Review
Medicine, General & Internal
Hafiza Sidra Tul Muntaha, Mubashar Munir, Syeda Haleema Sajid, Zouina Sarfraz, Azza Sarfraz, Karla Robles-Velasco, Muzna Sarfraz, Miguel Felix, Ivan Cherrez-Ojeda
Summary: This study provides the latest evidence for the efficacy of ileal bile acid transport (IBAT) blockers in patients with Alagille syndrome (ALGS). The results demonstrate that these drugs can significantly reduce itch and serum bile acid levels, while improving fatigue and quality of life. However, these drugs may lead to elevated levels of alanine aminotransferase (ALT).
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Jacqueline A. G. M. Langedijk, Ulrich H. Beuers, Ronald P. J. Oude Elferink
Summary: This article discusses the debilitating symptom of pruritus in various cholestatic disorders, the unresolved molecular mechanisms, and the current guidelines-approved therapy. Experimental therapeutic approaches are also necessary to improve patients' quality of life.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Katrin Panzitt, Peter Fickert, Martin Wagner
Summary: Autophagy is a cellular degradation pathway that helps cells survive in harsh environments by providing nutrients and eliminating unnecessary or damaged components. Hepatic autophagy plays a crucial role in lipid, glycogen, and protein metabolism, and its dysregulation is associated with various liver diseases.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Gastroenterology & Hepatology
Bo Li, Jun Zhang, Yong Chen, Qixia Wang, Li Yan, Rui Wang, Yiran Wei, Zhengrui You, Yikang Li, Qi Miao, Xiao Xiao, Min Lian, Weihua Chen, Dekai Qiu, Jingyuan Fang, M. Eric Gershwin, Ruqi Tang, Xiong Ma
Summary: The study revealed significant individual variability in the therapeutic effects of cholestyramine in icteric PBC patients. Differences in gut microbial composition and metabolites were observed between patients with superior remission (SR) and inferior remission (IR). Patients in the SR group showed enrichment of specific bacterial species producing short-chain fatty acids (SCFAs), while the IR group exhibited an increase in Klebsiella pneumonia.
Article
Gastroenterology & Hepatology
Atsushi Tanaka, Masanori Atsukawa, Keiji Tsuji, Kazuo Notsumata, Akari Suyama, Hiroshi Ito, Sugato Das, Robyn von Maltzahn, Megan M. McLaughlin
Summary: This study aimed to compare patient characteristics and outcomes between the overall and Japanese populations in the treatment of pruritus in patients with primary biliary cholangitis. The results showed similar demographics and baseline clinical characteristics across treatment groups and between both populations. The therapeutic responses and safety of linerixibat were consistent in both the Japanese and overall populations, indicating its effectiveness as a treatment option for cholestatic pruritus in patients with primary biliary cholangitis.
HEPATOLOGY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jing Zeng, Jiangao Fan, Huiping Zhou
Summary: Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), gradually progress to liver fibrosis, cirrhosis, and failure. Disruption of bile acid metabolism and intrahepatic circulation plays a crucial role in accelerating the progression of cholestatic liver diseases. Bile acids not only act as detergents for nutrition absorption but also function as key signaling molecules that regulate hepatic metabolism and immune responses. This review focuses on the role of bile acid-mediated signaling in cholestatic liver disease.
CELL AND BIOSCIENCE
(2023)
Article
Veterinary Sciences
Lara Baptista, Danica Pollard, Andrea Di Bella
Summary: This study aimed to evaluate the differences in resting serum bile acid concentrations between septic and non-septic dogs. The results showed significantly higher resting serum bile acid concentrations in the septic group compared to the non-septic group. However, when comparing the septic group with a control group of dogs admitted for elective orthopedic procedures, no difference in bile acid concentrations was found.
VETERINARY SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Juan Hao, Xiaoyu Shen, Xiaohong Shao, Chunling Zhu, Kan Lu, Yi Xu, Yiyue Chen, Jibo Liu, Yaqin Ding, Xin Xie, Jian Wu, Quanjun Yang
Summary: This study evaluated the therapeutic effect of honokiol (HNK) on chronic cholestasis liver injury through two experiments. The results showed that HNK can reduce ductular reaction, regulate bile acid metabolism, alleviate fibrosis, and inhibit inflammatory response. Moreover, HNK exhibits no hepatotoxicity even with long-term high-dose treatment. In conclusion, HNK has the potential to be a therapeutic agent for cholestasis liver disease.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Plant Sciences
Shasha Qin, Jingzhuo Tian, Yong Zhao, Lianmei Wang, Jinyu Wang, Suyan Liu, Jing Meng, Fang Wang, Chenyue Liu, Jiayin Han, Chen Pan, Yushi Zhang, Yan Yi, Chunying Li, Meiting Liu, Aihua Liang
Summary: This study aims to systematically elucidate the mechanism by which Gardenia extract ameliorates ANIT-induced cholestatic liver injury.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Chemistry, Multidisciplinary
Kai-li Fu, Pan Chen, Yan-ying Zhou, Yi-ming Jiang, Yue Gao, Hui-zhen Zhang, Li-huan Guan, Cong-hui Wang, Jun-ling Liu, Min Huang, Hui-chang Bi
Summary: Hepatic deficiency of Vps33b exacerbates cholestatic liver injury, leading to abnormal serum markers and liver function, as well as altered metabolism of bile acids. Metabolomics analysis reveals that Vps33b deficiency changes the profile of bile acids, accompanied by alterations in gene expression of bile acid metabolizing enzymes and transporters.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Obstetrics & Gynecology
Rebecca Horgan, Christiana Bitas, Alfred Abuhamad
Summary: This study compared the guidelines for the diagnosis, antepartum surveillance, and timing of delivery of pregnancies complicated by intrahepatic cholestasis of pregnancy published by the Society for Maternal-Fetal Medicine and the Royal College of Obstetricians and Gynaecologists. The two organizations have several key differences in their clinical guidelines, including the criteria for diagnosing intrahepatic cholestasis of pregnancy and the recommended treatments. The Society for Maternal-Fetal Medicine recommends fetal surveillance and specific delivery timing based on bile acid levels, while the Royal College of Obstetricians and Gynaecologists does not recommend additional fetal testing beyond kick count assessment and stratifies delivery timing based on bile acid levels.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Gastroenterology & Hepatology
Beng San Yeoh, Piu Saha, Rachel M. Golonka, Jun Zou, Jessica L. Petrick, Ahmed A. Abokor, Xia Xiao, Venugopal R. Bovilla, Alexis C. A. Bretin, Jesus Rivera-Esteban, Dominick Parisi, Andrea A. Florio, Stephanie J. Weinstein, Demetrius Albanes, Gordon J. Freeman, Amira F. Gohara, Andreea Ciudin, Juan M. Pericas, Bina Joe, Robert F. Schwabe, Katherine A. McGlynn, Andrew T. Gewirtz, Matam Vijay-Kumar
Summary: This study reveals the association between portosystemic shunt (PSS) and the development of hepatocellular carcinoma (HCC). In mice, PSS combined with a fermentable fiber-enriched diet leads to increased serum bile acids (BA), causing liver injury and progression to cholestatic HCC. Human serum analysis also shows that elevated BA is associated with future development of HCC.
Article
Immunology
Yanbo Kou, Xingping Zheng, Liyuan Meng, Mengnan Liu, Shihong Xu, Qiyue Jing, Shenghan Zhang, Hanying Wang, Jinzhi Han, Zhuanzhuan Liu, Yanxia Wei, Yugang Wang
Summary: HVEM and BTLA deficiencies exacerbate liver injury and impair liver repair, potentially due to impaired neutrophil accumulation after injury. HVEM and BTLA deficiencies affect hepatic neutrophil accumulation and may restrain liver injury by regulating gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Leilei Yu, Yaru Liu, Shunhe Wang, Qingsong Zhang, Jianxin Zhao, Hao Zhang, Arjan Narbad, Fengwei Tian, Qixiao Zhai, Wei Chen
Summary: Cholestasis is a condition characterized by abnormal bile production or excretion, which can have various causes with complex factors. A better understanding and distinction of cholestasis from different etiologies is essential and will provide theoretical support for the development of corresponding therapeutic drugs.
Article
Pharmacology & Pharmacy
Ivone Cristina Igreja Sa, Katarina Tripska, Fatemeh Alaei Faradonbeh, Milos Hroch, Hana Lastuvkova, Jolana Schreiberova, Marian Kacerovsky, Miguel Pericacho, Petr Nachtigal, Stanislav Micuda
Summary: Labetalol exacerbates the accumulation of bile acids (BA) in estrogen-induced cholestasis and soluble endoglin (sEng) aggravates this retention. Increased sEng levels might explain the coincidence of intrahepatic cholestasis of pregnancy (ICP) with preeclampsia. Monitoring of BA in pregnant women with preeclampsia and labetalol therapy is recommended.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pediatrics
Hanaa M. El-Karaksy, Mortada M. El-Shabrawi, Nabil A. Mohsen, Nehal M. El-Koofy, Wafaa A. El-Akel, Mona E. Fahmy, Noha A. Yassin
INDIAN JOURNAL OF PEDIATRICS
(2011)
Article
Gastroenterology & Hepatology
Hanaa M. El-Karaksy, Lamiaa M. Mohsen, Doa'a A. Saleh, Mona S. Hamdy, Noha A. Yassin, Mohamed Farouk, Mohamed E. Salit, Mortada H. El-Shabrawi
WORLD JOURNAL OF GASTROENTEROLOGY
(2014)
Article
Pediatrics
Engy A. Mogahed, Hanaa El-Karaksy, Hala Abdullatif, Noha A. Yasin, Ahmed Nagy, Shereen Abdel Alem, Hadeel Gamal Eldeen, Mona S. El-Raziky
Summary: Egyptian children infected with HCV genotype 4 achieved significant regression in liver stiffness after treatment with direct acting antivirals. Improvement in liver stiffness, APRI, and FIB-4 index was observed in patients 1 year after achievement of SVR. Comorbid conditions and previous treatment with interferon were not associated with increased liver stiffness.
