Article
Engineering, Biomedical
Megan K. DeBari, Xiaodan Niu, Jacqueline V. Scott, Mallory D. Griffin, Sean R. Pereira, Keith E. Cook, Bin He, Rosalyn D. Abbott
Summary: The study reveals that therapeutic ultrasound can noninvasively trigger enhanced degradation of silk fibroin scaffolds by removing microbubbles on the scaffold surface. This ultrasound-responsive biomaterial is proven safe for human cells and effectively triggers scaffold degradation through human skin, increasing clinical relevance. The degradation profile can be adjusted noninvasively to improve regenerative outcomes.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Hao Miao, Runqing Shen, Wenhai Zhang, Zaifu Lin, Hao Wang, Likun Yang, Xiang-Yang Liu, Naibo Lin
Summary: Silk fibroin scaffolds with a near-infrared light response show significant cytotoxicity to MG63 cancer cells, making them potentially useful for bone tumor treatment. The superior structure and performance of these scaffolds also demonstrate great potential for photothermal therapy applications.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Chuang Wang, Maihao Zhu, Hou-Yong Yu, Somia Yassin Hussain Abdalkarim, Zhaofeng Ouyang, Jiaying Zhu, Juming Yao
Summary: The study demonstrates that incorporating cellulose nanocrystals with acrylamide photopolymerization can produce robust silk fibroin gels with excellent mechanical stability and adhesion to various materials. The gel can rapidly recover its ionic conductivity within 20 seconds and stretch to a maximum strain of 498% after healing for 10 hours with an efficiency of 95.2%.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Tingting Huang, Zhihao Zhou, Qiaoyuan Li, Xiaoxuan Tang, Xiaoli Chen, Yifan Ge, Jue Ling
Summary: A light responsive hemostatic film was developed for effective handling of liver bleeding, achieving excellent tissue adhesion and hemostasis within 2 minutes of UV exposure. The film has potential as a multifunctional biomedical material in tissue repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Liyang Zhao, Yuan Tian, Xiangnan Wang, Dingdong Liu, Yifan Xie, Jingang Hu, Gang Zou
Summary: Recently, polymerization-induced self-assembly (PISA) has gained significant attention as a novel approach for synthesizing functional polymer nanomaterials. However, the current understanding of the PISA process and gelation behavior is limited. In this study, we proposed a new PISA formulation based on light-triggered thiol-ene based click polymerization and gelation. The photoluminescence of polymers with nonaromatic chromophores was found to be highly dependent on molecular arrangement, which could be utilized for in situ monitoring of the PISA process.
Article
Chemistry, Multidisciplinary
Wei Chen, Hao Miao, Guoqing Meng, Kailun Huang, Lingqing Kong, Zaifu Lin, Xudong Wang, Xiaobao Li, Jinghan Li, Xiang-Yang Liu, Naibo Lin
Summary: Polydopamine-induced functionalization of regenerated silk fibroin fibers results in materials with photothermal conversion ability and flexibility. These materials can adjust their temperature under light and heat irradiation and exhibit effective photothermal cytotoxicity both in vitro and in vivo. Therefore, they have the potential for use in flexible wearable electronic devices.
Article
Biochemistry & Molecular Biology
Zhuochen Lv, Ting Shu, Jing Ren, Leitao Cao, Ying Pei, Zhengzhong Shao, Shengjie Ling
Summary: Mechanical training of silk materials leads to the rapid formation of a molecular cross-linking network, enhancing the mechanical properties. The study categorizes the structural evaluation of silk proteins during mechanical training into three stages and establishes a five-parameter viscoelastic model to understand the structure-property relationship. This research provides insights into the design of soft silk functional materials.
Article
Chemistry, Multidisciplinary
Hui Zhang, Hong Chen, Ling Lu, Huan Wang, Yuanjin Zhao, Renjie Chai
Summary: This paper presents a novel multifunctional delivery system using silk fibroin-polydopamine composited inverse opal microcarriers for inner ear drug delivery and noise-induced hearing loss therapy. The microcarriers can rapidly load active biomolecules and remain in the round window niche for precise local and directed drug delivery to the inner ear.
Article
Chemistry, Physical
Suman Nayak, Prolay Das, Manoj K. Singh
Summary: Aggregation Induced Emission (AIE) from Carbon Dots (CDs) is typically induced by hydrophobic interactions, but this study revealed AIE in predominantly hydrophilic pristine CDs. The emission from CDs shifted from yellow to blue in acidic and alkaline conditions, respectively, with irreversible changes observed in the latter. pH-triggered disintegration of CD aggregates in alkaline medium was observed through microscopic and Light Scattering studies.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2021)
Review
Chemistry, Analytical
Fengli Gao, Gang Liu, Mingyi Qiao, Yingying Li, Xinyao Yi
Summary: Enzymes are critical in complex biochemical processes and can be used as biomarkers for disease diagnosis. This work summarizes the advances in AIE-based probes and sensing platforms for the fluorescent detection of enzymes, including proteases, phosphatases, glycosidases, cholinesterases, telomerase, and others. The AIEgens used in this study involve organic dyes and metal nanoclusters, providing valuable references for the design of novel AIE-based sensing platforms.
Article
Biochemistry & Molecular Biology
Huanhuan Qiao, Shujie Wang, Li Liu, Wei Wu, Leitao Cao, Zhongkai Wang, Ke Zheng
Summary: Silk fibroin birefringent fibers (SBFs) with tunable birefringence were successfully fabricated using an injection technique and binary solvent-exchange-induced self-assembly (BSEISA) strategy. External stimuli such as tensile force and solvent swelling were critical to the structural deformation and birefringence of the SBFs. This study demonstrated the potential of SBFs as sensors and code labels for optical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Ziyang Sun, Haoran Liu, Dandan Dai, Hao Lyu, Ruochuan Huang, Wenzhao Wang, Chengchen Guo
Summary: This study presents a promising injectable cell-laden hydrogel system based on silk acid, which exhibits good cytocompatibility and injectability. The hydrogel has potential applications in 3D cell culture, targeted cell delivery, and tissue engineering.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Giorgio Rizzo, Marco Lo Presti, Cinzia Giannini, Teresa Sibillano, Antonella Milella, Giulia Guidetti, Roberta Musio, Fiorenzo G. Omenetto, Gianluca M. Farinola
Summary: Silk Fibroin (SF) obtained from Bombyx mori can be processed into scaffolds from aqueous solutions using chaotropic salts. By modifying the standard Ajisawa's method with CeCl3, it is possible to regenerate SF as a fibrous material with an ordered structure and doped with Ce+3 ions. Lanthanide ions are found to solubilize SF and favor the reprecipitation of fibrous SF, making them potential candidates for developing new photonic systems.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lifeng Xu, Jungang Cao, Shuangling Zhong, Jingfei Wang, Yongyan Yang, Yan Gao, Xuejun Cui
Summary: Tilapia skin collagen is an abundant protein with aggregation-induced emission property, which has important research significance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Analytical
Xiaoye Wen, Fang Li, Yan Wang, Zhefeng Fan
Summary: A ratiometric fluorescence system (SiNPs@CuNCs) based on aggregation-induced emission (AIE) strategy was designed to directly detect acetylcholinesterase (AChE) activity without any intermediate quencher. This system showed high sensitivity and reliability for the quantitative detection of AChE.
MICROCHEMICAL JOURNAL
(2023)
