Effect of Ulinastatin on Early Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Surgery: A Systemic Review and Meta-Analysis

The Potential Role of the NLRP3 Inflammasome Activation as a Link Between Mitochondria ROS Generation and Neuroinflammation in Postoperative Cognitive Dysfunction

(2019) Penghui Wei et al.   Frontiers in Cellular Neuroscience

Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway

(2018) Si-tong Li et al.   ACTA PHARMACOLOGICA SINICA

TEMPORARY REMOVAL: Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018

(2018) L. Evered et al.   BRITISH JOURNAL OF ANAESTHESIA

Ulinastatin protects brain against cerebral ischemia/reperfusion injury through inhibiting MMP-9 and alleviating loss of ZO-1 and occludin proteins in mice

(2018) Xiao-Fang Li et al.   EXPERIMENTAL NEUROLOGY

Correction: Inflammatory markers in postoperative delirium (POD) and cognitive dysfunction (POCD): A meta-analysis of observational studies

(2018) Xuling Liu et al.   PLoS One

Ulinastatin May Significantly Improve Postoperative Cognitive Function of Elderly Patients Undergoing Spinal Surgery by Reducing the Translocation of Lipopolysaccharide and Systemic Inflammation

(2018) Min Zhang et al.   Frontiers in Pharmacology

The post-op brain

(2017) Mitch Leslie   SCIENCE

Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review

(2017) Eric Peter Thelin et al.   Frontiers in Neurology

Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery

(2016) Jan Hirsch et al.   Journal of Neuroinflammation

Effects of ulinastatin on early postoperative cognitive function after one-lung ventilation surgery in elderly patients receiving neoadjuvant chemotherapy

(2016) Kai-yuan Wang et al.   METABOLIC BRAIN DISEASE

Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats

(2016) Min Hui Kan et al.   Frontiers in Aging Neuroscience

Gut barrier function and systemic endotoxemia after laparotomy or laparoscopic resection for colon cancer: A prospective randomized study

(2016) Beatrice Pessia et al.   Journal of Minimal Access Surgery

Ulinastatin decreases permeability of blood--brain barrier by inhibiting expression of MMP-9 and t-PA in postoperative aged rats

(2015) Li Ma et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Serum CRP and urinary trypsin inhibitor implicate postoperative cognitive dysfunction especially in elderly patients

(2014) Yan-Hua Zhang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Alzheimer’s Disease, Anesthesia, and Surgery: A Clinically Focused Review

(2014) Miles Berger et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Prolonged Neuroinflammation after Lipopolysaccharide Exposure in Aged Rats

(2014) Hui Qun Fu et al.   PLoS One

Intestinal permeability, systemic endotoxemia, and bacterial translocation after open or laparoscopic resection for colon cancer: a prospective randomized study.

(2013) Mario Schietroma et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Ulinastatin Alleviates Neuroinflammation but Fails to Improve Cognitive Function in Aged Rats Following Partial Hepatectomy

(2013) Ma Li et al.   NEUROCHEMICAL RESEARCH

A preliminary study of the effects of ulinastatin on early postoperative cognition function in patients undergoing abdominal surgery

(2013) Xu Lili et al.   NEUROSCIENCE LETTERS

Role of Peripheral Inflammatory Markers in Postoperative Cognitive Dysfunction (POCD): A Meta-Analysis

(2013) Linying Peng et al.   PLoS One

Perioperative inflammatory response and protein S-100β concentrations - relationship with post-operative cognitive dysfunction in elderly patients

(2012) Y-C. LI et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease

(2012) Jeffrey N. Browndyke et al.   Alzheimers & Dementia

Alarmins: awaiting a clinical response

(2012) James K. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

GRADE guidelines: 3. Rating the quality of evidence

(2011) Howard Balshem et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Systemic inflammation enhances surgery-induced cognitive dysfunction in mice

(2011) António Rei Fidalgo et al.   NEUROSCIENCE LETTERS

Does mild cognitive impairment increase the risk of developing postoperative cognitive dysfunction?

(2010) Alex Bekker et al.   AMERICAN JOURNAL OF SURGERY

Elevated postoperative inflammatory biomarkers are associated with short- and medium-term cognitive dysfunction after coronary artery surgery

(2010) Judith A. Hudetz et al.   Journal of Anesthesia

Tumor necrosis factor-  triggers a cytokine cascade yielding postoperative cognitive decline

(2010) N. Terrando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective role of urinary trypsin inhibitor in lung expression of proinflammatory cytokines accompanied by lethal liver injury in mice

(2009) Ken-ichiro Inoue et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2009) David Moher et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY