Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.702211
Keywords
BMP4; glycolysis; interferon-gamma (IFNg); CD4+T activation; metabolism
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Funding
- National Science Foundation of China [81300896, 82001067]
- Beijing Municipal Natural Science Foundation [7142069]
- Beijing NOVA program [2015B062]
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The study indicates that BMP4 may regulate the activation and IFN-gamma production of CD4+ T cells through metabolism moderation, suggesting it could be a potential therapeutic supplement in autoinflammatory diseases.
BMP4 is a key growth factor well known in promoting bone regeneration and has been reported to be able to regulate T cell development in the thymus. Here, we showed that BMP4 downregulates the activation of naive CD4+ T cells and the IFN-gamma production of CD4+ T cells without increasing regulatory T cells. BMP4 could also moderate glycolysis of T cells and regulate Hif1 alpha expression. Furthermore, BMP4 showed a suppressive function on the IFN-gamma production of CD4+ T cells in vivo. These findings indicating a mechanism by which BMP-4 may regulate activation and IFN-gamma production in CD4+ T cells via metabolism moderation and suggests that BMP4 may be a potential therapeutic supplement in autoinflammatory diseases.
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