Article
Nutrition & Dietetics
Jinqiu Zhou, Li Luo, Lingling Xie, Song Hu, Lingling Tan, Xiaozhen Lei, Xiaozhen Luo, Ming Yang
Summary: The ESPEN and EASO have released the international consensus on the diagnostic criteria for sarcopenic obesity (SO), recommending skeletal muscle mass adjusted for body weight (SMM/W) for determining low muscle mass. This study aimed to evaluate the agreement between different diagnostic criteria for SO and to compare their predictive abilities for mortality in patients with advanced NSCLC. The results showed that SOESPEN, SOESPEN-M, and SOAWGS were significantly associated with mortality, while SOCT and SOFM were not.
CLINICAL NUTRITION
(2023)
Article
Oncology
Elisa Daffre, Mathilde Prieto, Katharina Martini, Trieu-Nghi Hoang-Thi, Nara Halm, Herve Dermine, Antonio Bobbio, Guillaume Chassagnon, Marie Pierre Revel, Marco Alifano
Summary: Lung cancer surgery is still the main treatment for non-small cell lung cancer, but it is associated with high postoperative mortality. Computed tomography scans can be used to assess sarcopenia by evaluating the psoas and parietal muscles, which are important prognostic factors for survival in lung cancer patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyewon Choi, Young Sik Park, Kwon Joong Na, Samina Park, In Kyu Park, Chang Hyun Kang, Young Tae Kim, Jin Mo Goo, Soon Ho Yoon
Summary: This study investigated the association between baseline adipopenia and outcomes in patients with early-stage NSCLC. The results showed that adipopenia was associated with a reduced 5-year overall survival rate, indicating a potential risk for non-cancer-related death.
Article
Medicine, General & Internal
Jingsheng Cai, Fan Yang, Xun Wang
Summary: This study aims to investigate occult non-small cell lung cancer (NSCLC), an underappreciated tumor, and found that it is an aggressive tumor with poor prognosis. Surgery is the preferred treatment. More attention should be paid to this overlooked disease due to no evidence of tumor imaging.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Shawn J. Rice, Chandra P. Belani
Summary: Blood-based biomarkers, including systemic inflammation indicators and circulating factors, are associated with poor prognosis in lung cancer patients. Elevated levels of inflammation markers were found in non-small cell lung cancer (NSCLC) patients compared to small cell lung cancer (SCLC) and disease-free (DF) patients. Specific markers were identified as predictors of progression and overall survival in NSCLC patients, highlighting the potential for personalized treatment strategies.
Article
Multidisciplinary Sciences
Qing Li, Zhen Lin, Ye Hong, Yang Fu, Yueyun Chen, Ting Liu, Yue Zheng, Jiangfang Tian, Chunhua Liu, Wei Pu, Zhenyu Ding, Chun Wang
Summary: Patients with advanced non-small cell lung cancer are susceptible to brain metastases, including brain parenchymal metastases and leptomeningeal metastases. Patients with leptomeningeal metastases have a higher proportion of EGFR exon 21 point mutations and shorter survival compared to patients without brain metastases or with brain parenchymal metastases. Two prediction models were developed to predict the development of brain parenchymal metastases and leptomeningeal metastases in advanced non-small cell lung cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Nasser Altorki, Xiaofei Wang, David Kozono, Colleen Watt, Rodney Landrenau, Dennis Wigle, Jeffrey Port, David R. Jones, Massimo Conti, Ahmad S. Ashrafi, Moishe Liberman, Kazuhiro Yasufuku, Stephen Yang, John D. Mitchell, Harvey Pass, Robert Keenan, Thomas Bauer, Daniel Miller, Leslie J. Kohman, Thomas E. Stinchcombe, Everett Vokes
Summary: This study compared lobectomy and sublobar resection in lung cancer patients. The results showed that in patients with tumors sized 2 cm or less and negative lymph nodes, sublobar resection was not inferior to lobectomy in terms of disease-free survival, and overall survival was similar between the two procedures.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Huseyin Ulas Cinar, Burcin Celik, Gulten Taskin, Ozgur Ince
Summary: This study investigated the impact of preoperative skeletal muscle quantity and quality on survival after NSCLC resection. The results showed that low preoperative skeletal muscle quantity and quality were independent factors associated with poor prognosis and lower survival rates. These findings provide important insights for pre-rehabilitation and nutritional support programs.
