Target Heterogeneity in Oncology: The Best Predictor for Differential Response to Radioligand Therapy in Neuroendocrine Tumors and Prostate Cancer

Tumor Microenvironment in Prostate Cancer: Toward Identification of Novel Molecular Biomarkers for Diagnosis, Prognosis, and Therapy Development

(2021) Hisham F. Bahmad et al.   Frontiers in Genetics

Blood-Derived Biomarkers of Diagnosis, Prognosis and Therapy Response in Prostate Cancer Patients

(2021) Katalin Balázs et al.   Journal of Personalized Medicine

Investigating PSMA-targeted radioligand therapy efficacy as a function of cellular PSMA levels and intra-tumoral PSMA heterogeneity

(2020) Kyle Current et al.   CLINICAL CANCER RESEARCH

NANETS/SNMMI Consensus Statement on Patient Selection and Appropriate Use of 177Lu-DOTATATE Peptide Receptor Radionuclide Therapy

(2020) Thomas A. Hope et al.   JOURNAL OF NUCLEAR MEDICINE

Radiomics prediction model for the improved diagnosis of clinically significant prostate cancer on biparametric MRI

(2020) Mengjuan Li et al.   Quantitative Imaging in Medicine and Surgery

Treatment-related changes in neuroendocrine tumors as assessed by textural features derived from 68Ga-DOTATOC PET/MRI with simultaneous acquisition of apparent diffusion coefficient

(2020) Manuel Weber et al.   BMC CANCER

Mechanistic Insights for Optimizing PSMA Radioligand Therapy

(2020) Aravind S. Ravi Kumar et al.   CLINICAL CANCER RESEARCH

Response and outcome of liver metastases in patients with metastatic castration-resistant prostate cancer (mCRPC) undergoing 177Lu-PSMA-617 radioligand therapy

(2020) Fadi Khreish et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Radiomics Based on MRI as a Biomarker to Guide Therapy by Predicting Upgrading of Prostate Cancer From Biopsy to Radical Prostatectomy

(2020) Gu‐mu‐yang Zhang et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Multiparametric MRI for Prostate Cancer Characterization: Combined Use of Radiomics Model with PI-RADS and Clinical Parameters

(2020) Piotr Woźnicki et al.   Cancers

Magnetic resonance imaging radiomic analysis can preoperatively predict G1 and G2/3 grades in patients with NF-pNETs

(2020) Yun Bian et al.   Abdominal Radiology

Radiomics Analysis Based on Diffusion Kurtosis Imaging and T2 Weighted Imaging for Differentiation of Pancreatic Neuroendocrine Tumors From Solid Pseudopapillary Tumors

(2020) Yan-Jie Shi et al.   Frontiers in Oncology

Tumor growth rate as a metric of progression, response, and prognosis in pancreatic and intestinal neuroendocrine tumors

(2019) Clarisse Dromain et al.   BMC CANCER

Pancreatic neuroendocrine tumor: prediction of the tumor grade using magnetic resonance imaging findings and texture analysis with 3-T magnetic resonance

(2019) Chuan-gen Guo et al.   Cancer Management and Research

Using biparametric MRI radiomics signature to differentiate between benign and malignant prostate lesions

(2019) Min Xu et al.   EUROPEAN JOURNAL OF RADIOLOGY

FAPI-PET/CT: Mean intensity of tracer-uptake (SUV) in 28 different kinds of cancer

(2019) Clemens Kratochwil et al.   JOURNAL OF NUCLEAR MEDICINE

CT radiomics may predict the grade of pancreatic neuroendocrine tumors: a multicenter study

(2019) Dongsheng Gu et al.   EUROPEAN RADIOLOGY

Prostate-specific Membrane Antigen Heterogeneity and DNA Repair Defects in Prostate Cancer

(2019) Alec Paschalis et al.   EUROPEAN UROLOGY

Preoperative Prediction of Extracapsular Extension: Radiomics Signature Based on Magnetic Resonance Imaging to Stage Prostate Cancer

(2019) Shuai Ma et al.   MOLECULAR IMAGING AND BIOLOGY

Evolution of the Liquid Biopsy in Metastatic Prostate Cancer

(2019) Jose G. Moreno et al.   UROLOGY

Molecular Imaging and Therapy for Neuroendocrine Tumors

(2019) Hemant Desai et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Prognostic Significance of Somatostatin Receptor Heterogeneity in Progressive Neuroendocrine Tumor Treated with Lu-177 DOTATOC or Lu-177 DOTATATE

(2019) Josephine Graf et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

The added value of intravoxel incoherent motion diffusion weighted imaging parameters in differentiating high‑grade pancreatic neuroendocrine neoplasms from pancreatic ductal adenocarcinoma

(2019) Wanling Ma et al.   Oncology Letters

A Radiogenomic Approach for Decoding Molecular Mechanisms Underlying Tumor Progression in Prostate Cancer

