Journal
FRONTIERS IN IMMUNOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.670040
Keywords
non-small cell lung cancer; immunotherapy; SWI; SNF complex; PD-1; PD-L1 inhibitors; anti-PD1; PD-L1
Categories
Funding
- National Natural Science Foundation of China [82072595, 81773207, 61973232]
- Natural Science Foundation of Tianjin [17YFZCSY00840, 18PTZWHZ00240, 19YFZCSY00040, 19JCYBJC27000]
- Shihezi University Oasis Scholars Research Startup Project [LX202002]
- Special Support Program for the High-Tech Leader and Team of Tianjin [TJTZJH-GCCCXCYTD-2-6]
Ask authors/readers for more resources
The research found that patients with ARID1A, ARID1B, and ARID2 mutations in the SWI/SNF complex in non-small cell lung cancer were more likely to benefit from immune checkpoint inhibitor therapy.
Worldwide, non-small cell lung cancer (NSCLC) has the highest morbidity and mortality of all malignancies. The lack of responsiveness to checkpoint inhibitors is a central problem in the modern era of cancer immunotherapy, with the rapid development of immune checkpoint inhibitors (ICIs) in recent years. The human switch/sucrose nonfermentable (SWI/SNF) chromatin-remodeling complex has been reported to be recurrently mutated in patients with cancer, and those with SWI/SNF mutations have been reported to be sensitive to ICIs. Six reported cohorts, a total of 3416 patients, were used to analyze the mutation status of ARID1A, ARID1B, ARID2 and SMARCA4 in patients with NSCLC and the effect of mutations on prognosis after ICIs. Finally, a nomogram was established to guide the clinical use of ICIs. The results show that patients with NSCLC who have ARID1A, ARID1B, and ARID2 mutations of the SWI/SNF complex were more likely to benefit from ICI therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available