Review
Multidisciplinary Sciences
Daniel M. Altmann, Rosemary J. Boyton
Summary: A diverse range of first-generation SARS-CoV-2 vaccines have been successful in controlling the COVID-19 pandemic, although inequitable distribution remains an issue. Future challenges include optimizing immunological boosting strategies and building an immune repertoire that can protect against upcoming viral variants.
Article
Immunology
Mark B. Salzman, Cheng-Wei Huang, Christopher M. O'Brien, Rhina D. Castillo
Summary: This report discusses 3 cases of patients in California who experienced multisystem inflammatory syndrome (MIS) after receiving vaccination and being infected with SARS-CoV-2. It also mentions 3 cases of adults who were not vaccinated developing MIS during a period when around 7% of the adult population had received at least one vaccine.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Benedicte Caron, Elise Neuville, Laurent Peyrin-Biroulet
Summary: Approximately half of patients with inflammatory bowel disease are willing to receive the COVID-19 vaccine, citing reasons such as vaccine efficacy, social responsibility, herd immunity, and the desire to return to normal life. Reasons for vaccine hesitancy include unknown long-term safety, risk of adverse reactions, and concerns about the speed of vaccine development. Despite some concerns, patients with inflammatory bowel disease recognize the necessity of being vaccinated against COVID-19.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Xia Wu, Jue Lin, Heena Buch, Quchen Ding, Faming Zhang, Bota Cui, Guozhong Ji
Summary: This study revealed hesitancy towards COVID-19 vaccination among patients with IBD, especially among women and those without medical or biomedical backgrounds. Factors influencing acceptance included history of immune-modifying therapies and the perceived importance of vaccination to personal and public health. Concerns regarding safety, potential adverse reactions, personal immunity, efficacy, and reliability of the vaccines were common among participants, regardless of their willingness to vaccinate.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Cardiac & Cardiovascular Systems
Manuela De Michele, Joshua Kahan, Irene Berto, Oscar G. Schiavo, Marta Iacobucci, Danilo Toni, Alexander E. Merkler
Summary: The risk of stroke and cerebrovascular disease complicating SARS-CoV-2 infection has been extensively reported. The rapid development and mass vaccination of DNA and mRNA vaccines against SARS-CoV-2 have led to rare but catastrophic cases of thrombosis. This review provides an overview of stroke and cerebrovascular complications of SARS-CoV-2 infection, as well as vaccinations, with a focus on vaccine-induced immune thrombotic thrombocytopenia. A therapeutic protocol is proposed based on available data.
CIRCULATION RESEARCH
(2022)
Article
Oncology
Astha Thakkar, Jesus D. Gonzalez-Lugo, Niyati Goradia, Radhika Gali, Lauren C. Shapiro, Kith Pradhan, Shafia Rahman, So Yeon Kim, Brian Ko, R. Alejandro Sica, Noah Kornblum, Lizamarie Bachier-Rodriguez, Margaret McCort, Sanjay Goel, Roman Perez-Soler, Stuart Packer, Joseph Sparano, Benjamin Gartrell, Della Makower, Yitz D. Goldstein, Lucia Wolgast, Amit Verma, Balazs Halmos
Summary: Most cancer patients show high seroconversion rates after receiving COVID-19 vaccines, but those with hematologic malignancies, especially after highly immunosuppressive therapies, exhibit lower conversion rates. Patients on immune checkpoint inhibitor therapy or hormonal therapy display high conversion rates.
Article
Gastroenterology & Hepatology
Kimberly N. Weaver, Xian Zhang, Xiangfeng Dai, Wenli Chen, Runa Watkins, Jeremy Adler, Marla C. Dubinsky, Arthur Kastl, Athos Bousvaros, Jennifer A. Strople, Raymond K. Cross, Peter D. R. Higgins, Ryan C. Ungaro, Meenakshi Bewtra, Emanuelle Bellaguarda, Francis A. Farraye, Riley Craig, Cristian Hernandez, Margie E. Boccieri, Ann Firestine, Kelly Y. Chun, Millie D. Long, Michael D. Kappelman
Summary: In this study, we found low rates of breakthrough COVID-19 infection and mild illness in a large cohort of inflammatory bowel disease patients following vaccination with severe acute respiratory syndrome coronavirus 2. Residence in southern United States and lower median anti-receptor binding antibody level were associated with the development of COVID-19.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Medicine, General & Internal
Nickolas Lewis, Laura C. Chambers, Huong T. Chu, Taylor Fortnam, Roberta De Vito, Lisa M. Gargano, Philip A. Chan, James McDonald, Joseph W. Hogan
Summary: This study aimed to investigate the effect of vaccination after recovery from COVID-19 on preventing SARS-CoV-2 reinfection. The findings suggest that individuals who remained unvaccinated faced a relatively high risk of reinfection, while vaccination after recovery from COVID-19 was associated with reducing the risk of reinfection by approximately half.
Article
Medicine, General & Internal
Mark W. Tenforde, Wesley H. Self, Katherine Adams, Manjusha Gaglani, Adit A. Ginde, Tresa McNeal, Shekhar Ghamande, David J. Douin, H. Keipp Talbot, Jonathan D. Casey, Nicholas M. Mohr, Anne Zepeski, Nathan Shapiro, Kevin W. Gibbs, D. Clark Files, David N. Hager, Arber Shehu, Matthew E. Prekker, Heidi L. Erickson, Matthew C. Exline, Michelle N. Gong, Amira Mohamed, Daniel J. Henning, Jay S. Steingrub, Ithan D. Peltan, Samuel M. Brown, Emily T. Martin, Arnold S. Monto, Akram Khan, Catherine L. Hough, Laurence W. Busse, Caitlin C. Ten Lohuis, Abhijit Duggal, Jennifer G. Wilson, Alexandra June Gordon, Nida Qadir, Steven Y. Chang, Christopher Mallow, Carolina Rivas, Hilary M. Babcock, Jennie H. Kwon, Natasha Halasa, James D. Chappell, Adam S. Lauring, Carlos G. Grijalva, Todd W. Rice, Ian D. Jones, William B. Stubblefield, Adrienne Baughman, Kelsey N. Womack, Jillian P. Rhoads, Christopher J. Lindsell, Kimberly W. Hart, Yuwei Zhu, Samantha M. Olson, Miwako Kobayashi, Jennifer R. Verani, Manish M. Patel
Summary: This study evaluated the association between mRNA COVID-19 vaccines and COVID-19 hospitalization, as well as disease progression to critical illness among hospitalized patients. The results showed that vaccination with mRNA COVID-19 vaccines significantly decreased the likelihood of COVID-19 hospitalization and disease progression to death or mechanical ventilation.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Immunology
Tafadzwa Dzinamarira, Nigel Tungwarara, Itai Chitungo, Munashe Chimene, Patrick Gad Iradukunda, Moreblessing Mashora, Grant Murewanhema, Gallican Nshogoza Rwibasira, Godfrey Musuka
Summary: Despite global public health interventions, SARS-CoV-2 continues to spread, and breakthrough infections and waning immunity pose challenges for controlling the pandemic. Addressing vaccine hesitancy and implementing booster shots are crucial for global vaccination programs.
