Review
Infectious Diseases
Armel Jackson Seukep, Helene Gueaba Mbuntcha, Victor Kuete, Yindi Chu, Enguo Fan, Ming-Quan Guo
Summary: An effective response to antimicrobial resistance (AMR) requires a combination of prevention and treatment. Bacteria have developed strategies, such as over-expression of efflux pumps (EPs), to become resistant to antibiotics. Efforts are focused on developing resistance breakers, including natural plant extracts and alternative methods, to combat AMR.
Review
Microbiology
Jerusha Stephen, Manjusha Lekshmi, Parvathi Ammini, Sanath H. Kumar, Manuel F. Varela
Summary: Infectious diseases caused by bacteria of the Vibrio genus have significant impacts on human health. The mechanisms of antimicrobial resistance in Vibrio spp. include biofilm formation and active antimicrobial efflux. Understanding these antimicrobial transport systems is important for studying Vibrio spp. pathogenesis and virulence.
Review
Biochemistry & Molecular Biology
Manuel F. Varela, Jerusha Stephen, Deeksha Bharti, Manjusha Lekshmi, Sanath Kumar
Summary: Bacterial pathogens resistant to multiple antimicrobial agents through active efflux pose a serious threat to public health. This review discusses recent molecular studies focused on modulating the antimicrobial efflux transporters to restore the clinical efficacy of infectious disease chemotherapy.
Review
Biochemistry & Molecular Biology
Andre Bittencourt Lorusso, Joao Antonio Carrara, Carolina Deuttner Neumann Barroso, Felipe Francisco Tuon, Helisson Faoro
Summary: Antimicrobial resistance is a global public health crisis caused by the emergence of resistant organisms and different mechanisms of antibiotic resistance. Efflux pumps, particularly in Gram-negative bacteria like Pseudomonas aeruginosa, play a significant role in multidrug resistance and extensively drug-resistant bacteria. Understanding their function, structure, and regulation is essential in combating antibiotic resistance and developing new drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Bertha N. Moiketsi, Katlego P. P. Makale, Gaolathe Rantong, Teddie O. Rahube, Abdullah Makhzoum
Summary: Antimicrobial resistance is a global health threat, especially for low- and middle-income countries. Bioactive compounds from African traditional medicinal plants offer potential alternative options in antibiotic therapy against multi-drug-resistant bacteria, and synergism with antibiotics has been discussed.
Review
Infectious Diseases
Asiyeh Avakh, Gary D. Grant, Matthew J. Cheesman, Tejaswini Kalkundri, Susan Hall
Summary: Pseudomonas aeruginosa (P. aeruginosa) is a problematic bacterium due to its multidrug resistance (MDR) phenotype. It exhibits intrinsic and acquired resistance to many antibiotics, and efflux pumps, particularly the Mex pumps, play a crucial role in driving MDR. Developing efflux pump inhibitors (EPIs) holds great potential for overcoming MDR and restoring the efficacy of antipseudomonal drugs.
Review
Chemistry, Medicinal
Mohammad Vikas Ashraf, Shreekar Pant, M. A. Hannan Khan, Ali Asghar Shah, Sazada Siddiqui, Mouna Jeridi, Heba Waheeb Saeed Alhamdi, Shoeb Ahmad
Summary: Antibiotics are crucial in treating infectious diseases, but their effectiveness is threatened by antimicrobial resistance. Overuse and misuse of antibiotics have accelerated the development of multidrug-resistant pathogens, limiting treatment options. Phytochemicals have emerged as a potential alternative in combating antimicrobial resistance with their diverse and multitarget antimicrobial effects. This review provides an overview of antimicrobial phytochemicals from 123 Himalayan medicinal plants, offering valuable information for researchers exploring phytochemicals to combat antimicrobial resistance.
Review
Infectious Diseases
Giuseppe Valerio De Gaetano, Germana Lentini, Agata Fama, Francesco Coppolino, Concetta Beninati
Summary: The number of multidrug-resistant bacteria is rapidly spreading worldwide. Multidrug efflux pumps play an important role in antimicrobial resistance as they export harmful substances, leading to multidrug resistance (MDR) and treatment failures. Transcriptional regulators and two-component systems (TCS) control the expression of multidrug efflux pumps. Targeting TCS, along with efflux pump inhibitors, could be a beneficial strategy to combat the growing antibiotic resistance.
Article
Infectious Diseases
Elisa Rampacci, Tommaso Felicetti, Giada Cernicchi, Valentina Stefanetti, Stefano Sabatini, Fabrizio Passamonti
Summary: One approach to treating antibiotic-resistant bacteria is to co-administer efflux pump inhibitors (EPIs) with antibiotics to break resistances connected with antibacterial efflux. In this study, ten compounds were evaluated for their ability to inhibit efflux and synergize with different antibiotics in Staphylococcus pseudintermedius. Hit compounds 1, 6, and 8 were considered the best EPIs for S. pseudintermedius. These findings provide valuable data for further optimization and development of EPIs for treating staphylococcal infections.
Article
Microbiology
Tobias Gundolf, Roland Kalb, Peter Rossmanith, Patrick Mester
Summary: The effective elimination of foodborne pathogens is crucial to the food processing industry, but the increasing spread of resistant strains is a major concern. This study explores the role of multidrug efflux pumps in the resistance of Escherichia coli and Salmonella enterica serovar Typhimurium to antimicrobial ionic liquids. The results highlight the importance of efflux pumps in IL toxicity studies and provide insights for the development of effective biocides against multidrug resistant bacteria.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Microbiology
Kunihiko Nishino, Seiji Yamasaki, Ryosuke Nakashima, Martijn Zwama, Mitsuko Hayashi-Nishino
Summary: Multidrug efflux pumps are inner membrane transporters that export multiple antibiotics from bacterial cells, contributing to multidrug resistance. They are abundant in bacteria, and their co-crystal structural analysis reveals drug recognition and export mechanisms, emphasizing the importance of developing inhibitors to combat infectious diseases caused by multidrug-resistant bacteria.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jyoti Mehta, Rajan Rolta, Deeksha Salaria, Oladoja Awofisayo, Olatomide A. Fadare, Prem Prakash Sharma, Brijesh Rathi, Adity Chopra, Neha Kaushik, Eun Ha Choi, Nagendra Kumar Kaushik
Summary: The study investigated the binding affinity of major phytocompounds from 35 medicinal plants with the RamR protein of S. typhimurium. Among all compounds, beta-sitosterol showed the most efficacious binding affinity and was non-toxic. This indicates that beta-sitosterol has the potential to be used as an antimicrobial and further explored as a drug to inhibit efflux pumps.
Article
Microbiology
Seiji Yamasaki, Naoki Koga, Martijn Zwama, Keisuke Sakurai, Ryosuke Nakashima, Akihito Yamaguchi, Kunihiko Nishino
Summary: This study found that different Trp mutations at different locations in the structure of MexB can affect the inhibitory effect of EPIs, without affecting the function of the efflux pumps.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Infectious Diseases
Martijn Zwama, Kunihiko Nishino
Summary: The rise in multidrug resistance poses a major threat to human health globally due to the over-expression of multidrug efflux pumps and amino acid substitutions within the pumps themselves causing increased drug efflux efficiency. Studies on clinically, environmentally and laboratory-evolved Gram-negative bacterial strains have shown mutations in the RND-type pumps leading to decreased drug sensitivity. Understanding the evolution and variations in efflux pumps is crucial for the development of novel antibiotics and efflux pump inhibitors.
Review
Infectious Diseases
Lulu Huang, Cuirong Wu, Haijiao Gao, Chao Xu, Menghong Dai, Lingli Huang, Haihong Hao, Xu Wang, Guyue Cheng
Summary: This review comprehensively discusses the role and potential applications of multidrug efflux pumps in bacterial resistance to antimicrobial agents. These pumps not only decrease the intracellular concentration of drugs but also promote multidrug resistance, biofilm formation, quorum sensing, and other biological functions in bacteria. The potential applications of efflux pump-related genes/proteins for the detection of antibiotic residues and antimicrobial resistance are also analyzed. Additionally, the review discusses efflux pump inhibitors, especially those of plant origin.
Review
Plant Sciences
Monica Jamla, Shrushti Joshi, Suraj Patil, Bhumi Nath Tripathi, Vinay Kumar
Summary: This article discusses the significance and roles of miRNAs in plant nutrition and nutrient homeostasis, and how they play key roles in plant responses to nutrient imbalances/deficiencies/toxicities. The article also explores the prospects of developing miRNA-engineered biofortified crops and discusses current challenges and future strategies.
Review
Plant Sciences
Polavarapu B. Kavi Kishor, Showkat Ahmad Ganie, Shabir H. Wani, Rajasheker Guddimalli, Appa Rao Karumanchi, Sujatha Edupuganti, Jalaja Naravula, Vinay Kumar, Rathnagiri Polavarapu, Prashanth Suravajhala, Suprasanna Penna
Summary: NF-Y is a ubiquitous family of transcription factors that regulate plant growth, development, and stress responses. They interact with various signaling pathways to modulate plant stress responses and play important roles in multiple aspects of plant physiology.
JOURNAL OF PLANT GROWTH REGULATION
(2023)
Review
Pharmacology & Pharmacy
Lei Zhang, Biwei Ye, Zhuo Chen, Zhe-Sheng Chen
Summary: Chemotherapy is an important method for treating cancer, but multi-drug resistance (MDR) is a major reason for its failure. Almost all anti-tumor drugs develop drug resistance over time, reducing their effectiveness in killing cancer cells. Chemoresistance can lead to rapid cancer recurrence and patient death.
ACTA PHARMACEUTICA SINICA B
(2023)
Editorial Material
Pharmacology & Pharmacy
Ting Wang, Zhe-Sheng Chen, Chen Shi, Liang Ouyang, Hongtao Xiao
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Tingting Guo, Zixu Sa, Pengfei Wei, Yuxuan Jian, Xiang Chen, Zhesheng Chen, Jose Avila, Pavel Dudin, Zai-xing Yang, Xiufeng Song, Fengjing Liu, Shengli Zhang
Summary: Flexible broadband optoelectronic devices have great potential in various applications such as wearable optoelectronic systems, health care, and bio-imaging systems. This study demonstrates a high-performance photodetector based on Ta2NiSe5 nanosheets, which exhibit adjustable bandgap and excellent optical and electrical properties. The photodetector shows broad photodetection capability in the visible-infrared spectrum and retains its performance after bending cycles, indicating the great potential of 2D Ta2NiSe5 semiconductor in future wearable IR optoelectronic devices.
Article
Plant Sciences
Shrushti Joshi, Sripati Abhiram Sahoo, Tushar Khare, Ashish Kumar Srivastava, Vinay Kumar
Summary: This study identifies five putative BONZAI genes in soybean and analyzes their tissue-specific expression using real-time qPCR. This is the first report on BONZAI in soybean.
CURRENT PLANT BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jia Fu, Wei Qin, Lu-Qi Cao, Zhe-Sheng Chen, Hui-Ling Cao
Summary: This review summarizes the applications and immobilization methods of receptor chromatography, which is widely used for high-throughput separation and accurate drug screening. The review focuses on screening active compounds in natural products, as well as the design and application of receptor chromatography in drug-receptor interactions.
DRUG DISCOVERY TODAY
(2023)
Review
Pharmacology & Pharmacy
Juan Jin, Yuhao Xie, Jin-Shi Zhang, Jing-Quan Wang, Shi-Jie Dai, Wen-fang He, Shou-Ye Li, Charles R. Ashby Jr, Zhe-Sheng Chen, Qiang He
Summary: Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer, and targeted therapy with Sunitinib has become the main treatment option due to the lack of efficacy in radiation therapy and chemotherapy. However, many patients develop resistance to Sunitinib within months of therapy. In this review, we discuss the molecular mechanisms of Sunitinib resistance, strategies to overcome it, and potential predictive biomarkers.
