Haematopoietic and immune defects associated withGATA2mutation

Identification of acquired mutations by whole-genome sequencing in GATA-2 deficiency evolving into myelodysplasia and acute leukemia

(2014) Tohru Fujiwara et al.   ANNALS OF HEMATOLOGY

A Remote GATA2 Hematopoietic Enhancer Drives Leukemogenesis in inv(3)(q21;q26) by Activating EVI1 Expression

(2014) Hiromi Yamazaki et al.   CANCER CELL

A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia

(2014) Stefan Gröschel et al.   CELL

GATA-2 inhibits transforming growth factor-β signaling pathway through interaction with Smad4

(2014) Xiao-Ming Dong et al.   CELLULAR SIGNALLING

Collaborating constitutive and somatic genetic events in myeloid malignancies: ASXL1 mutations in patients with germline GATA2 mutations

(2014) J.-B. Micol et al.   HAEMATOLOGICA

Presence of hypogammaglobulinemia and abnormal antibody responses in GATA2 deficiency

(2014) Janet Chou et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Heritable GATA2 mutations associated with familial AML-MDS: a case report and review of literature

(2014) Juehua Gao et al.   Journal of Hematology & Oncology

Effector Memory    T Lymphocytes Can Express Fc RIIIa and Mediate Antibody-Dependent Cellular Cytotoxicity

(2014) B. Clemenceau et al.   JOURNAL OF IMMUNOLOGY

Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia

(2014) M Celton et al.   LEUKEMIA

Mechanism governing a stem cell-generating cis-regulatory element

(2014) R. Sanalkumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes

(2013) D. Beck et al.   BLOOD

CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age

(2013) C. Gekas et al.   BLOOD

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56bright subset

(2013) E. M. Mace et al.   BLOOD

GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity

(2013) M. A. Spinner et al.   BLOOD

The evolution of cellular deficiency in GATA2 mutation

(2013) R. E. Dickinson et al.   BLOOD

Clinical and biological implications of driver mutations in myelodysplastic syndromes

(2013) E. Papaemmanuil et al.   BLOOD

GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome

(2013) A. P. Hsu et al.   BLOOD

Generalized verrucosis in a patient withGATA2deficiency

(2013) E.S. West et al.   BRITISH JOURNAL OF DERMATOLOGY

Mutations of theGATA2andCEBPAgenes in paediatric acute myeloid leukaemia

(2013) Norio Shiba et al.   BRITISH JOURNAL OF HAEMATOLOGY

GATA2mutations in sporadic and familial acute myeloid leukaemia patients withCEBPAmutations

(2013) Claire L. Green et al.   BRITISH JOURNAL OF HAEMATOLOGY

CEBPAdouble-mutated acute myeloid leukaemia harbours concomitant molecular mutations in 76·8% of cases withTET2andGATA2alterations impacting prognosis

(2013) Vera Grossmann et al.   BRITISH JOURNAL OF HAEMATOLOGY

Dynamic Analysis of Gene Expression and Genome-wide Transcription Factor Binding during Lineage Specification of Multipotent Progenitors

(2013) Gillian May et al.   Cell Stem Cell

MonoMAC Syndrome in a Patient With a GATA2 Mutation: Case Report and Review of the Literature

(2013) J. F. Camargo et al.   CLINICAL INFECTIOUS DISEASES

Resilient and resourceful: Genome maintenance strategies in hematopoietic stem cells

(2013) Sietske T. Bakker et al.   EXPERIMENTAL HEMATOLOGY

Acquired ASXL1 mutations are common in patients with inherited GATA2 mutations and correlate with myeloid transformation

(2013) R. R. West et al.   HAEMATOLOGICA

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

(2013) Daigo Hashimoto et al.   IMMUNITY

SON Protein Regulates GATA-2 through Transcriptional Control of the MicroRNA 23a∼27a∼24-2 Cluster

(2013) Erin Eun-Young Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gata2cis-element is required for hematopoietic stem cell generation in the mammalian embryo

(2013) Xin Gao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gata2is required for HSC generation and survival

(2013) Emma de Pater et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Highly variable clinical manifestations in a large family with a novel GATA2 mutation

(2013) P G N J Mutsaers et al.   LEUKEMIA

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

(2013) Alejandra Sanjuan-Pla et al.   NATURE

GATA-2 Transduces LPS-Induced il-1β Gene Expression in Macrophages via a Toll-Like Receptor 4/MD88/MAPK-Dependent Mechanism

(2013) Tsu-Tuan Wu et al.   PLoS One

The inverted CD4/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study

(2012) J. Strindhall et al.   AGE

GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia

(2012) P. A. Greif et al.   BLOOD

High GATA2 expression is a poor prognostic marker in pediatric acute myeloid leukemia

(2012) M. Luesink et al.   BLOOD

Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis

(2012) L. C. Dore et al.   BLOOD

High frequency of GATA2 mutations in patients with mild chronic neutropenia evolving to MonoMac syndrome, myelodysplasia, and acute myeloid leukemia

(2012) M. Pasquet et al.   BLOOD

Cytokine activation induces human memory-like NK cells

(2012) R. Romee et al.   BLOOD

Marked genetic heterogeneity in familial myelodysplasia/acute myeloid leukaemia

(2012) Harriet Holme et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hematopoiesis: A Human Perspective

(2012) Sergei Doulatov et al.   Cell Stem Cell

GATA-2 anomaly and clinical phenotype of a sporadic case of lymphedema, dendritic cell, monocyte, B- and NK-cell (DCML) deficiency, and myelodysplasia

(2012) Hiroyuki Ishida et al.   EUROPEAN JOURNAL OF PEDIATRICS

GATA2 is expressed at critical times in the mouse uterus during pregnancy

(2012) Cory A. Rubel et al.   GENE EXPRESSION PATTERNS

GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-γ1

(2012) Yasushi Ishijima et al.   GENES TO CELLS

Germ-line GATA2 p.THR354MET mutation in familial myelodysplastic syndrome with acquired monosomy 7 and ASXL1 mutation demonstrating rapid onset and poor survival

(2012) C. Bodor et al.   HAEMATOLOGICA

Conditional Gata2 inactivation results in HSC loss and lymphatic mispatterning

(2012) Kim-Chew Lim et al.   JOURNAL OF CLINICAL INVESTIGATION

Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity

(2012) Kirby D. Johnson et al.   JOURNAL OF CLINICAL INVESTIGATION

Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling

(2012) Jordi Guiu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GATA2 mutations are frequent in intermediate-risk karyotype AML with biallelic CEBPA mutations and are associated with favorable prognosis

(2012) A Fasan et al.   LEUKEMIA

Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature

(2011) J. Kazenwadel et al.   BLOOD

Successful allogeneic hematopoietic stem cell transplantation for GATA2 deficiency

(2011) J. Cuellar-Rodriguez et al.   BLOOD

Context-dependent function of "GATA switch" sites in vivo

(2011) J. W. Snow et al.   BLOOD

Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency

(2011) R. E. Dickinson et al.   BLOOD

Mutations in GATA2 are associated with the autosomal dominant and sporadic monocytopenia and mycobacterial infection (MonoMAC) syndrome

(2011) A. P. Hsu et al.   BLOOD

Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

(2011) Nicolas Goardon et al.   CANCER CELL

The role of the GATA2 transcription factor in normal and malignant hematopoiesis

(2011) Carmen Vicente et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Myelodysplasia in autosomal dominant and sporadic monocytopenia immunodeficiency syndrome: diagnostic features and clinical implications

(2011) K. R. Calvo et al.   HAEMATOLOGICA

GATA-2 mediated regulation of normal hematopoietic stem/progenitor cell function, myelodysplasia and myeloid leukemia

(2011) Neil P. Rodrigues et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency

(2011) Venetia Bigley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GATA2 mutations lead to MDS and AML

(2011) R. Katherine Hyde et al.   NATURE GENETICS

Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome)

(2011) Pia Ostergaard et al.   NATURE GENETICS

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

(2011) Christopher N Hahn et al.   NATURE GENETICS

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

(2011) Xiao-Jing Yan et al.   NATURE GENETICS

Poor prognosis in familial acute myeloid leukaemia with combined biallelic CEBPA mutations and downstream events affecting the ATM, FLT3 and CDX2 genes

(2010) Catherine L. Carmichael et al.   BRITISH JOURNAL OF HAEMATOLOGY

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

(2010) Nicola K. Wilson et al.   Cell Stem Cell

The molecular basis of pulmonary alveolar proteinosis

(2010) Brenna Carey et al.   CLINICAL IMMUNOLOGY

Gata2 is required for the development of inner ear semicircular ducts and the surrounding perilymphatic space

(2010) Maarja Haugas et al.   DEVELOPMENTAL DYNAMICS

GATA Switches as Developmental Drivers

(2010) Emery H. Bresnick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Revised map of the human progenitor hierarchy shows the origin of macrophages and dendritic cells in early lymphoid development

(2010) Sergei Doulatov et al.   NATURE IMMUNOLOGY

High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle

(2009) A. J. Tipping et al.   BLOOD

Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia

(2009) D. C. Vinh et al.   BLOOD

Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation

(2009) Muzlifah Haniffa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

(2009) Guillaume Darrasse-Jèze et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GATA-2 L359 V mutation is exclusively associated with CML progression but not other hematological malignancies and GATA-2 P250A is a novel single nucleotide polymorphism

(2009) Su-Jiang Zhang et al.   LEUKEMIA RESEARCH

Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy

(2008) C. J. Owen et al.   BLOOD

GATA-2 regulates granulocyte-macrophage progenitor cell function

(2008) N. P. Rodrigues et al.   BLOOD

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

Defining the Functional Boundaries of theGata2Locus by Rescue with a Linked Bacterial Artificial Chromosome Transgene

(2008) William Brandt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structures of Multiple GATA Zinc Fingers Bound to DNA Reveal New Insights into DNA Recognition and Self-Association by GATA

(2008) Darren L. Bates et al.   JOURNAL OF MOLECULAR BIOLOGY

Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia

(2008) S.-J. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA