Review
Cell Biology
Wei-Zhan Zhuang, Yi-Heng Lin, Long-Jyun Su, Meng-Shiue Wu, Han-Yin Jeng, Huan-Cheng Chang, Yen-Hua Huang, Thai-Yen Ling
Summary: Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy due to their high immunomodulation ability and tropism towards inflamed and injured tissues. However, the lack of standardized methods to evaluate the safety, efficacy, and biodistribution of MSCs has been a major hindrance to their clinical application.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Chiara Valsecchi, Stefania Croce, Elisa Lenta, Gloria Acquafredda, Patrizia Comoli, Maria Antonietta Avanzini
Summary: Clinical applications of Mesenchymal Stromal Cells (MSCs) have been widely reported, showing therapeutic potential in various diseases. MSCs, isolated from human tissues and easily expanded in vitro, have the ability to differentiate into various cell types and interact with immunological cells, exhibiting immunosuppressive and tissue repair properties. Extracellular Vesicles (EVs) released by MSCs have shown great potential in the treatment of damaged tissues and organs, as well as modulation of the immune system. EV-based therapies have advantages in crossing barriers and are not influenced by the surrounding environment.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Rashi Srivastava, Aidong Li, Tirtharaj Datta, Niraj Kumar Jha, Salehikram Talukder, Saurabh Kumar Jha, Zhe-Sheng Chen
Summary: Deposition of misfolded proteins and synaptic failure in Alzheimer's disease lead to memory loss and cognitive impairment. Stromal cells show potential as a treatment for AD due to their pluripotency and ability to differentiate into nerve cells and glial cells. Successful evidence in animal models and promising clinical trials suggest the use of stromal cell therapy, but further research is needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zhilong Ma, Jie Hua, Jiang Liu, Bo Zhang, Wei Wang, Xianjun Yu, Jin Xu
Summary: Pancreatic cancer is a highly aggressive malignant tumor with poor prognosis and high mortality rates. Despite advancements in diagnosis and treatment, the current therapeutic strategies for pancreatic cancer have limited efficacy, necessitating urgent exploration of alternative options. Mesenchymal stromal cells (MSCs) have gained attention as a potential therapy for pancreatic cancer due to their tumor-homing properties, but the specific antitumor effect of MSCs remains controversial. Therefore, this study aims to focus on the potential of the MSC-based approach for anti-cancer treatment and summarize the current challenges in the clinical application of MSCs for pancreatic cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Trinidad Montero-Vilchez, Alvaro Sierra-Sanchez, Manuel Sanchez-Diaz, Maria Isabel Quinones-Vico, Raquel Sanabria-de-la-Torre, Antonio Martinez-Lopez, Salvador Arias-Santiago
Summary: Mesenchymal stromal cell-conditioned medium (MSC-CM) shows promising potential in treating skin conditions by improving wound healing, hair restoration, skin rejuvenation, and some inflammatory skin diseases. Further research is needed to confirm its safety, effectiveness, and to standardize the manufacturing process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Andreas Nicodemou, Sona Bernatova, Michaela Cehakova, Lubos Danisovic
Summary: Despite efforts made by researchers and clinicians, cancer remains a leading cause of death worldwide. Mesenchymal stem/stromal cells (MSCs) have unique biological properties and therapeutic functions, with MSC-derived extracellular vesicles (MSC-EVs) being one of the central mediators. MSC-EVs, rich in proteins, lipids, and nucleic acids, can promote or inhibit tumor growth and are involved in cancer progression suppression through the delivery of therapeutic molecules.
