Journal
FRONTIERS IN MICROBIOLOGY
Volume 12, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.626553
Keywords
COVID-19; SARS-CoV-2; ACE2 (angiotensin converting enzyme 2); animal model; pathogenesis
Categories
Funding
- Major Science and Technology Project for the Prevention and Treatment of Major Infectious Diseases [2018ZX10301208]
- National Base Cultivation Project [20DZ2210404]
- Special Research Project on Prevention and Treatment of SARS-CoV-2 Infection and Pneumonia (Fudan University)
- National Natural Science Foundation of China [81971921]
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Selecting appropriate animal models for SARS-CoV-2 research is crucial for antiviral drug development and therapeutic effect evaluation.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus causing acute respiratory tract infection in humans. The virus has the characteristics of rapid transmission, long incubation period and strong pathogenicity, and has spread all over the world. Therefore, it is of great significance to select appropriate animal models for antiviral drug development and therapeutic effect evaluation. Here, we review and compare the current animal models of SARS-CoV-2.
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