Nanoengineering InP Quantum Dot-Based Photoactive Biointerfaces for Optical Control of Neurons

Light-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectrical response of InP QD-based biointerfaces via nanoengineering from QD to device-level. At QD level, thin ZnS shell growth (similar to 0.65 nm) enhances the current level of biointerfaces over an order of magnitude with respect to only InP core QDs. At device-level, band alignment engineering allows for the bidirectional photoelectrochemical current generation, which enables light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons. Our findings show that nanoengineering QD-based biointerfaces hold great promise for next-generation neurostimulation devices.

Automated summary

The translation reveals the potential of InP quantum dots for controlling neural activity through light-activated biointerfaces. By nanoengineering QD-based biointerfaces at both the QD and device level, it is possible to enhance the current level of biointerfaces, enable bidirectional photoelectrochemical current generation, and achieve light-induced action potential generation and hyperpolarization on primary hippocampal neurons, showing promise for next-generation neurostimulation devices.