Article
Pharmacology & Pharmacy
Long Xi, Zibei Lin, Fen Qiu, Shaokui Chen, Ping Li, Xin Chen, Zhenping Wang, Ying Zheng
Summary: This study demonstrates the effectiveness of celastrol-loaded mannose-modified liposomes (CEL-MAN-LPs) in the treatment of psoriasis. The results show that these modified liposomes enhance dendritic cell uptake and inhibit the expression of maturation markers. Intradermal injection of CEL-MAN-LPs significantly improves psoriasis symptoms compared to free drug or unmodified liposomes.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Pharmacology & Pharmacy
Jing Xian, Xuemei Zhong, Huan Gu, Xiao Wang, Jiaxin Li, Jingjing Li, Yihan Wu, Chen Zhang, Jinming Zhang
Summary: A flexible oral colon-targeting delivery system mediated by pectin-trimethyl chitosan coating was developed to enhance anti-UC efficacy. The system, with a bilayer coating of polysaccharides, reduced drug cytotoxicity, improved mucosal adhesion, and prolonged drug retention in the colon. Ultimately, this system significantly alleviated colitis symptoms and accelerated colitis repair in mice by regulating inflammation-related factors.
Article
Engineering, Biomedical
Jingyi Sheng, Yang Liu, He Ding, Linyuan Wu, Lan Liu, Guangxiang Si, Yan Shen, Fang Yang, Ning Gu
Summary: This study demonstrates the potential of magnetic targeting as an effective strategy for delivering cancer vaccines and activating the immune response. By targeting antigen-loaded magnetic liposomes to the lymph nodes, the population of active dendritic cells and cytotoxic T lymphocytes is increased, resulting in effective tumor growth inhibition.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hua Zhang, Wei-Lun Tang, Azadeh Kheirolomoom, Brett Z. Fite, Bo Wu, Kenneth Lau, Mo Baikoghli, Marina Nura Raie, Spencer K. Tumbale, Josquin Foiret, Elizabeth S. Ingham, Lisa M. Mahakian, Sarah M. Tam, R. Holland Cheng, Alexander D. Borowsky, Katherine W. Ferrara
Summary: A formulation using R848-loaded thermosensitive liposomes (TSLs) was developed for intravenous delivery, showing efficacy in tumor regression and enhanced survival when combined with alpha PD-1 in mouse models of breast cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Ana Mateos-Maroto, Meiyu Gai, Maximilian Brueckner, Richard da Costa Marques, Iain Harley, Johanna Simon, Volker Mailaender, Svenja Morsbach, Katharina Landfester
Summary: This study investigates the interaction between liposomes and cell membranes and how it affects their cellular uptake. The researchers found that by adjusting the lipid composition of liposomes, they could enhance their internalization by dendritic cells. This finding is significant for the design of specific drug carriers.
ACTA BIOMATERIALIA
(2023)
Article
Biophysics
Muhammad Asim Farooq, Huang Xinyu, Amna Jabeen, Anam Ahsan, Theodora Amanda Seidu, Perpetua Takunda Kutoka, Bo Wang
Summary: The study demonstrated that TPGS-coated liposomes enhanced cytotoxicity and cellular uptake of VOR in breast cancer cells, with improved stability and encapsulation efficiency. TPGS-coated liposomes also improved solubility of VOR and showed sustained release, making them promising drug carriers for effective delivery of hydrophobic drugs in cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Oncology
Adeleh Taghi Khani, Farzaneh Sharifzad, Soura Mardpour, Zuhair Mohammad Hassan, Marzieh Ebrahimi
Summary: Modified tumor-derived Extracellular Vesicles (mt-EVs) with miRNA loading show potential in enhancing dendritic cell maturation and antigen presenting function, presenting a promising strategy for cancer therapy.
