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Oncology
Reihaneh Rafiee, Ehsan Razmara, Mahsa Motavaf, Majid Mossahebi-Mohammadi, Shima Khajehsharifi, Fatemeh Rouhollah, Sadegh Babashah
Summary: This study confirms the capability of circulating serum miR-1229 and miR-1246 as novel diagnostic biomarkers for colorectal cancer (CRC). The expression levels of miR-1229 and miR-1246 were significantly higher in CRC patients compared to healthy controls, and were associated with lymph node metastasis.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Toxicology
Peiyuan Li, Weisheng Xiao
Summary: Circ_0005758 acts as a tumor suppressor in gastric cancer by inhibiting progression through the miR-1229-3p/GCNT4 axis.
TOXICOLOGY IN VITRO
(2022)
Article
Oncology
Hongli Li, Yiwei Zhang, Huiqin Song, Li Li
Summary: The study revealed that circRFX3 functions as a tumor promoter in glioma by modulating the miR-1179/miR-1229-VASP axis, promoting cell proliferation, migration, and invasion while reducing apoptosis. These findings provide a new target and therapeutic strategy for glioma treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Article
Cell Biology
Xisheng Liu, Xiaole Meng, Xiao Peng, Qianlan Yao, Fangming Zhu, Zhongyi Ding, Hongze Sun, Xueni Liu, Dan Li, Ying Lu, Huamei Tang, Bin Li, Zhihai Peng
Summary: The global downregulation of miRNA expression, potentially due to defects in miRNA processing machinery, is a hallmark of human cancer. In colorectal cancer (CRC), downregulation of the key regulator of miRNA processing, Argonaute 2 (AGO2), has been found to promote epithelial-mesenchymal transition (EMT) and indicate poor prognosis. Knockdown of AGO2 in CRC cells enhanced migration, invasion, and metastasis, while integrated analyses revealed neuropilin 1 (NRP1) as a new substrate of AGO2 via miR-185-3p. Therapeutically targeting the AGO2/miR-185-3p/NRP1 axis may offer a potential treatment approach for CRC.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Enoch Kang, Sung Cheol Jung, Soo Kyung Nam, Yujun Park, Soo Hyun Seo, Kyoung Un Park, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee
Summary: This study evaluated the prognostic potential of EMT-related miRNAs as biomarkers in colorectal cancer (CRC). The results showed that the tissue expression of miR-200c-3p and the plasma levels of miR-1290 were associated with poor prognosis.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Rilei Jiang, Xiaolei Chen, Shaohua Ge, Qin Wang, Yichang Liu, Haijun Chen, Jiatuo Xu, Jiang Wu
Summary: The study revealed that miR-21-5p induces pyroptosis in colorectal cancer through TGFBI regulation, providing important mechanistic insights and expanding its potential for clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Babak Jahangiri, Mohammad Khalaj-Kondori, Elahe Asadollahi, Leyli Purrafee Dizaj, Majid Sadeghizadeh
Summary: This study found that exosomes derived from mesenchymal stem cells (MSC-Exos) can suppress proliferation, migration, invasion, and metastasis while inducing apoptosis of colorectal cancer (CRC) cells through the miR-100/mTOR/miR-143 axis. These findings suggest that MSC-Exo treatment and miR-100 restoration may be potential therapeutic strategies for CRC.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Xijuan Chen, Yingqiang Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Junqi Liu
Summary: miR-590-3p delivered through exosomes derived from CAFs enhances radioresistance in CRC by positively regulating the CLCA4-dependent PI3K/Akt signaling pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biotechnology & Applied Microbiology
Hongwei Fan, Rong Ai, Suen Mu, Xuemin Niu, Zhengrong Guo, Lin Liu
Summary: Research has found that miR-19a promotes the proliferation, migration, and invasion of colorectal cancer cells. It has been discovered that miR-19a suppresses ferroptosis by negatively regulating IREB2. This finding reveals a novel mechanism of miR-19a-mediated ferroptosis in CRC.
Article
Cell Biology
Dong Wang, Xiaohui Wang, Yujia Song, Mahan Si, Yuqi Sun, Xiaohui Liu, Shuxiang Cui, Xianjun Qu, Xinfeng Yu
Summary: This study found a significant positive correlation between CXCR7 expression and CAF activation markers in colonic tissues and transgenic mice. RNA sequencing revealed an increase in miR-146a-5p and miR-155-5p levels in CXCR7-overexpressing CRC cells and their exosomes. Furthermore, these CRC cell-derived miRNAs could be uptaken by CAFs via exosomes and promote their activation, leading to enhanced invasive capacity of CRC cells and pro-metastatic switch. The activation of CAFs by miR-146a-5p and miR-155-5p also facilitated tumor formation and lung metastasis of CRC in vivo. Therefore, these findings provide new insights into CXCR7-mediated CRC metastasis and suggest potential biomarkers and therapeutic targets for inhibiting CRC metastasis.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Dan Song, Qian Zhang, Hao Zhang, Liangliang Zhan, Xinchen Sun
Summary: The study reveals that miR-130b-3p is upregulated in colorectal cancer (CRC) tissues and cells and can be detected in the feces of CRC patients. Inhibition of miR-130b-3p suppresses CRC cell proliferation and tumor growth in vivo. The mechanism involves direct targeting of chromodomain helicase DNA binding protein 9 (CHD9) by miR-130b-3p.
Article
Biochemistry & Molecular Biology
Paulina Gil-Kulik, Alicja Petniak, Natalia Kluz, Grzegorz Wallner, Tomasz Skoczylas, Aleksander Ciechanski, Janusz Kocki
Summary: Colorectal cancer is the second leading cause of cancer-related death worldwide, often diagnosed at an advanced stage due to being asymptomatic. The expression of miR-3613-3p is downregulated in colorectal cancer cells and tumors, but increased in surrounding tissue and after radiotherapy, showing potential as a therapeutic target for CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Elisa Martino, Anna Balestrieri, Francesca Aragona, Giovanna Bifulco, Luigi Mele, Giuseppe Campanile, Maria Luisa Balestrieri, Nunzia D'Onofrio
Summary: This study reports the antineoplastic effect of miR-148a-3p overexpression in a colorectal cancer (CRC) model, which occurs through apoptosis, mitochondrial impairment, lipid peroxidation, and ferroptosis sustained by the ACSL4/TFRC/Ferritin axis. The downregulation of SLC7A11 by miR-148a-3p may contribute to the cytotoxicity. These findings highlight the oncosuppressor role of miR-148a-3p and its potential as a diagnostic and therapeutic biomarker in CRC.
Article
Cell Biology
Yonghuan Mao, Ji Miao, Ling Xi, Hanwen Tong, Xiaofei Shen, Qiang Li, Chunzhao Yu
Summary: Colorectal cancer (CRC) is a common and deadly cancer worldwide. This study investigated the role of circRNAs in CRC and identified circSKA3 as the most significantly upregulated circRNA in CRC tissues. Further experiments showed that circSKA3 promotes the proliferation, migration, and invasion of CRC cells. The study also revealed that circSKA3 interacts with miR-1238 and YTHDF2, leading to decreased methylation of STAT5A. These findings suggest that circSKA3 could be a novel target for CRC treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)