APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context

Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair

(2016) Nicholas J. Haradhvala et al.   CELL

APOBEC3A damages the cellular genome during DNA replication

(2016) Abby M. Green et al.   CELL CYCLE

Clustered mutations in hominid genome evolution are consistent with APOBEC3G enzymatic activity

(2016) Yishay Pinto et al.   GENOME RESEARCH

APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

(2016) Vladimir B. Seplyarskiy et al.   GENOME RESEARCH

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

An expanded sequence context model broadly explains variability in polymorphism levels across the human genome

(2016) Varun Aggarwala et al.   NATURE GENETICS

Parent-of-origin-specific signatures of de novo mutations

(2016) Jakob M Goldmann et al.   NATURE GENETICS

Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B

(2016) Monica K. Akre et al.   PLoS One

Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations inEscherichia coli

(2016) Ashok S. Bhagwat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

(2016) Gabriel J. Starrett et al.   Nature Communications

New observations on maternal age effect on germline de novo mutations

(2016) Wendy S. W. Wong et al.   Nature Communications

The topography of mutational processes in breast cancer genomes

(2016) Sandro Morganella et al.   Nature Communications

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication

(2016) James I. Hoopes et al.   Cell Reports

Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells

(2016) Foad J. Rouhani et al.   PLoS Genetics

Genome-wide characteristics of de novo mutations in autism

(2016) Ryan KC Yuen et al.   npj Genomic Medicine

Concurrent Nucleotide Substitution Mutations in the Human Genome Are Characterized by a Significantly Decreased Transition/Transversion Ratio

(2015) Wenjuan Zhu et al.   HUMAN MUTATION

DNA Editing of LTR Retrotransposons Reveals the Impact of APOBECs on Vertebrate Genomes

(2015) Binyamin A. Knisbacher et al.   MOLECULAR BIOLOGY AND EVOLUTION

Polymerase ζ Activity Is Linked to Replication Timing in Humans: Evidence from Mutational Signatures

(2015) Vladimir B. Seplyarskiy et al.   MOLECULAR BIOLOGY AND EVOLUTION

Parent–progeny sequencing indicates higher mutation rates in heterozygotes

(2015) Sihai Yang et al.   NATURE

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Genome-wide patterns and properties of de novo mutations in humans

(2015) Laurent C Francioli et al.   NATURE GENETICS

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

(2015) Kin Chan et al.   NATURE GENETICS

Timing, rates and spectra of human germline mutation

(2015) Raheleh Rahbari et al.   NATURE GENETICS

Crossovers are associated with mutation and biased gene conversion at recombination hotspots

(2015) Barbara Arbeithuber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatic mutation in cancer and normal cells

(2015) I. Martincorena et al.   SCIENCE

The origins, determinants, and consequences of human mutations

(2015) J. Shendure et al.   SCIENCE

DNA Polymerase ζ-Dependent Lesion Bypass in Saccharomyces cerevisiae Is Accompanied by Error-Prone Copying of Long Stretches of Adjacent DNA

(2015) Olga V. Kochenova et al.   PLoS Genetics

Genetic Variation in Human DNA Replication Timing

(2014) Amnon Koren et al.   CELL

Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

(2014) Katherine A. Hoadley et al.   CELL

A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression

(2014) K. Skourti-Stathaki et al.   GENES & DEVELOPMENT

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition

(2014) Scott A. Lujan et al.   GENOME RESEARCH

Error-prone polymerase activity causes multinucleotide mutations in humans

(2014) Kelley Harris et al.   GENOME RESEARCH

Mechanisms underlying mutational signatures in human cancers

(2014) Thomas Helleday et al.   NATURE REVIEWS GENETICS

Recombination initiation maps of individual human genomes

(2014) F. Pratto et al.   SCIENCE

Mutational Context and Diverse Clonal Development in Early and Late Bladder Cancer

(2014) Iver Nordentoft et al.   Cell Reports

Demography and the Age of Rare Variants

(2014) Iain Mathieson et al.   PLoS Genetics

Human APOBEC3 Induced Mutation of Human Immunodeficiency Virus Type-1 Contributes to Adaptation and Evolution in Natural Infection

(2014) Eun-Young Kim et al.   PLoS Pathogens

Repair of naturally occurring mismatches can induce mutations in flanking DNA

(2014) Jia Chen et al.   eLife

The choice of nucleotide inserted opposite abasic sites formed within chromosomal DNA reveals the polymerase activities participating in translesion DNA synthesis

(2013) Kin Chan et al.   DNA REPAIR

The origin, evolution, and functional impact of short insertion-deletion variants identified in 179 human genomes

(2013) S. B. Montgomery et al.   GENOME RESEARCH

Prevalence of Multinucleotide Replacements in Evolution of Primates and Drosophila

(2013) Nadezhda V. Terekhanova et al.   MOLECULAR BIOLOGY AND EVOLUTION

APOBEC3B is an enzymatic source of mutation in breast cancer

(2013) Michael B. Burns et al.   NATURE

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Evidence for APOBEC3B mutagenesis in multiple human cancers

(2013) Michael B Burns et al.   NATURE GENETICS

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis

(2013) Benjamin JM Taylor et al.   eLife

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Heterogeneity of the Transition/Transversion Ratio in Drosophila and Hominidae Genomes

(2012) V. B. Seplyarskiy et al.   MOLECULAR BIOLOGY AND EVOLUTION

Rate of de novo mutations and the importance of father’s age to disease risk

(2012) Augustine Kong et al.   NATURE

Replication Fork Polarity Gradients Revealed by Megabase-Sized U-Shaped Replication Timing Domains in Human Cell Lines

(2012) Antoine Baker et al.   PLoS Computational Biology

Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity

(2012) Scott A. Lujan et al.   PLoS Genetics

Pervasive Multinucleotide Mutational Events in Eukaryotes

(2011) Daniel R. Schrider et al.   CURRENT BIOLOGY

Mutation Rate Distribution Inferred from Coincident SNPs and Coincident Substitutions

(2011) Philip L. F. Johnson et al.   Genome Biology and Evolution

Replication-Associated Mutational Asymmetry in the Human Genome

(2011) Chun-Long Chen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Analysis of genomic variation in non-coding elements using population-scale sequencing data from the 1000 Genomes Project

(2011) Xinmeng Jasmine Mu et al.   NUCLEIC ACIDS RESEARCH

Evidence for Sequential and Increasing Activation of Replication Origins along Replication Timing Gradients in the Human Genome

(2011) Guillaume Guilbaud et al.   PLoS Computational Biology

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

Cryptic Variation in the Human Mutation Rate

(2009) Alan Hodgkinson et al.   PLOS BIOLOGY

Global organization of replication time zones of the mouse genome

(2008) S. Farkash-Amar et al.   GENOME RESEARCH

Transcription induces strand-specific mutations at the 5' end of human genes

(2008) P. Polak et al.   GENOME RESEARCH

Transcription-Induced Mutational Strand Bias and Its Effect on Substitution Rates in Human Genes

(2008) C. F. Mugal et al.   MOLECULAR BIOLOGY AND EVOLUTION