Article
Agriculture, Multidisciplinary
Yu-chen Ma, Hua-yuan Chen, Shen-yan Gao, Xiao-zhan Zhang, Yong-tao Li, Xia Yang, Jun Zhao, Zeng Wang
Summary: In this study, a novel short transcript isoform of chicken IRF7, named chIRF7-iso, was identified. Overexpression of chIRF7 activated the IFN-beta promoter and inhibited the replication of NDV and FAdV-4, while overexpression of chIRF7-iso blocked the IFN-beta promoter activity and facilitated the replication of NDV and FAdV-4.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)
Article
Fisheries
Xifeng Hu, Xiangdong Wu, Zhen Ding, Zheng Chen, Huansheng Wu
Summary: It has been found that chhnRNPU inhibits IFN-I3 production via interacting with MDA5 and MAVS, and facilitates IBDV replication via associating with genomic dsRNA of IBDV.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Review
Immunology
Wei Ma, Gang Huang, Zhi Wang, Li Wang, Qiangguo Gao
Summary: This review provides a comprehensive overview of the role of IRF7 in immunity and autoimmunity, focusing on the regulatory mechanisms of IRF7 in IFN-I and its involvement in IFN-III and COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Zhigao Chen, Min Yin, Haixue Jia, Qian Chen, Hongbing Zhang
Summary: This study found that enhancing endogenous double-stranded RNA (dsRNA) expression can activate anti-tumor immunity in ovarian carcinoma through induction of type I interferon (IFN). Patients in the immune intervention group had a better prognosis, and the ISG20 gene was identified as playing a crucial role in this process.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Xusheng Du, Defang Zhou, Jing Zhou, Jingwen Xue, Guihua Wang, Ziqiang Cheng
Summary: This study reveals the significant role of unique-short kinase 3 (Us3) in the replication of Marek's disease virus (MDV). Us3 promotes MDV replication by inhibiting the production of interferon-β (IFN-β) and disrupting the cytosolic DNA sensing pathway through targeting IRF7.
VETERINARY MICROBIOLOGY
(2022)
Article
Immunology
Davide Di Fusco, Maria Teresa Segreto, Andrea Iannucci, Claudia Maresca, Eleonora Franze, Giulia Di Maggio, Antonio Di Grazia, Siro Boccanera, Federica Laudisi, Irene Marafini, Omero Alessandro Paoluzi, Alessandro Michenzi, Giovanni Monteleone, Ivan Monteleone
Summary: ADAR1, an RNA-editing enzyme, is down-regulated in the gut mucosa of CD patients. Inhibition of ADAR1 enhances the occurrence and development of gut inflammation in CD patients. These findings suggest that ADAR1 plays an important regulatory role in intestinal immune homeostasis, and defective ADAR1 expression may contribute to amplified pathogenic responses in CD intestinal mucosa.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Esther Arnaiz, Ana Miar, Antonio Gregorio Dias, Naveen Prasad, Ulrike Schulze, Dominic Waithe, James A. Nathan, Jan Rehwinkel, Adrian L. Harris
Summary: Hypoxia affects the generation of mitochondrial dsRNA in breast cancer cells, leading to a decrease in type I interferon production and signaling. This reveals a new mechanism of hypoxia-induced immunosuppression that could be targeted by hypoxia-activated therapies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bao-qin Liu, Rong-bei Liu, Wen-ping Li, Xin-tao Mao, Yi-ning Li, Tao Huang, Hao-li Wang, Hao-tian Chen, Jiang-yan Zhong, Bing Yang, Ren-jie Chai, Qian Cao, Jin Jin, Yi-yuan Li
Summary: IRF3 and IRF7 are crucial regulators of type I interferon-dependent antiviral innate immunity. This study uncovers the unexpected functions of the XAF1-XIAP axis and KLHL22 in the regulation of IRF7 stability, providing an important target for antiviral innate immunity.
Article
Microbiology
Kailu Wang, Pengfei Cui, Ruiqi Ni, Huiling Gong, Hao Li, Wenjun Yan, Xue Fu, Liang Chen, Changwei Lei, Hongning Wang, Xin Yang
Summary: This study investigated the role of chicken LGP2 in host immune recognition of Infectious bronchitis virus (IBV). The results demonstrated that chLGP2 inhibited IBV proliferation and could identify and bind to IBV RNA. Additionally, the study identified an interaction between chTRBP and chLGP2, which promoted their mutual expression.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Hemin Jiang, Yue Li, Min Shen, Yucheng Liang, Yu Qian, Hao Dai, Kuanfeng Xu, Xinyu Xu, Hui Lv, Jie Zhang, Tao Yang, Qi Fu
Summary: IFN-α promotes the progression of autoimmune insulitis in NOD mice by enhancing the proliferation of CD8+ T cells. It upregulates the expression of antigen presentation related genes in a time and dose-dependent manner, and acts through the STAT1-IRF7-MHC I complex axis in islets. The IRF7-STAT2 cascade amplifies signals and accelerates the process of T1D.
Article
Immunology
Meifeng Li, Jihuan Hu, Huiling Mao, Dongming Li, Zeyin Jiang, Zhichao Sun, Tingting Yu, Chengyu Hu, Xiaowen Xu
Summary: In this study, it was found that grass carp KAT8 blocked the activities of IRF3 and IRF7 by acetylating them, resulting in the inhibition of nucleic acids-induced innate immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Fan-Xiang Gao, Wei-Jia Lu, Yan Shi, Li Zhou, Jian-Fang Gui, Zhe Zhao
Summary: IRF7, a key regulator in the type I interferon response, has been found to have three alternative splicing variants in obscure puffer fish. These variants show differences in their abilities to induce transcription of interferon and interferon-stimulated genes, suggesting potential distinct roles in immune response regulation.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Virology
Can Zhang, Long-Feng Lu, Zhuo-Cong Li, Ke-Jia Han, Xue-Li Wang, Dan-Dan Chen, Feng Xiong, Xi-Yin Li, Li Zhou, Feng Ge, Shun Li
Summary: Zebrafish MAP2K7 plays a crucial positive role in the host antiviral process, as it stabilizes host IRF7 and degrades SVCV P protein to protect the host during viral infection.
JOURNAL OF VIROLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Aiyun Xu, Xiang Zhu, Tao Song, Zhenyuan Zhang, Fei Fei, Qingxiao Zhu, Xinyue Chang, Hongmei Liu, Fangfang Chen, Fazhi Xu, Lin Li, Xuelan Liu
Summary: In this study, chicken mitochondrial-targeted NLRX1 protein was identified. It was found to negatively regulate type-I interferon production by attenuating the STING-TBK1 interaction. This finding is important for understanding the innate immune response in chickens.
Article
Fisheries
Xifeng Hu, Xiangdong Wu, Meijia Xue, Yiting Chen, Beiyi Zhou, Tong Wan, Hongnan You, Huansheng Wu
Summary: The study found that chTAX1 inhibits IFN expression by promoting degradation of chicken MAVS, and after IBDV infection, the distribution of chTAX1 changes and co-localizes with VP1 and VP3. Overexpression of chTAX1 promotes IBDV replication.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)