Periodontitis Exacerbates and Promotes the Progression of Chronic Kidney Disease Through Oral Flora, Cytokines, and Oxidative Stress

Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy

(2021) Koichiro Kajiwara et al.   BMC Nephrology

Characterization of the subgingival microbiota in the peritoneal dialysis patients with periodontitis

(2020) Xuyun Zhang et al.   ARCHIVES OF ORAL BIOLOGY

Melatonin improves periodontitis‐induced kidney damages by decreasing inflammatory stress and apoptosis in rats

(2020) Oğuz Kose et al.   JOURNAL OF PERIODONTOLOGY

Interleukin-17A blockade reduces albuminuria and kidney injury in an accelerated model of diabetic nephropathy

(2019) Carolina Lavoz et al.   KIDNEY INTERNATIONAL

Asymmetric (ADMA) and Symmetric (SDMA) Dimethylarginines in Chronic Kidney Disease: A Clinical Approach

(2019) Elena Oliva-Damaso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Severe Periodontitis May Influence Cementum and Dental Pulp Through Inflammation, Oxidative Stress and Apoptosis

(2019) Xiangchun Li et al.   JOURNAL OF PERIODONTOLOGY

Long Pentraxin 3 as a Broader Biomarker for Multiple Risk Factors in End-Stage Renal Disease: Association with All-Cause Mortality

(2019) Maria João Valente et al.   MEDIATORS OF INFLAMMATION

Interleukin 17A Participates in Renal Inflammation Associated to Experimental and Human Hypertension

(2019) Macarena Orejudo et al.   Frontiers in Pharmacology

Distribution of plasma oxidised phosphatidylcholines in chronic kidney disease and periodontitis as a co-morbidity

(2019) Opeyemi Stella Ademowo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Status of periodontal health in German patients suffering from chronic kidney disease—Data from the GCKD study

(2019) Bettina Dannewitz et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Periodontitis and vascular inflammatory biomarkers: an experimental in vivo study in rats

(2019) Yago Leira et al.   Odontology

Current Position on the Role of Monomeric C-reactive Protein in Vascular Pathology and Atherothrombosis

(2019) Ivan S. Melnikov et al.   CURRENT PHARMACEUTICAL DESIGN

Association between severe periodontitis and chronic kidney disease severity in predialytic patients: A cross‐sectional study

(2019) Jasper da Silva Schütz et al.   ORAL DISEASES

Nephritis-associated plasmin receptor (NAPlr) positive glomerulonephritis caused by Aggregatibacter actinomycetemcomitans bacteremia: A case report

(2018) Yohei Komaru et al.   CLINICAL NEPHROLOGY

Periodontal profile class is associated with prevalent diabetes, coronary heart disease, stroke, and systemic markers of C-reactive protein and interleukin-6

(2018) James D. Beck et al.   JOURNAL OF PERIODONTOLOGY

Effect of systemic administration of lipopolysaccharides derived from Porphyromonas gingivalis on gene expression in mice kidney

(2018) Fumiya Harada et al.   Medical Molecular Morphology

Anti-Inflammatory Effect of Melittin on Porphyromonas Gingivalis LPS-Stimulated Human Keratinocytes

(2018) Woon-Hae Kim et al.   MOLECULES

Periodontal Disease, Regular Dental Care Use, and Incident Ischemic Stroke

(2018) Souvik Sen et al.   STROKE

Peptidoglycan-associated lipoprotein of Aggregatibacter actinomycetemcomitans induces apoptosis and production of proinflammatory cytokines via TLR2 in murine macrophages RAW 264.7 in vitro

(2018) Riikka Ihalin et al.   Journal of Oral Microbiology

Defining the gut microbiota in individuals with periodontal diseases: an exploratory study

(2018) Talita Gomes Baeta Lourenςo et al.   Journal of Oral Microbiology

The association between periodontal conditions, inflammation, nutritional status and calcium-phosphate metabolism disorders in hemodialysis patients

(2018) Marta Cholewa et al.   Journal of Applied Oral Science

The oral microbiota: dynamic communities and host interactions

(2018) Richard J. Lamont et al.   NATURE REVIEWS MICROBIOLOGY

Periodontitis changes renal structures by oxidative stress and lipid peroxidation

(2017) Luiz Felipe C. França et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Global epidemiology of dental caries and severe periodontitis - a comprehensive review

(2017) Jo E. Frencken et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Two-dimensional and three-dimensional models for studying atherosclerosis pathogenesis induced by periodontopathogenic microorganisms

(2017) D.F. Gualtero et al.   Molecular Oral Microbiology

Association between periodontal disease and mortality in people with CKD: a meta-analysis of cohort studies

(2017) Jian Zhang et al.   BMC Nephrology

Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88

(2017) Hasnaa Makkawi et al.   Frontiers in Cellular and Infection Microbiology

Porphyromonas gingivalis Uses Specific Domain Rearrangements and Allelic Exchange to Generate Diversity in Surface Virulence Factors

(2017) Stuart G. Dashper et al.   Frontiers in Microbiology

Characterization of Fusobacterium varium Fv113-g1 isolated from a patient with ulcerative colitis based on complete genome sequence and transcriptome analysis

(2017) Tsuyoshi Sekizuka et al.   PLoS One

Endothelial dysfunction in rats with ligature-induced periodontitis: Participation of nitric oxide and cycloxygenase-2-derived products

(2016) Paula Campi et al.   ARCHIVES OF ORAL BIOLOGY

Fusobacterium nucleatum infection of gingival epithelial cells leads to NLRP3 inflammasome-dependent secretion of IL-1β and the danger signals ASC and HMGB1

(2016) Fiona Q. Bui et al.   CELLULAR MICROBIOLOGY

Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300

(2016) H. Jane Dyson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association between periodontitis and mortality in stages 3-5 chronic kidney disease: NHANES III and linked mortality study

(2016) Praveen Sharma et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Periodontal treatment in patients with chronic kidney disease: a pilot study

(2016) S. Almeida et al.   JOURNAL OF PERIODONTAL RESEARCH

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

Polymorphonuclear neutrophils in periodontitis and their possible modulation as a therapeutic approach

(2016) Elena A. Nicu et al.   PERIODONTOLOGY 2000

Serum Amyloid A3 Gene Expression in Adipocytes is an Indicator of the Interaction with Macrophages

(2016) Yohei Sanada et al.   Scientific Reports

Impact of CDT Toxin on Human Diseases

(2016) Tiphanie Faïs et al.   Toxins

Effects of Aggregatibacter actinomycetemcomitans leukotoxin on neutrophil migration and extracellular trap formation

(2016) Josefine Hirschfeld et al.   Journal of Oral Microbiology

Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Activates the NLRP3 Inflammasome in Human Macrophages, Leading to the Release of Proinflammatory Cytokines

(2015) Bruce J. Shenker et al.   INFECTION AND IMMUNITY

Association between levels of pentraxin 3 and incidence of chronic kidney disease in the elderly

(2015) B. Sjöberg et al.   JOURNAL OF INTERNAL MEDICINE

Periodontal Inflammatory Burden and Salivary Matrix Metalloproteinase-8 Concentration Among Patients With Chronic Kidney Disease at the Predialysis Stage

(2015) Karita M. Nylund et al.   JOURNAL OF PERIODONTOLOGY

Loss of matrix metalloproteinase-8 is associated with worsened recovery after ischemic kidney injury

(2015) Rajit K. Basu et al.   RENAL FAILURE

CD14, TLR4 and TRAM Show Different Trafficking Dynamics During LPS Stimulation

(2015) Dionne C.G. Klein et al.   TRAFFIC

Caspase Functions in Cell Death and Disease: Figure 1.

(2015) David R. McIlwain et al.   Cold Spring Harbor Perspectives in Biology

Oral findings in chronic kidney disease: implications for management in developing countries

(2015) Elijah O Oyetola et al.   BMC Oral Health

Fusobacterium nucleatum Alters Atherosclerosis Risk Factors and Enhances Inflammatory Markers with an Atheroprotective Immune Response in ApoEnull Mice

(2015) Irina M. Velsko et al.   PLoS One

Outer Membrane Vesicle-Mediated Export of Processed PrtV Protease from Vibrio cholerae

(2015) Pramod K. Rompikuntal et al.   PLoS One

Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis

(2014) Tomoki Maekawa et al.   Cell Host & Microbe

The implication of periodontitis in vascular endothelial dysfunction

(2014) Abhijit N. Gurav   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Resveratrol improves oxidative stress and prevents the progression of periodontitis via the activation of the Sirt1/AMPK and the Nrf2/antioxidant defense pathways in a rat periodontitis model

(2014) Naofumi Tamaki et al.   FREE RADICAL BIOLOGY AND MEDICINE

Diverse Toll-Like Receptors Mediate Cytokine Production by Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans in Macrophages

(2014) Se-Ra Park et al.   INFECTION AND IMMUNITY

Aggregatibacter actinomycetemcomitans Outer Membrane Vesicles Are Internalized in Human Host Cells and Trigger NOD1- and NOD2-Dependent NF-κB Activation

(2014) Bernard Thay et al.   INFECTION AND IMMUNITY

Porphyromonas gingivalis Lipopolysaccharide Weakly Activates M1 and M2 Polarized Mouse Macrophages but Induces Inflammatory Cytokines

(2014) James A. Holden et al.   INFECTION AND IMMUNITY

Serum and Salivary Matrix Metalloproteinases, Neutrophil Elastase, Myeloperoxidase in Patients with Chronic or Aggressive Periodontitis

(2014) Nejat Nizam et al.   INFLAMMATION

An ignored cause of inflammation in patients undergoing continuous ambulatory peritoneal dialysis: periodontal problems

(2014) Ismail Kocyigit et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Miropin, a Novel Bacterial Serpin from the PeriodontopathogenTannerella forsythia, Inhibits a Broad Range of Proteases by Using Different Peptide Bonds within the Reactive Center Loop

(2014) Miroslaw Ksiazek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of Periodontitis and Bone Loss in Patients Undergoing Hemodialysis

(2014) Dan Zhao et al.   JOURNAL OF PERIODONTOLOGY

LPS fromP. gingivalisand Hypoxia Increases Oxidative Stress in Periodontal Ligament Fibroblasts and Contributes to Periodontitis

(2014) L. Gölz et al.   MEDIATORS OF INFLAMMATION

A pathogenic trace ofTannerella forsythia- shedding of soluble fully active tumor necrosis factor α from the macrophage surface by karilysin

(2014) D. Bryzek et al.   Molecular Oral Microbiology

Expression of Toll-Like Receptor 2 in Glomerular Endothelial Cells and Promotion of Diabetic Nephropathy by Porphyromonas gingivalis Lipopolysaccharide

(2014) Yoshihiko Sawa et al.   PLoS One

The odontogenic-related microinflammation in patients with chronic kidney disease

(2014) Iwona Niedzielska et al.   RENAL FAILURE

Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

(2013) Mara Roxana Rubinstein et al.   Cell Host & Microbe

Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology

(2013) Leticia Reyes et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Multi-organ injuries caused by lipopolysaccharide-induced periodontal inflammation in rats: role of melatonin

(2013) K. Gulle et al.   JOURNAL OF PERIODONTAL RESEARCH

Association Among Oral Health Parameters, Periodontitis, and Its Treatment and Mortality in Patients Undergoing Hemodialysis

(2013) Cleber M. de Souza et al.   JOURNAL OF PERIODONTOLOGY

Surgical Treatment for Patients With Periodontal Disease Reduces Risk of End-Stage Renal Disease: A Nationwide Population-Based Retrospective Cohort Study

(2013) Chun-Feng Lee et al.   JOURNAL OF PERIODONTOLOGY

Evolving importance of kidney disease: from subspecialty to global health burden

(2013) Kai-Uwe Eckardt et al.   LANCET

Porphyromonas gingivalis Regulates TREM-1 in Human Polymorphonuclear Neutrophils via Its Gingipains

(2013) Nagihan Bostanci et al.   PLoS One

Effect of Nonsurgical Periodontal Treatment on C-Reactive Protein Levels in Maintenance Hemodialysis Patients

(2013) Farin Kiany Yazdi et al.   RENAL FAILURE

Role of complement in host–microbe homeostasis of the periodontium

(2013) George Hajishengallis et al.   SEMINARS IN IMMUNOLOGY

Analysis of IL1 gene polymorphisms and transcript levels in periodontal and chronic kidney disease

(2012) Ana Paula Ribeiro Braosi et al.   CYTOKINE

Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen

(2012) Nagihan Bostanci et al.   FEMS MICROBIOLOGY LETTERS

Immune modulatory and antioxidant effects of melatonin in experimental periodontitis in rats

(2012) Adem Kara et al.   FREE RADICAL BIOLOGY AND MEDICINE

Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitis

(2012) Niki M. Moutsopoulos et al.   JOURNAL OF AUTOIMMUNITY

Leukotoxin (Leukothera®) Targets Active Leukocyte Function Antigen-1 (LFA-1) Protein and Triggers a Lysosomal Mediated Cell Death Pathway

(2012) Kristina M. DiFranco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil Serine Proteases Promote IL-1  Generation and Injury in Necrotizing Crescentic Glomerulonephritis

(2012) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The keystone-pathogen hypothesis

(2012) George Hajishengallis et al.   NATURE REVIEWS MICROBIOLOGY

Angiotensin II Receptor Blocker Improves Tumor Necrosis Factor-a-Induced Cytotoxicity via Antioxidative Effect in Human Glomerular Endothelial Cells

(2012) Yuki Izawa-Ishizawa et al.   PHARMACOLOGY

Chronic kidney disease and use of dental services in a united states public healthcare system: a retrospective cohort study

(2012) Vanessa Grubbs et al.   BMC Nephrology

Identification of periodontal pathogens and severity of periodontitis in patients with and without chronic kidney disease

(2011) Jessica A. Bastos et al.   ARCHIVES OF ORAL BIOLOGY

Relationships between periodontal inflammation, lipid peroxide and oxidative damage of multiple organs in rats

(2011) Takaaki Tomofuji et al.   BIOMEDICAL RESEARCH-TOKYO

Periodontitis and diabetes: a two-way relationship

(2011) P. M. Preshaw et al.   DIABETOLOGIA

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

NOD-Like Receptor Activation by Outer Membrane Vesicles fromVibrio choleraeNon-O1 Non-O139 Strains Is Modulated by the Quorum-Sensing Regulator HapR

(2011) H. Bielig et al.   INFECTION AND IMMUNITY

Risk factors for chronic kidney diseases may include periodontal diseases, as estimated by the correlations of plasma pentraxin-3 levels: a case–control study

(2011) A. R. Pradeep et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Periodontal health status and bacteraemia from daily oral activities: systematic review/meta-analysis

(2011) Inmaculada Tomás et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Extent and severity of chronic periodontitis in chronic kidney disease patients

(2011) F. Brito et al.   JOURNAL OF PERIODONTAL RESEARCH

Salivary infectious agents and periodontal disease status

(2011) I. Saygun et al.   JOURNAL OF PERIODONTAL RESEARCH

XCL1 and XCR1 in the immune system

(2011) Yu Lei et al.   MICROBES AND INFECTION

Aggregatibacter actinomycetemcomitans Leukotoxin: A Powerful Tool with Capacity to Cause Imbalance in the Host Inflammatory Response

(2011) Anders Johansson   Toxins

Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats

(2010) Bruno S. Herrera et al.   ARCHIVES OF ORAL BIOLOGY

Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway

(2010) Hiroki Takeuchi et al.   CELLULAR MICROBIOLOGY

C-reactive protein as a systemic marker of inflammation in periodontitis

(2010) A. Pejcic et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Effects of non-surgical periodontal therapy on the glomerular filtration rate of the kidney: an exploratory trial

(2010) Filippo Graziani et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Patients' experiences of the impact of periodontal disease

(2010) Louise K. O'Dowd et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

IL-17 in Sera from Patients with Aggressive Periodontitis

(2010) H.A. Schenkein et al.   JOURNAL OF DENTAL RESEARCH

The Th17 immune response in renal inflammation

(2010) Jan-Eric Turner et al.   KIDNEY INTERNATIONAL

Bidirectional relationship between chronic kidney and periodontal disease: a study using structural equation modeling

(2010) Monica A. Fisher et al.   KIDNEY INTERNATIONAL

Urinary levels of regenerating islet-derived protein III β and gelsolin differentiate gentamicin from cisplatin-induced acute kidney injury in rats

(2010) Laura Ferreira et al.   KIDNEY INTERNATIONAL

Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon’s knife to a meat chopper-like brutal degradation of proteins

(2010) Yonghua Guo et al.   PERIODONTOLOGY 2000

Microbial Hijacking of Complement-Toll-Like Receptor Crosstalk

(2010) M. Wang et al.   Science Signaling

Effect of non-surgical periodontal treatment on chronic kidney disease patients

(2010) Hilana Paula Carillo Artese et al.   Brazilian Oral Research

Definition and Classification of CKD: The Debate Should Be About Patient Prognosis—A Position Statement From KDOQI and KDIGO

(2009) Kai-Uwe Eckardt et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Complementation of the fadA Mutation in Fusobacterium nucleatum Demonstrates that the Surface-Exposed Adhesin Promotes Cellular Invasion and Placental Colonization

(2009) A. Ikegami et al.   INFECTION AND IMMUNITY

Periodontal disease adversely affects the survival of patients with end-stage renal disease

(2009) Abhijit V. Kshirsagar et al.   KIDNEY INTERNATIONAL

Renal Alterations in Prediabetic Rats With Periodontitis

(2008) Carla C. Pontes Andersen et al.   JOURNAL OF PERIODONTOLOGY

Clinical and Serologic Markers of Periodontal Infection and Chronic Kidney Disease

(2008) Monica A. Fisher et al.   JOURNAL OF PERIODONTOLOGY

Detection of oral bacteria in cardiovascular specimens

(2008) K. Nakano et al.   Oral microbiology and immunology