Article
Biochemistry & Molecular Biology
Alvaro del Real, Sergio Ciordia, Carolina Sanudo, Carmen Garcia-Ibarbia, Adriel Roa-Bautista, Javier G. Ocejo-Vinals, Fernando Corrales, Jose A. Riancho
Summary: The aim of this study was to explore new markers in serum proteome associated with the response to antiosteoporosis drugs. The results showed significant differences in protein levels, particularly those related to the innate immune system, in the serum after treatment with teriparatide and denosumab.
Article
Biochemistry & Molecular Biology
Francesca Manuela Johnson de Sousa Brito, Andrew Butcher, Addolorata Pisconti, Blandine Poulet, Amanda Prior, Gemma Charlesworth, Catherine Sperinck, Michele Scotto di Mase, Ke Liu, George Bou-Gharios, Robert Jurgen van 't Hof, Anna Daroszewska
Summary: Syndecan-3 promotes new bone formation in osteoblasts by enhancing WNT signaling, and its deficiency in mice results in an early osteoporosis-like phenotype due to delayed osteoblast maturation and impaired function. Overexpressing Sdc3 in osteoblasts rescues the low bone volume phenotype and increases bone mass, making SDC3 a potential target for novel bone anabolic drug development.
Article
Biochemistry & Molecular Biology
Gaoyang Chen, Shang Wang, Canling Long, Zhenmin Wang, Xin Chen, Wanze Tang, Xiaoqin He, Zhiteng Bao, Baoyu Tan, William W. Lu, Zhizhong Li, Dazhi Yang, Guozhi Xiao, Songlin Peng
Summary: Bone remodeling is a dynamic process involving bone formation and resorption. PiRNA-63049, through the Wnt2b/13-β-catenin signaling pathway, has been shown to inhibit bone formation, making it a potential target for increasing bone formation in disorders such as postmenopausal osteoporosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Margarita M. Ivanova, Julia Dao, Neil Kasaci, Andrew Friedman, Lauren Noll, Ozlem Goker-Alpan
Summary: This study revealed that elevated levels of sclerostin in GD patients are associated with bone pain, BMI, and EM flask deformity. Most patients with elevated sclerostin also have osteopenia. Additionally, sclerostin levels increase with age in GD patients, and are higher compared to healthy controls in the same age group.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yongguang Gao, Na Chen, Zhanda Fu, Qing Zhang
Summary: Osteoporosis is a serious health disease characterized by bone mass loss, bone density reduction, and degeneration of bone microstructure, leading to bone fragility and a higher risk of fracture. More than 200 million people worldwide suffer from this condition, with estimated treatment costs of at least $25 billion by 2025. The Wnt signaling pathway plays a crucial role in bone development, metabolism, and the differentiation and proliferation of bone-related cells. Inhibitory proteins Dkk-1 and SOST, which block the activation of the canonical Wnt signaling pathway, have potential as targets for osteoporosis treatment. This review provides an analysis of the mechanisms of Wnt proteins, beta-catenin, and signaling molecules, highlighting the importance of the Wnt signaling pathway in osteoporosis and offering new perspectives and approaches for diagnosis and treatment.
Article
Cell Biology
Xinwei Chen, Xuzhuo Chen, Rui Chao, Yexin Wang, Yi Mao, Baoting Fan, Yaosheng Zhang, Weifeng Xu, An Qin, Shanyong Zhang
Summary: This study demonstrates the important role of Dlk2 in osteoclast development and bone homeostasis, as well as the interaction between Dlk2 and the Syap1 signaling pathway. The results indicate that Dlk2 deletion inhibits osteoclast formation and leads to a high-bone-mass phenotype, with increased bone mass observed in ovariectomized mice.