DRUG RESISTANCE UPDATES
(2023)
Review
Pharmacology & Pharmacy
Jiaqi Xuan, Weiguo Feng, Jiaye Wang, Ruichen Wang, Bowen Zhang, Letao Bo, Zhe-Sheng Chen, Hui Yang, Leming Sun
Summary: The long-term use of antibiotics leading to drug resistance has become a major concern. As the problem worsens, infections caused by multiple bacteria are increasing rapidly and posing serious threats to human health. Antimicrobial peptides (AMPs) offer a promising alternative to traditional antibiotics as they exhibit strong antimicrobial activity and unique mechanisms against drug-resistant bacterial infections. Current research on AMPs focuses on integrating new technologies, such as modifying the amino acid structure and exploring different delivery methods. This article provides valuable insights into the properties, mechanisms, and advancements of AMPs in combating drug-resistant bacterial infections.
DRUG RESISTANCE UPDATES
(2023)
Article
Chemistry, Medicinal
Xinnan Li, Xiaotong Ze, Shengnan Zhou, Zhaoxin Hu, Chen He, Yilin Jia, Lihua Liu, Tao Wang, Junda Li, Shengtao Xu, Dong-Hua Yang, Zhe-Sheng Chen, Hequan Yao, Jinyi Xu, Hong Yao
Summary: A novel compound D26, identified through the exploration and optimization of the first-in-class POLRMT inhibitor IMT1B, exhibits a strong antiproliferative effect on cancer cells and decreases mitochondrial-related gene expression. Mechanism studies revealed that D26 arrests the cell cycle at the G1 phase without affecting apoptosis, mitochondrial depolarization, or reactive oxidative stress generation. In vivo studies further demonstrated that D26 has more potent anticancer activity than the lead compound IMT1B, and no toxicity was observed.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Longyang Liu, Chunlin Chen, Ping Liu, Jing Li, Zhanjun Pang, Jiayu Zhu, Zhongqiu Lin, Haixu Zhou, Yingying Xie, Tiancai Lan, Zhe-Sheng Chen, Zhaoyang Zeng, Weiyi Fang
Summary: In this study, the expression and function of MYH10 in serous ovarian cancer (SOC) were investigated. It was found that MYH10 is associated with the invasive capacity and cisplatin resistance of SOC cells. Further experiments revealed that MYH10 interacts with MYH9 to promote tumorigenesis, progression, and cisplatin resistance in SOC. Clinical samples also showed elevated expression of MYH10 in SOC samples, which correlated positively with MYH9 expression. Co-expression of MYH10+/MYH9+ was identified as an independent prognostic factor for SOC patient survival.
Editorial Material
Immunology
Jingxian Chen, Zhesheng Chen, Barkat Ali Khan, Kaijian Hou
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Letao Bo, Youyou Wang, Yidong Li, John N. D. Wurpel, Zoufang Huang, Zhe-Sheng Chen
Summary: The survival rate for pediatric cancers has significantly improved in recent years. Conventional chemotherapy is crucial, especially in low- and middle-income countries with limited access to advanced treatments. Despite the expanded FDA approval of chemotherapy drugs for children, patients still face side effects and multidrug resistance remains a major challenge. This review focuses on the severe side effects of pediatric chemotherapy, mechanisms of multidrug resistance, and potential therapeutic options offered by drug transporters in pediatric tumors.
Article
Environmental Sciences
Chandani R. Verma, Pradeep Kumkar, Tejashree Shendage, Pratiksha Shinde, Vinay Kumar, Sanjay S. Kharat, Tushar Khare, Lukas Kalous
Summary: Carbon nanofibers have toxic effects on benthic fishes, causing hepatic oxidative damage and loss of predator-recognition ability.
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
(2023)
