Article
Medicine, Research & Experimental
Ye Huang, Lin Zhu, Hui Li, Jianwen Ye, Na Lin, Min Chen, Danling Pan, Zheng Chen
Summary: This study found that exosomes derived from endometriosis and miR-301a-3p can affect the polarization of macrophages. Exosomes mediate the polarization of macrophages to M2 macrophages by regulating the PTEN-PI3K axis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Chong Li, Shiyu Feng, Ling Chen
Summary: In TMZ-resistant glioma, high expression of MSC-AS1 was found to be associated with reduced overall survival rate, while inhibition of MSC-AS1 decreased IC50 value of TMZ, promoted apoptosis, and affected PI3K/Akt pathway. Further investigation revealed that MSC-AS1 acted as a miR-373-3p sponge and miR-373-3p targeted CPEB4 directly, influencing TMZ sensitivity. Silencing miR-373-3p reversed the promoting effect of MSC-AS1 or CPEB4 knockdown on TMZ sensitivity, indicating a potential regulatory mechanism for chemoresistance.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Jie Yao, Zefen Wang, Yong Cheng, Chao Ma, Yahua Zhong, Yilei Xiao, Xu Gao, Zhiqiang Li
Summary: This study found that exosomal miR-15a and miR-92a derived from M2 macrophages inhibit cell migration and invasion of glioma cells by activating the PI3K/AKT/mTOR signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, General & Internal
Shuhong Yin, Xiuying Lin
Summary: The study found that miR-21 is up-regulated in CSCC tissues, while TIMP3 is down-regulated, and this is associated with poor survival in patients. Depletion of miR-21 impedes CSCC cell invasion and metastasis by enhancing TIMP3 and suppressing PI3K/AKT pathway activation.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mayra Colardo, Marco Segatto, Sabrina Di Bartolomeo
Summary: Gliomas are the most common and challenging malignant tumors of the central nervous system, with limited treatment efficacy and the development of resistance leading to tumor recurrence. Therefore, finding effective and well-tolerated pharmacological approaches is crucial in combating this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xiangyu Zhang, Feiyu Chen, Peiran Huang, Xinyu Wang, Kaiqian Zhou, Cheng Zhou, Lei Yu, Yuanfei Peng, Jia Fan, Jian Zhou, Zuohua Lu, Jie Hu, Zheng Wang
Summary: MiR-148a-3p derived from activated HSCs accelerates HCC progression through ITGA5/PI3K/Akt signaling pathway. These findings contribute to a better understanding of the molecular mechanisms underlying the development of HCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Environmental Sciences
Jisong Liu, Fuxi Xing, Quanyou Fu, Bo He, Zhigang Jia, Juan Du, Yong Li, Xiangzhou Zhang, Xulin Chen
Summary: This study aimed to investigate the molecular mechanism of exosomal miR-451 from hUC-MSCs on ALI by regulating macrophage polarization. The results showed that hUC-MSCs-derived exosomal miR-451 alleviated ALI development and promoted macrophage M1 to M2 polarization. MIF and the PI3K/AKT signaling pathway were involved in the regulation of ALI.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Cell Biology
Tianshi Que, Haojie Zheng, Yu Zeng, Xinru Liu, Ge Qi, Qingcuo La, Tuo Liang, Zhiyong Li, Guozhong Yi, Shichao Zhang, Junjie Li, Jing Nie, Jian-er Tan, Guanglong Huang
Summary: The study revealed that HMGA1 and MYH9 were upregulated in gliomas and significantly correlated with patient survival, serving as independent prognostic factors. HMGA1 promoted the acquisition of malignant phenotypes and chemoresistance of glioma cells by regulating MYH9 expression.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Kevin J. Pridham, Farah Shah, Kevin L. Sheng, Sujuan Guo, Min Liu, Pratik Kanabur, Samy Lamouille, Gabrielle Lewis, Marc Morales, Jane Jourdan, Christina L. Grek, Gautam G. Ghatnekar, Robin Varghese, Deborah F. Kelly, Robert G. Gourdie, Zhi Sheng
Summary: This study reveals that the protein connexin 43 (Cx43) is highly expressed in a subpopulation of glioblastoma and is associated with poor prognosis and chemoresistance. Targeting Cx43 can sensitize glioblastoma cells to chemotherapy by inactivating phosphatidylinositol-3 kinase (PI3K). Furthermore, combining Cx43 inhibition with PIK3CB/p110 beta-selective inhibitors can synergistically overcome chemoresistance in glioblastoma cells.
Article
Cell Biology
Meng-Yao Sun, Bo Xu, Qiu-Xue Wu, Wen-Lian Chen, Si Cai, Hui Zhang, Qing-Feng Tang
Summary: Cisplatin-resistant gastric cancer cells communicate with sensitive cells through exosomal RPS3 protein, activating the PI3K-Akt-cofilin-1 signaling pathway and leading to chemotherapy resistance. Targeting exosomal RPS3 protein may be a promising strategy to overcome cisplatin resistance in gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Stefano Ratti, Raffaella Mauro, Cristina Rocchi, Sara Mongiorgi, Giulia Ramazzotti, Mauro Gargiulo, Lucia Manzoli, Lucio Cocco, Roberta Fiume
Summary: This review examines the importance of critical enzymes such as PI3K, AKT, and mTOR in the maturation and failure of arteriovenous fistula (AVF) for haemodialysis treatment. These enzymes play a role in various cellular activities and are associated with multiple diseases. They are also druggable targets, which can be targeted to control specific aspects of AVF and provide more personalized therapy.
Article
Plant Sciences
Hong-Bin Xu, Xian-Zhen Chen, Zhou-Lun Yu, Fei Xue
Summary: This study aimed to investigate whether guggulsterone enhances the anti-glioblastoma efficacy of temozolomide by down-regulating EGFR/PI3K/Akt signaling pathway and NF-KB activation.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Liming Jin, Tao Mi, Xin Wu, Zhang Wang, Zhaoxia Zhang, Jiayan Liu, Zhaoying Wang, Jinkui Wang, Mujie Li, Chunnian Ren, Peng Guo, Dawei He
Summary: In this study, bioinformatics was used to analyze prognostic genes and the small molecular drug BI-D1870 was identified as a potential treatment for malignant neuroblastoma. In vivo and in vitro experiments confirmed the anti-proliferative effects of BI-D1870 on neuroblastoma cells, which was attributed to its inhibition of tumor cell mitosis through the regulation of the PI3K-Akt-mTORC1 signaling axis. This study provides a novel approach for drug prediction and highlights the therapeutic potential of BI-D1870 for neuroblastoma treatment.
Article
Cell Biology
Sixuan Wang, Jun Duan, Jiangquan Liao, Yan Wang, Xiang Xiao, Lin Li, Yi Liu, Huan Gu, Peng Yang, Dongliang Fu, Jinhang Du, Xianlun Li, Mingjing Shao
Summary: The study reveals that lncRNAH19 can attenuate DCM in DM by reducing cardiomyocyte apoptosis and improving fibrosis. Additionally, H19 can repress ERS, oxidative stress, and apoptosis, and this effect may be achieved by inhibiting the activation of the PI3K/AKT/mTOR signaling pathway.
Review
Pharmacology & Pharmacy
Amin Iranpanah, Leila Kooshki, Seyed Zachariah Moradi, Luciano Saso, Sajad Fakhri, Haroon Khan
Summary: As a major public health concern, neurological diseases and neurodegenerative diseases significantly impact the growing aging population, leading to disability and mortality. Apoptosis, inflammation, and oxidative stress play crucial roles in the development of neurodegenerative diseases, with the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway being a key player. The blood-brain barrier poses challenges for drug delivery, but exosomes have emerged as potential nano-sized vehicles for central nervous system drug delivery due to their ability to cross the blood-brain barrier and their unique characteristics such as low immunogenicity and great tissue/cell penetration capabilities. This systematic review highlights the therapeutic potential of exosomes targeting the PI3K/Akt/mTOR signaling pathway in the context of neurodegenerative diseases and neurological diseases.
Review
Medicine, Research & Experimental
Yufei Lan, Boyang Liu, Hongbo Guo
Summary: The article summarizes the important role of N-6-methyladenosine (m(6)A) modification in the regulation and function of tumor-related long non-coding RNAs (lncRNAs), and discusses potential applications and future directions in the field.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Multidisciplinary Sciences
Yufei Lan, Tao Yang, Qu Yue, Zhao Wang, Xiangyang Zhong, Xin Luo, Boming Zuo, Manqing Zhang, Tianci Zeng, Boyang Liu, Hongbo Guo
Summary: This study demonstrated, for the first time, that amplifying IRP1 signals can reverse TMZ resistance and suppress tumor growth in vivo by inhibiting NFKB2 in the noncanonical NF-kappa B signaling pathway. Additionally, we identified that NFKB2 affects the TMZ sensitivity of GBM by modulating the expression of LCN2 and FPN1. In conclusion, this study reveals the role of the IRP1/NFKB2 pathway in regulating the LCN2/FPN1 signaling axis during the progression of TMZ resistance, suggesting a potential innovative therapeutic strategy for GBM.
