Article
Health Care Sciences & Services
Rachel Ann Elliott, Elizabeth Camacho, Dina Jankovic, Mark J. Sculpher, Rita Faria
Summary: The study provides national estimates of medication errors in the National Health Service (NHS) in England, with 237 million medication errors occurring annually. Most errors have little potential for harm, with prescribing in primary care accounting for a significant portion of clinically significant errors. The estimated cost of definitely avoidable adverse drug events (ADEs) on the NHS is £98,462,582 per year, with associated healthcare resource use and deaths.
BMJ QUALITY & SAFETY
(2021)
Article
Ophthalmology
Junxing Chay, Rachael Wei Chao Tang, Tien-En Tan, Choi Mun Chan, Ranjana Mathur, Brian J. H. Lee, Hiok Hong Chan, Shaun S. K. P. Sim, Saadia Farooqui, Kelvin Y. C. Teo, Eva K. Fenwick, Ecosse L. Lamoureux, Chui Ming Gemmy Cheung, Beau J. Fenner
Summary: This study aimed to assess the economic impact of inherited retinal disease (IRD) among Singaporeans. The study found that while employment rates were the same as the general population, patients with IRD had significantly lower income. Economic losses were driven by male patients and those with early age of onset, while direct healthcare costs contributed relatively little to the financial burden.
Article
Clinical Neurology
Christina Wolfson, Danielle E. Gauvin, Foluso Ishola, Maryam Oskoui
Summary: The objective of this systematic review was to describe the global incidence and prevalence of ALS. A total of 140 articles were selected for data extraction, and the results showed variations in the incidence and prevalence of ALS across the world, as well as differences in reporting quality.
Article
Rheumatology
Zachary S. Wallace, Gandarvaka Miles, Ekaterina Smolkina, Natalia Petruski-Ivleva, Duane Madziva, Claire Cook, Xiaoqing Fu, Yuqing Zhang, John H. Stone, Hyon K. Choi
Summary: This study describes the epidemiology of IgG4-related disease (IgG4-RD) in the USA, finding that the incidence and prevalence of IgG4-RD are increasing, and patients with IgG4-RD have a higher risk of death.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, General & Internal
Alexiane Baloche, Claude Dussart, Pierrick Bedouch, Florence Carrouel, Gerard Mick
Summary: This scoping review aims to analyze the epidemiology and clinical burden of invasive meningococcal disease (IMD) in France by reporting epidemiological parameters and describing the clinical consequences and care pathway of patients. The incidence of IMD cases in France has fluctuated over time, with a decrease in Sg B cases and an increase in Sg W cases. The most frequently reported sequelae are severe neurological disorder, epilepsy, and anxiety, but data on sequelae and care pathways are limited.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Ali Duarte-Garcia, Mehmet Hocaoglu, Maria Valenzuela-Almada, Shirley-Ann Osei-Onomah, Jesse Y. Dabit, Alain Sanchez-Rodriguez, Stephanie Q. Duong, Rachel E. Giblon, Hannah E. Langenfeld, Graciela S. Alarcon, Charles G. Helmick, Cynthia S. Crowson
Summary: The incidence and prevalence of systemic lupus erythematosus (SLE) are increasing in the US population, potentially due to the rising ethnic diversity. However, the severity of SLE and the survival gap between SLE and the general population have remained unchanged over time.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Sheila Isanaka, Christopher T. Andersen, Simon Cousens, Mark Myatt, Andre Briend, Julia Krasevec, Chika Hayashi, Amy Mayberry, Louise Mwirigi, Saul Guerrero
Summary: This study aimed to update estimates of the incidence correction factor to improve programme planning and inform the approach to burden estimation for severe wasting. Results show that incidence correction factors vary between sites and the currently recommended incidence correction factor of 1.6 may often underestimate the burden of severe wasting.
Review
Medicine, General & Internal
Paul McCann, Alison G. Abraham, Darren G. Gregory, Scott Hauswirth, Cristos Ifantides, Su-Hsun Liu, Ian J. Saldanha, Tianjing Li
Summary: This study aims to conduct a systematic review and meta-analysis of the prevalence and incidence of dry eye in the USA, focusing on relevant research since 2010. Ethical approval is not required for this review, and the results will be published in a peer-reviewed journal.
Review
Public, Environmental & Occupational Health
Xuanxuan Niu, Lin Zhu, Yifan Xu, Menghan Zhang, Yanxu Hao, Lei Ma, Yan Li, Huichun Xing
Summary: This review investigated the global prevalence of alcohol-related liver disease (ARLD) and found that it is 4.8%. The prevalence is higher in males and Caucasians. Alcoholic liver cirrhosis is the most common type of ARLD, and ascites is the most common complication. The incidence rate of ARLD is 0.208/1000 person-years, and the overall mortality rate is 23.9%, with liver-related mortality at 21.6%. Urgent measures are needed to reduce the factors contributing to the high disease prevalence.
Review
Medicine, General & Internal
Alan Schurle, Jay L. Koyner
Summary: CSA-AKI, a common complication following cardiac surgery, relies on the loss of renal function for diagnosis. New diagnostic injury biomarkers have shown promise in identifying renal injury risk early. Treatment is limited to supportive care, and costs are difficult to estimate accurately, but are increasing with the global rise in cardiac surgery volume.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sahajal Dhooria, Inderpaul Singh Sehgal, Ritesh Agarwal, Valliappan Muthu, Kuruswamy Thurai Prasad, Soundappan Kathirvel, Mandeep Garg, Amanjit Bal, Ashutosh Nath Aggarwal, Digambar Behera
Summary: In contrast to developed countries, sarcoidosis and hypersensitivity pneumonitis are the interstitial lung diseases with the highest burden in India.
Article
Medicine, General & Internal
Dominic Pilon, Charmi Patel, Marie-Helene Lafeuille, Maryia Zhdanava, Dee Lin, Aurelie Cote-Sergent, Carmine Rossi, Kruti Joshi, Patrick Lefebvre
Summary: The study estimated the prevalence, incidence, and economic burden of schizophrenia among Medicaid beneficiaries, finding variation by state but stability over time. Adults with schizophrenia incurred significantly higher healthcare costs and resource utilization compared to controls, with a similar burden seen among young adults.
CURRENT MEDICAL RESEARCH AND OPINION
(2021)
Article
Gastroenterology & Hepatology
Ami D. Sperber, Shrikant Bangdiwala, Douglas A. Drossman, Uday C. Ghoshal, Magnus Simren, Jan Tack, William E. Whitehead, Dan L. Dumitrascu, Xuicai Fang, Shin Fukudo, John Kellow, Edith Okeke, Eamonn M. M. Quigley, Max Schmulson, Peter Whorwell, Timothy Archampong, Payman Adibi, Viola Andresen, Marc A. Benninga, Bruno Bonaz, Serhat Bor, Luis Bustos Fernandez, Suck Chei Choi, Enrico S. Corazziari, Carlos Francisconi, Albis Hani, Leonid Lazebnik, Yeong Yeh Lee, Agata Mulak, M. Masudur Rahman, Javier Santos, Mashiko Setshedi, Ari Fahrial Syam, Stephen Vanner, Reuben K. Wong, Aurelio Lopez-Colombo, Valeria Costa, Ram Dickman, Motoyori Kanazawa, Ammar Hassanzadeh Keshteli, Rutaba Khatun, Iradj Maleki, Pierre Poitras, Nitesh Pratap, Oksana Stefanyuk, Sandie Thomson, Judith Zeevenhooven, Olafur S. Palsson
Summary: FGIDs have a high prevalence globally, especially among women. Individuals with FGIDs experience lower quality of life and require more frequent medical visits. The proportion of irritable bowel syndrome patients diagnosed using the Rome IV criteria is lower compared to the Rome III criteria.
Article
Gastroenterology & Hepatology
Eileen Morgan, Melina Arnold, A. Gini, V Lorenzoni, C. J. Cabasag, Mathieu Laversanne, Jerome Vignat, Jacques Ferlay, Neil Murphy, Freddie Bray
Summary: Colorectal cancer is the third most common cancer worldwide, with the highest incidence rates in Australia/New Zealand and Europe, and the lowest rates in Africa and Southern Asia. The burden of colorectal cancer is projected to increase by 2040, with the majority of cases predicted to occur in high HDI countries.
Article
Gastroenterology & Hepatology
Charles E. Gaber, Swathi Eluri, Cary C. Cotton, Paula D. Strassle, Timothy M. Farrell, Jennifer L. Lund, Evan S. Dellon
Summary: This study estimated the incidence, prevalence, and direct medical costs of achalasia in the United States. The results showed that achalasia has a higher epidemiologic and economic burden in the US than previously suggested, with a particularly increasing diagnosis in older patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Sport Sciences
Luigi Di Luigi, Emanuela A. Greco, Chiara Fossati, Antonio Aversa, Paolo Sgro, Cristina Antinozzi
Summary: Various endogenous and exogenous variables affect the hormone levels and sports performance in female athletes, and differences in sex chromosome abnormalities contribute to biological, functional, and hormonal variations among athletes. Physicians need to be aware of and understand the hormone variability and related health concerns in order to support healthy, fair, and inclusive sports participation for female athletes.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Article
Social Sciences, Interdisciplinary
Maria Grazia Vaccaro, Giulia Izzo, Alessia Sarica, Sandro La Vignera, Antonio Aversa
Summary: This study aims to analyze the different perceptions of sociosexual experiences among the southern population during the COVID-19 pandemic. Through cluster analysis, we identified eleven clusters and found intra- and inter-diagnostic heterogeneity in the sexual profile of participants. We also discovered significant gender differences, with women showing a greater propensity for positive sexual attitudes and desires compared to men.
SEXUALITY RESEARCH AND SOCIAL POLICY
(2023)
Article
Genetics & Heredity
Maria Carmela Zagari, Paola Chiarello, Stefano Iuliano, Lucia D'Antona, Valentina Rocca, Emma Colao, Nicola Perrotti, Francesca Greco, Rodolfo Iuliano, Antonio Aversa
Summary: Loss of function mutations in the PHEX gene can lead to X-linked dominant hypophosphatemia, the most common form of genetic rickets. This condition is characterized by renal phosphate wasting, increased fibroblast growth factor 23 (FGF-23), growth retardation, bone deformities, and musculoskeletal manifestations. Despite the discovery of numerous mutations in the PHEX gene, there are currently no clear genotype-phenotype correlations in patients with hypophosphatemic rickets (XLH).
Article
Medicine, General & Internal
Sandro La Vignera, Rosita A. Condorelli, Aldo E. Calogero, Rossella Cannarella, Antonio Aversa
Summary: This study prospectively investigates the effects of liraglutide, a GLP1 analog, on reproductive and sexual function in men with metabolic hypogonadism. The results show that liraglutide significantly improves sperm parameters and erectile function, as well as increasing testosterone and sex hormone-binding globulin levels. This suggests that liraglutide is a useful pharmacological treatment for male patients with metabolic hypogonadism.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Andrology
Andrea Crafa, Rosita Angela Condorelli, Sandro La Vignera, Aldo Eugenio Calogero, Rossella Cannarella
Summary: This article presents a clinical case of a globozoospermic patient with a new mutation of the DPY19L2 gene and provides recommendations based on a systematic literature review on gene mutations, assisted reproductive techniques, and the risk of genetic abnormalities transmission. The study highlights the importance of genetic evaluation and specific assisted reproductive techniques in managing globozoospermia patients.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Medicine, General & Internal
Andrea Crafa, Aldo Eugenio Calogero, Rossella Cannarella, Rosita Angela Condorelli, Antonio Aversa, Sandro La Vignera
Summary: Male infertility and prostate cancer are the most researched andrological diseases, followed by benign prostatic hyperplasia and erectile dysfunction, which are expected to increase in prevalence due to population aging. However, research on inflammation of the accessory sexual glands is relatively scarce.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Livia Basile, Rosita A. Condorelli, Aldo E. Calogero, Rossella Cannarella, Federica Barbagallo, Andrea Crafa, Antonio Aversa, Sandro La Vignera
