Article
Agricultural Engineering
Nadav Danziger, Nirit Bernstein
Summary: Plant architecture modulation can increase standardization of the cannabinoid profile in cannabis by increasing concentrations at the lower parts of the plant. Genotype and architectural modulation have specific effects on cannabinoid standardization.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Review
Pharmacology & Pharmacy
Arash Salehi, Keely Puchalski, Yalda Shokoohinia, Behzad Zolfaghari, Sedigheh Asgary
Summary: Hemp and marijuana differ in terms of chemical and genetic composition, production practices, product uses, and regulatory status. Hemp seed and hemp seed oil have nutritional value, and the non-intoxicating phytocannabinoid CBD has high medicinal potential. It is now easier to differentiate between hemp and marijuana in the laboratory, and regulations and testing guidelines for cannabis are still evolving.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agricultural Engineering
Avia Saloner, Nirit Bernstein
Summary: Nitrogen supply affects cannabinoid and terpenoid metabolism, with the optimal N level for both yield quantity and relatively high secondary metabolites content being 160 mg L-1. High N supply has adverse effects on the production of secondary compounds in cannabis, while promoting plant growth and biomass production.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Plant Sciences
Nadav Danziger, Nirit Bernstein
Summary: Plant organs sense their environment locally, leading to spatial variability in plant tissue physiology and secondary metabolism due to gradients of micro-climates in the plant shoot; Plant architecture, affecting micro-climate in the shoot, significantly impacts the uniformity of cannabinoids in Cannabis sativa plants; Manipulations of plant architecture that increase light penetration can enhance cannabinoid uniformity and yield biomass in large cannabis plants.
Review
Chemistry, Analytical
Cristiano Bolchi, Marco Pallavicini, Eleonora Casagni, Edgardo Vieira de Manincor, Veniero Gambaro, Michele Dei Cas, Gabriella Roda
Summary: Research has shown that the cannabis chemotype can be determined effectively at an early stage of a plant's growth, avoiding economic and legal issues during cultivation. Various studies have demonstrated the feasibility of this procedure through diverse methods.
ANALYTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Zaid H. Maayah, Pamela J. F. Raposo, Heidi Silver, Rupasri Mandal, Lee Ellis, Abrar S. Alam, Shingo Takahara, Mourad Ferdaoussi, Kyle E. Mathewson, Dean T. Eurich, Karim Fouad, David S. Wishart, Jason R. B. Dyck
Summary: This study aimed to identify a panel of blood-based metabolites that can predict behavioral effects induced by cannabis. The results showed that only rats treated with full-spectrum cannabis extract exhibited behavioral changes, while the other groups did not show any behavioral changes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Matthew M. Cousins, Mary L. Jannausch, Lara N. Coughlin, Reshma Jagsi, Mark A. Ilgen
Summary: The study found that patients with cancer were less likely to report cannabis use, but there were different cannabis perceptions and use patterns among patients of different ages.
Article
Agricultural Engineering
Jafar Mehdi, Danish Husain, Abhilasha Srivastava, Namita Gupta, Karuna Shanker, Mohammad Talha, Raj Kishori Lal, Birendra Kumar, Anil Kumar Gupta
Summary: This study conducted extensive morphometric and chemometric mapping of natural populations of Cannabis in India, revealing a strong correlation between their genetic diversity and regional distribution. The findings provide a foundation for identifying and selecting lines with key agronomic traits for maximizing the potential of this promising crop.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Analytical
Alfredo Fabrizio Lo Faro, Beatrice Venanzi, Giulia Pilli, Umberto Ripani, Giuseppe Basile, Simona Pichini, Francesco Paolo Busardo
Summary: A method for fast and accurate determination of THC, CBD, and their metabolites in hair samples was developed. This method is suitable for monitoring patients undergoing medical cannabis treatments.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Agricultural Engineering
Kai Su, Elizabeth Maghirang, Jia Wen Tan, Ju Young Yoon, Paul Armstrong, Pradeep Kachroo, David Hildebrand
Summary: This study demonstrates the use of near-infrared spectroscopy for rapid measurement of industrial hemp, allowing for accurate identification of legal and illegal hemp. It shows good prediction results and will be beneficial for the hemp industry, regulators, farmers, and consumers.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Psychology, Clinical
Evan A. Winiger, Leah N. Hitchcock, Angela D. Bryan, L. Cinnamon Bidwell
Summary: The study aimed to investigate the relationship between cannabis use, expectations of cannabis as a sleep aid, subjective sleep outcomes, and the influence of age. Results showed that endorsing current cannabis use and more days of use were associated with increased expectations of improved sleep, while frequency of edible use showed negative associations with sleep efficiency, duration, and overall sleep quality. Age was found to moderate the relationship between CBD concentration and sleep duration and quality. The study suggests that while cannabis users have high expectations of cannabis as a sleep aid, actual associations with sleep outcomes are limited.
ADDICTIVE BEHAVIORS
(2021)
Article
Anesthesiology
Rebecca M. Craft, Hannah Y. Gogulski, Timothy G. Freels, Nicholas C. Glodosky, Ryan J. McLaughlin
Summary: Preclinical studies show strong antinociceptive effects of cannabinoids in rodent pain models, however, clinical trials in chronic pain patients report limited pain relief. Discrepancies may be due to differences in administration, type of cannabis, and pain measurement. Vaporized THC-dominant extract shows modest effectiveness against inflammatory pain, while CBD-dominant extract may only be effective in male rats.
Article
Plant Sciences
Victorio Morello, Vincent Desaulniers Brousseau, Natalie Wu, Bo-Sen Wu, Sarah MacPherson, Mark Lefsrud
Summary: This study investigated the impact of six different light spectra on cannabis growth and secondary metabolite profiles. Results showed that blue light treatment had a significant effect on THC concentration and certain terpene concentrations, increasing their levels. Choosing the appropriate spectral design based on the specific goals of cannabis production may lead to improved outcomes in cannabinoid production.
Article
Plant Sciences
Alessandra Manca, Alice Palermiti, Jacopo Mula, Elisa Delia De Vivo, Sandra Zeaiter, Marco Simiele, Amedeo De Nicolo, Marco Cantu, Jessica Cusato, Antonio D'Avolio
Summary: This study investigates the variability of cannabis oil preparations among different galenic laboratories, highlighting the importance of titration activity. The results reveal significant differences in the composition of cannabis oil among different galenic laboratories, and the concentrations of compounds are also influenced by seasonal variability.
Article
Chemistry, Analytical
Rafal Typek, Piotr Holowinski, Andrzej L. Dawidowicz, Michal P. Dybowski, Michal Rombel
Summary: This study aims to improve the analysis methods for detecting and quantification of cannabinoids in bio-matrices. It is found that CBD cyclizes to A9-THC and A9-THC isomerizes to A8-THC under acidic conditions. The paper presents a method to block the cyclization and isomerization process, and describes the formation of new CBD derivatives. The analysis of CBD derivatives is performed using NMR, GC-MS, and LC-MS techniques.