A Novel High-Content Screening-Based Method for Anti-Trypanosoma cruzi Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Generation of three control iPS cell lines for sickle cell disease studies by reprogramming erythroblasts from individuals without hemoglobinopathies

(2019) Bruno Diaz Paredes et al.   Stem Cell Research

Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues

(2018) Andrea Leonard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondria-Targeting Small Molecules Effectively Prevent Cardiotoxicity Induced by Doxorubicin

(2018) Wei Shi et al.   MOLECULES

Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi

(2017) Gevanio Bezerra de Oliveira Filho et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Assessment of acute and chronic toxicity of doxorubicin in human induced pluripotent stem cell-derived cardiomyocytes

(2017) Jochem Louisse et al.   TOXICOLOGY IN VITRO

In vitro drug susceptibility of two strains of the wildlife trypanosome, Trypanosoma copemani : A comparison with Trypanosoma cruzi

(2017) Adriana Botero et al.   International Journal for Parasitology-Drugs and Drug Resistance

Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?

(2016) Luca Sala et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antiparasitic evaluation of betulinic acid derivatives reveals effective and selective anti-Trypanosoma cruzi inhibitors

(2016) Cássio Santana Meira et al.   EXPERIMENTAL PARASITOLOGY

Evolution of strategies to improve preclinical cardiac safety testing

(2016) Gary Gintant et al.   NATURE REVIEWS DRUG DISCOVERY

Drug-induced mitochondrial dysfunction and cardiotoxicity

(2015) Zoltán V Varga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Structural design, synthesis and pharmacological evaluation of 4-thiazolidinones against Trypanosoma cruzi

(2015) Gevanio Bezerra de Oliveira Filho et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Matrigel Mattress: A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

(2015) Tromondae K Feaster et al.   CIRCULATION RESEARCH

Chagas’ Disease

(2015) Caryn Bern   NEW ENGLAND JOURNAL OF MEDICINE

In vitro and in vivo antiparasitic activity of Physalis angulata L. concentrated ethanolic extract against Trypanosoma cruzi

(2015) Cássio Santana Meira et al.   PHYTOMEDICINE

Induced pluripotent stem cell-derived cardiomyocytes for drug development and toxicity testing

(2014) Daniel Sinnecker et al.   PHARMACOLOGY & THERAPEUTICS

Disease Modeling and Phenotypic Drug Screening for Diabetic Cardiomyopathy using Human Induced Pluripotent Stem Cells

(2014) Faye M. Drawnel et al.   Cell Reports

Structural Design, Synthesis and Structure-Activity Relationships of Thiazolidinones with Enhanced Anti-Trypanosoma cruziActivity

(2013) Diogo Rodrigo Magalhães Moreira et al.   ChemMedChem

The Reality of Heart Failure in Latin America

(2013) Edimar Alcides Bocchi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitochondrial quality control: an integrated network of pathways

(2012) Fabian Fischer et al.   TRENDS IN BIOCHEMICAL SCIENCES

Activation of Benznidazole by Trypanosomal Type I Nitroreductases Results in Glyoxal Formation

(2011) Belinda S. Hall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antitrypanosomal Therapy for Chronic Chagas' Disease

(2011) Caryn Bern   NEW ENGLAND JOURNAL OF MEDICINE

Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents

(2010) Marcelo Zaldini Hernandes et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The role of parasite persistence in pathogenesis of Chagas heart disease

(2009) F. R. S. GUTIERREZ et al.   PARASITE IMMUNOLOGY

Antiprotozoal activity of Betulinic acid derivatives

(2009) D.B. Domínguez-Carmona et al.   PHYTOMEDICINE

Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal

(2008) E. D. Cohen et al.   DEVELOPMENT

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols