Article
Biochemical Research Methods
Ann Morgell, Julie A. Reisz, Zeeshan Ateeb, Haleh Davanian, Susanne E. Reinsbach, Asif Halimi, Rogier Gaiser, Roberto Valente, Urban Arnelo, Marco Del Chiaro, Margaret Sallberg Chen, Angelo D'Alessandro
Summary: Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, with a low 5-year survival rate. Lack of reliable tools for early diagnosis complicates its management. Research has identified novel metabolic markers that can help determine the progression of pancreatic cysts and pancreatic cancer. These findings suggest a potential role of bacterial infections in the development and severity of pancreatic cancer, similar to other cancers like Helicobacter pylori and gastric cancer.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Medicine, General & Internal
Ronald C. Turner, Jared T. Melnychuk, Wei Chen, Daniel Jones, Somashekar G. Krishna
Summary: Early detection and diagnosis of precursor lesions for pancreatic malignancy is crucial. Current diagnostic tools for cystic precursor lesions, such as CEA levels and cytology, have limitations. Molecular analysis of cystic fluid can improve the diagnosis and risk stratification of pancreatic malignancy precursor lesions.
Review
Gastroenterology & Hepatology
Michael Johannes Pflueger, Kevin Tony Jamouss, Elham Afghani, Su Jin Lim, Salvador Rodriguez Franco, Harrison Mayo, Marcus Spann, Hao Wang, Aatur Singhi, Anne Marie Lennon, Laura D. Wood
Summary: Analysis of cyst fluid biomarkers showed that mutations in KRAS and/or GNAS can efficiently identify mucinous cysts, while mutations in VHL are specific for serous cystadenomas. DNA-based cyst fluid biomarkers are crucial for accurately distinguishing pancreatic cyst types.
Article
Gastroenterology & Hepatology
Mahmoud A. Rahal, John M. DeWitt, Harsh Patel, C. Max Schmidt, Eugene P. Ceppa, Rachel E. Simpson, Stuart Sherman, Mohammad Al-Haddad
Summary: This study aims to examine the natural history of KRAS mutations in mucinous pancreatic cysts (MPCs) and found that KRAS mutations in pancreatic cyst fluid frequently occur during long-term surveillance, with age being the only predictor for KRAS changes over time.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Oncology
Joanne Lundy, Hugh Gao, William Berry, Samar Masoumi-Moghoddam, Brendan J. Jenkins, Daniel Croagh
Summary: This study investigated the potential of combining transcriptomic and mutation analysis with standard cytology to improve the accuracy of PDAC diagnosis and identified an effective diagnostic gene signature. KRAS mutation analysis significantly improved diagnostic accuracy to 91.3% in external validation sets and 91.6% in the validation cohort. Additionally, exploratory analysis suggested that KRAS mutant allele fraction may serve as a novel surrogate marker of tumor cellularity in snap-frozen EUS-FNA biopsies.
CLINICAL CANCER RESEARCH
(2021)
Review
Oncology
Tommaso Pollini, Paul Wong, Ajay V. Maker
Summary: Modern studies show a high prevalence of pancreatic cysts in the general population, with half of them being pancreatic cystic neoplasms that have different degrees of malignant potential. Intraductal papillary mucinous neoplasms are the most common type and can lead to pancreatic adenocarcinoma. These cysts are one of the few precursors of pancreatic cancer that can be identified through radiographic imaging, allowing for early detection and surgical resection. Due to their high prevalence and potential for malignant progression, it is important to discuss the best management of IPMNs and improve the current standard of care.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Tommaso Pollini, Paul Wong, Ajay V. V. Maker
Summary: Modern series have found that up to 50% of the general population may have pancreatic cysts, with about half of them being pancreatic cystic neoplasms (PCNs). The most common PCNs are intraductal papillary mucinous neoplasms (IPMNs), which are known as precursors of pancreatic adenocarcinoma. IPMNs are one of the few radiographically identifiable precursors of pancreatic cancer, providing an opportunity for early detection and surgical resection. This highlights the importance of discussing the best management of IPMNs and improving the existing standard of care, including prevalence, guidelines, surveillance, biomarkers, and immune landscape.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jun Yashika, Eizaburo Ohno, Takuya Ishikawa, Tadashi Iida, Hirotaka Suzuki, Kota Uetsuki, Kenta Yamada, Masakatsu Yoshikawa, Noriaki Gibo, Yoshie Shimoyama, Eri Ishikawa, Kazuhiro Furukawa, Masanao Nakamura, Takashi Honda, Masatoshi Ishigami, Yoshiki Hirooka, Hiroki Kawashima, Mitsuhiro Fujishiro
Summary: The contrast-enhanced harmonic endoscopic ultrasound (CEH-EUS) is a useful method for differentiating between invasive IPMC and PDAC.
Article
Gastroenterology & Hepatology
Asif Halimi, Giorgio Gabarrini, Michal Jacek Sobkowiak, Zeeshan Ateeb, Haleh Davanian, Rogier Aaron Gaiser, Urban Arnelo, Roberto Valente, Alicia Y. W. Wong, Carlos Fernandez Moro, Marco Del Chiaro, Volkan Ozenci, Margaret Sallberg Chen
Summary: The study reveals a potential link between pancreatic cystic lesions and cancer, with cultivated bacteria demonstrating pathogenic properties such as intracellular survival capability, cell death induction, and causing DNA double-strand breaks in surviving cells.
Article
Surgery
Brett L. Ecker, Shannan M. Dickinson, Lily V. Saadat, Alice J. Tao, Alessandra Pulvirenti, Vinod P. Balachandran, Michael I. D'Angelica, Jeffrey A. Drebin, T. P. Kingham, William R. Jarnagin, Alice C. Wei, Mithat Gonen, Kevin C. Soares
Summary: This study aimed to determine if the morphologic features of the main pancreatic duct (MPD) have implications for the risk of malignancy and extent of resection in main-duct-involved-intraductal papillary mucinous neoplasm (IPMN) patients. The results showed that for most patients with segmental main-duct-involved-IPMN, the MPD morphology conferred malignancy risk. However, duct morphology was not predictive for the development of HGD/PDAC in the pancreatic remnant.
Article
Biochemistry & Molecular Biology
L. Pedrosa, I. K. Araujo, M. Cuatrecasas, G. Soy, S. Lopez, J. Maurel, C. Sanchez-Montes, C. Montironi, T. Sauri, O. Sendino, F. M. Perez, F. Ausania, G. Fernandez-Esparrach, F. M. Esposito, E. C. Vaquero, A. Gines
Summary: The integration of transcriptomic testing into EUS-FNA samples is important for precision oncology in PDAC. The NanoString platform allows for transcriptome profiling in low yield RNA samples. The study found differential gene expression between EUS and surgical samples, with a more enriched cancer-associated fibroblasts and epithelial-mesenchymal transition transcriptomic profile observed in surgical specimens and more immunological biomarkers represented in EUS-FNA samples.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Oncology
Livia Archibugi, Ruggero Ponz de Leon Pisani, Maria Chiara Petrone, Gianpaolo Balzano, Massimo Falconi, Claudio Doglioni, Gabriele Capurso, Paolo Giorgio Arcidiacono
Summary: Needle-tract seeding (NTS) is a rare but serious complication of Endoscopic Ultrasound-guided biopsy of pancreatic adenocarcinoma. Our study aimed to deepen the understanding of NTS and highlight therapeutic approaches. The findings showed that NTS has a low incidence and usually occurs late, but aggressive treatment can lead to good results.
Article
Surgery
Jin-Seok Park, Jae Hoon Lee, Tae Jun Song, Joune Seup Lee, Seok Jung Jo, Dong Wook Oh, Ki Byung Song, Dae Wook Hwang, Do Hyun Park, Sang Soo Lee, Song Cheol Kim, Dong Wan Seo, Sung Koo Lee, Myung-Hwan Kim
Summary: Preoperative EUS-FNA has high diagnostic accuracy for resectable distal pancreatic cancer, helping patients avoid unnecessary surgery. It is not associated with increased risks of cancer-specific or overall survival, but potential risks of needle tract seeding should be considered when selecting patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Medicine, General & Internal
Elit Quingalahua, Mahmoud M. Al-Hawary, Jorge D. Machicado
Summary: Pancreatic cystic lesions (PCLs) are commonly found incidental findings on cross-sectional imaging. Magnetic resonance imaging (MRI) has become the preferred non-invasive method for predicting cyst type, stratifying risk of neoplasia, and monitoring changes in PCLs. In some cases, additional diagnostic approaches such as endoscopic ultrasound (EUS) and molecular analysis may be necessary for treatment decisions. The use of radiomics and artificial intelligence in MRI could enhance the stratification of PCLs and improve treatment guidance.