Article
Pharmacology & Pharmacy
Linyu Xiao, Bingjie Zhou, Shi Luo, Lang Deng, Yuan Xue, Ling Zhang, Peiwen Li, Li Wang, Bole Tian, Zhirong Zhang, Yingchum Zeng
Summary: A new combination therapy strategy against PDAC using a liposomal carrier co-loading with anti-inflammatory agent celastrol (CLT) and chemotherapeutic drug paclitaxel (PTX) was reported. The synergistic effect of CLT and PTX was verified and a co-delivery system CP-Lip was fabricated with high loading capabilities and sustained release. CP-Lip showed significantly improved tumor-specific accumulation and improved anti-tumor efficacy both in vitro and in vivo.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Chang Liu, Xiao Guo, Yutong Chen, Meijun Zhao, Shuai Shi, Zheng Luo, Jian Song, Zhihong Zhang, Wenchuang Yang, Keyi Liu
Summary: This study utilized the technology of flexible liposomes to co-load apigenin and doxycycline, which showed good encapsulation efficiency, drug loading, in vitro release, and transdermal efficiency. The A/D-FLip liposome exhibited anti-photoaging effects by combating oxidative stress, reducing inflammation, inhibiting MMPs activation, and preventing collagen loss. Cellular and animal experiments demonstrated that A/D-FLip could inhibit oxidative stress damage, decrease inflammatory factors, and prevent skin collagen loss, making it a promising skin care product or drug against UV damage and skin photoaging.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Afaf Abouzid, Abdelrhman Y. Moustafa, Natalie Allcock, Mohammad Najlah, Abdelbary Elhissi, Chi Wi Stanley, Waqar Ahmed, Peter Seville, StJohn Crean, Robert T. Forbes, Mohamed A. Elsawy
Summary: Oral aphthous stomatitis, a common disorder, was traditionally treated with Amlexanox (AMX) paste, but was discontinued due to adverse reactions. In this study, AMX-loaded nanoliposomes were developed as a potential alternative for local delivery of AMX. The optimal formulation showed high drug entrapment efficiency (94%) and demonstrated significant anti-inflammatory activity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Juan M. Galdoporpora, Camila Martinena, Ezequiel Bernabeu, Jennifer Riedel, Lucia Palmas, Ines Castangia, Maria Letizia Manca, Mariana Garces, Juan Lazaro-Martinez, Maria Jimena Salgueiro, Pablo Evelson, Nancy Liliana Tateosian, Diego Andres Chiappetta, Marcela Analia Moretton
Summary: Tuberculosis, the second deadliest infectious disease in 2020, can potentially be treated with inhaled nanocarriers for active targeting in the lungs.
Article
Materials Science, Biomaterials
Xu Liu, Na Xu, Ximing Pu, Juan Wang, Xiaoming Liao, Zhongbing Huang, Guangfu Yin
Summary: A facile two-step method was used to obtain indocyanine green (ICG) loaded-hyaluronic acid (HA) surface-coated polydopamine nanoparticles (IIPH) without core templates. The prepared nanoparticles showed excellent photothermal conversion capacity and efficient singlet oxygen production. In vitro and in vivo studies demonstrated that IIPH could effectively inhibit tumor growth through combined photothermal-photodynamic therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Engineering, Biomedical
Yijing Li, Yanhui Zhu, Jiaqi Chen, Huahua Wang, Weiwei Zhi, Ziang Wang, Yanbin Guan, Baiyan Wang, Yongyan Jia, Shengnan Huang, Xiali Zhu
Summary: Due to the complexity of tumor microenvironment, combination therapy has received increasing attention. In this study, a thermo-sensitive hydrogel loading with elemene (ELE)-loaded and nano graphene oxide (NGO)-based liposomes was prepared for enhanced combined therapy. The results showed that the ELE-GA/NGO-Lip-gel had high anti-tumor efficiency against SMMC-7721 cells upon 808 nm laser irradiation. This research might provide a potent platform for combined tumor therapy using thermos-sensitive injectable hydrogel.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Fen Qiu, Long Xi, Shengshuang Chen, Yonghua Zhao, Zhenping Wang, Ying Zheng
Summary: Cel Nio gel achieved the anti-psoriatic effect by inhibiting inflammation and hyperproliferation of keratinocytes in the skin, further suppressing systemic inflammation. The gel demonstrated significant local and systemic therapeutic effects in treating psoriasis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hamad Alrbyawi, Sai H. S. Boddu, Ishwor Poudel, Manjusha Annaji, Nur Mita, Robert D. Arnold, Amit K. Tiwari, R. Jayachandra Babu
Summary: This study developed a co-delivery system of daunorubicin and cardiolipin encapsulated in thermosensitive liposomes for the treatment of breast cancer. The liposomes exhibited high drug encapsulation efficiency, small size, and rapid release under mild hyperthermia, resulting in significantly higher cytotoxicity against breast cancer cells compared to daunorubicin or conventional liposomes. This research lays the foundation for future development of liposomal co-delivery systems for breast cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
