Review
Immunology
Huizhen Cao, Tianyu Wu, Xue Zhou, Shuyang Xie, Hongfang Sun, Yunxiao Sun, Youjie Li
Summary: Leukemia cells induce immunosuppression of the bone marrow microenvironment, preventing the immune system from clearing tumor cells. The PD-1/PD-L1 axis acts as a significant mechanism for tumor cells to evade immune surveillance. The development of drugs targeting PD-1/PD-L1 in leukemia is still at the clinical-trial stage.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Adam P. Curnock, Giovanna Bossi, Jyothi Kumaran, Lindsay J. Bawden, Rita Figueiredo, Rajeevkumar Tawar, Katherine Wiseman, Emma Henderson, Sec Julie Hoong, Veronica Gonzalez, Hemza Ghadbane, David Eo Knight, Ronan O'Dwyer, David X. Overton, Christina M. Lucato, Nicola Mg Smith, Carlos R. Reis, Keith Page, Lorraine M. Whaley, Michelle L. McCully, Stephen Hearty, Tara M. Mahon, Peter Weber
Summary: The study developed PD-1 agonist ImmTAAI molecules that can inhibit T cell function by mimicking the action of PD-L1. These molecules specifically bind to target cells and effectively activate the PD-1 receptor on interacting T cells, achieving immune suppression.
Article
Engineering, Biomedical
Jianqing Li, Jun Dai, Zeyan Zhuang, Zijuan Meng, Jing-Jing Hu, Xiaoding Lou, Fan Xia, Zujin Zhao, Ben Zhong Tang
Summary: This study presents a novel photosensitizer that can trigger endoplasmic reticulum stress and induce effective immunogenic cell death. Combining with immune checkpoint blockade, it can significantly inhibit tumor growth and provoke a systemic antitumor immune response.
Article
Pharmacology & Pharmacy
Taisuke Kaiho, Hidemi Suzuki, Atsushi Hata, Hiroki Matsumoto, Kazuhisa Tanaka, Yuichi Sakairi, Shinichiro Motohashi, Ichiro Yoshino
Summary: Immune checkpoint molecules, such as PD-1 and PD-L1, have been shown to be important in lung cancer treatment. This study explored the role of these proteins in acute rejection in a mouse model of tracheal transplantation and found that PD-L1 Fc recombinant protein could decrease inflammatory cytokines and reduce the proportion of CD4+ T cells, suggesting a potential novel target for immunotherapy in lung transplantation.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Chao Cheng, Lingdun Zhuge, Xin Xiao, Siyuan Luan, Yong Yuan
Summary: As the predominant treatment option for advanced esophageal cancer, PD-1 and PD-L1 inhibitors provide new hope to clinical practice. However, some patients do not respond to this therapy and most initially sensitive patients eventually develop resistance. Therefore, it is critical to understand the mechanisms of resistance and explore efficient strategies to overcome it, in order to expand the benefit of immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Yuedi Zhang, Qiulin Cui, Manman Xu, Duo Liu, Shuzhong Yao, Ming Chen
Summary: Immunotherapies have revolutionized cancer treatment, but recurrent ovarian cancer remains difficult to treat. Recurrent ovarian cancer is a cold tumor with limited response to immunotherapy. However, combining immunotherapy with other treatments may improve outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Chia-Jung Li, Li-Te Lin, Ming-Feng Hou, Pei-Yi Chu
Summary: Significant progress has been made in understanding the role of PD-L1 in breast cancer, especially in TNBC. Early clinical trials of PD-L1/PD-1 inhibitors have shown efficacy in refractory metastatic breast cancer patients, particularly in TNBC. Mechanisms and factors influencing the immunoediting process have been summarized and analyzed in detail.
Article
Biochemistry & Molecular Biology
Andrzej Kowalski, Katarzyna Malinowska, Jurek Olszewski, Hanna Zielinska-Blizniewska
Summary: The interaction of PD-1 and PD-L1 in laryngeal tumors allows cancer cells to escape from the immune system. Gene expression of PD-1 and PD-L1 was significantly higher in tumor tissue compared to unchanged mucosa, with higher expression levels associated with larger tumor sizes. These findings suggest potential for targeted immunotherapy with anti-PD1 and anti-PD-L1 monoclonal antibodies in treating laryngeal tumors.
