Article
Oncology
Hourin Cho, Masayoshi Yamada, Shigeki Sekine, Noriko Tanabe, Mineko Ushiama, Makoto Hirata, Gakuto Ogawa, Masahiro Gotoh, Teruhiko Yoshida, Takaki Yoshikawa, Yutaka Saito, Aya Kuchiba, Ichiro Oda, Kokichi Sugano
Summary: This study investigated the incidence risk and clinicopathological features of gastric neoplasms in Lynch syndrome (LS) patients, finding that LS patients with atrophic gastritis are at higher risk of developing gastric tumors, often presenting with multiple tumors. Endoscopic surveillance for gastric cancer is recommended for LS patients, especially those with atrophic gastritis.
Article
Oncology
Ombretta Repetto, Valli De Re, Paolo Giuffrida, Marco Vincenzo Lenti, Raffaella Magris, Marino Venerito, Agostino Steffan, Antonio Di Sabatino, Renato Cannizzaro
Summary: This study identified a proteomics signature of AAG, with many differential proteins shared by GC, potentially involved in the progression of AAG to GC.
Article
Medicine, General & Internal
Kai Zhao, Yu Zhang, Suhong Xia, Lina Feng, Wangdong Zhou, Mingyu Zhang, Ruonan Dong, Dean Tian, Mei Liu, Jiazhi Liao
Summary: EBV infection is significantly associated with atrophic gastritis, particularly in H. pylori-negative patients. EBV infection also influences gastric function by decreasing the PG I/PG II ratio. Co-infection of EBV and H. pylori does not increase the risk of atrophic gastritis.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Junhui Zheng, Xiaotao Jiang, Kailin Jiang, Yanhua Yan, Jinglin Pan, Fengbin Liu, Yi Wen, Peiwu Li
Summary: This study found that miR-196a-5p is associated with the progression of chronic atrophic gastritis to gastric cancer, and it induces malignant behaviors of gastric cancer cells by targeting ACER2. This provides a novel monitoring biomarker and target for gastric cancer prevention.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Wei Xu, Tianxiao Jiang, Kanger Shen, Dongxu Zhao, Man Zhang, Wenxin Zhu, Yunfei Liu, Chunfang Xu
Summary: In this study, pathogenic genes associated with chronic atrophic gastritis (CAG) were identified through comprehensive analysis of bulk transcriptome and single-cell transcriptome data. Among these genes, GADD45B was determined to be the most significant oncogene in CAG carcinogenesis, correlated with prognosis, immune infiltration, and metabolic pathways in gastric cancer (GC) patients. Furthermore, the CD99 and CDH signaling pathways were found to have a significant impact on the microenvironment of gastric tissue during the development of CAG, and key metabolic pathways involved in GC progression were identified.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Laura Conti, Marina Borro, Christian Milani, Maurizio Simmaco, Gianluca Esposito, Giulia Canali, Emanuela Pilozzi, Marco Ventura, Bruno Annibale, Edith Lahner
Summary: Patients with corpus atrophic gastritis show reduced abundance and complexity in their gastric bacterial microbiota, characterized by higher colonization of Firmicutes, especially Streptococcus, associated with severe atrophy/metaplasia stages and higher risk of gastric cancer.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Minoru Kato, Yoshito Hayashi, Tsutomu Nishida, Masahide Oshita, Fumihiko Nakanishi, Shinjiro Yamaguchi, Shinji Kitamura, Akihiro Nishihara, Tomofumi Akasaka, Hideharu Ogiyama, Masanori Nakahara, Takuya Yamada, Osamu Kishida, Masashi Yamamoto, Akinori Shimayoshi, Yoshiki Tsujii, Motohiko Kato, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara
Summary: Helicobacter pylori eradication has a preventive effect on the development of metachronous gastric cancer in patients with mild-to-moderate atrophic gastritis, but the effect is not significant in patients with severe atrophic gastritis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jong Min Park, Young Min Han, Ki Baik Hahm
Summary: Chronic Helicobacter pylori infection can lead to gastric cancer through the progression of precancerous chronic atrophic gastritis. This study explored the use of human placenta-derived mesenchymal stem cells (PD-MSCs) to treat H. pylori-associated CAG, showing significant reductions in various pathological parameters and demonstrating the potential of PD-MSCs as a novel agent in preventing the progression of H. pylori-associated premalignant lesions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Xin-Yuan Liu, Tian-Qi Zhang, Qi Zhang, Jing Guo, Peng Zhang, Tao Mao, Zi-Bin Tian, Cui-Ping Zhang, Xiao-Yu Li
Summary: This study analyzed the differential expression of lncRNAs in samples of different pathological stages of gastric cancer (GC) and identified specific lncRNAs that could serve as potential biomarkers for early diagnosis of GC.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Sara Massironi, Camilla Gallo, Alessandra Elvevi, Marta Stegagnini, Lorenzo Andrea Coltro, Pietro Invernizzi
Summary: The incidence and prevalence of type I gastric neuroendocrine neoplasms (gNENs) in patients with autoimmune gastritis (AIG) have been increasing. Gastrin, a potential marker for early diagnosis, has low diagnostic accuracy, highlighting the need for effective strategies for early detection and treatment.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Microbiology
Giulia Pivetta, Ludovica Dottori, Federico Fontana, Sophia Cingolani, Irene Ligato, Emanuele Dilaghi, Christian Milani, Marco Ventura, Marina Borro, Gianluca Esposito, Bruno Annibale, Edith Lahner
Summary: This study aimed to assess gender differences in gastric bacterial microbiota between subjects with healthy stomachs and those with autoimmune atrophic gastritis. Results showed that women with healthy stomachs had a higher gastric bacterial abundance and less microbial diversity compared to men. Autoimmune atrophic gastritis seems to reset gender differences in gastric bacterial abundance and reduce biodiversity in males.
