Integration of population and functional genomics to understand mechanisms of artemisinin resistance in Plasmodium falciparum

Essential Genes of the Parasitic Apicomplexa

(2021) Jenna Oberstaller et al.   TRENDS IN PARASITOLOGY

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

Influence of Plasmodium falciparum Calcium-Dependent Protein Kinase 5 (PfCDPK5) on the Late Schizont Stage Phosphoproteome

(2020) Karin Blomqvist et al.   mSphere

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

(2020) Nina F. Gnädig et al.   PLoS Pathogens

An exported kinase family mediates species-specific erythrocyte remodelling and virulence in human malaria

(2020) Heledd Davies et al.   Nature Microbiology

K13, the Cytostome, and Artemisinin Resistance

(2020) Stanley C. Xie et al.   TRENDS IN PARASITOLOGY

K13-Mediated Reduced Susceptibility to Artemisinin in Plasmodium falciparum Is Overlaid on a Trait of Enhanced DNA Damage Repair

(2020) Aoli Xiong et al.   Cell Reports

Inhibition of PfMYST HAT activity blocks Plasmodium falciparum growth and survival

(2020) Utsav Sen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Plasmodium falciparum replication factor C subunit 1 is involved in genotoxic stress response

(2020) Omar Sheriff et al.   CELLULAR MICROBIOLOGY

Elucidation of DNA Repair Function of PfBlm and Potentiation of Artemisinin Action by a Small-Molecule Inhibitor of RecQ Helicase

(2020) Niranjan Suthram et al.   mSphere

Illuminating how malaria parasites export proteins into host erythrocytes

(2019) Kathryn M. Matthews et al.   CELLULAR MICROBIOLOGY

Plasmodium falciparum clearance is pitting-dependent with artemisinin-based drugs but pitting-independent with atovaquone-proguanil or mefloquine Short tittle: Drug-specific pitting in malaria

(2019) Mariusz Wojnarski et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of essential exportedPlasmodium falciparumprotein kinases in malaria‐infected red blood cells

(2019) Ghizal Siddiqui et al.   BRITISH JOURNAL OF HAEMATOLOGY

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

(2019) Tuo Yang et al.   Cell Reports

Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle

(2019) Xue Li et al.   PLoS Genetics

Identifying the favored mutation in a positive selective sweep

(2018) Ali Akbari et al.   NATURE METHODS

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

(2018) Annie N. Cowell et al.   SCIENCE

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations

(2018) Xiaonan Liu et al.   Nature Communications

Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

(2018) Frances Rocamora et al.   PLoS Pathogens

Altered expression of K13 disrupts DNA replication and repair in Plasmodium falciparum

(2018) Justin Gibbons et al.   BMC GENOMICS

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility

(2018) Allison R. Demas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

(2018) Lei Zhu et al.   Nature Communications

Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity

(2017) Sonia Agrawal et al.   JOURNAL OF INFECTIOUS DISEASES

Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association study

(2017) Roberto Amato et al.   LANCET INFECTIOUS DISEASES

A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study

(2017) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

Artemisinin resistance without pfkelch13 mutations in Plasmodium falciparum isolates from Cambodia

(2017) Angana Mukherjee et al.   MALARIA JOURNAL

Functional analysis of Plasmodium falciparum subpopulations associated with artemisinin resistance in Cambodia

(2017) Ankit Dwivedi et al.   MALARIA JOURNAL

Antimalarial Drug Resistance: A Threat to Malaria Elimination

(2017) Didier Menard et al.   Cold Spring Harbor Perspectives in Medicine

Co‐recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR‐induced ubiquitylation

(2016) Guillaume Voisinne et al.   Molecular Systems Biology

Plasmodium species: master renovators of their host cells

(2016) Tania F. de Koning-Ward et al.   NATURE REVIEWS MICROBIOLOGY

Genome-wide association analysis identifies genetic loci associated with resistance to multiple antimalarials in Plasmodium falciparum from China-Myanmar border

(2016) Zenglei Wang et al.   Scientific Reports

Protein Export into Malaria Parasite–Infected Erythrocytes: Mechanisms and Functional Consequences

(2015) Natalie J. Spillman et al.   Annual Review of Biochemistry

Pooled Sequencing and Rare Variant Association Tests for Identifying the Determinants of Emerging Drug Resistance in Malaria Parasites

(2015) Ian H. Cheeseman et al.   MOLECULAR BIOLOGY AND EVOLUTION

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Genetic architecture of artemisinin-resistant Plasmodium falciparum

(2015) Olivo Miotto et al.   NATURE GENETICS

Chemogenomic profiling of Plasmodium falciparum as a tool to aid antimalarial drug discovery

(2015) Anupam Pradhan et al.   Scientific Reports

Predicting Carriers of Ongoing Selective Sweeps without Knowledge of the Favored Allele

(2015) Roy Ronen et al.   PLoS Genetics

An exported kinase (FIKK4.2) that mediates virulence-associated changes in Plasmodium falciparum-infected red blood cells

(2014) Lev M. Kats et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

PlasmodiumfalciparumClearance Is Rapid and Pitting Independent in Immune Malian Children Treated With Artesunate for Malaria

(2014) Papa Alioune Ndour et al.   JOURNAL OF INFECTIOUS DISEASES

Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

(2014) Shannon Takala-Harrison et al.   JOURNAL OF INFECTIOUS DISEASES

A Genome Wide Association Study of Plasmodium falciparum Susceptibility to 22 Antimalarial Drugs in Kenya

(2014) Jason P. Wendler et al.   PLoS One

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

(2014) S. Mok et al.   SCIENCE

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

(2013) Olivo Miotto et al.   NATURE GENETICS

Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya

(2013) Steffen Borrmann et al.   Scientific Reports

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

(2012) S. Takala-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite

(2012) D. J. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Major Genome Region Underlying Artemisinin Resistance in Malaria

(2012) I. H. Cheeseman et al.   SCIENCE

GeneDB--an annotation database for pathogens

(2011) F. J. Logan-Klumpler et al.   NUCLEIC ACIDS RESEARCH

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical Genomic Profiling for Antimalarial Therapies, Response Signatures, and Molecular Targets

(2011) J. Yuan et al.   SCIENCE

Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum

(2011) Daria Van Tyne et al.   PLoS Genetics

Increased Tolerance to Artemisinin in Plasmodium falciparum Is Mediated by a Quiescence Mechanism

(2010) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

The MYST family histone acetyltransferase regulates gene expression and cell cycle in malaria parasite Plasmodium falciparum

(2010) Jun Miao et al.   MOLECULAR MICROBIOLOGY

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs

(2010) Jianbing Mu et al.   NATURE GENETICS

A Plant-Like Kinase in Plasmodium falciparum Regulates Parasite Egress from Erythrocytes

(2010) J. D. Dvorin et al.   SCIENCE

Plasmodium falciparum Erythrocyte Membrane Protein 1 Diversity in Seven Genomes – Divide and Conquer

(2010) Thomas S. Rask et al.   PLoS Computational Biology

A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum

(2009) Werner Leber et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

(2008) Harald Noedl et al.   NEW ENGLAND JOURNAL OF MEDICINE

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH