Journal
FRONTIERS IN PHARMACOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.664349
Keywords
COVID-19; pulmonary edema; abnormal lung humoral metabolism; syndrome coronavirus 2; drug; traditional Chinese medicine
Categories
Funding
- Natural Science Foundation of China [81673563, 81102762, 81274199]
- Open Project Program of Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization [ZDXM-1-14, FJGJS-2015-15]
- Fund of Quality Standardization of Liu-Shen-Wan [BA2016104, ZYBZH-C-JS-30]
- Jiangsu Qing Lan Project for Young Academic Leaders of China
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COVID-19 mortality is primarily driven by abnormal alveolar fluid metabolism of the lung, understanding these mechanisms may lead to proper treatment and reduction in death rates.
COVID-19 mortality is primarily driven by abnormal alveolar fluid metabolism of the lung, leading to fluid accumulation in the alveolar airspace. This condition is generally referred to as pulmonary edema and is a direct consequence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. There are multiple potential mechanisms leading to pulmonary edema in severe Coronavirus Disease (COVID-19) patients and understanding of those mechanisms may enable proper management of this condition. Here, we provide a perspective on abnormal lung humoral metabolism of pulmonary edema in COVID-19 patients, review the mechanisms by which pulmonary edema may be induced in COVID-19 patients, and propose putative drug targets that may be of use in treating COVID-19. Among the currently pursued therapeutic strategies against COVID-19, little attention has been paid to abnormal lung humoral metabolism. Perplexingly, successful balance of lung humoral metabolism may lead to the reduction of the number of COVID-19 death limiting the possibility of healthcare services with insufficient capacity to provide ventilator-assisted respiration.
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