(2019) Fischer et al.   Cancers

The Future of PSMA-Targeted Radionuclide Therapy: An Overview of Recent Preclinical Research

(2019) Eline A.M. Ruigrok et al.   Pharmaceutics

Prediction of Pancreatic Neuroendocrine Tumor Grade Based on CT Features and Texture Analysis

(2018) Rodrigo Canellas et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

PRRT genomic signature in blood for prediction of 177Lu-octreotate efficacy

(2018) Lisa Bodei et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

68Ga-PSMA-11 PET/CT-derived metabolic parameters for determination of whole-body tumor burden and treatment response in prostate cancer

(2018) Christian Schmidkonz et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Targeting fibroblast activation protein in cancer ndash Prospects and caveats

(2018) Aleksi Sedo   Frontiers in Bioscience-Landmark

Radiomics in Nuclear Medicine applied to Radiation Therapy: methods, pitfalls and challenges

(2018) Sylvain Reuzé et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Radiomic features from pretreatment biparametric MRI predict prostate cancer biochemical recurrence: Preliminary findings

(2018) Rakesh Shiradkar et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

[ 177 Lu]-PSMA-617 radionuclide treatment in patients with metastatic castration-resistant prostate cancer (LuPSMA trial): a single-centre, single-arm, phase 2 study

(2018) Michael S Hofman et al.   LANCET ONCOLOGY

The Heterogeneity of Prostate Cancer: A Practical Approach

(2018) Yuri Tolkach et al.   PATHOBIOLOGY

Genetic heterogeneity of primary lesion and metastasis in small intestine neuroendocrine tumors

(2018) Dirk Walter et al.   Scientific Reports

The NETest

(2018) Irvin M. Modlin et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Role of textural heterogeneity parameters in patient selection for 177Lu-PSMA therapy via response prediction

(2018) Zain Khurshid et al.   Oncotarget

Textural analysis on contrast-enhanced CT in pancreatic neuroendocrine neoplasms: association with WHO grade

(2018) Chuangen Guo et al.   Abdominal Radiology

A Combined Nomogram Model to Preoperatively Predict Histologic Grade in Pancreatic Neuroendocrine Tumors

(2018) Wenjie Liang et al.   CLINICAL CANCER RESEARCH

Inter- and intra-tumoral heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma

(2018) Cindy Neuzillet et al.   JOURNAL OF PATHOLOGY

Preclinical evaluation of PSMA expression in response to androgen receptor blockade for theranostics in prostate cancer

(2018) Katharina Lückerath et al.   EJNMMI Research

Neuroendocrine liver metastases: Vascular patterns on triple-phase MDCT are indicative of primary tumour location

(2017) Maxime Ronot et al.   EUROPEAN JOURNAL OF RADIOLOGY

Tackling intra- and inter-tumor heterogeneity to combat triple negative breast cancer

(2017) Ritu Aneja   Frontiers in Bioscience-Landmark

Liquid biopsy: a step forward towards precision medicine in urologic malignancies

(2017) Ashley Di Meo et al.   Molecular Cancer

Intra-tumor heterogeneity from a cancer stem cell perspective

(2017) Pramudita R. Prasetyanti et al.   Molecular Cancer

Tumour heterogeneity and resistance to cancer therapies

(2017) Ibiayi Dagogo-Jack et al.   Nature Reviews Clinical Oncology

Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors

(2017) Jonathan Strosberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Imaging Biomarkers of Tumor Response in Neuroendocrine Liver Metastases Treated with Transarterial Chemoembolization: Can Enhancing Tumor Burden of the Whole Liver Help Predict Patient Survival?

(2017) Sonia Sahu et al.   RADIOLOGY

Pancreatic neuroendocrine neoplasms: Magnetic resonance imaging features according to grade and stage

(2017) Riccardo De Robertis et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The NETPET Score: Combining FDG and Somatostatin Receptor Imaging for Optimal Management of Patients with Metastatic Well-Differentiated Neuroendocrine Tumors

(2017) Elif Hindié   Theranostics

Liquid Biopsy: Approaches to Dynamic Genotyping in Cancer

(2017) Nikolas von Bubnoff   Oncology Research and Treatment

Prediction of pancreatic neuroendocrine tumour grade with MR imaging features: added value of diffusion-weighted imaging

(2016) Emad Lotfalizadeh et al.   EUROPEAN RADIOLOGY

Haralick textural features onT2-weighted MRI are associated with biochemical recurrence following radiotherapy for peripheral zone prostate cancer

(2016) Khémara Gnep et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

177Lu-Labeled Prostate-Specific Membrane Antigen Radioligand Therapy of Metastatic Castration-Resistant Prostate Cancer: Safety and Efficacy

(2016) R. P. Baum et al.   JOURNAL OF NUCLEAR MEDICINE

NET Blood Transcript Analysis Defines the Crossing of the Clinical Rubicon: When Stable Disease Becomes Progressive

(2016) Marianne Pavel et al.   NEUROENDOCRINOLOGY

Combined imaging with 68Ga-DOTA-TATE and 18F-FDG PET/CT on the basis of volumetric parameters in neuroendocrine tumors

(2016) Ummuhan Abdulrezzak et al.   NUCLEAR MEDICINE COMMUNICATIONS

GRK3 is a direct target of CREB activation and regulates neuroendocrine differentiation of prostate cancer cells

(2016) Meixiang Sang et al.   Oncotarget

Circulating tumor DNA: a promising biomarker in the liquid biopsy of cancer

(2016) Feifei Cheng et al.   Oncotarget

Association of multiparametric MRI quantitative imaging features with prostate cancer gene expression in MRI-targeted prostate biopsies

(2016) Radka Stoyanova et al.   Oncotarget

Survival prediction in patients undergoing radionuclide therapy based on intratumoral somatostatin-receptor heterogeneity

(2016) Rudolf A. Werner et al.   Oncotarget

Biological and Therapeutic Impact of Intratumor Heterogeneity in Cancer Evolution

(2015) Nicholas McGranahan et al.   CANCER CELL

Pancreatic neuroendocrine tumors: Correlation between the contrast-enhanced computed tomography features and the pathological tumor grade

(2015) Koji Takumi et al.   EUROPEAN JOURNAL OF RADIOLOGY

Consensus on biomarkers for neuroendocrine tumour disease

(2015) Kjell Oberg et al.   LANCET ONCOLOGY

Automatic classification of prostate cancer Gleason scores from multiparametric magnetic resonance images

(2015) Duc Fehr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging Intratumor Heterogeneity: Role in Therapy Response, Resistance, and Clinical Outcome

(2014) J. P. B. O'Connor et al.   CLINICAL CANCER RESEARCH

Staging accuracy of MR for pancreatic neuroendocrine tumor and imaging findings according to the tumor grade

(2013) Jung Hoon Kim et al.   ABDOMINAL IMAGING

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Somatic mutation of CDKN1B in small intestine neuroendocrine tumors

(2013) Joshua M Francis et al.   NATURE GENETICS

The Correlation between Apparent Diffusion Coefficient and Tumor Cellularity in Patients: A Meta-Analysis

(2013) Lihua Chen et al.   PLoS One

High Sensitivity of Diffusion-weighted MR Imaging for the Detection of Liver Metastases from Neuroendocrine Tumors: Comparison with T2-weighted and Dynamic Gadolinium-enhanced MR Imaging

(2013) Gaspard d’Assignies et al.   RADIOLOGY

Ki67 proliferation index, hepatic tumor load, and pretreatment tumor growth predict the antitumoral efficacy of lanreotide in patients with malignant digestive neuroendocrine tumors

(2012) Maxime Palazzo et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

ENETS 2011 Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Tumors: An Update

(2012) Ramon Salazar et al.   NEUROENDOCRINOLOGY

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

(2011) Y. Jiao et al.   SCIENCE

Neuroendocrine gastroenteropancreatic tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2010) K. Oberg et al.   ANNALS OF ONCOLOGY

Hepatic Metastases From Neuroendocrine Tumors With a “Thin Slice” Pathological Examination

(2010) Dominique Elias et al.   ANNALS OF SURGERY

Chromogranin A—Biological Function and Clinical Utility in Neuro Endocrine Tumor Disease

(2010) Irvin M. Modlin et al.   ANNALS OF SURGICAL ONCOLOGY

Comparison of Biexponential and Monoexponential Model of Diffusion Weighted Imaging in Evaluation of Renal Lesions

(2010) Hersh Chandarana et al.   INVESTIGATIVE RADIOLOGY

The North American Neuroendocrine Tumor Society (NANETS) Guidelines

(2010) Larry K. Kvols et al.   PANCREAS

Prognostic factors influencing survival from metastatic (stage IV) gastroenteropancreatic well-differentiated endocrine carcinoma

(2009) Cosimo Durante et al.   ENDOCRINE-RELATED CANCER

Angiogenesis as a strategic target for prostate cancer therapy

(2009) Yong Li et al.   MEDICINAL RESEARCH REVIEWS

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Biochemical Markers

(2009) Dermot O’Toole et al.   NEUROENDOCRINOLOGY

In vitro experimental study of the relationship between the apparent diffusion coefficient and changes in cellularity and cell morphology

(2009) Kuroda   ONCOLOGY REPORTS

Relation between cancer cellularity and apparent diffusion coefficient values using diffusion-weighted magnetic resonance imaging in breast cancer

(2008) Miho I. Yoshikawa et al.  

Pancreatic Endocrine Tumors: Tumor Blood Flow Assessed with Perfusion CT Reflects Angiogenesis and Correlates with Prognostic Factors1

(2008) Gaspard d'Assignies et al.   RADIOLOGY