CELL DEATH & DISEASE
(2023)
Article
Orthopedics
Kewen Zhang, Wuxia Qiu, Hui Li, Jun Li, Pai Wang, Zhihao Chen, Xiao Lin, Airong Qian
Summary: MACF1 plays a positive regulatory role in osteogenesis and bone formation in MSCs through the TCF4/miR-335-5p signaling pathway in SOP, suggesting it as a potential therapeutic target for SOP.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Endocrinology & Metabolism
Roy B. Choi, April M. Hoggatt, Daniel J. Horan, Emily Z. Rogers, Gabriela G. Loots, Alexander G. Robling
Summary: The development of Wnt-based osteoanabolic agents has progressed rapidly in recent years, showing potent effects on bone homeostasis. Simultaneous inhibition of sclerostin and Dkk1 can enhance the effects in the cancellous bone. Further research reveals that Sostdc1 can be co-inhibited with sclerostin to improve cortical bone properties. Combined administration of sclerostin antibody and Sostdc1 antibody produces potentiation of cortical bone gain.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Cell Biology
Changsheng Yang, Panpan Yang, Peilin Liu, Hong Wang, Ee Ke, Kai Li, Huibo Yan
Summary: This study revealed that FLNA plays a crucial role in osteoporosis by inhibiting osteogenesis and promoting osteoclastogenesis. Inhibiting FLNA and activating the WNT/β-catenin signaling pathway can protect against bone loss in postmenopausal osteoporosis.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Jesus Delgado-Calle, Kevin McAndrews, Gerald Wu, Ashley L. Orr, Adam Ferrari, Xiaolin Tu, Venkatesan Srinivasan, G. David Roodman, Frank H. Ebetino, Robert K. Boeckman, Teresita Bellido
Summary: This study reveals that PTH signaling upregulates Notch pathway components, and Notch activation contributes to the catabolic actions of PTH in bone. Deleting the PTH receptor or overexpressing sclerostin in osteocytes abolishes the increase in Notch components caused by PTH. Moreover, bone-targeted Notch inhibition enhances the bone anabolic effects of intermittent PTH.
Article
Biology
Michala Steinerova, Cenek Horecky, Eliska Horecka, Ales Knoll, Sarka Nedomova, Petr Slama, Ales Pavlik
Summary: The Wnt signaling pathway plays a critical role in skeletal development, and targeting this pathway has implications for skeletal health. This study investigated single nucleotide polymorphisms in selected genes involved in this pathway and their associations with bone parameters in hens. Thirteen polymorphisms were found in the GPR177 gene, but only one was associated with bone length, and it was located in an intron. The ESR1 and RUNX2 genes were monomorphic in the tested regions.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Orthopedics
Junjie Xu, Zipeng Ye, Chang'an Chen, Xueying Zhang, Kang Han, Xiulin Wu, Ziyun Li, Jia Jiang, Xiaoyu Yan, Jiangyu Cai, Jinzhong Zhao
Summary: This study suggests that anabolic therapy with abaloparatide is more effective than antiresorptive therapy with denosumab in promoting rotator cuff healing in osteoporotic rats. Abaloparatide improves the quality of mineralized tissue and collagen maturity at the reattachment site, leading to improved biomechanical properties.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Multidisciplinary Sciences
Mehran Ashrafi, Farzan Ghalichi, Behnam Mirzakouchaki, Manuel Doblare
Summary: Bone remodeling is a crucial process involving new bone formation and old bone resorption. Dental implantation post-surgery bone remodeling is significant, especially for patients with osteoporosis, with studies showing increased demand and success rates for dental implants in such patients. Antiresorptive drugs have been shown to improve bone density after dental implantation, but their effects on bone quality and brittleness require further study.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Yanjun Wang, Lin Liu, Zechao Qu, Dong Wang, Wangli Huang, Lingbo Kong, Liang Yan