Review
Veterinary Sciences
Manon Jammes, Romain Contentin, Frederic Casse, Philippe Galera
Summary: Osteoarthritis is a degenerative disease without a curative treatment. Studying equine OA can help improve horse health and serve as preclinical studies for human medicine. The immunomodulatory and regenerative potentials of mesenchymal stromal cells (MSCs) and their extracellular vesicles (EVs) offer promising acellular therapy options. Optimizing MSC secretome potential and exploring pro-inflammatory environments could enhance MSC therapies for managing OA.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Immunology
Michele Aramburu Serafini, Dienifer Hermann Sirena, Ana Beatriz Tittoni da Silveira, Monique Franco-da-Silva, Mariana Rauback Aubin, Tuane Nerissa Alves Garcez, Anelise Araujo, Fernanda dos Santos Pereira, Martin J. Hoogduijn, Fabiany da Costa Goncalves, Ana Helena Paz
Summary: Inflammatory bowel diseases (IBD), including ulcerative colitis, are chronic inflammations of the gastrointestinal tract. Mesenchymal stromal cells (MSC) have shown promise as a therapy for IBD, but practical complexities arise from using living cells. This study investigated the potential of MSC-derived membrane particles (MP) and conditioned media (CM) as cell-free therapies for IBD, and found that they ameliorated colitis symptoms in a mouse model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Editorial Material
Cell Biology
Dina Moench, Marlies E. J. Reinders, Marc H. Dahlke, Martin J. Hoogduijn
Summary: This article discusses how to make sense of the overwhelming number of publications on mesenchymal stromal cells and highlights the need for further research on their therapeutic effects.
Article
Dentistry, Oral Surgery & Medicine
Ilan Pinkhasov, Liron Kabakov, Carlos E. E. Nemcovsky, Miron Weinreb, Pnina Schlesinger, Omer Bender, Maayan Gal, Daniel Z. Z. Bar, Evgeny Weinberg
Summary: The aim of this study was to investigate the heterogeneity of ex vivo-cultured human mesenchymal stromal cells derived from different regions of the oral mucosa. Single-cell RNA sequencing analysis revealed distinct cell sub-populations, with a higher proportion of mesenchymal stem cells in the masticatory mucosa. These findings have important implications for understanding cell function and potential therapeutic interventions.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Cell & Tissue Engineering
Yoann Athiel, Justine Nasone, Lousineh Arakelian, Lionel Faivre, Anais Dugas, Jean-Marie Jouannic, Jerome Larghero, Lucie Guilbaud
Summary: The study aimed to assess the biodistribution of umbilical cord-derived mesenchymal stromal cells (UC-MSCs) in lambs who had a prenatal myelomeningocele repair. The results showed no detection of GFP lentivirus genomic DNA in the organs of the grafted lambs, providing support for translational application in humans.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biotechnology & Applied Microbiology
Maria Cecilia Sanmartin, Francisco Raul Borzone, Maria Belen Giorello, Gustavo Yannarelli, Norma Alejandra Chasseing
Summary: Cancer is the second leading cause of death globally. Extracellular vesicles, particularly those derived from mesenchymal stem/stromal cells, have emerged as a promising platform for drug delivery in cancer therapy due to their advantageous properties and safety compared to the cells themselves.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Immunology
E. Eduardo Sanchez-Castro, Cecilia Pajuelo-Reyes, Rebeca Tejedo, Barbara Soria-Juan, Rafael Tapia-Limonchi, Etelvina Andreu, Ana B. Hitos, Franz Martin, Gladys M. Cahuana, Clara Guerra-Duarte, Thamyres C. Silva de Assis, Francisco J. Bedoya, Bernat Soria, Carlos Chavez-Olortegui, Juan R. Tejedo
Summary: Snakebite envenoming is a neglected global disease with limited treatment options, potentially leading to permanent sequelae from local damage. Using mesenchymal stromal cells or their cell-free products may induce skeletal muscle regeneration in snakebite victims, improving treatment outcomes. Applying MSCs-based therapies to snakebite victims holds promise for providing a safe and cost-effective treatment option for this neglected health issue, particularly in areas with limited healthcare resources.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell & Tissue Engineering
Ji Chen, Chen-Xi Zheng, Yan Jin, Cheng-Hu Hu
Summary: Type 2 diabetes mellitus (T2DM) poses a major threat to global public health, with immune dysfunction recognized as a crucial contributor to its pathogenesis. Mesenchymal stromal cells (MSCs) have emerged as promising therapeutic agents for T2DM, with their immunomodulatory effects mediated through paracrine mechanisms and extracellular vesicles (EVs). Preclinical studies have shown the benefits of MSCs in improving islet function and insulin resistance, while clinical trials have further supported their therapeutic potential for T2DM.
Review
Health Care Sciences & Services
Caroline Hochheuser, Nina Y. Kunze, Godelieve A. M. Tytgat, Carlijn Voermans, Ilse Timmerman
Summary: Neuroblastoma is a common pediatric cancer with limited treatment options for high-risk patients. Recent research suggests mesenchymal stromal cells could be a promising approach in cancer therapy, but their potential risks need careful consideration.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dermatology
Ximena Wortsman, Francisco Reyes-Baraona, Cristian Ramirez-Cornejo, Camila Ferreira-Wortsman, Raffaele Dante Caposiena Caro, Alejandro Molina-Leyva, Salvador Arias-Santiago, Priscila Giavedoni, Antonio Martorell, Jorge Romani, Claudia Gonzalez, Fernando Alfageme
Summary: The aim of this study was to assess the presence of pain generated by ultrasound examinations in patients with HS. The results showed that pain caused by ultrasound examinations is infrequent in HS patients.
Article
Dermatology
Manuel Sanchez-Diaz, Pablo Diaz-Calvillo, Juan Angel Rodriguez-Pozo, Salvador Arias-Santiago, Alejandro Molina-Leyva
Summary: Acitretin may be considered as a therapeutic option for HS patients, with follicular phenotype or a history of components of follicular occlusion syndrome potentially associated with better outcomes. Most patients did not experience significant adverse events during acitretin treatment.
Review
Dermatology
Manuel Sanchez-Diaz, Trinidad Montero-Vilchez, Maria I. Quinones-Vico, Alvaro Sierra-Sanchez, Ana Ubago-Rodriguez, Raquel Senabria-De La Torre, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: Type D personality, characterized by social inhibition and negative affectivity, has been associated with poorer outcomes and quality of life in patients with non-dermatological diseases. However, research on the relationship between type D personality and skin diseases is limited. This review aims to summarize the current evidence regarding type D personality and skin diseases.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Dermatology
Carlos Cuenca-Barrales, Trinidad Montero-Vilchez, Manuel Sanchez-Diaz, Juan-Angel Rodriguez-Pozo, Pablo Diaz-Calvillo, Antonio Martinez-Lopez, Salvador Arias-Santiago, Alejandro Molina-Leyva
Summary: This study aimed to characterize the surgical recurrences in patients with hidradenitis suppurativa (HS) treated with wide excision and second-intention healing. It was found that the severity of Hurley stage II at the surgical site, obesity, and higher IHS4 scores after surgery and at week 68 increased the risk of recurrence. Tunnel recurrence originated in the depth of the surgical scar, while AN recurrence originated in the borders of the surgical scar and may benefit from preoperative ultrasound.
Article
Dermatology
Manuel Sanchez-Diaz, Trinidad Montero-Vilchez, Carlos Cuenca-Barrales, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: This study found a higher prevalence of TDp in patients with AA, accompanied by higher rates of anxiety, depression, and poorer quality of life. Screening for this personality trait may help identify patients who would benefit from additional psychological support in addition to medical treatment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Alberto Soto-Moreno, Clara Urena-Paniego, Trinidad Montero-Vilchez, Manuel Sanchez-Diaz, Pablo Diaz-Calvillo, Juan Angel Rodriguez-Pozo, Alejandro Molina-Leyva, Antonio Martinez-Lopez, Salvador Arias-Santiago
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Trinidad Montero-Vilchez, Isabel Navarro-Pelayo, Manuel Sanchez-Diaz, Maria-Jose Ortega-Acosta, Salvador Arias-Santiago, Jesus Tercedor-Sanchez
Summary: The case of a neonate with blueberry muffin syndrome caused by ganglioneuroblastoma, a rare variant of neuroblastoma, is reported. This syndrome may be the only visible manifestation of a neonatal tumor and highlights the importance of early recognition and initiation of therapy to reduce mortality.