Review
Biochemistry & Molecular Biology
Helge Waldum, Reidar Fossmark
Summary: Despite a decrease in prevalence over the past few decades, gastric cancer remains a significant global cause of death, with Helicobacter pylori infection reduction being a key factor. The carcinogenic effects of H. pylori are likely due to hypergastrinemia and autoimmune gastritis, while long-term use of proton pump inhibitors may also predispose individuals to ECL cell neoplasia. Additionally, gastric polyps, although generally low in malignant potential, can still pose a cancer risk and share some common risk factors and mechanisms with gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Angelo Zullo, Bastianello Germana, Ermenegildo Galliani, Andrea Iori, Giovanni de Pretis, Guido Manfredi, Elisabetta Buscarini, Mario Ciuffi, Orazio Ignomirelli, Fabio Farinati, Edoardo Savarino, Paolo Pallini, Luisa Milan, Rita Conigliaro, Giuseppe Grande, Renato Cannizzaro, Stefania Maiero, Antonio Pisani, Stefania Marangi, Raffaele Manta, Olivia Morelli, Sergio Peralta, Alessia La Mantia, Matteo Rossano Buonocore, Kareem Khalal, Cesare Hassan, Fabio Monica
Summary: This study evaluated the accuracy of EndoFaster(R) device in ruling out gastric mucosal atrophy and found that it had a high negative predictive value in excluding atrophic gastritis, reducing the need for gastric biopsies.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Oncology
Lu Sun, Xiaoliang Jin, Liang Huang, Jing Zhao, Haifeng Jin, Mingtao Chen, Chunli Zhang, Bin Lu
Summary: This study analyzed the progression of chronic atrophic gastritis (CAG) and found that a minority of patients may progress to gastric cancer (GC). Patients with OLGA/OLGIM III and IV staging and C3-O3 Kimura-Takemoto classification were found to have a higher risk of progression. The study also revealed that the disease-associated risk may be underestimated in one-third of patients classified as low-risk by initial endoscopy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Multidisciplinary Sciences
Liangjun Yang, Xinying Liu, Jiajie Zhu, Xi Zhang, Ya Li, Jiabing Chen, Haiyan Liu
Summary: Chronic gastritis is a persistent inflammation of the gastric mucosa that causes discomfort to patients. Traditional Chinese medicine has been widely used to treat this condition due to its precise efficacy, minimal side effects, and holistic approach. Clinical studies have confirmed its effectiveness, although the underlying mechanisms are not fully understood. In this review, we summarize the clinical research and mechanisms of traditional Chinese medicine for the treatment of chronic gastritis.
Article
Allergy
Ju Hee Kim, Seung Won Lee, Dong Keon Yon, Eun Kyo Ha, Hye Mi Jee, Myongsoon Sung, Hyeon Jeong Sim, Jung Won Yoon, Sun-Hee Choi, Youn Ho Shin, Seung In Seo, Hey-Sung Baek, Man Yong Han
Summary: The study found that dyslipidemia in children might be associated with atopic dermatitis, with high levels of total cholesterol and triglycerides linked to disease severity. Moreover, high levels of total cholesterol were significantly associated with an increased risk of atopic dermatitis onset.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sang Hyoung Park, Seung Kyu Jeong, Ji Hyun Lee, Kyoung Hoon Rhee, Young-Ho Kim, Sung Noh Hong, Kyung Ho Kim, Seung In Seo, Jae Myung Cha, Sun Yong Park, Hyunju Park, Joo Sung Kim, Jong Pil Im, Hyuk Yoon, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim, Seong Suh, Young Kyun Kim, Byong Duk Ye, Suk-Kyun Yang
Summary: This study evaluated the clinical characteristics and long-term prognosis of elderly-onset ulcerative colitis (EOUC) in Korean patients over a 30-year period. The results showed that medication use pattern and disease course were similar between patients with EOUC and non-EOUC (N-EOUC), indicating comparable outcomes for both groups.