JOURNAL OF PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Hany William Z. Hanna, Cristiano Rizzo, Radwa Marawan Abdel Halim, Hemmat Elewa El Haddad, Randa Salam, Hazem El-Sayed Abou-Youssef
Summary: The study found a stronger association between the FokI AA genotype and HT in Egyptian patients compared to hypothyroid non-HT controls, with patients having FokI AA genotype showing higher levels of 25-OH-vitamin D3 despite normal levels of vitamin D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Rheumatology
Noha Adel Yassin, Mai Haroon, Azza Elhamshary
Summary: The study aimed to evaluate the frequency of hepatotoxicity in JIA children receiving MTX, with 28% of patients developing liver chemistry abnormalities. Children on MTX had higher ALT and AST levels, but lower ALP levels compared to those not on MTX, with no significant differences in other factors.
CURRENT RHEUMATOLOGY REVIEWS
(2021)
Article
Gastroenterology & Hepatology
Nora Selim, Heba Omair, Hanaa El-Karaksy, Marianne Fathy, Enas Mahmoud, Sherif Baroudy, Mona Fathy, Noha Yassin
Summary: This study aimed to detect variations in exons 14, 15, and 24 of the ABCB11 gene in Egyptian infants and children with suspected PFIC2. Two variations were found in exons 14 and 24, while no variations were identified in exon 15. This suggests that exons 14, 15, and 24 are not hot spots for common mutations in Egyptian PFIC2 patients.
ARAB JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Hany William Z. Hanna, Randa Salam, Mohamed Mamdouh Youssef, Rokaya A. B. D. El Aziz, Moustafa Saeed
Summary: This study aimed to evaluate cardiac troponin I as a predictive factor for poor in-hospital outcomes in COVID-19 patients. The results showed that there was a significant difference in troponin levels between COVID-19 survivors and non-survivors, with a higher proportion of non-survivors requiring mechanical ventilation and a higher APACHE II score in the non-survivors group. Therefore, cardiac troponin I is a good prognostic factor for poor in-hospital outcomes among COVID-19 patients.
ALEXANDRIA JOURNAL OF MEDICINE
(2023)
Article
Respiratory System
Iman Atef Mandour, Sabah Ahmed Hussein, Hany William Z. Hanna, Salma Ahmed Abdellatif, Balsam Sherif Fahmy
Summary: This study aimed to determine the levels of vitamins A and E in COVID-19 patients. The results showed that vitamin A levels were significantly reduced in ICU-admitted COVID-19 patients, and vitamin A deficiency was associated with disease severity. The study suggests the importance of vitamin A supplementation in disease management.
EGYPTIAN JOURNAL OF BRONCHOLOGY
(2023)
Article
Pediatrics
Noha A. Yassin, Salma Z. El-Houchi, Sarah F. Abd El-Shafy, Noha S. Soliman, Mohamed A. Elmonem, Nehal El-Koofy
Summary: This study found that hepatitis A infection is common in Egyptian children under 5 years old with gastroenteritis-like manifestations and anicteric hepatitis. Some social, demographic, and hygienic factors may be associated with the occurrence of hepatitis A.
EGYPTIAN PEDIATRIC ASSOCIATION GAZETTE
(2022)
Article
Genetics & Heredity
Rabab Khairat, Hanaa El-Karaksy, Hala T. El-Bassyouni, Ahmed K. Saad, Eman Rabie, Khaled Hamed, Noha A. Yassin
Summary: This study investigated the clinical features of ALGS in 17 pediatric patients from Egypt and identified five novel pathogenic variations in the JAG1 gene. The findings provide insights into the genetic basis of ALGS in the Egyptian population and highlight the importance of molecular studies in understanding rare genetic disorders.
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2022)
Article
Gastroenterology & Hepatology
Abeer Awad Abdellatif, Mohamad Sherif Mogawer, Mostafa El-Shazli, Hanaa El-Karaksy, Ayman Salah, Amany Abdel-Maqsod, Mona El-Amir, Mohamed Said, Naglaa Zayed, Karim Hosny, Hadeel Gamal Eldeen, Ayman M. A. Osman, Doaa A. Mansour, Ahmed Nabil, Ahmed Abdel-Ghani, Engy A. Mogahed, Noha A. Yasin
Summary: Solid organ transplantation services have been disrupted due to COVID-19 pandemic, and there is a need to identify safe practices for resuming activities. This study explores the experience of resuming living donor liver transplantation and the obstacles faced in Egypt. Careful screening, adequate protective equipment, and effective infection control measures are essential for a safe return to transplantation practice.
EGYPTIAN LIVER JOURNAL
(2021)
Review
Pediatrics
N. A. Yassin, E. A. Mogahed, H. El-Karaksy
SOUTH AFRICAN JOURNAL OF CHILD HEALTH
(2020)
Article
Pediatrics
Noha Adet Yassin, Gamal El-Tagy, Omar Nagy Abdethakeem, Noha Asem, Hanaa El-Karaksy
PEDIATRIC GASTROENTEROLOGY HEPATOLOGY & NUTRITION
(2020)
