Genetic Profiling of a Cohort of Italian Patients with ACTH-Secreting Pituitary Tumors and Characterization of a Novel USP8 Gene Variant

Regulation of the EGFR Pathway by HSP90 Is Involved in the Pathogenesis of Cushing’s Disease

(2021) Yue Shen et al.   Frontiers in Endocrinology

Differential microRNA Expression in USP8-Mutated and Wild-Type Corticotroph Pituitary Tumors Reflect the Difference in Protein Ubiquitination Processes

(2021) Mateusz Bujko et al.   Journal of Clinical Medicine

Filamin A is required for somatostatin receptor type 5 expression and pasireotide-mediated signaling in pituitary corticotroph tumor cells

(2021) Donatella Treppiedi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Novel Mechanism Regulating Dopamine Receptor Type 2 Signal Transduction in Pituitary Tumoral Cells: The Role of cAMP/PKA-Induced Filamin A Phosphorylation

(2021) Federica Mangili et al.   Frontiers in Endocrinology

USP8 Mutations and Cell Cycle Regulation in Corticotroph Adenomas

(2020) Clarissa Silva Martins et al.   HORMONE AND METABOLIC RESEARCH

SST5 expression and USP8 mutation in functioning and silent corticotroph pituitary tumors

(2020) Solène Castellnou et al.   Endocrine Connections

Outcomes of pituitary surgery for Cushing’s disease: a systematic review and meta-analysis

(2020) Anna Stroud et al.   Pituitary

Medical Treatment of Cushing's Disease: An Overview of the Current and Recent Clinical Trials

(2020) Rosario Pivonello et al.   Frontiers in Endocrinology

Somatostatin analogs regulate tumor corticotrophs growth by reducing ERK1/2 activity

(2019) Donatella Treppiedi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Impact of USP8 gene mutations on protein deregulation in Cushing’s disease

(2019) Isabel Weigand et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Driver mutations in USP8 wild-type Cushing’s disease

(2019) Silviu Sbiera et al.   NEURO-ONCOLOGY

Cushing’s disease due to somatic USP8 mutations: a systematic review and meta-analysis

(2019) Ingrid Quevedo Wanichi et al.   Pituitary

Emerging Role of USP8, HMGA, and Non-Coding RNAs in Pituitary Tumorigenesis

(2019) Daniela D’Angelo et al.   Cancers

Ubiquitin-Specific Protease 8 Mutant Corticotrope Adenomas Present Unique Secretory and Molecular Features and Shed Light on the Role of Ubiquitylation on ACTH Processing

(2019) Antonella Sesta et al.   NEUROENDOCRINOLOGY

Determinants of outcome of transsphenoidal surgery for Cushing disease in a single-centre series

(2019) A. L. Serban et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

The New Genetic Landscape of Cushing’s Disease: Deubiquitinases in the Spotlight

(2019) Silviu Sbiera et al.   Cancers

Ubiquitin-specific protease 8 (USP8/UBPy): a prototypic multidomain deubiquitinating enzyme with pleiotropic functions

(2019) Almut Dufner et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

USP8 mutations in corticotroph adenomas determine a distinct gene expression profile irrespective of functional tumour status

(2019) Mateusz Bujko et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Biophysical and structural insight into the USP8/14-3-3 interaction

(2018) Federica Centorrino et al.   FEBS LETTERS

Gene expression profiling in human corticotrope tumors reveals distinct, neuroendocrine profiles

(2018) Maria Francesca Cassarino et al.   JOURNAL OF NEUROENDOCRINOLOGY

Identification of recurrent USP48 and BRAF mutations in Cushing’s disease

(2018) Jianhua Chen et al.   Nature Communications

Somatic USP8 mutations are frequent events in corticotroph tumor progression causing Nelson’s tumor

(2017) Luis G Pérez-Rivas et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Somatic USP8 Gene Mutations Are a Common Cause of Pediatric Cushing Disease

(2017) Fabio R Faucz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Transcriptome Analysis Showed a Differential Signature between Invasive and Non-invasive Corticotrophinomas

(2017) Leonardo Jose Tadeu de Araújo et al.   Frontiers in Endocrinology

Characterization of Disease-Associated Mutations in Human Transmembrane Proteins

(2016) János Molnár et al.   PLoS One

Recurrent gain-of-function USP8 mutations in Cushing's disease

(2015) Zeng-Yi Ma et al.   CELL RESEARCH

The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease

(2015) K. Hayashi et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The Gene of the Ubiquitin-Specific Protease 8 Is Frequently Mutated in Adenomas Causing Cushing's Disease

(2015) Luis G. Perez-Rivas et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutations in the deubiquitinase gene USP8 cause Cushing's disease

(2014) Martin Reincke et al.   NATURE GENETICS

EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas

(2011) Hidenori Fukuoka et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel erythroid anion exchange variant (Gly796Arg) of hereditary stomatocytosis associated with dyserythropoiesis

(2009) A. Iolascon et al.   HAEMATOLOGICA

Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing

(2008) Jin Li et al.   NATURE MEDICINE