Article
Medicine, Research & Experimental
Yuan Gu, Gianni Pais, Vivien Becker, Christina Korbel, Emmanuel Ampofo, Elke Ebert, Johannes Hohneck, Nicole Ludwig, Eckart Meese, Rainer M. Bohle, Yingjun Zhao, Michael D. Menger, Matthias W. Laschke
Summary: The research demonstrates that miR-22 is highly expressed in ECs and significantly downregulated in NSCLC tissues. Endothelial miR-22 acts as an angiogenesis inhibitor by targeting sirtuin 1 and FGFR1 to inhibit ECs' angiogenic activities, thus suppressing NSCLC growth.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Nutrition & Dietetics
Maria Landgrebe, Randi Tobberup, Andreas Carus, Henrik Hojgaard Rasmussen
Summary: This study aimed to evaluate the impact of malnutrition and good nutritional status on clinical outcomes and Quality of Life (QoL) in non-small cell lung cancer (NSCLC) patients and determine the predictive validity of GLIM criteria. The results showed that malnourished NSCLC patients had worse outcomes in terms of treatment cessation, disease progression, overall survival, and poorer QoL compared to well-nourished patients.
CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Qing Ye, Nancy Lan Guo
Summary: Currently, there are no accurate biomarkers for optimal treatment selection in early-stage non-small cell lung cancer (NSCLC). This study demonstrates that hub genes in genome-scale regulatory networks are associated with NSCLC tumorigenesis, proliferation, and survival. These findings have implications for prioritizing therapeutic targets to improve patient survival outcomes.
Article
Nutrition & Dietetics
Wenyi Zhang, Jing Tang, Huiyu Tang, Lingling Xie, Jing Wang, Jinhui Wu, Ming Yang
Summary: This study compared the predictive effects of SMD-defined and IMAT-defined myosteatosis on OS in patients with advanced NSCLC, and found that patients with both low SMD and high IMAT had a shorter OS.
CLINICAL NUTRITION
(2023)
Article
Oncology
Arpad Hasenauer, Celine Forster, Johan Hungerbuhler, Jean Yannis Perentes, Etienne Abdelnour-Berchtold, Joachim Koerfer, Thorsten Krueger, Fabio Becce, Michel Gonzalez
Summary: This study aimed to evaluate the impact of CT-derived preoperative sarcopenia on postoperative outcomes and survival in patients that underwent thoracoscopic anatomical pulmonary resection for non-small cell lung cancer. The results showed that CT-derived sarcopenia has a small impact on early postoperative outcomes but no effect on overall survival. Preoperative sarcopenia screening may be a useful tool in surgical risk assessment.
Article
Oncology
Pietro Rosellini, Samuel Amintas, Charline Caumont, Remi Veillon, Sigolene Galland-Girodet, Alain Cuguilliere, Laurent Nguyen, Charlotte Domblides, Amandine Gouverneur, Jean-Philippe Merlio, Julien Bezin, Pierre-Olivier Girodet
Summary: STK11 mutation is associated with poor prognosis in non-small cell lung cancer (NSCLC), leading to decreased response to immunotherapy treatment.
EUROPEAN JOURNAL OF CANCER
(2022)
Letter
Medicine, General & Internal
Hollis Viray, Deepa Rangachari, Daniel B. Costa
Summary: The study reported initial data of trastuzumab deruxtecan in the treatment of lung cancers with ERBB2 mutations, including patients who had previously received ineffective ERBB2 tyrosine kinase inhibitors.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Marc A. Schneider, Sarah Richtmann, Anna R. Grunding, Sabine Wrenger, Tobias Welte, Michael Meister, Mark Kriegsmann, Hauke Winter, Thomas Muley, Sabina Janciauskiene
Summary: This study found that lower expression of TMPRSS2 in tumor tissues is associated with poor overall survival in patients with lung adenocarcinoma. The correlation between AAT and TMPRSS2 proteins requires further investigation.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Philip Baum, Jacopo Lenzi, Johannes Diers, Christoph Rust, Martin E. Eichhorn, Samantha Taber, Christoph-Thomas Germer, Hauke Winter, Armin Wiegering
Summary: This study investigates the use of risk-standardized mortality rate (RSMR) as a proxy for surgical quality, and finds that it outperforms volume in terms of effectiveness, efficiency, and hospital availability for patients. The results show that centralization based on RSMR leads to lower median travel times and better hospital accessibility.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Respiratory System
Philip Baum, Martin E. Eichhorn, Johannes Diers, Armin Wiegering, Laura V. Klotz, Hauke Winter
Summary: This study analyzed sex-specific differences after lung cancer resections and found that women who underwent lung cancer surgery in Germany were younger, had fewer comorbidities, and had lower in-hospital mortality and postoperative complication rates compared to men.
Article
Surgery
Martin Eichhorn, Wolfgang Behnisch, Hauke Winter, Hans Hoffmann
Summary: Primary lung and chest wall tumors, as well as lung metastases, are rare diseases in children. Thoracic surgery, as part of multimodal cancer treatment, has been shown to greatly improve survival in pediatric patients with solid tumors. This review article aims to summarize the indications and current surgical treatment options for malignant chest wall and lung tumors, while also shedding light on the current role of pulmonary metastasectomy in children.
ZENTRALBLATT FUR CHIRURGIE
(2022)
Review
Oncology
Fabian M. Troschel, Kai Kroeger, Jan J. Siats, Kambiz Rahbar, Hans Theodor Eich, Sergiu Scobioala
Summary: This study evaluates the role of cranio-spinal irradiation (CSI) in the treatment of primary extraosseous intraspinal Ewing sarcoma (EwS). The results demonstrate promising outcomes with CSI, despite the presence of unfavorable characteristics such as multifocal lesions and intradural tumor location. Treatment should be individualized based on tumor and patient characteristics in the absence of prospective trials.
Article
Surgery
Martin Eichhorn, Andre Rotarmel, Johannes Haag, Philip Baum, Hauke Winter
Summary: This study analyzed the learning curve and safety of establishing a RATS program at a high-volume thoracic surgery center, and quantified the costs of the surgical procedure in Germany. The results showed that RATS can be safely established, performed, and trained, with low complication rates and acceptable costs for consumables.
ZENTRALBLATT FUR CHIRURGIE
(2023)
Article
Pathology
Moritz Jesinghaus, Melanie Boxberg, Maxime Schmitt, Mark Kriegsmann, Alexander Harms, Corinna Lang, Thomas Muley, Hauke Winter, Katharina Kriegsmann, Arne Warth, Albrecht Stenzinger, Carsten Denkert, Hans Hoffmann, Seyer Safi, Wilko Weichert
Summary: Cellular dissociation grading (CDG) based on tumor budding and cell nest size can be used on biopsies of pulmonary squamous cell carcinoma (pSCC) and has a significant impact on disease prognosis.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2022)
Article
Oncology
Julia Walter, Diego Kauffmann-Guerrero, Thomas Muley, Martin Reck, Jan Fuge, Andreas Guenther, Raphael W. Majeed, Rajkumar Savai, Ina Koch, Julien Dinkel, Christian Schneider, Karsten Senghas, Sonja Kobinger, Farkhad Manapov, Michael Thomas, Kathrin Kahnert, Hauke Winter, Juergen Behr, Martin Tammemagi, Amanda Tufman
Summary: Using risk-based selection score can improve the sensitivity of lung cancer screening, but there are gender disparities that need to be addressed to close the gender gap in implementing a large-scale screening program.
Article
Oncology
Tanja Eichkorn, Jonathan W. Lischalk, Cedric Stuewe, Eric Tonndorf-Martini, Kai Schubert, Lisa-Antonia Dinges, Sebastian Regnery, Farastuk Bozorgmehr, Laila Koenig, Petros Christopoulos, Juliane Hoerner-Rieber, Sebastian Adeberg, Klaus Herfarth, Hauke Winter, Michael Thomas, Stefan Rieken, Juergen Debus, Rami A. El Shafie
Summary: This study investigates the feasibility of combining stereotactic body radiation therapy (SBRT) with volumetric arc therapy (VMAT) for the treatment of high-risk patients with inoperable locally advanced non-small cell lung cancer (NSCLC). The results show that SBRT+MLN significantly improves treatment outcomes and reduces the risk of side effects.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Laura V. Klotz, Hans Hoffmann, Rajiv Shah, Florian Eichhorn, Christiane Gruenewald, Elena L. Bulut, Raffaella Griffo, Thomas Muley, Petros Christopoulos, Philip Baum, Peter Huber, Seyer Safi, Marc Kriegsmann, Michael Thomas, Helge Bischoff, Hauke Winter, Martin E. Eichhorn
Summary: This study analyzed a 20-year experience of surgery for malignant pleural mesothelioma (MPM) and found that extended pleurectomy/decortication combined with hyperthermic intrathoracic chemoperfusion and adjuvant chemotherapy resulted in higher overall survival compared to trimodal extrapleural pneumonectomy (EPP). The perioperative morbidity was also lower in the surgery group.
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Tiffany S. Haiduk, Mark Sicking, Kathrin A. Bruecksken, Nancy A. Espinoza-Sanchez, Kai Moritz Eder, Bjoern Kemper, Hans Theodor Eich, Martin Goette, Burkhard Greve, Fabian M. Troschel
Summary: This study reveals the crucial role of Musashi RNA-binding proteins in inflammatory breast cancer, as they are associated with tumor proliferation, cancer stem cell characteristics, and therapy resistance. Inhibiting the expression of MSI genes can alleviate drug resistance and tumor growth.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Surgery
Martin Eichhorn, Andre Rotarmel, Johannes Haag, Philip Baum, Hauke Winter
Summary: The study analyzed the learning curve and safety of establishing a RATS program at a high-volume thoracic surgery center and quantified the costs of the surgical procedure in Germany. It found that RATS can be safely performed with low complication rates and acceptable costs.
ZENTRALBLATT FUR CHIRURGIE
(2023)