Review
Chemistry, Medicinal
Giuseppe Derosa, Pamela Maffioli, Angela D'Angelo, Francesco Di Pierro
Summary: COVID-19, caused by novel coronavirus (SARS-CoV-2), was first detected in Wuhan City, China. Quercetin has the potential to inhibit virus replication and possesses anti-inflammatory and thrombin-inhibitory actions.
PHYTOTHERAPY RESEARCH
(2021)
Review
Medicine, General & Internal
Yu-Ting Shen, Liang Chen, Wen-Wen Yue, Hui-Xiong Xu
Summary: The COVID-19 crisis in 2020 has accelerated the development of telemedicine powered by digital technologies such as IoT, 5G networks, AI, big data analytics, blockchain, and robotics. These technologies have enabled efficient sharing of epidemiological data, improved healthcare quality, minimized disease transmission risks, and preserved healthcare resources.
FRONTIERS IN MEDICINE
(2021)
Editorial Material
Geriatrics & Gerontology
Rodrigo Nunez-Cortes, Ruben Lopez-Bueno, Rodrigo Torres-Castro, Camilo Soto-Carmona, Maritza Ortega-Palavecinos, Sofia Perez-Alenda, Lilian Solis-Navarro, Oscar Diaz-Cambronero, Francisco M. Martinez-Arnau, Joaquin Calatayud
Summary: The aim of this prospective study was to examine the risk factors most associated with mortality one year after diagnosis of COVID-19. The study found that age was the most important risk factor, and disabilities, institutionalization, and socioeconomic status were also significantly associated with mortality.
Article
Immunology
Bing-ke Bai, Qi-yu Jiang, Jun Hou
Summary: The COVID-19 epidemic has had an impact on other infectious diseases in China, with a higher decline rate observed for respiratory infectious diseases compared to diseases transmitted through the digestive tract and animal-borne diseases. The measures implemented by the Chinese government to prevent the spread of SARS-CoV-2 have proven effective not only in preventing the spread of respiratory infectious diseases, but also to some extent in preventing the spread of notifiable infectious diseases through other routes.
MICROBES AND INFECTION
(2022)
Review
Cell Biology
Fan Liu, Feng Liu, Lu Wang
Summary: COVID-19, caused by SARS-CoV-2, not only affects the lungs but also has severe implications in the cardiovascular system. Understanding the mechanisms of cardiovascular injury in COVID-19 patients is crucial for appropriate identification and treatment.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Immunology
Nicola Principi, Susanna Esposito
Summary: The rapid development of numerous vaccines for COVID-19 has mainly focused on healthy adults and, to a lesser extent, the elderly, with limited involvement of children. However, the urgent need for a safe and effective pediatric vaccine highlights the necessity for strong collaboration among governments, researchers, and pharmaceutical companies.
Review
Biochemistry & Molecular Biology
Priti Tagde, Sandeep Tagde, Pooja Tagde, Tanima Bhattacharya, Shams Minhaz Monzur, Md Habibur Rahman, Pavel Otrisal, Tapan Behl, Syed Shams ul Hassan, Mohamed M. Abdel-Daim, Lotfi Aleya, Simona Bungau
Summary: The global transmission of SARS-CoV-2 causes widespread impact on society due to its unpredictable spread. While traditional treatments have uncertain effects, nutraceuticals and herbs may help reduce infection risk and alleviate symptoms.
Review
Nutrition & Dietetics
Ronan Lordan
Summary: During the pandemic, the global scientific community has been exploring the potential of dietary supplements and nutraceuticals in treating COVID-19, particularly focusing on the link between nutritional status and patient outcomes.
Review
Microbiology
Renuka Roche, Nouha H. Odeh, Abhay U. Andar, Mohan E. Tulapurkar, Joseph A. Roche
Summary: Anti-SARS-CoV-2 vaccines have played a crucial role in reducing severe illness from COVID-19, but even vaccinated individuals can still be infected with high viral loads. The main question is whether these vaccines primarily protect against severe illness or prevent infection altogether. Answering this question is important for understanding vaccine effectiveness and informing public health policies. Lessons learned from COVID-19 highlight the need to reevaluate healthcare policies and redefine vaccine effectiveness.
Article
Biochemical Research Methods
Rosanna W. Peeling, Samuel K. Sia
Summary: Throughout the COVID-19 pandemic, the role of testing has been critical and expanding. However, there are still gaps in developing tests to fit public health needs and providing equitable access. This article reviews the evolution of testing use cases during the pandemic and highlights challenges faced by test developers at each phase. Lessons learned and future cooperative efforts among stakeholders are summarized, including the development of new funding models, investment in adaptable open-platform technologies, building data connectivity infrastructures, and facilitating the translation of innovation into use.
Article
Environmental Sciences
Claudio S. Quilodran, Mathias Currat, Juan I. Montoya-Burgos
Summary: Climate factors such as air temperature and UV Index can impact the spread and mortality rate of Covid-19, with higher temperatures and UV levels lowering mortality rates. In addition to climate factors, age structure and access to healthcare are also critical factors influencing mortality rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Immunology
Lara Danziger-Isakov, Nadim Khalil, Allison Divanovic, Robert Frenck, Michael Grimley, Ilias Iliopoulos, Rebecca Marsh, Grant Paulsen, Christine L. Phillips, Grant Schulert, Paul Spearman, Samantha Blum, Jennifer Hui-Chin Ho
Summary: A 10-month-old female with respiratory distress secondary to COVID-19 was successfully treated with nebulized DAS181. The therapy was well tolerated and resulted in rapid resolution of respiratory distress and positive viral polymerase chain reaction.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2021)
Review
Microbiology
Ronan Lordan, Halie M. Rando, Casey S. Greene
Summary: This review critically evaluates the evidence surrounding the potential prophylactic and therapeutic value of dietary supplements and nutraceuticals for COVID-19. While nutritional status plays a significant role in patient outcomes and certain products like vitamin D may hold promise, further research is necessary to formulate evidence-based recommendations. Sales of these products have surged during the pandemic, but more research is needed to determine their efficacy against SARS-CoV-2 and COVID-19.
Review
Immunology
Anna Allue-Guardia, Jordi B. Torrelles, Alex Sigal
Summary: Although caused by different pathogens, SARS-CoV-2 and Mycobacterium tuberculosis infections both result in greater disease burden in older adults. This could be attributed to factors such as comorbidities, deteriorating lung environment, autoimmunity, and reduced antibody response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Lyn R. Frumkin, Michaela Lucas, Curtis L. Scribner, Nastassja Ortega-Heinly, Jayden Rogers, Gang Yin, Trevor J. Hallam, Alice Yam, Kristin Bedard, Rebecca Begley, Courtney A. Cohen, Catherine V. Badger, Shawn A. Abbasi, John M. Dye, Brian McMillan, Michael Wallach, Traci L. Bricker, Astha Joshi, Adrianus C. M. Boon, Suman Pokhrel, Benjamin R. Kraemer, Lucia Lee, Stephen Kargotich, Mahima Agochiya, Tom St. John, Daria Mochly-Rosen
Summary: The article discusses the need for additional prevention strategies against SARS-CoV-2 due to challenges in vaccine manufacturing and the emergence of variants. The study found that antibodies derived from eggs showed promising results in capturing the virus on the nasal mucosa, with broad effectiveness against different variants. The use of these antibodies as prophylaxis warrants further evaluation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Giuseppe Derosa, Gabriele Catena, Laura Scelsi, Angela D'Angelo, Riccardo Raddino, Eugenio Cosentino, Antonio Maggi, Gianfranco Pasini, Claudio Borghi, Pamela Maffioli
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2020)
Article
Chemistry, Medicinal
Giuseppe Derosa, Angela D'Angelo, Pamela Maffioli
PHYTOTHERAPY RESEARCH
(2020)
Review
Cardiac & Cardiovascular Systems
Giuseppe Derosa, Alessandro Colletti, Pamela Maffioli, Angela D'Angelo, Alessandro Lupi, Giovanni B. Zito, Gian Francesco Mureddu, Riccardo Raddino, Francesco Fedele, Arrigo F. G. Cicero
JOURNAL OF CARDIOVASCULAR MEDICINE
(2020)
Review
Chemistry, Medicinal
Giuseppe Derosa, Pamela Maffioli, Angela D'Angelo, Francesco Di Pierro
Summary: COVID-19, caused by novel coronavirus (SARS-CoV-2), was first detected in Wuhan City, China. Quercetin has the potential to inhibit virus replication and possesses anti-inflammatory and thrombin-inhibitory actions.
PHYTOTHERAPY RESEARCH
(2021)
Article
Nutrition & Dietetics
Giuseppe Derosa, Pamela Maffioli, Angela D'Angelo, Paola S. Preti, Giancarlo Tenore, Ettore Novellino
Article
Chemistry, Medicinal
Giuseppe Derosa, Angela D'Angelo, Paola Preti, Pamela Maffioli
DRUG DESIGN DEVELOPMENT AND THERAPY
(2020)
Article
Medicine, General & Internal
Valeria Brazzelli, Pamela Maffioli, Vittorio Bolcato, Christian Ciolfi, Angela D. Angelo, Carmine Tinelli, Giuseppe Derosa
Summary: This study found that diabetic patients with psoriasis exhibited higher levels of insulin resistance, lipid abnormalities, and cardiovascular risk compared to other patient groups and healthy subjects, suggesting a potential pathogenic link between psoriasis and diabetes.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Giuseppe Derosa, Pamela Maffioli, Angela D'Angelo, Giovanna Cipolla, Elisabetta Moro, Francesca Crema
Summary: This study assessed the effects of chronic inflammation on incretin levels, inflammatory markers, and enteric neuronal function in rat smooth muscle preparations. The results showed that chronic inflammation led to increased levels of incretin hormones and decreased functional response of colon intestinal smooth muscle after electrical stimulation.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Biology
Giuseppe Derosa, Angela D'Angelo, Pamela Maffioli
Summary: The study demonstrates that a nutraceutical containing Ilex paraguariensis, white mulberry, and chromium picolinate can significantly improve glycemic status and lipid profiles, benefiting patients with dysglycemia.
Article
Medicine, General & Internal
Francesco Di Pierro, Somia Iqtadar, Amjad Khan, Sami Ullah Mumtaz, Mohsin Masud Chaudhry, Alexander Bertuccioli, Giuseppe Derosa, Pamela Maffioli, Stefano Togni, Antonella Riva, Pietro Allegrini, Saeed Khan
Summary: Treatment with QP in COVID-19 patients can lead to faster virus clearance, reduced symptoms severity, and improved blood parameters, showing promising potential as a therapeutic intervention for the disease.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Medicine, General & Internal
Francesco Di Pierro, Giuseppe Derosa, Pamela Maffioli, Alexander Bertuccioli, Stefano Togni, Antonella Riva, Pietro Allegrini, Amjad Khan, Saeed Khan, Bilal Ahmad Khan, Naireen Altaf, Maria Zahid, Ikram Din Ujjan, Roohi Nigar, Mehwish Imam Khushk, Maryam Phulpoto, Amanullah Lail, Bikha Ram Devrajani, Sagheer Ahmed
Summary: The study indicates that Quercetin Phytosome may have potential therapeutic effects for COVID-19 patients, reducing hospitalization and mortality rates. It is also shown to be safe and may have anti-fatigue and appetite-enhancing properties.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Pamela Maffioli, Angela D'Angelo, Carmine Tinelli, Colomba Falcone, Gennaro Galasso, Giuseppe Derosa
Summary: The study found a significant correlation between BAG3 serum levels and dyslipidemia and diabetic disease in AMI patients, while no significant correlations were observed with smoking habit, hypertension, or familiarity for AMI. Some patients were BAG3-positive and characterized by particular features such as comorbidity presence or concomitant therapies.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Review
Chemistry, Medicinal
Giuseppe Derosa, Angela D'Angelo, Pamela Maffioli
Summary: This review analyzed clinical trial results on the effects of nutraceuticals on blood glucose management. The study found that some nutraceuticals have positive impacts on glycemia, while the effects of others are still controversial and require further long-term clinical trials for confirmation.
PHYTOTHERAPY RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Francesco Di Pierro, Amjad Khan, Alexander Bertuccioli, Pamela Maffioli, Giuseppe Derosa, Saeed Khan, Bilal A. Khan, Roohi Nigar, Ikram Ujjan, Bikha R. Devrajani
Summary: Research has shown that quercetin may be an important antiviral compound against COVID-19, but its low oral bioavailability presents a challenge. A phospholipid delivery form of quercetin is being tested to address this issue and improve its potential as a candidate for clinical treatment of COVID-19.
MINERVA GASTROENTEROLOGY
(2021)
