Role of inner mitochondrial protein OPA1 in mitochondrial dysfunction by tobacco smoking and in the pathogenesis of COPD

Pharmacological Overview of the BGP-15 Chemical Agent as a New Drug Candidate for the Treatment of Symptoms of Metabolic Syndrome

(2020) Ágota Pető et al.   MOLECULES

Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function

(2020) Yongxing Lai et al.   Redox Biology

SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping

(2020) Gagandeep Kaur et al.   Journal of Inflammation-London

Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis

(2020) Krishna P. Maremanda et al.   Frontiers in Pharmacology

The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses

(2019) Daniel Munro et al.   AGING CELL

Mitochondrial dynamics and their potential as a therapeutic target

(2019) B.N. Whitley et al.   MITOCHONDRION

A Missense Mutation in OPA1 Causes Dominant Optic Atrophy in a Chinese Family

(2019) Shaoyi Mei et al.   Journal of Ophthalmology

Mitochondrial fusion promoter restores mitochondrial dynamics balance and ameliorates diabetic cardiomyopathy in an optic atrophy 1‐dependent way

(2019) Mingge Ding et al.   Acta Physiologica

Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice

(2019) Krishna Prahlad Maremanda et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Triptolide induces toxicity in inner ear stem cells via promoting DNA damage

(2019) Xuxia Tang et al.   TOXICOLOGY IN VITRO

Mitochondrial dysfunction is associated with Miro1 reduction in lung epithelial cells by cigarette smoke

(2019) Isaac K. Sundar et al.   TOXICOLOGY LETTERS

Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases

(2018) Aliz Szabo et al.   BIOCHEMICAL PHARMACOLOGY

Eight human OPA1 isoforms, long and short: What are they for?

(2018) Valentina Del Dotto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Stomatin-like protein 2 inhibits cisplatin-induced apoptosis through MEK/ERK signaling and the mitochondrial apoptosis pathway in cervical cancer cells

(2018) Guolin Hu et al.   CANCER SCIENCE

Altered skeletal muscle mitochondrial phenotype in COPD: disease vs. disuse

(2018) Jayson R. Gifford et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mitochondrial Quality Control in COPD and IPF

(2018) Hiromichi Hara et al.   Cells

The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure

(2017) Hakjoo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Naked mole-rats maintain healthy skeletal muscle and Complex IV mitochondrial enzyme function into old age

(2016) Elizabeth A Stoll et al.   Aging-US

The membrane scaffold SLP2 anchors a proteolytic hub in mitochondria containing PARL and the i ‐AAA protease YME1L

(2016) Timothy Wai et al.   EMBO REPORTS

Novel targets for mitochondrial medicine

(2016) Wang Wang et al.   Science Translational Medicine

Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease

(2015) Tanveer Ahmad et al.   FASEB JOURNAL

Cigarette toxicity triggers Leber’s hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways

(2015) L Giordano et al.   Cell Death & Disease

Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD

(2015) Isaac K. Sundar et al.   Scientific Reports

Cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle

(2014) Bharathi Aravamudan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments

(2014) Li Zuo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cigarette smoke extract affects mitochondrial function in alveolar epithelial cells

(2014) Korbinian Ballweg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD

(2014) Kenji Mizumura et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence

(2013) Hiromichi Hara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells

(2013) Roland F Hoffmann et al.   RESPIRATORY RESEARCH

A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells

(2012) Danling Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Dominant optic atrophy

(2012) Guy Lenaers et al.   Orphanet Journal of Rare Diseases

Downregulation of lung mitochondrial prohibitin in COPD

(2012) Nikolaos Soulitzis et al.   RESPIRATORY MEDICINE

Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin

(2011) Shin-ichi Sato et al.   CHEMISTRY & BIOLOGY

SLP-2 is required for stress-induced mitochondrial hyperfusion

(2009) Daniel Tondera et al.   EMBO JOURNAL

Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat

(2009) A. Seluanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prohibitin function within mitochondria: Essential roles for cell proliferation and cristae morphogenesis

(2008) Carsten Merkwirth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH