Review
Endocrinology & Metabolism
Natural Chu, Juliana C. N. Chan, Elaine Chow
Summary: Pharmacomicrobiomics investigates the interactions between foreign compounds and the gut microbiome, which play a significant role in the efficacy, side effects, and toxicity of the compounds. Glucose lowering drugs work by regulating insulin and energy disposal. In addition to genetic, ecological, and lifestyle factors, maintaining a balanced gut microbiome is crucial for human health. Different compositions of microbiota can influence patients' responses to glucose-lowering drugs. This article summarizes the differences in gut microbiota composition between individuals with type 2 diabetes and healthy individuals, and explores how Western Medicine and Traditional Chinese Medicine can shape the gut microbiota to improve immunity and metabolic health.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Evdoxia Bletsa, Sebastien Filippas-Dekouan, Christina Kostara, Panagiotis Dafopoulos, Aikaterini Dimou, Eleni Pappa, Styliani Chasapi, Georgios Spyroulias, Anastasios Koutsovasilis, Eleni Bairaktari, Ele Ferrannini, Vasilis Tsimihodimos
Summary: Dapagliflozin significantly alters urine metabolome in patients with type 2 diabetes in a glucose lowering-independent way. Most of the observed changes can be considered beneficial and may contribute to the renoprotective properties of dapagliflozin.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Integrative & Complementary Medicine
Yanling He, Hefang Zhang, Yufei Yang, Xianghui Yu, Xiao Zhang, Qiaolin Xing, Gengliang Zhang
Summary: The incidence of diabetes worldwide is rising, with over 90% of cases being type 2 diabetes. Metabolomics research helps to identify biomarkers associated with the risk of T2D and reveal potential pathogenesis. Traditional Chinese Medicine shows unique advantages in the treatment of T2D, providing valuable biomarkers and novel drug targets.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Review
Integrative & Complementary Medicine
Jingying Liu, Chun Yao, Yitao Wang, Jinmin Zhao, Hua Luo
Summary: Traditional Chinese medicine (TCM) has potential for preventing and managing type 2 diabetes through nonpharmacological interventions such as healthy diet, physical activity, emotional therapy, and acupuncture. Studies have shown significant improvement in blood glucose status for prediabetes and type 2 diabetes patients after TCM non-drug interventions. However, the methodological quality of clinical trials involving TCM is generally low and further exploration is needed to validate its effectiveness and underlying mechanism for preventing type 2 diabetes.
Article
Endocrinology & Metabolism
Zhili Dou, Ye Xia, Jiawei Zhang, Yizhen Li, Yunan Zhang, Lei Zhao, Zhe Huang, Haonan Sun, Lin Wu, Dongran Han, Yixing Liu
Summary: This study systematically summarized and categorized the syndrome differentiation, medication rules, and acupoint therapy for type 2 diabetes mellitus in traditional Chinese medicine literature. Most TCM syndrome differentiation for T2DM was identified as Zhongxiao and Xiaxiao deficiency syndromes, with a focus on the Spleen Channel and Kidney Channel for medications and acupoint therapies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Dandan Xie, Kai Li, Ruxue Feng, Man Xiao, Zhifeng Sheng, Yiqiang Xie
Summary: Ferroptosis, a regulated programmed cell death pathway, has attracted significant attention in recent years. It is characterized by the accumulation of lipid peroxides and damage to cellular membranes, dependent on iron. Traditional Chinese medicine (TCM) has advantages in treating type 2 diabetes mellitus (T2DM) due to its anti-inflammatory, antioxidant, immunomodulatory, and intestinal flora-regulating properties. Studies have revealed that TCM may have therapeutic effects on T2DM by modulating the ferroptosis-related pathways. Understanding the role of ferroptosis in T2DM and its treatment with TCM is therefore important for developing effective drugs and broadening the treatment options for T2DM.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Review
Pharmacology & Pharmacy
Xiang Li, Jia-Jia Geng-Ji, Yun-Yun Quan, Lu-Ming Qi, Qiang Sun, Qun Huang, Hai-Mei Jiang, Zi-Jian Sun, Hong-Mei Liu, Xin Xie
Summary: This article reviews the bioactive metabolites derived from traditional Chinese medicine (TCM) with the potential treatment of type 2 diabetes mellitus (T2DM). These metabolites show promising prospects for treating T2DM due to their excellent biocompatibility and fewer adverse reactions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Wu Lun, Gao Yue, Su Yang, Li Jing, Ren Wen-Chen, Wang Qiu-Hong, Kuang Hai-Xue
Summary: This article systematically summarizes the anti-diabetic effects of traditional Chinese medicine polysaccharides. These polysaccharides regulate the metabolism of sugar and lipids, improve symptoms such as high blood glucose and abnormal metabolism, and are beneficial for human health.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Article
Endocrinology & Metabolism
Fiona Bragg, Christiana Kartsonaki, Yu Guo, Michael Holmes, Huaidong Du, Canqing Yu, Pei Pei, Ling Yang, Donghui Jin, Yiping Chen, Dan Schmidt, Daniel Avery, Jun Lv, Junshi Chen, Robert Clarke, Michael Hill, Liming Li, Iona Millwood, Zhengming Chen
Summary: A study conducted on Chinese adults found that circulating metabolites are independently associated with the risk of type 2 diabetes (T2D), providing valuable insights into the etiology of the disease and potential for improving T2D risk prediction.
Article
Endocrinology & Metabolism
Fiona Bragg, Christiana Kartsonaki, Yu Guo, Michael Holmes, Huaidong Du, Canqing Yu, Pei Pei, Ling Yang, Donghui Jin, Yiping Chen, Dan Schmidt, Daniel Avery, Jun Lv, Junshi Chen, Robert Clarke, Michael Hill, Liming Li, Iona Millwood, Zhengming Chen
Summary: Metabolites across diverse pathways were independently associated with the risk of T2D in Chinese adults, providing valuable etiological insights and potential to improve T2D risk prediction.
Article
Integrative & Complementary Medicine
Si-qi Tang, Yun-liang Wang, Zi-ye Xie, Yang Zhang, Yi Guo, Kang-li Gao, Tang-you Mao, Chun-e Xie, Jun-xiang Li, Xiao-yan Gao
Summary: This study revealed through serum metabolomics that different TCM syndrome types in IBS-D may exhibit distinct metabolic patterns, with glycerophospholipid metabolism being a significant pathway affected differently among the three TCM syndromes.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Review
Chemistry, Medicinal
Yanxia Chen, Mian Wang
Summary: Type 2 diabetes mellitus is a common metabolic disease characterized by chronic hyperglycemia, in which the gut microbiota plays a significant role. Some anti-hyperglycemic agents and traditional Chinese medicine may improve glucose metabolism by altering the gut microbiota composition, potentially providing new therapeutic targets for diabetes treatment.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Endocrinology & Metabolism
Jianwei Zhang, Wei Wu, Ke Huang, Guanping Dong, Xuefeng Chen, Cuifang Xu, Yan Ni, Junfen Fu
Summary: This study used untargeted metabolomics to study pediatric patients with T1D and identified differential metabolites associated with T1D. These metabolites mainly included carbohydrates, indoles, unsaturated fatty acids, amino acids, and organic acids. The study also revealed the close relationship between carbohydrate metabolism, unsaturated fatty acid biosynthesis, gut microbial metabolism, and T1D.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Guangqi Wang, Jiajia Song, Chen Wang, Xiaoyong Chen, Huayi Suo
Summary: In this study, it was found that treatment with Lactobacillus plantarum SHY130 (LPSHY130) improved liver function and pathological damage in a murine model of type 2 diabetes (T2D). Untargeted metabolome analysis revealed that LPSHY130 treatment regulated changes in 11 metabolites involved in purine metabolism, amino acid metabolism, choline metabolism, and pantothenate and coenzyme A biosynthesis pathways. Furthermore, correlation analysis indicated that intestinal microbiota can adjust hepatic metabolic changes.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Review
Plant Sciences
Yujiao Zheng, Qiyou Ding, Yu Wei, Xiaowen Gou, Jiaxing Tian, Min Li, Xiaolin Tong
Summary: Recent studies have shown the significant role of gut microbiota in the development of type 2 diabetes mellitus (T2DM) and the potential therapeutic effect of traditional Chinese medicine (TCM) on T2DM. This systematic review included five randomized controlled trials (RCTs) on TCM interventions targeting gut microbiota in T2DM patients, showing statistically significant improvements in HbA1c, fasting blood glucose, postprandial blood glucose, insulin resistance, and beta-cell function. While TCM was found to modulate gut microbiota and improve glucose metabolism, further studies are needed to explore its effects on inflammation.