Article
Gastroenterology & Hepatology
Ante Markovinovic, Joshua Quan, Michelle Herauf, Lindsay Hracs, Joseph W. Windsor, Nastaran Sharifi, Stephanie Coward, Lea Caplan, Julia Gorospe, Kenneth Ernest-Suarez, Christopher Ma, Remo Panaccione, Richard J. M. Ingram, Jamil N. Kanji, Graham Tipples, Jessalyn K. Holodinsky, Charles N. Bernstein, Douglas J. Mahoney, Sasha Bernatsky, Eric I. Benchimol, Gilaad G. Kaplan
Summary: SARS-CoV-2 vaccines are safe for patients with IBD, with no cases of IBD flare observed. Injection site reactions after the fourth dose may indicate increased antibody levels.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Immunology
Han Zheng, Ting Zhang, Yiyao Xu, Xin Lu, Xinting Sang
Summary: Cases of autoimmune hepatitis (AIH) after COVID-19 vaccination have been reported, suggesting a potential autoimmune reaction. This study summarizes 27 cases of AIH, providing emerging evidence of such autoimmune phenomena in response to COVID-19 vaccines. Factors such as molecular mimicry, adjuvants, epitope spreading, and bystander activation may contribute to the development of AIH. Corticosteroids appear to be effective in treating post-vaccination AIH, but further research is needed to determine the exact mechanism and causality.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Chunxiu Yang, Shu-Yuan Xiao
Summary: COVID-19, caused by SARS-CoV-2, can lead to severe complications such as multiple organ failure, with most patients also experiencing gastrointestinal symptoms. Managing these symptoms presents challenges for patients with inflammatory bowel disease (IBD) due to potential interactions between the immune response to COVID-19 and dysregulated immunity associated with IBD.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
E. L. P. E. Geubbels, J. A. Backer, F. Bakhshi-Raiez, R. F. H. J. van der Beek, B. H. B. van Benthem, J. van den Boogaard, E. H. Broekman, D. A. Dongelmans, D. Eggink, R. D. van Gaalen, A. van Gageldonk, S. Hahne, K. Hajji, A. Hofhuis, A. J. van Hoek, M. N. Kooijman, A. Kroneman, W. Lodder, M. van Rooijen, W. Roorda, N. Smorenburg, F. Zwagemaker, N. F. de Keizer, I. van Walle, A. M. de Roda Husman, C. Ruijs, S. van den Hof
Summary: The Dutch national open database on COVID-19 has provided comprehensive and detailed data on various aspects of the pandemic including symptoms, testing, cases, deaths, and more. The data is collected from multiple sources and is regularly analyzed and published by the National Institute for Public Health and the Environment. This data is crucial for understanding the epidemiology of COVID-19 in the Netherlands and can be used for future research on the impact of interventions and weather factors.
Article
Gastroenterology & Hepatology
Gregory J. Botwin, Dalin Li, Jane Figueiredo, Susan Cheng, Jonathan Braun, Dermot P. B. McGovern, Gil Y. Melmed
Summary: Patients with immune-mediated inflammatory diseases like IBD who are on immunosuppressive and biologic therapies were largely excluded from COVID-19 mRNA vaccine trials. A study on 246 adults with IBD found that adverse events after mRNA vaccination were similar to the general population. Adverse events were more common in younger patients and those with previous COVID-19, but less common in individuals receiving advanced therapies with biologics or small-molecule inhibitors.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Laurens A. van Kleef, Robert J. de Knegt, Willem Pieter Brouwer
Summary: The study aimed to investigate the mortality risk of MAFLD in relation to excessive alcohol consumption and its potential interactions. The results showed that MAFLD increases mortality risk independent of excessive alcohol consumption. Furthermore, participants with both MAFLD and excessive alcohol consumption have the highest mortality risk.
Article
Gastroenterology & Hepatology
Diego Casas-Deza, Luis Javier Lamuela-Calvo, Fernando Gomollon, Jose Miguel Arbones-Mainar, Berta Caballol, Javier P. Gisbert, Montserrat Rivero, Eugenia Sanchez-Rodriguez, Lara Arias Garcia, Ana Gutierrez Casbas, Olga Merino, Lucia Marquez, Viviana Laredo, Maria Dolores Martin-Arranz, Pilar Lopez Serrano, Sabino Riestra Menendez, Carlos Gonzalez-Munoza, Luisa de Castro Parga, Marta Calvo Moya, Esteban Fuentes-Valenzuela, Maria Esteve, Marisa Iborra, Miguel Dura Gil, Manuel Barreiro-De Acosta, Rufo Humberto Lorente-Poyatos, Noemi Mancenido, Margalida Calafat, Iago Rodriguez-Lago, Jordi Guardiola Capo, Maria Antonia Payeras, Victor Jair Morales Alvarado, Carlos Tardillo, Luis Bujanda, Jose Fernando Munoz-Nunez, Yolanda Ber Nieto, Fernando Bermejo, Pedro Almela, Merce Navarro-Llavat, Pilar Martinez Montiel, Cristina Rodriguez Gutierrez, Manuel Van Domselaar, Eva Sese, Teresa Martinez Perez, Elena Ricart, Maria Chaparro, Maria Jose Garcia, Antonio Lopez-Sanroman, Beatriz Sicilia, Beatriz Orts, Alicia Lopez-Garcia, Eduardo Martin-Larraz, Jose Lazaro Perez-Calle, Ruth de Francisco, Esther Garcia-Planella, Eugeni Domenech, Santiago Garcia-Loper
Summary: Ustekinumab shows similar effectiveness in elderly patients with CD as it does in non-elderly patients. The safety profile is also similar, except for a higher rate of de novo neoplasms in elderly patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Immunology
Sylvia M. Brakenhoff, Margo J. H. van Campenhout, Annemiek A. van der Eijk, Willem P. Brouwer, Florian van Bommel, Bettina E. Hansen, Thomas Berg, Harry L. A. Janssen, Robert A. de Man, Milan J. Sonneveld
Summary: The study aimed to investigate the relationship between off-treatment ALT flares and virological outcomes, as well as to explore whether serum levels of novel biomarkers at the end of treatment can predict flares. The results showed that ALT flares were associated with decreased sustained response rates, and higher levels of HBsAg, HBV RNA, and HBcrAg were associated with an increased risk of flares.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Letter
Gastroenterology & Hepatology
Laurens A. van Kleef, Robert J. de Knegt, Willem Pieter Brouwer
Article
Gastroenterology & Hepatology
Manuel Barreiro-de Acosta, Agnes Fernandez-Clotet, Francisco Mesonero, Francisco Javier Garcia-Alonso, Maria Jose Casanova, Margarita Fernandez-de la Varga, Fiorella Canete, Luisa de Castro, Ana Gutierrez, Beatriz Sicilia, Victoria Cano, Olga Merino, Ruth de Francisco, Irene Gonzalez-Partida, Gerard Suris, Leyanira Torrealba, Rocio Ferreiro-Iglesias, Beatriz Castro, Lucia Marquez, Ana Sobrino, Ainara Elorza, Xavier Calvet, Pilar Varela, Raquel Vicente, Luis Bujanda, Laura Lario, Noemi Mancenido, Mariana F. Garcia-Sepulcre, Eva Iglesias, Cristina Rodriguez, Marta Piqueras, Juan Angel Ferrer Rosique, Alfredo J. Lucendo, Olga Benitez, Melody Garcia, David Olivares, Carlos Gonzalez-Munoza, Beatriz Lopez-Cauce, Victor Jair Morales Alvarado, Katerina Spicakova, Alicia Brotons, Fernando Bermejo, Pedro Almela, Nahia Ispizua, Pau Gilabert, Carlos Tardillo, Fernando Munoz, Pablo Navarro, Rosa Eva Madrigal Dominguez, Pau Sendra, Esther Hinojosa, Empar Sainz, Maria Dolores Martin-Arranz, Daniel Carpio, Elena Ricart, Berta Caballol, Laura Nunez, Jesus Barrio, Javier P. Gisbert, Marisa Iborra, Margalida Calafat, Vicent Hernandez, Roser Munoz Perez, Jose Luis Cabriada, Eugeni Domenech, Iago Rodriguez-Lago
Summary: This study evaluated the effectiveness of biologic agents in Crohn's disease complicated with internal fistulizing disease. It found that biologic therapy is beneficial for approximately three-quarters of patients, achieving a fistula closure rate of 24%, but around one-third of patients still require surgery. Patient- and lesion-related factors can identify patients who will obtain more benefit from these drugs.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Nutrition & Dietetics
Lucas Wauters, Solene Dermine, Brune de Dreuille, Joanna Bettolo, Coralie Hutinet, Ashiq Mohamed, Emilie Lecoq, Lore Billiauws, Alexandre Nuzzo, Olivier Corcos, Francisca Joly
Summary: This study investigated the differences in outcomes after weaning off intravenous support in adult patients with chronic intestinal failure. Nutritional and functional markers were assessed, and it was found that malnutrition and reduced muscle mass were common in these patients. Treatment with teduglutide was effective in preventing these complications.