Summary: Red wine is rich in nutrients and has been the focus of numerous scientific studies. It has been reported that moderate consumption of red wine, with its phenolic and antioxidant properties, can have positive effects on various diseases. Additionally, the ethanol content in red wine has shown various biological properties. However, little is known about the correlation between red wine consumption and male sexual function. This review aimed to evaluate the effects of moderate red wine consumption on erectile function and found potential benefits in patients with erectile dysfunction as well as positive influences on reproductive function through vasorelaxant and antioxidant mechanisms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Rossella Cannarella, Cristina M. B. Petralia, Rosita A. Condorelli, Antonio Aversa, Aldo E. Calogero, Sandro La Vignera
Summary: This article provides an overview of the molecular mechanisms and usage of follicle-stimulating hormone (FSH) in the treatment of male infertility. It also evaluates the predictor factors of FSH administration response and the indications of the latest guidelines on the use of FSH in male infertility treatment.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Genetics & Heredity
Andrea Crafa, Claudia Leanza, Rosita A. Condorelli, Sandro La Vignera, Aldo E. Calogero, Rossella Cannarella
Summary: This study suggests that the methylation degree of the LINE1 gene in sperm does not play a determining role in male infertility and/or abnormal sperm parameters. It also indicates that LINE1 should not be included in the genetic panel for identifying the most representative and cost-effective genes in couples undergoing ART cycles.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Review
Endocrinology & Metabolism
Cristina Antinozzi, Emanuela A. Greco, Paolo Sgro, Ivan Dimauro, Antonio Aversa, Luigi Di Luigi
Summary: In addition to its mechanical roles, the skeletal muscle system plays a crucial role in thermoregulation, secondary sexual characteristics, hormone metabolism, glucose uptake and storage, and energetic metabolism. PDE5i drugs, such as tadalafil, can influence skeletal muscle physiology and endocrine-metabolic pathways by increasing the intracellular level of cGMP. These drugs can modulate insulin-related metabolic pathways and hormone responses, protein metabolism, and anabolism/catabolism during and after physical exercise-related stress.
MINERVA ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Walter Vena, Liborio Vaccalluzzo, Sandro La Vignera, Emanuela Morenghi, Cristina D'Agostino, Anna Perri, Bruno Giammusso, Andrea G. Lania, Antonio Aversa, Alessandro Pizzocaro
Summary: This study aimed to evaluate the improvement of penile vascular flows after LISWT treatment in patients with ED. The results showed that LISWT improved erectile hardness and satisfaction rates among patients with ED.
MINERVA ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Vincenzo Garofalo, Rosita A. Condorelli, Rossella Cannarella, Antonio Aversa, Aldo E. Calogero, Sandro La Vignera
Summary: This systematic review and meta-analysis examines the relationship between iron deficiency and thyroid function. The analysis reveals that patients with iron deficiency have lower thyroid hormone levels, especially in pregnant women. It also shows that iron deficiency increases the prevalence of thyroid autoantibodies.
Review
Andrology
Rossella Cannarella, Claudia Leanza, Andrea Crafa, Federica Barbagallo, Sandro La Vignera, Rosita Angela Condorelli, Aldo Eugenio Calogero
Summary: This study examined the impact of MEST gene methylation pattern on sperm parameters in infertile patients and found that MEST gene methylation was higher in infertile patients compared to normal men.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Endocrinology & Metabolism
Stefano Iuliano, Francesca Greco, Giuseppe Seminara, Maria C. Zagari, Paolo Sgro, Gianfranco Di Gennaro, Emanuela A. Greco, Antonio Aversa
Summary: This study suggests that the combination of unsupervised physical activity and a nutraceutical supplement can improve body composition, insulin sensitivity, and testosterone production in overweight-obese men with subclinical hypogonadism. Further long-term controlled studies are necessary to elucidate the potential impact on fertility.
MINERVA ENDOCRINOLOGY
(2023)
Letter
Endocrinology & Metabolism
Rossella Cannarella, Aldo E. Calogero, Rosita A. Condorelli, Emanuela A. Greco, Antonio Aversa, Sandro LA Vignera
MINERVA ENDOCRINOLOGY
(2022)
