Article
Medical Informatics
Faraz Faghri, Fabian Brunn, Anant Dadu, Elisabetta Zucchi, Ilaria Martinelli, Letizia Mazzini, Rosario Vasta, Antonio Canosa, Cristina Moglia, Andrea Calvo, Michael A. Nalls, Roy H. Campbell, Jessica Mandrioli, Bryan J. Traynor, Adriano Chio
Summary: This study used machine learning techniques to classify ALS and found that the Chia classification system successfully identified ALS subtypes. The results contribute to a better understanding of disease heterogeneity and provide guidance for clinical care and clinical trial design.
LANCET DIGITAL HEALTH
(2022)
Article
Immunology
Alba Torres-Valle, Larraitz Aragon, Susana L. Silva, Cristina Serrano, Miguel Marcos, Josefa Melero, Carolien Bonroy, Pedro Pablo Arenas-Caro, David Monzon Casado, Pedro Mikel Requejo Olaizola, Jana Neirinck, Mattias Hofmans, Sonia de Arriba, Maria Jara, Carlos Prieto, Ana E. Sousa, Alvaro Prada, Jacques J. M. van Dongen, Martin Perez-Andres, Alberto Orfao
Summary: Good syndrome is a rare adult-onset immunodeficiency characterized by the coexistence of a thymoma and hypogammaglobulinemia, leading to increased susceptibility to infections and autoimmunity. The immune cell defects of GS patients mainly involve reduced B-cell and CD4(+) T-cell counts, as well as alterations in other immune cell populations. In addition, GS patients who develop hypogammaglobulinemia after thymoma diagnosis show a phenotype more similar to combined immune humoral and cellular defects, with poorer response to immunoglobulin replacement therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Ke Dong, Chenchen Geng, Xiaohong Zhan, Zhi Sun, Qian Pu, Peng Li, Haiyun Song, Guanghui Zhao, Haidong Gao
Summary: GREB1L is highly expressed in breast cancer tissues and cells. KEGG enrichment analysis suggests its involvement in the regulation of the Hedgehog signaling pathway. Changes in GREB1L expression affect the migration and invasion abilities of MCF7 and MDA-MB-231 cells. Although changes in GREB1L expression do not affect their proliferation and colony formation abilities in vitro and in vivo, they impact the expression of metastasis-related genes in vivo. Overexpression of GREB1L predicts a favorable prognosis in breast cancer.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Infectious Diseases
Lianpeng Wu, Yong Pan, Ke Xu
Summary: This study analyzed the clinical characteristics of AIDS with dTSM, particularly in patients with poor prognosis. The most common clinical manifestations were lymph-node enlargement and fever. The study identified procalcitonin, blood urea nitrogen, shock, and antiretroviral therapy as risk factors for poor outcomes.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Microbiology
Yesim Yilmaz Demirdag, Sudhir Gupta
Summary: DNA repair defects encompass a wide range of conditions with diverse clinical manifestations, including increased cancer risk, accelerated aging, and developmental defects in organs and systems. Some of these disorders can also affect the immune system, leading to susceptibility to infections and autoimmunity. Infections in DNA repair defects may result from primary defects in immune cells or other factors, causing a spectrum of infections ranging from mild respiratory tract infections to severe opportunistic and potentially fatal infections with various pathogens. This article discusses infections in 15 rare and sporadic DNA repair defects associated with immunodeficiencies, highlighting the limited information available due to the rarity of these conditions.
Review
Medicine, General & Internal
Veena R. Gujju, Bushra Akram, Dena R. Shibib, Miranda A. McGhee, Douglas A. Drevets
Summary: Bordetella bronchiseptica is a common cause of upper respiratory tract infections in domesticated dogs and cats, and a rare zoonotic pathogen in immunocompromised humans. In patients with HIV/AIDS, this infection can lead to pneumonia with interstitial infiltrates, often accompanied by sepsis. Advanced immune suppression and other chronic conditions that compromise host defenses are commonly associated with B bronchiseptica infection in patients who do not have HIV infection.
Review
Pediatrics
Giorgio Costagliola, Diego G. Peroni, Rita Consolini
Summary: This paper discusses the non-infectious manifestations of patients with inborn errors of immunity (IEI) and highlights the importance of these manifestations in the diagnosis of the disease.