Review
Gastroenterology & Hepatology
Rishad Khan, Hoomam Homsi, Nikko Gimpaya, James Lisondra, Nasruddin Sabrie, Reza Gholami, Rishi Bansal, Michael A. Scaffidi, David Lightfoot, Paul D. James, Keith Siau, Nauzer Forbes, Sachin Wani, Rajesh N. Keswani, Catharine M. Walsh, Samir C. Grover
Summary: This study systematically evaluated the validity evidence of observational assessment tools for endoscopic retrograde cholangiopancreatography (ERCP). The BESAT, ERCP DOPS, and TEESAT showed strong validity evidence compared with other assessments. Integrating these tools into training may facilitate learners’ development and support competency decision making.
Editorial Material
Gastroenterology & Hepatology
Milan J. Sonneveld, Willem Pieter Brouwer, Harry L. A. Janssen
News Item
Gastroenterology & Hepatology
Katarzyna M. M. Pawlak, Rashid N. N. Lui, Mohammad Bilal, Keith Siau
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Gastroenterology & Hepatology
Fernando Magro, Paula Leao Moreira, Gaia Catalano, Catarina Alves, Joana Roseira, Maria Manuela Estevinho, Isabel Silva, Axel Dignass, Laurent Peyrin-Biroulet, Silvio Danese, Vipul Jairath, Claudia Camila Dias, Mafalda Santiago
Summary: This systematic review and meta-analysis found that the clinical response and remission rates in Crohn's disease patients treated with biological agents have remained stable over the years. The publication year did not significantly influence these outcomes, except for a decreased effect on clinical remission in maintenance studies.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Fernando Magro, Maria Manuela Estevinho, Gaia Catalano, Marta Patita, Bruno Arroja, Paula Lago, Isadora Rosa, Helena Tavares de Sousa, Paula Ministro, Irina Mocanu, Ana Vieira, Joana Castela, Joana Moleiro, Joana Roseira, Eugenia Cancela, Paula Sousa, Francisco Portela, Luis Correia, Paula Moreira, Mafalda Santiago, Sandra Dias, Joana Afonso, Silvio Danese, Laurent Peyrin-Biroulet, Claudia Camila Dias
Summary: This study aimed to evaluate the performance of readily available biomarkers and develop risk matrices for predicting Crohn's disease (CD) progression. The results showed that the presence of anemia, highly elevated CRP, and FC in at least one visit were significant predictors. Combining these biomarkers in risk matrices had good ability to predict disease progression.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Immunology
Candida Abreu, Antonio Martins, Fernando Silva, Gabriela Canelas, Lucia Ribeiro, Stefano Pinto, Antonio Sarmento, Fernando Magro
Summary: Patients with immune-mediated inflammatory diseases treated with immunomodulatory therapy are at higher risk of infections, but adherence to vaccination is suboptimal. In this study, less than 5% of patients had all their vaccines up-to-date, and a majority did not fully adhere to the recommended vaccination schedule.
Article
Gastroenterology & Hepatology
Katarzyna M. Pawlak, Nadeem Tehami, Ben Maher, Shujaath Asif, Krishn Kant Rawal, Daniel Vasile Balaban, Mohammed Tag-Adeen, Fahd Ghalim, Wael A. Abbas, Elsayed Ghoneem, Khaled Ragab, Mahmoud El-Ansary, Shanil Kadir, Sunil Amin, Keith Siau, Anna Wiechowska-Kozlowska, Klaus Monkemuller, Dalia Abdelfatah, Abeer Abdellatef, Sundeep Lakhtakia, Hussein Hassan Okasha
Summary: Solid pseudopapillary neoplasm (SPN) is an uncommon pancreatic pathology with unpredictable malignant potential. Endoscopic ultrasound (EUS) plays a vital role in assessing the characteristics of SPN and confirming the diagnosis. However, there is limited data regarding the imaging assessment of these lesions.
WORLD JOURNAL OF GASTROINTESTINAL ENDOSCOPY
(2023)
Editorial Material
Gastroenterology & Hepatology
Fernando Magro, Maria Manuela Estevinho
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Editorial Material
Gastroenterology & Hepatology
Oscar Cahyadi, Keith Siau
ENDOSCOPY INTERNATIONAL OPEN
(2023)
