Article
Chemistry, Physical
Ismahene Ben Khemis, Houda Smati, Fatma Aouaini, Salah Knani, Abdelmottaleb Ben Lamine
Summary: The adsorption mechanism of musk tibetene, muscone, and dihydrocivetone on the human musk olfactory receptor OR5AN1 has been investigated using statistical physics. Two advanced adsorption models derived from statistical physics approach were fitted to experimental data, showing a good correlation. The findings provide important insights into the adsorption process and contribute to a better understanding of olfaction.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Plant Sciences
Bingbing Han, Yangang Zhao, Jing Yao, Na Li, Tianhe Fang, Yuan Wang, Zhaoqing Meng, Wei Liu
Summary: This study aimed to identify the target of muscone in the treatment of ischemic stroke using network pharmacology, an animal model of ischemic stroke, and differential proteomics. The results showed that muscone can reduce neuronal necrosis, protect the blood-brain barrier, and improve neurological damage caused by cerebral ischemia mainly through the regulation of neuronal synaptic connections. Muscone is an important active component responsible for the consciousness-restoring resuscitation effect of musk on ischemic stroke.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Meng Ding, Jun-Li Fan, Dong-Fang Huang, Yue Jiang, Meng-Ning Li, Yu-Qing Zheng, Xiao-Ping Yang, Ping Li, Hua Yang
Summary: A metabolomics-based strategy was developed to discriminate natural and artificial musk, and two chemical markers were selected for the identification of musk in traditional Chinese medicine preparations.
Article
Zoology
Xinyu Bo, Jialing Chen, Jinzhan Mu, Xianggui Dong, Zhanjun Ren, Jinyao Liu, Shuhui Wang
Summary: This study successfully changed the hormone levels, intestinal microorganisms, and musk microorganisms of male forest musk deer (FMD) by predicting the function of quercetin and adding it to their diet. The addition of quercetin significantly increased the production of muscone, the most effective ingredient in musk, while reducing the stress during musk secretion, thereby protecting the health of FMD.
INTEGRATIVE ZOOLOGY
(2023)
Article
Biology
Naixiu Yuan, Yuhong Qin, Jing Wang, Liquan Shen, Haoxiang Gao, Rongwei Xiang, Yinjiu Zhu, Yong Li, Mi Zhou, Shoulin Bai, Yan Sheng, Xiuxiang Meng
Summary: The study found that muscone content decreases with age and poor health, while adults have significantly higher muscone content than older individuals and healthy males have significantly higher muscone content than weaker ones. However, mating history or captive environment had insignificant effect on muscone levels.
Review
Plant Sciences
Wen-jin Zhang, Zhen-yu Zhao, Li-kun Chang, Ye Cao, Sheng Wang, Chuan-zhi Kang, Hong-yang Wang, Li Zhou, Lu-qi Huang, Lan-ping Guo
Summary: Atractylodis Rhizoma, including Atractylodes lancea and Atractylodes chinensis, is widely used in East Asia for its diuretic and stomachic properties, as well as its treatment of rheumatic diseases, digestive disorders, night blindness, and influenza. Research has shown that it contains a variety of medicinal components and exhibits various pharmacological activities, particularly in improving gastrointestinal function.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Wenhua Chen, Jiemiao Lu, Jiahao Zhang, Jianjun Wu, Lilong Yu, Luping Qin, Bo Zhu
Summary: Dendrobium officinale is a well-known plant used as a medicinal and food homologous product, containing various bioactive components and exhibiting diverse biological functions. The review summarizes research progress and aims to better understand the botany, traditional use, phytochemistry, pharmacology, quality control, and safety of D. officinale, providing references and potential directions for further studies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Yurong Zhao, Shuaixian Tao, Qiang Wang, Yan Liu, Wenke Yang, Shoude Zhang, Zhanhai Su, Xueman Ma
Summary: This study investigated the mechanism of action of muscone on breast cancer using network pharmacology and molecular docking techniques. The results suggest that muscone may exert anti-breast cancer effects through cancer pathways, ovarian steroidogenesis, and TNF signaling pathways, and has the potential to be developed as a clinical agent.
TRANSLATIONAL CANCER RESEARCH
(2022)
Review
Plant Sciences
Yi Xu, Junyu Liu, Yuanlian Zeng, Shenrui Jin, Wentao Liu, Zulun Li, Xuhua Qin, Yaolin Bai
Summary: Aralia, belonging to the Araliaceae family, has a long medicinal history and is widely used in the treatment of various diseases. More than 290 chemical constituents have been isolated from Aralia, showing a wide range of pharmacological activities. Further research is needed to understand the structure-activity relationship and safety of its bioactive components.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Plant Sciences
Linna Gong, Wei Zou, Keyang Zheng, Birui Shi, Menghua Liu
Summary: Herba Patriniae has been used traditionally in China for treating various diseases, with differences found between the two official recorded species in terms of phytochemistry, pharmacological effects, and compound contents. Further research on systematic pharmacology, quality control, pharmacokinetics, and clinical studies is needed for better clinical use.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Chunjiao He, Junyu Liu, Tongwei Ke, Yawen Luo, Shaowu Zhang, Ting Mao, Zulun Li, Xuhua Qin, Shenrui Jin
Summary: Pyrolae herba is a traditional Chinese medicine with diverse pharmacological activities such as anti-inflammatory, anti-bacterial, and antioxidant effects. However, there is limited research on the relationship between its chemical constituents and pharmacodynamics, calling for further investigation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Haiyan Jiang, Yaxin Zhang, Zhigang Liu, Xiangyi Wang, Jiuming He, Hongtao Jin
Summary: This paper summarizes the advanced applications of mass spectrometry imaging (MSI) technology in quality control, safety evaluations, and determination of toxicity mechanisms of Traditional Chinese Medicines (TCMs). MSI is a new analytical imaging technology that can detect and image metabolic changes of multiple components of TCMs in a high throughput manner. It has unique advantages in metabolic analysis, quality control, and action mechanism explorations of TCMs, contributing to the establishment of quality standards and exploring the safety and toxicology of TCMs.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Plant Sciences
Shujuan Chen, Lin Dong, Hongfeng Quan, Xirong Zhou, Jiahua Ma, Wenxin Xia, Hao Zhou, Xueyan Fu
Summary: Coltsfoot, known as a vital folk medicine, has diverse uses in traditional medicine, particularly for relieving inflammatory conditions and respiratory diseases. Many traditional uses are supported by modern pharmacological studies, but adverse events have resulted from the collection of the wrong plant containing toxic alkaloids.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Feng Wei, Xinzhou Yang, Kejian Pang, Hui Tang
Summary: Alhagi sparsifolia, commonly known as Kokyantak, is a traditional ethnic medicine used in Uyghur medicine for a variety of conditions. Studies have shown that it has antioxidant, anti-tumor, and organ-protective effects, with a high level of safety. Additionally, it serves as an important local source of nectar and forage grass, playing a crucial role in improving the ecological environment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Shuaishuai Chen, Xiaojuan Yang, Ziying Wei, Yanru Zhang, Ying Huang, Zhuo Shi, Ziteng Zhang, Jiabo Wang, Haizhu Zhang, Jianli Ma, Xiaohe Xiao, Ming Niu
Summary: This study used Lianhua Qingwen capsule as an example to investigate the feasibility of a bioassay for quality control, identifying its anti-inflammatory target through network pharmacology and establishing a bioassay method for quality evaluation. The results indicated that the bioassay was better at discriminating the quality variations of Lianhua Qingwen capsule compared to routine chemical determination methods.
