Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling

MDM4 is targeted by 1q gain and drives disease in Burkitt lymphoma

(2019) Jennifer Hüllein et al.   CANCER RESEARCH

Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities

(2019) Suhas Vasaikar et al.   CELL

Integrated Clinical, Histopathological, and Molecular Data Analysis of 190 Central Nervous System Germ Cell Tumors from the iGCT Consortium

(2019) Hirokazu Takami et al.   NEURO-ONCOLOGY

RRS1 gene expression involved in the progression of papillary thyroid carcinoma

(2018) Feng Chen et al.   Cancer Cell International

Germline Duplication of SNORA18L5 Increases Risk for HBV-related Hepatocellular Carcinoma by Altering Localization of Ribosomal Proteins and Decreasing Levels of p53

(2018) Pengbo Cao et al.   GASTROENTEROLOGY

Downregulation of ZC3H14 driven by chromosome 14q31 deletion promotes hepatocellular carcinoma progression by activating integrin signaling

(2018) Chuxiao Zhang et al.   CARCINOGENESIS

Functional role of RRS1 in breast cancer cell proliferation

(2018) Jinlian Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Knockdown of RRS1 by lentiviral-mediated RNAi promotes apoptosis and suppresses proliferation of human hepatocellular carcinoma cells

(2017) Jitao Wang et al.   ONCOLOGY REPORTS

RRS1 silencing suppresses colorectal cancer cell proliferation and tumorigenesis by inhibiting G2/M progression and angiogenesis

(2017) Xin-Lin Wu et al.   Oncotarget

A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer

(2016) Amon Asgharpour et al.   JOURNAL OF HEPATOLOGY

A modified multiplex ligation-dependent probe amplification method for the detection of 22q11.2 copy number variations in patients with congenital heart disease

(2015) Xiaoqing Zhang et al.   BMC GENOMICS

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Exploration of liver cancer genomes

(2014) Tatsuhiro Shibata et al.   Nature Reviews Gastroenterology & Hepatology

GSVA: gene set variation analysis for microarray and RNA-Seq data

(2013) Sonja Hänzelmann et al.   BMC BIOINFORMATICS

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma

(2013) Z. Kan et al.   GENOME RESEARCH

Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma

(2013) Kai Wang et al.   HEPATOLOGY

Comprehensive molecular characterization of clear cell renal cell carcinoma

(2013)   NATURE

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

The 5S RNP Couples p53 Homeostasis to Ribosome Biogenesis and Nucleolar Stress

(2013) Katherine E. Sloan et al.   Cell Reports

Gain of chromosome 8q is associated with metastases and poor survival of patients with clear cell renal cell carcinoma

(2012) Tobias Klatte et al.   CANCER

Serum and glucocorticoid kinase 3 at 8q13.1 promotes cell proliferation and survival in hepatocellular carcinoma

(2012) Ming Liu et al.   HEPATOLOGY

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

(2011) Eric T. Sawey et al.   CANCER CELL

Integrative Genomic Identification of Genes on 8p Associated With Hepatocellular Carcinoma Progression and Patient Survival

(2011) Stephanie Roessler et al.   GASTROENTEROLOGY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly

(2011) Dragomir B. Krastev et al.   NATURE CELL BIOLOGY

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11

(2011) Masato Sasaki et al.   NATURE MEDICINE

Genotypic Profiling of 452 Choroidal Melanomas with Multiplex Ligation-Dependent Probe Amplification

(2010) B. Damato et al.   CLINICAL CANCER RESEARCH

Comprehensive Mapping of p53 Pathway Alterations Reveals an Apparent Role for Both SNP309 and MDM2 Amplification in Sarcomagenesis

(2010) M. Ito et al.   CLINICAL CANCER RESEARCH

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers

(2010) Hongxing Zhang et al.   NATURE GENETICS

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway

(2010) C Deisenroth et al.   ONCOGENE

MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer

(2009) Guohong Hu et al.   CANCER CELL

Chromosome 8p Deletions and 8q Gains are Associated with Tumor Progression and Poor Prognosis in Prostate Cancer

(2009) A. T. El Gammal et al.   CLINICAL CANCER RESEARCH