Summary: This study aimed to explore the potential mechanism through which tanshinone can improve osteoporosis. Through bioinformatics analysis, 21 common KEGG pathways were identified between osteoporosis and tanshinone-targeted genes, and the regulation of AKT1 expression by tanshinone was validated.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Genetics & Heredity
Jingyao Cui, Haoran Chen, Kaiwen Zhang, Xin Li
Summary: Wnt pathway plays a crucial role in cancer bone metastasis and targeted therapeutic strategies have shown promise. Current progress includes research on pharmacological Wnt modulators against breast cancer bone metastasis and exploration of emerging therapeutic strategies based on Wnt pathway-related targets, providing new ideas for the development of Wnt-based intervention strategies in the future.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Engineering, Biomedical
Baisong Chang, Daifeng Li, Ying Ren, Chunrong Qu, Xiaojing Shi, Ruiqi Liu, Hongguang Liu, Jie Tian, Zhenhua Hu, Taolei Sun, Zhen Cheng
Summary: The development of a NIR-II phosphorescent probe made of glutathione-capped copper-indium-selenium nanotubes enables enhanced tumor-specific imaging in acidic environments, offering superior imaging performance in the second near-infrared spectral window.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Rheumatology
Shi-Hao He, Yu-Jie He, Kuang-Jin Guo, Xu Liang, Shan-Shan Li, Tian-Fang Li
Summary: In this study, clinical characteristics and risk factors related to the progression of interstitial lung disease (ILD) in patients with primary Sjogren's syndrome (pSS) were identified. The results indicated that male sex, non-sicca onset, reticular pattern on HRCT, higher levels of baseline lactic dehydrogenase (LDH), and low baseline forced vital capacity (FVC) were associated with the progression of ILD. A predictive model was developed and validated for ILD progression in pSS patients.
CLINICAL RHEUMATOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ying Yuan, Shanchao Diao, Xiaoyue Ni, Dong Zhang, Wanrong Yi, Chao Jian, Xiang Hu, Daifeng Li, Aixi Yu, Wen Zhou, Quli Fan
Summary: This study developed semiconductor polymer nanoparticles for targeted photothermal therapy and photodynamic therapy in osteosarcoma. The nanoparticles showed efficient cellular uptake and enhanced therapeutic effects, leading to significant anti-tumor activities both in vitro and in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Rheumatology
Shan-Shan Li, Na Du, Shi-Hao He, Xu Liang, Tian-Fang Li
Summary: This study found that patients with axial psoriatic arthritis (axPsA) who had dactylitis had higher disease activity and more severe joint damage compared to those without dactylitis. Careful examination and proper management of axial involvement are recommended.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Shan-Shan Li, Na Du, Shi-Hao He, Xu Liang, Tian-Fang Li
Summary: This study found that currently existing cutaneous lesions in PsA patients themselves are correlated with disease activity and severity of axial joint damage, while family history does not have a significant impact on the disease activity of PsA.
RHEUMATOLOGY AND THERAPY
(2022)
Article
Engineering, Environmental
Daifeng Li, Chi Zhang, Xiaoyan Tai, Denghui Xu, Jianzhong Xu, Pengfei Sun, Quli Fan, Zhen Cheng, Yi Zhang
Summary: This study developed a novel nanoplatform, P2NPs, with strong photothermal therapy and dual-modal optical tracking capabilities. In vitro and in vivo experiments demonstrated the potential of this platform in the treatment of osteosarcoma.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Pengfei Sun, Fan Qu, Chi Zhang, Pengfei Cheng, Xiangyu Li, Qingming Shen, Daifeng Li, Quli Fan
Summary: This study presents a phototheranostic approach using NIR-II excitation for breast cancer bone metastases. The approach combines NIR-II fluorescence imaging, NIR-II photoacoustic imaging, NIR-II photothermal therapy, chemotherapy, and chemodynamic therapy. The phototheranostic successfully suppresses tumor cell progression in bone tissue and provides insights for the development of NIR-II phototheranostics.
Review
Chemistry, Multidisciplinary
Yaping He, Daifeng Li, Li Wu, Xianzhen Yin, Xiaojian Zhang, Laurence H. Patterson, Jiwen Zhang
Summary: Gene therapy shows promise in treating cancer, viral infection, and gene disorders, while genetic detection is crucial for disease diagnosis and prevention. However, the existing delivery vectors have limitations. Metal-organic frameworks (MOFs) have gained attention for their high surface areas and tunable structures. This review highlights the potential of MOFs as nonviral vectors in gene delivery and detection.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Cell Biology
Xu Liang, Sen-Rui Li, Xin-Xin Zhang, Shi-Hao He, Shan-Shan Li, Tian-Fang Li
Summary: This study investigates the role of teriparatide in synovitis and cartilage degradation in osteoarthritis, demonstrating that it can prevent synovitis and cartilage degradation by suppressing TNF-alpha mediated MMP-13 overexpression.
CONNECTIVE TISSUE RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Daifeng Li, Shengnan Ma, Denghui Xu, Xiaocao Meng, Ningjing Lei, Chen Liu, Ying Zhao, Yingqiu Qi, Zhen Cheng, Fazhan Wang
Summary: In this study, a self-assembled nanoplatform named GENP was designed using stearic acid-modified GE11. The nanoplatform showed high drug loading efficiency and sustained drug release, and it significantly suppressed the proliferation of TNBC cells via inhibiting the PI3K/AKT signaling pathway downstream of EGFR. Further experiments demonstrated remarkable therapeutic efficacy with minimal biotoxicity in TNBC and its bone metastasis models.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Yaping He, Xuanzong Wang, Chi Zhang, Junkui Sun, Jianzhong Xu, Daifeng Li
Summary: A controllable antibacterial nanoplatform was constructed using cyclodextrin metal-organic frameworks (CD-MOFs) as a template to synthesize ultrafine silver nanoparticles (Ag NPs) in their porous structure. Polydopamine (PDA) was encapsulated on the CD-MOFs' surface to enhance water stability and enable hyperthermia capacity. The resulting Ag@MOF@PDA exhibited localized hyperthermia and controllable release of Ag+ for antibacterial activity.
Article
Engineering, Biomedical
Pengfei Sun, Wan Yang, Jiarong He, Liuliang He, Pengfei Chen, Wenjuan Xu, Qingming Shen, Daifeng Li, Quli Fan
Summary: In this study, multifunctional nanoparticles were developed for combined chemotherapy, photothermal therapy, and starvation therapy. The nanoparticles released drugs through donor-acceptor coordination interactions and PBA-diol bonds under acidic and oxidizing conditions. Additionally, 2-DG in the nanoparticles enhanced the therapeutic effects.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Pengfei Chen, Fan Qu, Liuliang He, Mingfei Li, Pengfei Sun, Quli Fan, Chi Zhang, Daifeng Li
Summary: By modifying with multiple sulfonate groups, a bone-targeted NIR-II small molecule (TTQF-SO3) was successfully synthesized for bone imaging. In vitro studies demonstrated its high affinity for hydroxyapatite and excellent macrophage accumulation ability. In vivo assays showed that TTQF-SO3 exhibited high bone uptake ability and high NIR-II bone imaging quality, highlighting its specific bone-targeting ability.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xuanzong Wang, Chi Zhang, Liuliang He, Mingfei Li, Pengfei Chen, Wan Yang, Pengfei Sun, Daifeng Li, Yi Zhang
Summary: The researchers proposed a novel nanoplatform for the synergistic use of photothermal therapy, chemodynamic therapy, and antibiotics in the treatment of drug-resistant bacterial biofilm infections. The nanoplatform caused damage to bacterial membrane structures through the release of antibiotics and generation of hydroxyl radicals in an acidic environment, and exhibited excellent hyperthermia and accelerated drug release under laser irradiation. Additionally, the nanoplatform enabled precise imaging of the infected sites.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Xin-Xin Zhang, Xu Liang, Sen-Rui Li, Kuang-Jin Guo, Dai-Feng Li, Tian-Fang Li
Summary: GC-induced avascular osteonecrosis of femoral head (AOFH) is a devastating complication without available cures. Modified bone marrow mesenchymal stem cell (BMMSCs) implantation can improve treatment efficacy by interfering with the COX-2-PGE-2-HIF-1α pathway and preventing AOFH.
CELL TRANSPLANTATION
(2022)