PHARMACEUTICAL BIOLOGY
(2021)
Review
Infectious Diseases
Mao Deng, Huijuan Chen, Jiaying Long, Jiawen Song, Long Xie, Xiaofang Li
Summary: CA is a phytoestrogen with a wide range of pharmacological activities, including anticancer, anti-inflammatory, anti-osteoporosis, neuroprotection, hepatoprotection, etc. It is promising for the treatment of many diseases. Future research directions may include conducting clinical trials, exploring the synergistic mechanism of CA with other drugs, and finding ways to increase the blood circulation concentration of CA.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2021)
Review
Pharmacology & Pharmacy
Kai Liu, Xumin Zhang, Long Xie, Mao Deng, Huijuan Chen, Jiawen Song, Jiaying Long, Xiaofang Li, Jia Luo
Summary: Lupeol, a natural triterpenoid found in fruits, vegetables, and medicinal plants, exhibits a wide range of pharmacological activities including anticancer, antioxidant, anti-inflammatory, and antimicrobial properties. Studies have shown that structural modifications to lupeol can lead to stronger bioactivities, such as antiprotozoal or anticancer effects.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Xumin Zhang, Long Xie, Jiaying Long, Qingxuan Xie, Yu Zheng, Kai Liu, Xiaofang Li
Summary: Salidroside, identified as a potent compound from Rhodiola plants, has various synthetic routes to address the contradiction between supply and demand, laying a foundation for new drug development. This promising drug shows diverse pharmacological properties, including cardiovascular, central nervous system activities, anti-fatigue, anti-cancer, anti-inflammatory, and antioxidant activities. Further research is needed to fully analyze its overall pharmacological aspects and provide references for its development and utilization.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Pharmacology & Pharmacy
Huijuan Chen, Mao Deng, Long Xie, Kai Liu, Xumin Zhang, Xiaofang Li
Summary: This study investigated the potential of gypenosides as natural stabilizers for the production of nanosuspensions. The results showed that gypenosides had superior stabilization efficiency compared to conventional stabilizers at low concentrations. Nanosuspensions stabilized by gypenosides exhibited smaller particle size, higher dissolution rate, and antioxidant activity compared to the coarse drug. The stability studies also demonstrated good storage stability for nanosuspensions stabilized with gypenosides.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Plant Sciences
Xian Wang, Long Xie, Jiaying Long, Kai Liu, Jing Lu, Youdan Liang, Yi Cao, Xiaolin Dai, Xiaofang Li
Summary: This review compiled the efficacy of baicalin in treating inflammatory bowel disease, showing that its mechanisms mainly include anti-inflammation, antioxidant, immune regulation, maintenance of intestinal barrier, and maintenance of intestinal flora balance.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Mao Deng, Huijuan Chen, Long Xie, Kai Liu, Xumin Zhang, Xiaofang Li
Summary: This study demonstrates the importance of tea saponins as emulsifiers and cryoprotectants in preparing silymarin nanoemulsion and preventing damage during freeze-drying. Tea saponins improve the solubility and stability of silymarin.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Kai Liu, Long Xie, Huan Gu, Jia Luo, Xiaofang Li
Summary: In this study, water-soluble oligosaccharides were extracted from red yeast rice using ultrasonic-assisted extraction method. The structural characterization of the extracted oligosaccharide RYRO1 revealed its antioxidant properties. Optimization of extraction parameters led to the discovery of a new oligosaccharide with potential health benefits.
FOOD SCIENCE & NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Meng-Ting Li, Long Xie, Hai-Mei Jiang, Qun Huang, Rong-Sheng Tong, Xiang Li, Xin Xie, Hong-Mei Liu
Summary: This review provides a comprehensive update on the pharmacology of Licochalcone A (LA) over the past decade. LA has been found to possess multiple pharmacological properties and acts through various signaling pathways. Recent studies have primarily focused on the anticancer properties of LA, highlighting the need for further research on other aspects of its pharmacology. The review is divided into three parts based on the pharmacological effects of LA, providing insights for future research.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Hongmei Liu, Yunyun Quan, Long Xie, Xiang Li, Xin Xie
Summary: Direct functionalization of inert C-H bonds is a powerful strategy for constructing complex structures. However, existing methods face challenges in meeting the requirements of modern green chemistry. Over the past decades, the use of hydride shift activation in the functionalization of inert C(sp(3))-H bonds has gained attention. This review summarizes the significant advances in cascade [1,5]-hydride shift/intramolecular C(sp(3))-H functionalization, focusing on the synthesis of spiro-tetrahydroquinoline derivatives containing various pharmaceutical units. Current limitations and future directions in this field are also discussed.