Article
Gastroenterology & Hepatology
Seung In Seo, Chan Hyuk Park, Seng Chan You, Jae Young Kim, Kyung Joo Lee, Jinseob Kim, Yerim Kim, Jong Jin Yoo, Won-Woo Seo, Hyung Seok Lee, Woon Geon Shin
Summary: This study aimed to evaluate the association between proton pump inhibitor (PPI) use and gastric cancer in a high-risk region like Korea. The results showed that PPI use was associated with an increased incidence of gastric cancer, regardless of Helicobacter pylori eradication status. Long-term use of PPI should be approached with caution in high-risk regions for gastric cancer.
Article
Medical Informatics
Hokyun Jeon, Seng Chan You, Seok Yun Kang, Seung In Seo, Jeremy L. Warner, Rimma Belenkaya, Rae Woong Park
Summary: This study aimed to compare anticancer treatment trajectories and patterns of clinical events according to regimen type. An algorithm was developed to extract chemotherapy episodes from medication records in an OMOP-CDM database, which was validated on the AUSOM database. The study generated treatment episodes for colorectal, breast, and lung cancer patients, identified trends in chemotherapy regimen use, and demonstrated the usability of the proposed framework through a distributed research network.
JMIR MEDICAL INFORMATICS
(2021)
Article
Gastroenterology & Hepatology
Byong Duk Ye, Sung Noh Hong, Seung In Seo, Ye-Jee Kim, Jae Myung Cha, Kyoung Hoon Rhee, Hyuk Yoon, Young-Ho Kim, Kyung Ho Kim, Sun Yong Park, Seung Kyu Jeong, Ji Hyun Lee, Hyunju Park, Joo Sung Kim, Jong Pil Im, Sung Hoon Kim, Jisun Jang, Jeong Hwan Kim, Seong O. Suh, Young Kyun Kim, Sang Hyoung Park, Suk-Kyun Yang
Summary: The study evaluated the long-term prognosis of Korean CD patients in a well-defined population-based cohort. Results showed that over time, behavioral progression and intestinal resection rates have decreased.
Review
Oncology
Seung In Seo, Chan Hyuk Park, Tae Jun Kim, Chang Seok Bang, Jae Young Kim, Kyung Joo Lee, Jinseob Kim, Hyon Hee Kim, Seng Chan You, Woon Geon Shin
Summary: The study found that the use of statin and aspirin was associated with significantly reduced risks of gastric cancer development, while the use of metformin was not associated with gastric cancer risk. Use of statin in diabetic patients can significantly reduce the risk of gastric cancer development. The meta-analysis showed that statin had the highest effect size on gastric cancer development, followed by aspirin and metformin.
Article
Health Care Sciences & Services
Seung In Seo, Tae Jun Kim, Chan Hyuk Park, Chang Seok Bang, Kyung Joo Lee, Jinseob Kim, Hyon Hee Kim, Woon Geon Shin
Summary: This study found that the use of metformin in patients with diabetes may reduce the risk of colorectal cancer incidence and improve overall survival, based on an analysis of the Korean National Health Insurance Service database.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Eun Jeong Gong, Chang Seok Bang, Kyoungwon Jung, Su Jin Kim, Jong Wook Kim, Seung In Seo, Uhmyung Lee, You Bin Maeng, Ye Ji Lee, Jae Ick Lee, Gwang Ho Baik, Jae Jun Lee
Summary: The study established a deep-learning model that accurately diagnoses esophageal cancers, precursor lesions, and non-neoplasms, confirmed its potential for generalizability through multicenter external tests, and demonstrated its explainability through attention map analysis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Health Care Sciences & Services
Eun Jeong Gong, Chang Seok Bang, Jae Jun Lee, Seung In Seo, Young Joo Yang, Gwang Ho Baik, Jong Wook Kim
Summary: This study aimed to establish deep-learning models for predicting colorectal polyp histology using no-code platforms, and compare their diagnostic performance with traditional models. The results showed that developing models using no-code platforms can reduce labor and programming expertise, while achieving high accuracy in predictions.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Seung In Seo, Jung-Ho Yoon, Hyo Joo Byun, Sang Kil Lee
Summary: The study revealed the interaction between HOTAIR, miR-148b, and DNMT1, leading to the methylation of PCDH10 and contributing to the progression of gastric cancer. These findings provide a better understanding of the detailed pathway of HOTAIR in the epigenetic mechanism of GC.
YONSEI MEDICAL JOURNAL
(2021)