Editorial Material
Health Care Sciences & Services
Cristian Baicus
Summary: Many observational studies have shown an association between the severity of COVID-19 and different white blood cell counts, but causality is yet to be determined. If these biomarkers are considered as potential therapeutic targets, causality becomes important. Randomized trials are not always feasible, but Mendelian randomization studies can provide evidence for causal relationships.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Yitang Sun, Jingqi Zhou, Kaixiong Ye
Summary: The study reveals causal protective effects of higher basophil count, basophil percentage of white blood cells, and myeloid white blood cell count on severe COVID-19, but no association with COVID-19 severity or susceptibility was found. Individuals with a lower genetic capacity for basophils may be at risk, while enhancing basophil production could be an effective therapeutic strategy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Shiu Lun Au Yeung, Jie V. Zhao, C. Mary Schooling
Summary: Using Mendelian randomization analysis, the study found no significant association between poorer glycemic traits and genetic predisposition to type 2 diabetes with the risk of COVID-19 and specific phenotypes. Further research is warranted to confirm these findings and explore the relationship between glycemic traits and COVID-19 severity.
Article
Virology
Ancha Baranova, Hongbao Cao, Shaolei Teng, Fuquan Zhang
Summary: Through genetic correlation analysis and Mendelian randomization analysis, this study identified several risk factors for COVID-19 hospitalization, including unhealthy lifestyle factors and health conditions. Additionally, protective factors such as higher education attainment, physical activity, and never smoking were also identified. These findings have important implications for risk stratification and prevention of severe outcomes in patients with COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Weifeng Shang, Hang Qian, Xuan Shen, Zhenliang Wen, Sheng Zhang, Dechang Chen
Summary: This study used two-sample Mendelian randomization (MR) analysis to evaluate the relationship between 486 blood metabolites and the risk of severe COVID-19. The results showed weak evidence of an association between 3-hydroxybutyrate and the risk of severe COVID-19.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Clinical Neurology
Hanyu Zhang, Zengyuan Zhou
Summary: This Mendelian randomization study suggests a potential association between genetically predicted COVID-19 and an increased risk of AD, as well as a reduced risk of ALS and MS.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Genetics & Heredity
Ana I. Hernandez Cordero, Xuan Li, Stephen Milne, Chen Xi Yang, Yohan Bosse, Philippe Joubert, Wim Timens, Maarten van den Berge, David Nickle, Ke Hao, Don D. Sin
Summary: The study identified 18 genes associated with COVID-19, with 12 of them related to the risk of COVID-19. A causal association between plasma ABO protein and COVID-19 was discovered in the study, suggesting that increased plasma levels of ABO protein may increase the risk of COVID-19 and severe COVID-19.
Article
Multidisciplinary Sciences
Xunying Zhao, Xueyao Wu, Jinyu Xiao, Li Zhang, Yu Hao, Chenghan Xiao, Ben Zhang, Jiayuan Li, Xia Jiang
Summary: Little is known about the long-term effects of COVID-19 on female-specific cancers and the shared genetic influences between them. A comprehensive genome-wide analysis found genetic correlations between COVID-19 (infection, hospitalization, and critical illness) and endometrial cancer, but no valid association with other cancer types. Shared genetic markers and genes were identified between COVID-19 and breast, ovarian, and endometrial cancer, suggesting common underlying mechanisms rather than causal associations.
Review
Public, Environmental & Occupational Health
Shan Luo, Ying Liang, Tommy Hon Ting Wong, Catherine Mary Schooling, Shiu Lun Au Yeung
Summary: This article summarizes the modifiable factors for COVID-19, such as smoking, obesity, and inflammatory factors, and provides potential proteomic signatures for treating COVID-19.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Biology
Lung-An Hsu, Semon Wu, Ming-Sheng Teng, Yu-Lin Ko
Summary: This study investigated the genetic variants associated with erythrocyte indices, cardiometabolic traits, and diabetes risk in Taiwanese individuals. The findings suggest that certain genetic variants around the alpha-globin genes can serve as surrogate markers for common alpha-thalassemia mutations in Taiwan. The study also revealed causal links between alpha-thalassemia-related erythrocyte indices, cardiometabolic traits, and heightened diabetes risk.
LIFE SCIENCE ALLIANCE
(2023)
Article
Medicine, General & Internal
Jiao Luo, Jesper Qvist Thomassen, Celine Bellenguez, Benjamin Grenier-Boley, Itziar de Rojas, Atahualpa Castillo, Kayenat Parveen, Fahri Kuecuekali, Aude Nicolas, Oliver Peters, Anja Schneider, Martin Dichgans, Dan Rujescu, Norbert Scherbaum, Deckert Juergen, Steffi Riedel-Heller, Lucrezia Hausner, Laura Molina Porcel, Emrah Duezel, Timo Grimmer, Jens Wiltfang, Stefanie Heilmann-Heimbach, Susanne Moebus, Thomas Tegos, Nikolaos Scarmeas, Jordi Clarimon, Fermin Moreno, Jordi Perez-Tur, Maria J. Bullido, Pau Pastor, Raquel Sanchez-Valle, Victoria Alvarez, Merce Boada, Pablo Garcia-Gonzalez, Raquel Puerta, Pablo Mir, Luis M. Real, Gerard Pinol-Ripoll, Jose Maria Garcia-Alberca, Jose Luis Royo, Eloy Rodriguez-Rodriguez, Hilkka Soininen, Teemu Kuulasmaa, Alexandre de Mendonca, Shima Mehrabian, Jakub Hort, Martin Vyhnalek, Sven van der Lee, Caroline Graff, Goran Papenberg, Vilmantas Giedraitis, Anne Boland, Delphine Bacq-Daian, Jean-Francois Deleuze, Gael Nicolas, Carole Dufouil, Florence Pasquier, Olivier Hanon, Stephanie Debette, Edna Gruenblatt, Julius Popp, Luisa Benussi, Daniela Galimberti, Beatrice Arosio, Patrizia Mecocci, Vincenzo Solfrizzi, Lucilla Parnetti, Alessio Squassina, Lucio Tremolizzo, Barbara Borroni, Benedetta Nacmias, Sandro Sorbi, Paolo Caffarra, Davide Seripa, Innocenzo Rainero, Antonio Daniele, Carlo Masullo, Gianfranco Spalletta, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick Kehoe, Tsolaki Magda, Giacomina Rossi, Pascual Sanchez-Juan, Kristel Sleegers, Martin Ingelsson, Ole A. Andreassen, Mikko Hiltunen, Cornelia Van Duijn, Rebecca Sims, Wiesje van der Flier, Agustin Ruiz, Alfredo Ramirez, Jean-Charles Lambert, Ruth Frikke-Schmidt
Summary: This genetic association study identifies novel genetic associations between high HDL cholesterol concentrations and high systolic blood pressure with increased risk of AD, potentially inspiring new drug targeting and improved prevention implementation.
Article
Virology
Ancha Baranova, Hongbao Cao, Fuquan Zhang
Summary: By conducting genetic correlation and Mendelian randomization analyses, the study confirms a genetic relationship between hypertension and COVID-19, and identifies molecular pathways linking hypertension to COVID-19. The analysis reveals shared genetic variation between hypertension and hospitalized COVID-19, as well as specific protein-coding risk genes. Pathway analysis suggests that hypertension may promote COVID-19 development through inflammatory pathways. The findings indicate that genetically determined hypertension may increase the risk for severe COVID-19 and establish causal links between hypertension and COVID-19 through shared genetic variation and molecular pathways.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Hongbao Cao, Ancha Baranova, Xuejuan Wei, Chun Wang, Fuquan Zhang
Summary: Observational studies have found a high comorbidity between T2D and COVID-19, and genetic correlation and MR analysis have shown a causal effect of T2D on hospitalized and critical COVID-19, as well as a causal effect of SARS-CoV-2 infection on T2D. Pathway analysis has also revealed potential mechanisms underlying the connection between T2D and COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Xuxu Liu, Zhiwei Du, Jing Wang, Qiang Wang, Yi Zheng, Le Niu, Chenjun Hao, Dongbo Xue, Yingmei Zhang
Summary: Traditional observational studies have shown a potential association between trans fatty acids (TFAs) and COVID-19, but the causal relationship is unclear. This study used Mendelian randomization analysis to investigate the causal link between genetically determined TFAs and COVID-19. The results indicate that trans, cis-18:2 TFAs have an independent and robust causal effect on COVID-19 hospitalization and severity.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Clinical Neurology
Shu Ran, Jia Yao, Baolin Liu
Summary: People with COVID-19 have poorer cognitive functioning, but the causal relationship between COVID-19 and cognitive impairment is still unclear. Using Mendelian randomization analysis, this study found a causal association between cognitive performance and COVID-19, suggesting that individuals with better cognitive performance are less likely to be infected. The reverse MR analysis treating COVID-19 as the exposure and cognitive performance as the outcome did not show a significant association, indicating a unidirectional relationship.
ALZHEIMERS & DEMENTIA
(2023)