FRONTIERS IN CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Youdan Liang, Xiaolin Dai, Yi Cao, Xian Wang, Jing Lu, Long Xie, Kai Liu, Xiaofang Li
Summary: The global epidemic of diabetes has led to increased pressure on public health, necessitating the development of new effective anti-diabetes strategies. Trigonelline, the main component of fenugreek, has been proven to have therapeutic effects on diabetes and its complications. The mechanisms by which trigonelline ameliorates diabetes include modulation of insulin secretion, reduction of oxidative stress, and improvement of glucose tolerance and insulin resistance. Additionally, trigonelline has been reported to possess neuroprotective properties against neurologic diseases such as Alzheimer's disease, Parkinson's disease, stroke, and depression. Comprehensive clinical trials are needed to evaluate the potential therapeutic effects of trigonelline.
Article
Biophysics
Jing Lu, Long Xie, Anxin Wu, Xian Wang, Youdan Liang, Xiaolin Dai, Yi Cao, Xiaofang Li
Summary: Silybin-loaded zein-pullulan nanoparticles were prepared to improve the water solubility and chemical stability of silybin, a natural flavonoid used in the treatment of cirrhosis. The optimized nanoparticles showed uniform distribution, smooth spherical shape, and high encapsulation efficiency. In vitro experiments demonstrated sustained release of silybin and enhanced antioxidant capacity using this novel delivery system.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Yuke Li, Long Xie, Kai Liu, Xiaofang Li, Fan Xie
Summary: This study compared the flowers, stems, and leaves of Lonicera japonica and found that they have high homogeneity in major bioactive components. However, differences in chemical component content may contribute to variations in their anti-inflammatory, anti-microorganism, and antioxidative activities. Notably, the leaves exhibited significant activities, even more active than the flowers.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xian Wang, Jing Lu, Yi Cao, Youdan Liang, Xiaolin Dai, Kai Liu, Long Xie, Xiaofang Li
Summary: This study aimed to compare the solubilization and emulsification abilities of tea saponins (TS), glycyrrhizic acid (GA), and their combination (the concentration ratio = 1:1, TS-GA). The results showed that TS-GA had higher solubilization capacity than the calculated value and exhibited superior stability in terms of ionic strength, temperature, and pH. The nanoemulsions formed by TS, GA, and TS-GA had small particle size, suitable turbidity, and absolute value of zeta potential.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Plant Sciences
Yu Zheng, Long Xie, Dejun Yang, Kaipei Luo, Xiaofang Li
Summary: This review examines the recent domestic and international studies on hepatic stellate cells (HSCs) targeting HSC pathways and the therapeutic effects of small molecule plants. The results demonstrate that plant monomers can inhibit HSC activation and proliferation, and promote HSC apoptosis through various pathways, leading to anti-liver fibrosis effects. The exploration of the structure-activity relationship between plant monomers and LF also provides new insights for the development of novel pharmaceuticals.
Review
Pharmacology & Pharmacy
Long Xie, Yu-Xin Zhao, Yu Zheng, Xiao-Fang Li
Summary: Platycodon grandiflorus A. DC. (PG) was widely used by Chinese doctors in ancient times to treat lung carbuncles. Modern clinical experiences have shown that PG has significant effects in treating chronic pharyngitis, plum pneumonia, pneumoconiosis, acute and chronic laryngitis, etc. Platycodin D (PLD), an active substance in PG, has been found to have various pharmacological activities, including anti-inflammatory, anti-viral, anti-oxidation, anti-obesity, anticoagulant, spermicidal, and anti-tumor effects.
FRONTIERS IN PHARMACOLOGY
(2023)