Review
Neurosciences
HaiXia Li, Chao Zheng, Jinming Han, Jie Zhu, Shan Liu, Tao Jin
Summary: The PD-1/PD-L1 axis plays a crucial role in multiple sclerosis (MS), and understanding the complex relationship between them may expand our knowledge of therapeutic approaches.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Immunology
Rilan Bai, Jiuwei Cui
Summary: Antibodies targeting PD-1/PD-L1 have been considered breakthrough therapies for cancer. In addition to T cell-driven immune responses, blocking PD-1/PD-L1 may also enhance the function and activity of NK cells, which are often overlooked in previous studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yu Liu, Zaigang Zhou, Jiting Hou, Wei Xiong, Heejeong Kim, Jiashe Chen, Chunjuan Zheng, Xin Jiang, Juyoung Yoon, Jianliang Shen
Summary: In this study, a new PD-L1 regulation strategy was developed by selectively down-regulating PD-L1 expression in tumors using mitochondria-targeted IR-LND@Alb nanoparticles. The anti-tumor efficacy of this strategy was found to be superior to conventional anti-PD-L1 monoclonal antibodies. Interestingly, IR-LND also showed potential as a novel photodynamic therapy (PDT) drug with self-oxygen and self-PD-L1 regulation capability.
ADVANCED MATERIALS
(2022)
Review
Immunology
Quanqing Tang, Shihao Li, Gaozhen Huang, Hongwei Liu
Summary: Urothelial carcinoma (UC) is a common malignant tumor. Platinum-based chemotherapy has been the standard treatment for metastatic UC, but immune checkpoint inhibitors (ICIs) offer hope for patients unfit for platinum therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Oncology
Mohammadsaleh Jahangir, Omid Yazdani, Mohammad Saeed Kahrizi, Sara Soltanzadeh, Hamidreza Javididashtbayaz, Azam Mivefroshan, Saba Ilkhani, Romina Esbati
Summary: PD-1/PD-L1 blockade therapy has significant clinical activity in the treatment of renal cell carcinoma, but only a small portion of patients show positive response. Recent studies have shown that combining other treatment modalities with PD-1/PD-L1 blockade therapy may improve clinical responses in renal cell carcinoma patients.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Zi Yin, Min Yu, Tingting Ma, Chuanzhao Zhang, Shanzhou Huang, Mohammad Reza Karimzadeh, Amir Abaas Momtazi-Borojeni, Sheng Chen
Summary: Exosomes, specifically those derived from cancer cells, contain immunosuppressive proteins such as PD-L1, which can hinder immune responses and promote tumor progression. Blocking the interaction between PD-1 and PD-L1 can enhance the efficacy of cancer treatment by restoring anti-tumor immunity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Hao Cai, Yichi Zhang, Jian Wang, Jinyang Gu
Summary: Macrophages can be categorized into M1 and M2 subsets, and reprogramming M2 to M1 macrophages has shown potential in cancer therapy. Key targets for reprogramming include CSF1, CSF1R, TLR7, TLR8, among others.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hongyue Yu, Yan Yu, Runfeng Lin, Minchao Liu, Qiaoyu Zhou, Mengli Liu, Liang Chen, Wenxing Wang, Ahmed A. Elzatahry, Dongyuan Zhao, Xiaomin Li
Summary: A camouflaged virus-like nanocarrier with a transformable rough surface composed of a mesoporous SiO2 nanoparticle and an acid-responsive polymer is reported. Under normal pH conditions, the spikes on the nanocarrier are hidden by the polymer shell, inhibiting non-specific strong nano-bio interactions. In an acidic tumor microenvironment, the nanocarrier sheds the polymer camouflage to expose its rough surface, improving retention ability and endocytosis efficiency. The rationally designed nanocarrier exhibits extended blood circulation time and enhanced tumor accumulation due to its dynamically variable rough surface.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Shouning Yang, Shengkun Wang, Yaru Wang, Jian Song, Yuqin Jiang, Liang Chen, Huayan Yang
Summary: In this study, a new type of 2D composite nanosheets with ternary heterostructures, BiOCl-Bi2S3-Cu2S, were synthesized for NIR photonic disinfection. The nanosheets exhibited strong NIR light-harvesting capability and could achieve enhanced photonic hyperthermia and ROS generation upon NIR light illumination, leading to effective bacteria killing through both photothermal and photodynamic mechanisms. Compared to binary composite nanosheets, the ternary heterostructures showed significantly improved photothermal conversion and ROS generation efficacy, making them highly effective for bacterial disinfection with NIR light.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biophysics
Shouning Yang, Shengkun Wang, Yanmin Zhang, Yijing Wang, Jinhong Yuan, Yuqin Jiang, Xing He, Lihong Liu, Jian Song, Liang Chen, Huayan Yang
Summary: In this study, a facile approach to prepare 2D BiOCl-Bi2S3 nanostructures was developed, which showed favorable photothermal conversion efficiency (32%) and synergistically reactive oxygen species (ROS) generating capability under NIR irradiation. The conjugation of synthetic targeting ligand to the surface of BiOCl-Bi2S3 endows the heterojunction effective tumor targeting ability and selective mitochondrial accumulation. The combined cancer targeting ability and synergistic PTT/PDT permit enhanced cooperative phototherapeutic efficiency of the 2D heterojunction.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Physical
Minchao Liu, Hongyue Yu, Liang Chen, Tiancong Zhao, Meng Fang, Mengli Liu, Qiaoyu Zhou, Fatemah Farraj AlHarbi, Ahmed Mohamed El-Toni, Fan Zhang, Dongyuan Zhao, Xiaomin Li
Summary: Chemodynamic therapy based on cascade catalytic nanomedicine shows promise as a cancer treatment strategy. By developing a spatially-asymmetric cascade nanocatalyst, the long-term stability and efficiency of chemodynamic therapy can be greatly improved, leading to enhanced cancer cell killing and tumor restrain efficiency.
Article
Chemistry, Multidisciplinary
Jiahuan Xu, Liang Chen, Sujun Ding, Xinyue Dai, Yanfei Dai, Yu Chen, Xuejun Ni
Summary: Through theoretical calculation, Nb2C MXenes are engineered as high-performance sonocatalysts/sonosensitizers through mild in-situ self-oxidation. The formation of efficient Schottky barriers after mild hydrothermal oxidation accelerates the separation of sono-triggered electron-hole pairs, enhancing the reactive oxygen species (ROS) generation efficiency of Nb2C-Ox under ultrasound irradiation.
Review
Materials Science, Biomaterials
Dongmiao Cao, Liang Chen, Ziwen Zhang, Yu Luo, Linjing Zhao, Chunping Yuan, Jie Lu, Xijian Liu, Jingchao Li
Summary: This article summarizes the application of degradable nanomaterials in cancer imaging and treatment. It presents four mechanisms of tumor microenvironment-responsive degradation and briefly summarizes external stimulation degradation. The applications of nanomaterials in bioimaging are outlined, and typical examples of biodegradable nanomaterials in various cancer therapies are focused.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Shanshan Zhang, Shujun Xia, Liang Chen, Yu Chen, Jianqiao Zhou
Summary: In this study, COF nanobowls were synthesized and utilized as activatable nanosensitizers with tumor-specific sonodynamic activity. The high crystallinity of the COF nanobowls enables efficient loading of the sonosensitizer and the in situ growth of manganese oxide inhibits non-specific damage to normal tissues. When reacting with tumor-overexpressed glutathione, the gatekeeper manganese oxide is decomposed to restore the ROS generation capability, leading to increased intracellular ROS stress and enhanced sonodynamic efficacy.
Article
Chemistry, Multidisciplinary
Yuyi Liu, Liang Chen, Zhiyang Chen, Minchao Liu, Xilei Li, Yufang Kou, MengMeng Hou, Huiren Wang, Xiaomin Li, Bo Tian, Jian Dong
Summary: In this study, a Janus nanoplatform (Janus-CPS) was developed for the simultaneous early diagnosis and effective treatment of rheumatoid arthritis (RA). The Janus nanostructure with increased reactive oxygen species scavenging capability and the loading of micheliolide in the mesopores showed promising results in vitro cellular experiments and in vivo collagen-induced arthritis (CIA) model. Additionally, the Janus-CPS exhibited desirable effectiveness in detecting early-stage RA lesions using near-infrared imaging.
Article
Chemistry, Multidisciplinary
Tiancong Zhao, Liang Chen, Minchao Liu, Runfeng Lin, Weiluo Cai, Chin-Te Hung, Shangfeng Wang, Linlin Duan, Fan Zhang, Ahmed Elzatahry, Xiaomin Li, Dongyuan Zhao
Summary: We demonstrate the fabrication of highly uniform Janus double-spherical MSN&mPDA nanoparticles using an emulsion-oriented assembly approach. The dual-mesoporous structure enables selective loading of guests in different compartments and the establishment of single-particle-level biological logic gates.
Article
Multidisciplinary Sciences
Minchao Liu, Cheng Shang, Tiancong Zhao, Hongyue Yu, Yufang Kou, Zirui Lv, Mengmeng Hou, Fan Zhang, Qiaowei Li, Dongyuan Zhao, Xiaomin Li
Summary: Porous anisotropic nanohybrids have attracted attention because of their unique properties including high surface area, tunable pore structures, and controllable compositions. Here, authors report a selective occupation strategy to achieve site-specific anisotropic growth of amorphous mesoporous subunits on crystalline MOFs.
NATURE COMMUNICATIONS
(2023)
Article
Infectious Diseases
Wei Xu, Qiankun Hu, Chong Chen, Weixia Li, Qiang Li, Liang Chen
Summary: This study aimed to evaluate the risk of liver fibrosis progression (LFP) in patients with chronic hepatitis B virus (HBV) infection and assess the role of noninvasive tests (NITs) in monitoring LFP. The study found that an increase in liver stiffness measurement (LSM) value was significantly associated with LFP on histology, and the LSM value increase rate had a higher predictive value for LFP compared to serum-based NITs. Therefore, serial LSM tests would be more reliable and easier to obtain than serial liver biopsy tests for identifying LFP.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Engineering, Biomedical
Wei Yang, Jianwei Cao, Hui Cheng, Liang Chen, Meihua Yu, Yu Chen, Xingang Cui
Summary: The approved use of two mRNA vaccines (BNT162b2 and mRNA-1273) worldwide in late 2020 has demonstrated the success of mRNA therapeutics and lipid nanoformulation technology in protecting against coronaviruses during the COVID-19 pandemic. This innovative approach with nanoformulations and mRNA therapeutics is believed to hold promise in targeted cancer immunotherapy.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Meng Fang, Minchao Liu, Mo Cheng, Tiancong Zhao, Peihang Xu, Weiluo Cai, Xiaomin Li, Wangjun Yan
Summary: Soft tissue sarcoma (STS) is difficult to treat with chemotherapy alone. A new asymmetric mesoporous Fe3O4&mSiO2-SRF nanoformulation is developed for combination therapy, where the Fe3O4 subunit is used for chemodynamic therapy and the mSiO2-SRF subunit is loaded with Sorafenib for chemotherapy. The spatial isolation of the subunits allows for enhanced Fenton reaction and Fe2+/Fe3+ release, leading to increased cell oxidation and improved tumor restrain efficiency. The combined effect of inhibiting GSH synthesis and ferroptosis induction further enhances cancer cell killing efficiency compared to traditional nanoformulations.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Zhiyang Chen, Liang Chen, Yiqun Ma, Yuyi Liu, Qianyi Zhang, Hao Qin, Yu Chen, Bo Tian, Jian Dong
Summary: A nanosystem is designed and fabricated for synergistic sonodynamic-immunometabolic therapy of spinal-metastasized tumors by integrating oxygen-deficient molybdenum oxide (ODM) nanosonosensitizers and R7 peptides. The nanosystem combines sonodynamic therapy with tumor metabolic regulation, achieving concurrent immune activation and immunosuppressive tumor microenvironment remodeling.
ADVANCED MATERIALS
(2023)
Article
Multidisciplinary Sciences
Yan Yu, Runfeng Lin, Hongyue Yu, Minchao Liu, Enyun Xing, Wenxing Wang, Fan Zhang, Dongyuan Zhao, Xiaomin Li
Summary: A hydrophilicity mediated interfacial selective assembly strategy is demonstrated for the versatile synthesis of metal compound based mesoporous Janus nanoparticles (mJNPs), providing a broad platform for the construction and application of mJNPs with rational designed functions and structures.
NATURE COMMUNICATIONS
(2023)