, Hwan-Jung Yun, Seon Young Kim, Jeong Eun Lee, Kyung Sook Shin, Deog-Yeon Jo
Summary: This retrospective study evaluated non-palpable splenomegaly in patients with polycythemia vera (PV) and found that the degree of splenomegaly may affect disease progression and prognosis.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)