PEDIATRIC DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Maria Librada Porrino-Bustamante, Trinidad Montero-Vilchez, Maria Antonia Fernandez-Pugnaire, Salvador Arias-Santiago
Summary: This study designed and validated a specific questionnaire, FFA-QLI, to assess the impairment of quality of life in patients with frontal fibrosing alopecia (FFA). The FFA-QLI showed a greater ability to discriminate severe cases of FFA compared to the DLQI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Dermatology
T. Montero-Vilchez, M. Molina-Cabrerizo, R. Ortega-Olmo, S. Serrano-Ortega, S. Arias-Santiago, A. Buendia-Eisman
ACTAS DERMO-SIFILIOGRAFICAS
(2023)
Article
Biochemistry & Molecular Biology
Francisco Andujar-Vera, Maria Ferrer-Millan, Cristina Garcia-Fontana, Beatriz Garcia-Fontana, Sheila Gonzalez-Salvatierra, Raquel de la Torre, Luis Martinez-Heredia, Blanca Riquelme-Gallego, Manuel Munoz-Torres
Summary: Non-alcoholic fatty liver disease (NAFLD) and atherosclerosis (ATH) may share some molecular connections, but the underlying pathways have not been explored. This study aimed to identify common factors and potential therapeutic targets for both diseases. Differentially expressed genes (DEGs) were analyzed and common DEGs were identified. Protein-protein interaction (PPI) network analysis revealed functional modules and hub genes. Gene Ontology (GO) and pathway analysis were performed. The study found 21 genes with similar regulation in NAFLD and ATH. The hub genes ADAMTS1 and CEBPA were found to be down- and up-regulated, respectively. Functional modules related to protein modification and immune response were identified, with ADAMTS1, ADAMTS4, and CSF3 playing potential key roles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dermatology
Trinidad Montero-Vilchez, Raquel Sanabria-de-la-Torre, Manuel Sanchez-Diaz, Clara Urena-Paniego, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: Skin barrier dysfunction is a significant factor in the development of atopic dermatitis. Dupilumab, an IL-4 and IL-13 inhibitor, has been shown to be effective in treating AD, but its effects on the epidermal barrier are not well studied. This systematic review aimed to evaluate the impact of dupilumab on skin barrier using non-invasive tools. Six prospective observational studies with a total of 233 participants were included. Dupilumab improved clinical scores and decreased transepidermal water loss (TEWL) on eczematous lesions and non-involved skin. Some studies also reported increased stratum corneum hydration (SCH) on eczematous lesions. Overall, dupilumab improved skin barrier function in AD patients, primarily demonstrated by decreased TEWL values.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Pablo Fernandez-Crehuet, Sofia Haselgruber, Alicia Padial-Gomez, Fiorella Vasquez-Chinchay, Maria Dolores Fernandez-Ballesteros, Irene Lopez-Riquelme, David Jimenez-Gallo, Juan Manuel Segura-Palacios, Marisol Contreras-Steyls, Giovana Fernanda Osorio-Gomez, Juan Carlos Hernandez-Rodriguez, Manuel Sanchez-Diaz, Carlos Cuenca-Barrales, Salvador Arias-Santiago, Alejandro Molina-Leyva
Summary: This study evaluates the effectiveness and safety of secukinumab in moderate to severe HS patients after 16 weeks of treatment, and explores potential predictors of clinical response. The results show favorable short-term effectiveness and safety of secukinumab in the treatment of severe HS patients. Female sex, lower BMI, and lower therapeutic burden may be associated with a higher probability of achieving HiSCR.
DERMATOLOGY AND THERAPY
(2023)
Letter
Dermatology
Sofia Haselgruber, Daniel Munoz Barba, Clara Urena Paniego, Silvia Lobo Benito, Salvador Arias Santiago, Alejandro Molina-Leyva
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Emergency Medicine
Alvaro Sierra-Sanchez, Brice Magne, Etienne Savard, Christian Martel, Karel Ferland, Martin A. Barbier, Anabelle Demers, Danielle Larouche, Salvador Arias-Santiago, Lucie Germain
Summary: In this in vitro study, two models of human bilayered tissue-engineered skin substitutes (SASS and HPSS) were compared for their biological characteristics. The results showed that SASS exhibited higher resistance to tensile forces but lower elasticity, with a higher number of proliferative cells. However, no significant difference was observed in the expression of markers related to epidermal differentiation. SASS also showed a higher production of type I and type IV collagens and stronger adhesive strength of the dermal-epidermal junction.