FRONTIERS IN PEDIATRICS
(2022)
Review
Immunology
Nina N. Brodsky, Carrie L. Lucas
Summary: Activated PI3K-delta Syndrome (APDS) is an immune deficiency disorder caused by genetic mutations, leading to early onset immunodeficiency, recurrent infections, lymphadenopathy, and autoimmunity. Patients typically require treatment with immunomodulatory agents and may necessitate hematopoietic stem cell transplants in some cases.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Review
Immunology
Kissy Guevara-Hoyer, Jesus Fuentes-Antras, Joaquin Calatayud Gastardi, Silvia Sanchez-Ramon
Summary: Good Syndrome is a rare disease associated with thymoma and immunodeficiency, with an unclear prognosis. Understanding the relationship between clinical presentation and immunological changes is crucial for preventing misdiagnosis and complications.
IMMUNOLOGY LETTERS
(2021)
Article
Immunology
Wenjing Tang, Yu Zhang, Chong Luo, Lina Zhou, Zhiyong Zhang, Xuemei Tang, Xiaodong Zhao, Yunfei An
Summary: This study evaluated the utility of mNGS for detecting pathogens in patients with PID, demonstrating its superiority over conventional methods in pathogen identification, especially in detecting rare opportunistic pathogens. Compared to traditional methods, mNGS can provide faster pathogen diagnosis, enabling clinicians to make more timely and targeted therapeutic decisions.
FRONTIERS IN IMMUNOLOGY
(2021)
Letter
Oncology
Xin Huang, Cunte Chen, Mengjun Zhong, Suxia Geng, Yujie Zhao, Minming Li, Chenxin Deng, Lingji Zeng, Ping Wu, Zesheng Lu, Jianyu Weng, Xin Du, Yangqiu Li
Summary: The study showed that lower expression of BCL11B in BM samples of MDS patients is associated with adverse clinical outcomes. Low BCL11B expression appears to be linked to poor overall survival, especially for high-risk MDS patients.
BIOMARKER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Young Choi, Hadong Kim, Simcha Pollack
Summary: In this study, the mRNA and protein expression of different isoforms of ER beta in various subtypes of breast cancer were simultaneously investigated. Each isoform of ER beta seems to play a significant role in different subtypes of breast cancer, and the expression of ER beta 2 mRNA is associated with poor prognosis. Further research in a larger cohort is needed to explore the potential usefulness of ER beta as a prognostic and predictive marker, as well as a therapeutic target in breast cancer. Standardization of ER beta testing may also be necessary for its clinical utilization.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jesus Perez-Gil
Summary: Over the past thirty years, the lives of thousands of premature babies have been saved through pulmonary surfactant replacement therapy. Research has focused on understanding the composition and structural determinants of pulmonary surfactant activity, leading to the development of efficient therapeutic surfactants and new perspectives in tailored surfactant therapies for respiratory pathologies.
BIOMEDICAL JOURNAL
(2022)
Article
Immunology
Guang Zhang, Hongqi Zhang, XiaoJiang Hu, Dongcheng Xu, Bo Tang, Mingxing Tang, Shaohua Liu, Yanbing Li, Wen Xu, Chaofeng Guo, Qile Gao
Summary: This study evaluated the impact of precise treatment based on metagenomic next-generation sequencing (mNGS) on the clinical outcomes of patients with spinal infections. The results showed that targeted antibiotics based on mNGS results can lead to faster clinical cure for spinal infection patients. The positive rate of mNGS for diagnosing spinal infections was significantly higher than that of traditional detection methods.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Clinical Neurology
Kang Qu, Lin Gan, Wei Jiang, Peng Yu, Ming Dong
Summary: Mixed alien hand syndrome is a rare disease characterized by uncoordinated hand movements and hand conflict. In the case presented, a patient with a mixed callosal-frontal variant of alien hand syndrome showed significant improvement after therapy involving medication and verbal-cue rehabilitation, ultimately regaining normal coordination.
FRONTIERS IN NEUROLOGY
(2021)
Review
Oncology
Chen Wang, David A. Sallman
Summary: TP53 is a crucial tumor suppressor gene frequently mutated in certain types of myelodysplastic syndromes and acute myeloid leukemia. Conventional treatments have limited effectiveness, but emerging targeted molecular and immunotherapies offer promise for this molecular subgroup. Unmet needs still exist for improving outcomes in TP53 mutated patients.
Review
Hematology
Chen Wang, David A. Sallman
Summary: Targeting the CD47/SIRPa axis in combination with other therapeutic agents shows promising treatment approach for patients with myeloid malignancies, especially the challenging TP53-mutated subgroup.
