Article
Engineering, Biomedical
Dong-Yang Zhang, Muhammad Rizwan Younis, Hengke Liu, Shan Lei, Yilin Wan, Junle Qu, Jing Lin, Peng Huang
Summary: This study introduced ultrasmall polyvinylpyrrolidone-coated iridium nanoparticles as a promising new artificial enzyme to scavenge RONS and protect against AKI. The nanoparticles showed preferential renal uptake and alleviated clinical symptoms in mice, with relatively low systemic side effects due to rapid renal clearance. The research demonstrates the clinically translatable potential of ultrasmall nanozymes for AKI management.
Article
Chemistry, Multidisciplinary
Rui Hou, Tianxiang Lu, Wei Gao, Jian Shen, Zheyuan Yu, Datao Li, Ruhong Zhang, Yuanyi Zheng, Xiaojun Cai
Summary: This study explores the use of Prussian blue nanozyme (PBzyme) to maintain a normal microenvironment and improve the survival rate of transplanted skin flaps. PBzyme exhibits anti-inflammatory, antiapoptotic, antinecroptotic, and antioxidant activities, resulting in significantly increased survival rate of the transplanted skin flaps in ischemia-reperfusion (I/R) injury models.
Article
Medicine, Research & Experimental
Xue Xie, Jiulong Zhao, Wei Gao, Jie Chen, Bing Hu, Xiaojun Cai, Yuanyi Zheng
Summary: The study found that PBzyme has potential anti-oxidative and anti-inflammatory effects in the prophylactic treatment of AP, possibly involving inhibition of signaling pathways and scavenging reactive oxygen species. This provides a foundation for the clinical application of PBzyme in the preventive treatment of AP.
Article
Nanoscience & Nanotechnology
Junlong Da, Ying Li, Kai Zhang, Junyu Ren, Jianqun Wang, Xinpeng Liu, Xiaoyao Liu, Jiahui Zhang, Lixue Liu, Wenxuan Zhang, Shujian Zhang, Yuyao Guo, Bin Zhang, Han Jin
Summary: A novel microenvironment-stimuli-responsive drug delivery nanoplatform was developed for the treatment of maxillofacial infection. The nanoplatform showed excellent biocompatibility and had the ability to scavenge ROS and inhibit inflammatory response, promoting tissue repair.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hyeryeon Oh, Dongwan Son, Jin Sil Lee, Myungwoong Kim, Daekyung Sung, Hoik Lee, Won Il Choi
Summary: This study developed PBChi/PVA nanofibers with antioxidant and cell proliferation properties as ROS-scavenging wound dressings. These nanofibers effectively removed reactive oxygen species and exhibited good biocompatibility and cell proliferation ability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Jian Liu, Jingyi Sun, Yanan Song, Mengyue Wang, Peng Zhao, Wendi Wang, Mingfeng Yang, Ying Wang, Yuqiang Song, Baoliang Sun
Summary: Ischemic stroke is a major cause of death and disability. The excessive production of reactive oxygen species (ROS) after ischemic injury leads to inflammatory reactions that worsen brain injury. However, current clinical drug treatments have limited efficacy. ROS scavengers, such as nanoenzymes, show promise in treating ischemic stroke. In this study, a Prussian blue nanoenzyme (PBzyme) was used to investigate its effects on ROS in vivo and in vitro. PBzyme inhibited macrophage activation and inflammatory factor release in the brain, promoted microglial polarization to M2, inhibited neuronal apoptosis, and improved neurological function recovery after ischemic stroke. This research highlights a potential application of nanoenzymes for brain disease treatment.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Xiaolei Song, Qin Ding, Wei Wei, Juan Zhang, Rongli Sun, Lihong Yin, Songqin Liu, Yuepu Pu
Summary: A novel near infrared responsive nanomaterial called PBK NPs was developed, which demonstrated excellent antioxidant activity and photothermal effect. PBK NPs can effectively eliminate excessive reactive oxygen species and dissociate A ss fibrils, showing potential therapeutic strategies for Alzheimer's disease.
Article
Engineering, Biomedical
Weiduo Hou, Chenyi Ye, Mo Chen, Wei Gao, Xue Xie, Jianrong Wu, Kai Zhang, Wei Zhang, Yuanyi Zheng, Xiaojun Cai
Summary: HPBzymes were designed to investigate their effects on chondrocytes and the progression of OA. They were found to protect chondrocytes and delay OA progression by inhibiting ROS and Rac1/NF-kappa B signaling, suggesting that deeply digging the intrinsic bioactivities of nanozymes is an effective strategy for ROS-associated chronic diseases. This study highlights the potential of nanomedicine for diagnosing and treating severe diseases through excavating their bioactivities.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Haitao Yuan, Fujing Wang, Zhen Wang, Di Gu, Wei Huang, Chunjin Fu, Xiaoxian Wang, Jingbo Ma, Zhijie Li, Lingyun Dai, Xinzhou Zhang, Wei Xiao, Jigang Wang
Summary: In this study, a metal-phenolic nanozyme named RosA-Mn NPs was designed with broad spectrum antioxidant functionalities. The nanozyme promotes the recovery of mitochondrial function, reduces endoplasmic reticulum stress and secondary inflammation, and mitigates kidney damage through renal tubular targeting. In addition, RosA-Mn NPs also protect the kidney from oxidation and inflammation in an animal model.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Hui Yang, Lili Xia, Xuanxuan Ye, Jiayi Xu, Tianfeng Liu, Linping Wang, Shuai Zhang, Wei Feng, Dongshu Du, Yu Chen
Summary: In this study, a specific nanozyme based on ultrathin two-dimensional (2D) niobium carbide (Nb2C) MXene, called Nb2C MXenzyme, was developed to combat hypertension by efficiently eliminating reactive oxygen species and inhibiting inflammatory factors. The biocompatible Nb2C MXenzyme exhibited multiple enzyme-mimicking activities and displayed cytoprotective effects by resisting oxidative stress, thereby alleviating inflammatory response and reducing blood pressure. The efficacy of this strategy was demonstrated in a stress-induced hypertension rat model, highlighting the potential of nanozymes in hypertension treatment and the biomedical applications of 2D MXene nanosystems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nanoscience & Nanotechnology
Zhao Xu, Yujing Liu, Rui Ma, Jing Chen, Jinmei Qiu, Shuang Du, Chengcheng Li, Zihan Wu, Xiaofan Yang, Zhenbing Chen, Tongkai Chen
Summary: Diabetic foot ulcer is a serious complication in diabetes patients, and oxidative stress is thought to be a key driver of the pathogenesis of such ulcers. In this study, researchers synthesized Prussian blue nanoparticles with the ability to efficiently scavenge reactive oxygen species and incorporated them into a hydrogel for the treatment of diabetic foot ulcers.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Xinxin Ma, Junnian Hao, Jianrong Wu, Yuehua Li, Xiaojun Cai, Yuanyi Zheng
Summary: This study demonstrates that Prussian blue nanozyme (PBzyme) can act as a pyroptosis inhibitor to alleviate neurodegeneration in mouse and cell models of Parkinson's disease. By scavenging reactive oxygen species, inhibiting activation of the inflammasome, and reducing the production of inflammatory factors, PBzyme exerts neuroprotective effects.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Quanyi Liu, Sheng Zhao, Yihong Zhang, Qi Fang, Wanling Liu, Rong Wu, Gen Wei, Hui Wei, Yan Du
Summary: Embedding antioxidant Prussian blue family nanozymes into cosmetic contact lenses can effectively prevent ocular surface diseases and provide a new strategy for the development of wearable biomedical devices using nanomaterials.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ying Zhang, Xue Yuan, Xinyue Guo, Huan Xu, Dongxin Zhang, Zhengyan Wu, Jia Zhang
Summary: This study demonstrates the exceptional efficiency and sensitivity of zinc-doped Prussian blue nanoparticles in capturing and isolating copper ions. It lays the groundwork for the future development of a practical copper sensor that can be applied in resource-constrained environments.
Article
Chemistry, Multidisciplinary
Keyi Wang, Yang Zhang, Weipu Mao, Wei Feng, Shuting Lu, Jian Wan, Xinran Song, Yu Chen, Bo Peng
Summary: The study introduces a novel nanozyme CaPB, which mimics the activity of multiple enzymes, effectively clearing harmful substances and inhibiting renal damage, showing potential for treating kidney injury. Additionally, CaPB nanozymes significantly increase the expression of ferroptosis regulator and protect the kidney from oxidative injury, indicating a promising approach for AKI treatment.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Jinfeng Xu, Muhammad Rizwan Younis, Zhaowenbin Zhang, Yanping Feng, Lefeng Su, Yumei Que, Yiren Jiao, Chen Fan, Jiang Chang, Siyu Ni, Chen Yang
Summary: In this study, a polydopamine/alginate/nanoselenium composite hydrogel (Alg-PDA-Se) was proposed for the treatment of infected wounds. The composite hydrogel combines controllable near-infrared photothermal properties of polydopamine with the excellent anti-oxidation, anti-inflammatory, pro-proliferative, pro-migration, and proangiogenic performances of low-dosage selenium nanoparticles (Se NPs). The combination of mild temperature with low-dosage Se NPs showed a synergistic effect on combating bacterial infections and promoting wound healing in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Muhammad Rizwan Younis, Yaling He, Xikuang Yao, Gang He, Hengke Liu, Peng Huang, Jing Lin
Summary: In this study, researchers developed an acidity/carbon dioxide-sensitive polymer for the precise release of chemotherapeutic drugs against glioblastoma. They successfully prepared multifunctional gold vesicles that were responsive to multiple stimuli, achieving the programmed release of chemotherapy drugs.
ACTA BIOMATERIALIA
(2023)
Article
Biophysics
Pengyu Zhu, Muhammad Rizwan Younis, Guiqi Ma, Qianting Zhang, Ruibing An, Kaiqi Wang, Jian Dong
Summary: Dendritic polymer-platinum conjugates (G5-PEG-Pt) were designed as pH-responsive nanovesicles for target delivery of platinum drugs. The G5-PEG-Pt exhibited a well-defined structure, intrinsic fluorescence, and acid-responsive drug release. They were able to enter cancer cells and achieve comparable cytotoxicity to free cisplatin. Furthermore, the nanovesicles showed enhanced tumor platinum uptake compared to free cisplatin, potentially improving the therapeutic efficacy of platinum drugs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Pingru Su, Biaowen Wei, Chenxing Guo, Yaqi Hu, Runxu Tang, Shunran Zhang, Chuanxin He, Jing Lin, Xiujun Yu, Zhi Chen, Haiyang Li, Heng Wang, Xiaopeng Li
Summary: In biological systems, biomacromolecules can undergo reversible interconversion among multiple states in response to external stimuli. Constructing metallo-supramolecular systems with reversible interconversion remains a challenge. In this study, a pH-responsive ligand was used to construct metallo-supramolecular hexagonal wreaths capable of in situ reversible interconversion among four states, with efficient conversion and structural integrity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Biomaterials
Li Deng, Lingwei Huang, Hao Pan, Qi Zhang, Yumei Que, Chen Fan, Jiang Chang, Siyu Ni, Chen Yang
Summary: In this study, single-phased strontium-zinc-phosphate (SZP) bioceramics were synthesized via solution combustion method and fabricated into SZP scaffolds using 3D printing technique. The 3D printed SZP scaffolds showed comparable physical properties but enhanced abilities of osteogenesis, angiogenesis, immunomodulation, and anti-bacterial activity compared to 3D printed beta-tricalcium phosphate (β-TCP) scaffolds.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Yurong Liu, Xinming Zhang, Shan Lei, Jing Lin, Peng Huang
Summary: The non-invasiveness, non-ionization, and impressive tissue penetration depth make photoacoustic (PA) imaging technology attractive for in vivo detection. Analyte-responsive organic PA probe-based in vivo imaging of bio-functional small anions has advanced real-time visualization of biological action, early diagnosis, and precision therapy of diseases. This mini review focuses on the anion-recognition mechanisms of PA probes from a chemistry perspective and exemplifies the structural design strategies of activatable organic PA probes. The challenges and outlooks for further development of PA probes for in vivo imaging of bio-functional small anions are discussed, providing an alternative approach to interpret anion-mediated biological events.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Nanoscience & Nanotechnology
Kai Guo, Dong Chen, Shuai Ren, Muhammad Rizwan Younis, Zhaogang Teng, Longjiang Zhang, Zhongqiu Wang, Ying Tian
Summary: Immune checkpoint blockade therapy and photothermal therapy have great potential in cancer treatment. Using MK-8628 and HPDA@MK as non-antibody methods, both PD-L1 and CD47 can be simultaneously suppressed, immune response can be activated, and the combined therapeutic effect can be enhanced, providing a feasible approach for the treatment of other solid tumors.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Xinming Zhang, Song Lin, Feng Zhao, Jing Zhang, Shan Lei, Fang Bai, Qiang Liu, Jiayingzi Wu, Ting He, Peng Huang, Jing Lin
Summary: A programmably controllable delivery system based on croconium dye (Croc)-ferrous ion (Fe2+) nanoprobes (CFNPs) is developed for multiscale dynamic imaging guided photothermal primed CDT. The CFNPs achieve pH-responsive visualization and accurate Fe2+ release in cancerous tissues under the coactivation of acidity and near-infrared (NIR) light. By leveraging multiscale dynamic imaging technologies, the complicated spatiotemporal release of Fe2+ is sketched in a programmably controllable manner, revealing the domino effect of tumor pH level, photothermal effect, and CDT within the disease microenvironment.
ADVANCED MATERIALS
(2023)
Review
Computer Science, Interdisciplinary Applications
Ting He, Anas Belouali, Jessica Patricoski, Harold Lehmann, Robert Ball, Valsamo Anagnostou, Kory Kreimeyer, Taxiarchis Botsis
Summary: Identifying patient cohorts with specific phenotypes is essential in biomedicine, and many research groups have developed pipelines to automate this task. This study conducted a systematic review on computable clinical phenotyping, analyzing 139 selected records to extract information on target use cases, data-related topics, phenotyping methodologies, evaluation strategies, and portability of developed solutions. The findings highlight the need for defining target use cases, moving away from sole machine learning strategies, and evaluating proposed solutions in real settings.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Article
Chemistry, Multidisciplinary
Ying Tian, Muhammad Rizwan Younis, Yatong Zhao, Kai Guo, Jiayingzi Wu, Longjiang Zhang, Peng Huang, Zhongqiu Wang
Summary: Researchers have developed a nanomodulator based on mesoporous polydopamine nanoparticles for combinational photothermal-immunotherapy. This nanomodulator improves immunotherapy outcomes by restoring immune suppression and providing thermal therapy for tumor treatment. The nanomodulator has excellent biocompatibility, water solubility, and imaging abilities. It can precisely deliver and release immune inhibitors at tumor sites, effectively reversing immune suppression and enhancing therapeutic efficacy.
Article
Chemistry, Multidisciplinary
Hebin Wang, Junzi Li, Haolin Lu, Sehrish Gull, Tianyin Shao, Yunxin Zhang, Tengfei He, Yongsheng Chen, Tingchao He, Guankui Long
Summary: In this study, a novel chiral hybrid germanium halide material was developed with large anisotropy factors and high laser-induced damage thresholds. Its linear and nonlinear chiroptical properties were systematically investigated, showing high values of anisotropy factors and second-order nonlinear optical coefficient. These findings provide a new avenue for lead-free chiral hybrid metal halides in nonlinear chiroptical applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Huan Liu, Peixian Chen, Xuanyu Zhang, Xiongbin Wang, Tingchao He, Rui Chen
Summary: Two-dimensional colloidal CdSe nanoplatelets (NPLs) with different structures were synthesized and their optical properties were characterized. It was found that the photoluminescence quantum yield of the NPLs improved significantly after the growth of the CdS crown layer. The emission intensity ratio at low temperatures suggested that the radiative recombination centers were mainly located on the lateral surface, which was confirmed by surface passivation experiment. Additionally, the ligand exchange experiment confirmed the presence of nonradiative recombination centers on the lateral surface. These findings highlight the importance of understanding the optical properties of the lateral surface of NPLs for optoelectronic applications.
Article
Chemistry, Multidisciplinary
Jiaying Lin, Rulin Liu, Peixian Chen, Yangfei Lv, Junjie Hao, Meijuan Chen, Dongxiang Zhang, Ruikun Pan, Yiwen Li, Xi Zhu, Tingchao He, Jiaji Cheng
Summary: Stimulating and harnessing circularly polarized luminescence (CPL) is crucial for understanding chirogenesis in physical chemistry and implementing it in research fields such as chiral optoelectronics and theranostics. In this study, red-emissive carbonized polymer dots (CPDs) with enhanced circular dichroism (CD) and CPL activities were synthesized using a biomolecule-tailored organic-inorganic co-assembly strategy. The obtained CPL signals can be manipulated in an excitation-dependent manner, indicating a synergistic-competition phenomenon between configurational chirality and intermolecular energy-transfer dynamics.
Article
Optics
Fuli Zhao, Yanyan Cui, Anfu Wang, Yang Gao, Tingchao He
Summary: This work reports the optical properties of inverted type-I ZnSe/InP/ZnS quantum dots (QDs) with photoluminescence (PL) emission in the near-infrared (NIR) range. The QDs exhibit higher exciton-binding energy and weaker carrier-phonon coupling effect than conventional type-I InP-based QDs. In addition, they show strong two-photon absorption characteristics in the second biological window.
JOURNAL OF LUMINESCENCE
(2024)
