Lymph Nodes-On-Chip: Promising Immune Platforms for Pharmacological and Toxicological Applications

Organs-on-chip are gaining increasing attention as promising platforms for drug screening and testing applications. However, lymph nodes-on-chip options remain limited although the lymph node is one of the main determinants of the immunotoxicity of newly developed pharmacological drugs. In this review, we describe existing biomimetic lymph nodes-on-chip, their design, and their physiological relevance to pharmacology and shed the light on future directions associated with lymph node-on-chip design and implementation in drug discovery and development.

Automated summary

Organs-on-chip are being increasingly recognized as promising platforms for drug screening and testing applications. Despite this, options for lymph nodes-on-chip remain limited, even though the lymph node plays a crucial role in determining the immunotoxicity of newly developed drugs. This review discusses existing biomimetic lymph nodes-on-chip, their physiological relevance to pharmacology, and sheds light on the future directions associated with the design and implementation of lymph nodes-on-chip in drug discovery and development.