CURRENT OPINION IN HEMATOLOGY
(2022)
Letter
Rheumatology
C. Wang
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2022)
Review
Hematology
Chen Wang, Jolan E. Walter
Summary: Immunodeficiency syndromes are a diverse group of genetic and acquired disorders characterized by various clinical manifestations. Autoantibodies, reflecting immune dysregulation, may contribute to certain clinical findings. The mechanism of autoantibody production in immunodeficiency is largely unknown, possibly influenced by genetic aberrations and infectious agents.
Review
Immunology
Yiyun Shi, Chen Wang
Summary: This study provides a comprehensive review of the clinical characteristics, treatment responses, and outcomes of lymphocytic variant hypereosinophilic syndrome (L-HES). The results show that L-HES patients have a heavier disease burden, and the presence of CD3(-)CD4(+) lymphocytes is associated with higher numbers of eosinophils and organ involvement. Corticosteroids are the most commonly used treatment, but additional therapies are often required. In addition, there is an increased risk of lymphoma transformation in L-HES patients, which may be associated with cardiovascular involvement and the use of imatinib.
CLINICAL IMMUNOLOGY
(2022)
Letter
Oncology
Chen Wang
LEUKEMIA & LYMPHOMA
(2022)
Meeting Abstract
Hematology
David A. Sallman, Hany Elmariah, Kendra Sweet, Asmita Mishra, Cheryl A. Cox, Marion Chakaith, Roshanak Semnani, Sheeba Shehzad, Asha Anderson, Helen Sabzevari, Amy Lankford, Onyee Chan, Luis SanchezMolina, Chen Wang, Eric Padron, Andrew Kuykendall, Rami S. Komrokji, Jeffrey E. Lancet, Marco L. Davila, Nelli Bejanyan
Meeting Abstract
Hematology
Chen Wang, Onyee Chan, Najla Al Ali, Andrew Kuykendall, Eric Padron, Kendra Sweet, Jeffrey E. Lancet, Rami S. Komrokji, David A. Sallman
Meeting Abstract
Hematology
Somedeb Ball, Akriti G. Jain, Parth C. Patel, Chen Wang, Luis E. Aguirre, Mohammad O. Hussaini, Onyee Chan, Seongseok Yun, Andrew Kuykendall, Eric Padron, Kendra Sweet, Jeffrey E. Lancet, Rami S. Komrokji, David A. Sallman
Meeting Abstract
Hematology
Chen Wang, Bijun Sun, Kevin Wu, Jocelyn Farmer, Boglarka Ujhazi, Christoph B. Geier, Sumai Gordon, Emma Westermann-Clark, Sinisa Savic, Sargur Ravishankar, Karin Chen, Cullen M. Dutmer, Maria G. Kanariou, Mehdi Adeli, Paolo Palma, Carmem Bonfim, Evangelia Lycopoulou, Beata Wolska-Kusnierz, Dbaibo Ghassan, Jack Bleesing, Despina Moshous, Benedicte Neven, Catharina Schuetz, Geha Raif, Luigi D. Notarangelo, Maurizio Miano, David K. Buchbinder, Krisztian Csomos, Wenjie Wang, Ji-Yang Wang, Xiaochuan Wang, Jolan E. Walter
Meeting Abstract
Hematology
Maggie Wong, Chen Wang, Cinnie Yentia Soekojo, Hung Chew Wong, Sanjay De Mel, Melissa Ooi, Miny Samuel, Yu Yang Soon, Wee Joo Chng
Letter
Medicine, General & Internal
Chen Wang, Yiyun Shi
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Oncology
Chen Wang, David A. Sallman
Summary: The heterogeneous nature of myelodysplastic syndromes requires a risk-adapted therapeutic approach, especially for higher risk MDS. Mutational data can help refine the risk assessment. The principal therapeutic goal is to prolong survival and modify the natural history.
LEUKEMIA & LYMPHOMA
(2023)
Editorial Material
Endocrinology & Metabolism
Chen Wang, Chuanhui Xu, Jian Li
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Chen Wang, David. A. A. Sallman
Summary: Lower risk myelodysplastic syndromes have a low risk of transformation into acute myeloid leukemia and are characterized by an indolent disease course. The revised International Prognostic Scoring System is used to identify these patients, with future use of its molecular version expected to change treatment strategies. Symptomatic control is the main goal of care, with anemia being the most common indication for disease-specific therapies. Erythropoiesis-stimulating agents and lenalidomide monotherapy are the standard upfront treatments, with other therapeutic options available after treatment failure.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)