Review
Oncology
Kylie E. Shockley, Briana To, Wei Chen, Gerard Lozanski, Zobeida Cruz-Monserrate, Somashekar G. Krishna
Summary: Intraductal papillary mucinous neoplasms (IPMNs) are benign pancreatic cysts with the potential to become pancreatic cancer. Identifying high-risk IPMNs and potential biomarkers can help prevent unnecessary surgery. This review summarizes the changes within IPMNs that promote their progression to pancreatic adenocarcinoma and highlights potential biomarkers for identifying high-risk IPMNs.
Article
Medicine, General & Internal
Naoki Mita, Takuji Iwashita, Shinya Uemura, Kensaku Yoshida, Yuhei Iwasa, Nobuhiro Ando, Keisuke Iwata, Mitsuru Okuno, Tsuyoshi Mukai, Masahito Shimizu
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Medicine, General & Internal
Yuhei Iwasa, Takuji Iwashita, Yuji Takeuchi, Hironao Ichikawa, Naoki Mita, Shinya Uemura, Masahito Shimizu, Yu-Ting Kuo, Hsiu-Po Wang, Takeshi Hara
Summary: The study found that automatic segmentation of pancreatic tumors using U-Net on CE-EUS video images had a decent concordance rate. The clarity of tumor boundary lowered the concordance rate, but respiratory movement did not have a significant impact.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Naoki Mita, Takuji Iwashita, Hironao Ichikawa, Yuhei Iwasa, Shinya Uemura, Katsutoshi Murase, Masahito Shimizu
Summary: Conversion surgery in patients with initially unresectable advanced pancreatic cancer who received first-line mFX treatment achieves long-term survival with a significantly longer overall survival compared to patients without conversion surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Katsunori Sekine, Ichiro Yasuda, Shinpei Doi, Noriyuki Kuniyoshi, Takayuki Tsujikawa, Yuichi Takano, Masatoshi Mabuchi, Kosuke Takahashi, Masashi Kawamoto, Mikiko Takahashi, Tatsuya Aso, Tatsuhiko Miyazaki, Takuji Iwashita
Summary: This study compared the diagnostic abilities of POCS-guided biopsy and conventional fluoroscopy-guided biopsy for bile duct cancer. The sensitivity of POCS-guided biopsy was similar to that of fluoroscopy-guided biopsy, but their combination increased the overall sensitivity. However, the limited specimen quantity and quality in POCS-guided biopsy may affect the diagnostic sensitivity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Shiori Sadaka, Takuji Iwashita, Hironori Fujii, Hiroko Kato-Hayashi, Koichi Ohata, Shinya Uemura, Masahito Shimizu, Akio Suzuki
Summary: This study aimed to evaluate the impact of first-line modified FOLFIRINOX-induced peripheral neuropathy (PN) on the efficacy of second-line gemcitabine plus nab-paclitaxel (GnP) treatment in patients with advanced pancreatic cancer (APC). The results showed that first-line mFFX-induced PN had little impact on the efficacy and safety of second-line GnP, suggesting that GnP could be a possible treatment option regardless of the presence of PN.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Akinori Maruta, Takuji Iwashita, Kensaku Yoshida, Keisuke Iwata, Shogo Shimizu, Masahito Shimizu
Summary: This study evaluated the feasibility, efficacy and safety of endoscopic internalization by cutting an ENGBD tube for acute cholecystitis. The results showed a high success rate and no significant complications, indicating that it can be an effective treatment option for preventing recurrent cholecystitis during the waiting period for cholecystectomy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Kensaku Yoshida, Takuji Iwashita, Naoki Mita, Yuhei Iwasa, Shinya Uemura, Masahito Shimizu
Summary: CE-EUS has been shown to be useful in differentiating indolent non-Hodgkin's lymphoma (NHL) from aggressive NHL. Qualitative evaluation of enhancement patterns and quantitative evaluation of time-intensity curves on CE-EUS can effectively distinguish between the two types of lymphoma. Combining both qualitative and quantitative evaluations improves the diagnostic capability of CE-EUS in differentiating between indolent NHL and aggressive NHL.
JOURNAL OF CLINICAL MEDICINE
(2023)
